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Saturday, April 12, 2025

'Fetterman explains how GLP-1 drugs changed his life

 A U.S. senator said a GLP-1 drug changed his life — and now he’s calling for widespread access to anti-obesity medications.

In a New York Times op-ed on April 8, Sen. John Fetterman, D-Pa., wrote about his experience with Mounjaro (tirzepatide).

The injectable prescription medicine is primarily used to treat type 2 diabetes. 

Fetterman was prescribed the medication in July 2024.

“As a stroke survivor, I was interested in studies showing [Mounjaro] could significantly reduce the risk of major cardiac events,” the senator wrote.

“Even though I started taking it for my heart health, I’ve been struck by how much better it has made me feel across the board. It’s made a significant impact on my overall health,” he continued. 

“Aches, pains and stiffness have vanished. Physically, I feel a decade younger, as well as clearer-headed and more optimistic than I’d been in years. As far as side effects, I’ve also lost around 20 pounds.”

Senator John Fetterman is calling for widespread access to anti-obesity medications after his experience with the medication known as Mounjaro.AFP via Getty Images

Beyond lowering blood sugar, GLP-1 medications have also been linked to a range of other benefits, including improved heart health, neurological function and metabolic health, as Fox News Digital has reported.

Eli Lilly, maker of Mounjaro, also offers another version of the drug called Zepbound, which is the same medication approved for weight loss, chronic weight management and sleep apnea. 

“Aches, pains and stiffness have vanished. Physically, I feel a decade younger, as well as clearer-headed and more optimistic than I’d been in years,” Fetterman wrote in a New York Times op-ed.REUTERS

Other GLP-1 medications include Ozempic, Wegovy, Victoza, Saxenda, all made by Novo Nordisk.

Fetterman noted that GLP-1 drugs have been found to have beneficial effects on cholesterol, heart rate and heart inflammation. 

“Some recent studies suggest they might even help curb alcohol addiction and support cognitive function, potentially slowing or preventing conditions like Parkinson’s and Alzheimer’s,” he wrote in the Times op-ed.

GLP-1 medications like Ozempic, Wegovy, Victoza and Saxenda can improve heart health, neurological function and metabolic health.REUTERS

“Physically, I feel a decade younger, as well as clearer-headed and more optimistic than I’d been in years.”

In the op-ed, Fetterman called for expanded access to these medications, which can cost up to $1,000 out of pocket if not covered by insurance.

“Currently, Medicare covers these drugs only under specific circumstances, such as for diabetes or heightened heart risk,” he wrote. “And Medicaid coverage is even more limited.”

Fetterman added that he was not compensated for sharing his experience.

“I’m just a guy who has benefited from these medications and wants to make sure that anyone else who could benefit from them can have access to them, too,” Fetterman wrote.AP

“I’m just a guy who has benefited from these medications and wants to make sure that anyone else who could benefit from them can have access to them, too,” he wrote.

While Fetterman shares HHS Sec. Robert F. Kennedy Jr.’s views of prioritizing nutrition and healthy living, he said he believes the medications are necessary for some.

“I fully agree that diet and lifestyle matter — a lot. But diet alone isn’t enough,” he wrote. 

While Fetterman says nutrition is important, he believes this medication can be necessary for some cases.Michael Brochstein/SOPA Images/Shutterstock

“For the millions of Americans struggling with serious health issues, medication can be a crucial first step to regaining enough control of their health to begin making meaningful lifestyle changes.”

Doctors discuss benefits and access

Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health and Fox News’ senior medical analyst, noted that semaglutides, including Ozempic and Wegovy, are “very important drugs” for type 2 diabetes, with increasing use for obesity. 

“Though these drugs appear to have beneficial uses for the heart and lipid profile — and also the brain and decreasing dementia risk — studies are ongoing and more data is still needed,” he told Fox News Digital.

The first approach to obesity is lifestyle changes, including exercise, improved diet and optimal sleep, Siegel said.

“Having said that, these weight-loss drugs (including Zepbound) are also good tools when lifestyle is not enough,” he noted. 

“They help prevent down-the-line diseases such as heart disease, stroke, high blood pressure and sleep apnea, which tend to come from obesity.”

He added, “Overall, we are saving the healthcare system money, so I would like to see Medicare and Medicaid approve them for diabetes and weight loss.”

“They help prevent down-the-line diseases such as heart disease, stroke, high blood pressure and sleep apnea, which tend to come from obesity,” Dr. Marc Siegel, clinical professor of medicine at NYU Langone Health, said.Bloomberg via Getty Images

Dr. Brett Osborn, a Florida neurologist and longevity expert, said he’s been prescribing GLP-1s to his patients since 2019.

“Mounjaro and its cousins aren’t just weight-loss tools — they’re metabolic reset buttons,” he told Fox News Digital.

“People with metabolic syndrome don’t need lectures on kale and the importance of exercise. They need help.” 

“People with metabolic syndrome don’t need lectures on kale and the importance of exercise. They need help,” Dr. Brett Osborn, a Florida neurologist who has been prescribing GLP-1s to his patients since 2019, said.REUTERS

Osborn agreed that lifestyle is essential, but is “rarely sufficient.”

“GLP-1s give patients momentum by getting the ball rolling,” he said. “And when that happens, health habits are formed. Diet improves. Movement improves. People start to feel the benefits of healthy living.”

Osborn noted that these medications aren’t cosmetic, but therapeutic. 

“I’ve seen what they can do firsthand: reductions in body fat, inflammation, glucose, triglycerides and insulin resistance — and with those, significant reductions in the incidence of stroke and heart attack.”

“I believe this is a signal aimed squarely at Big Pharma.”

President Donald Trump’s administration recently announced that Medicare and Medicaid would not cover the medications, as the Centers for Medicare and Medicaid Services said late Friday.

Osborn said the move to block coverage likely doesn’t have to do with efficacy.

“Trump knows these medications work,” Osborn said. “I believe this is a signal aimed squarely at Big Pharma: ‘Lower the price, or Medicare, the biggest buyer on the block, is out.’”

“This isn’t a dismissal — it’s leverage,” Osborn said, stating his opinion on the matter. “President Trump will likely negotiate until the ‘price is right,’ disempowering Big Pharma while concomitantly bettering the health of Americans.”

https://nypost.com/2025/04/12/us-news/senator-john-fetterman-says-mounjaro-makes-him-feel-a-decade-younger/

South Bow plans to restart Keystone at reduced rates by Tuesday

 South Bow plans to restart the Keystone pipeline by Tuesday, April 15, the company said on Saturday, after it shut the key conduit for the flow of Canadian oil to the U.S. due to an oil spill in North Dakota.

South Bow still needs written approval from the U.S. Pipeline and Hazardous Materials Safety Administration (PHMSA) before restarting the pipeline, the company said. Even after it restarts, Keystone will operate at reduced rates in the U.S. to address a corrective action order issued by the PHMSA on Friday, the company said.

Keystone will also reduce pressure on the Canadian sections of the pipeline, and it has notified with the Canada Energy Regulator of that, it said.

PHMSA earlier on Friday said that Keystone's history of issues shows a pattern of more frequent and larger oil spills on the over 600,000-barrel-per-day pipeline.

A 2021 report from the U.S. Government Accountability Office found 22 spills from the pipeline between 2010 and 2020.

PHMSA has also ordered South Bow to re-evaluate previous inspection tests of the pipeline, and conduct new mechanical and metallurgical testing. South Bow has also agreed to conduct a root cause failure analysis.

Keystone was pumping about 17,844 barrels of oil per hour when a part of the pipeline ruptured on Tuesday near Fort Ransom, North Dakota, spilling an estimated 3,500 barrels onto agricultural land.

As of 1 a.m. CDT on April 11, around 1,170 barrels of the spill had been recovered and cleanup operations were ongoing, according to the PHMSA.

The regulator said this week's rupture looked similar to another one on the same pipeline in North Dakota in 2019, in which over 4,000 barrels of oil were leaked. Initial findings of PHMSA's investigation show the failed pipe in both incidents was manufactured by Berg Steel Pipe.

Berg Steel did not immediately respond to a request for comment.

https://ca.finance.yahoo.com/news/south-bow-plans-restart-keystone-143347037.html

Germany's likely next chancellor casts doubt on coalition pledges

Germany's conservative chancellor-in-waiting has cast doubt on some of the commitments he had made to secure a coalition with the Social Democrats, hinting that his government might not deliver on promises of lower income tax cuts and minimum wage hikes.

Friedrich Merz, who won the February 23 national election, has seen his poll ratings slide following the coalition agreement he reached two weeks ago - the only two-way coalition available if he sticks to his pledge to keep the second-placed far-right Alternative for Germany out of power.

His hints, however, are likely to add to dissatisfaction in the SPD, whose 350,000 members must approve in a membership ballot the leadership's decision to place the old school conservative hard-liner in the German chancellery.

"We haven't agreed to that," he said of the SPD's assertion that the minimum wage would rise to 15 euros an hour by 2026 in an interview with the Bild am Sonntag newspaper. "We agreed that the minimum wage commission is thinking in that direction."

On plans for a low- and middle-income tax cut, he said: "That's not certain... We want to cut income taxes if the budget allows it."

Merz's party does not face a major election for almost a year, while the SPD membership ballot must be completed by the end of this month. His sagging popularity - the result of partly going back on campaign pledges not to borrow more - has propelled the far-right into first place in polls for the first time since World War Two.

His comments reflect the letter of the coalition agreement, and SPD co-leader Lars Klingbeil has also said that everything in it is conditional on public finances.

If the SPD membership agrees, the Bundestag will appoint Merz as chancellor on May 6. The loquacious 69-year-old, who has never held a government job, has a reputation for verbal gaffes that sometimes alienate supporters.

A poll this week found that almost two-thirds of voters thought Merz, who would take office at a time of unprecedented diplomatic and economic crisis, was unsuited for the job of chancellor, with even 28% of his own party's voters agreeing.

If the SPD rejected the coalition, Merz's party would have the choice of either seeking a different deal, perhaps with more concessions under a different leader, breaking the taboo against cooperating with the far right, or calling fresh elections.

https://www.yahoo.com/news/germanys-likely-next-chancellor-casts-220342758.html

Trump says nuclear talks with Iran are going 'OK'



US President Donald Trump said talks concerning Iran’s nuclear programme were “going pretty good”.

More negotiations are scheduled for next week, according to Iranian state television, after Saturday saw the first round of talks between the two countries since the Obama administration.

Iran’s state-run broadcaster revealed that US Middle East envoy Steve Witkoff and Iranian foreign minister Abbas Araghchi “briefly spoke” together.

Mr Trump told reporters on Air Force One on Saturday while flying to Miami for a UFC event that the talks are “going OK”.

“I can’t tell you because nothing matters until you get it done, so I don’t like talking about it, but it’s going OK. The Iran situation is going pretty good, I think,” he said.

The next round of talks will take place on April 19, according to the Iranian and American statements.

In a statement released on Saturday afternoon, the White House described the discussions in Oman as “very positive and constructive,” while conceding the issues that need to be resolved are “ very complicated”.

“Special Envoy Witkoff’s direct communication today was a step forward in achieving a mutually beneficial outcome,” the White House said.

Mr Araghchi described the meeting as constructive to Iranian state TV, with four rounds of messages exchanged during the indirect portion.

“Neither we nor the other side are interested in fruitless negotiations — so-called ‘talks for the sake of talks’, wasting time, or drawn-out, exhausting negotiations,” he said.

“Both sides, including the Americans, have said that their goal is also to reach an agreement in the shortest possible time. However, that will certainly not be an easy task.”

He sought to downplay the encounter as “a brief initial conversation, greetings and polite exchanges” — likely to avoid drawing the anger of hard-liners in Iran.

Badr al-Busaidi, Oman’s foreign minister who shuttled between the two sides, said the countries have a “shared aim of concluding a fair and binding agreement.”

“I would like to thank my two colleagues for this engagement, which took place in a friendly atmosphere conducive to bridging viewpoints and ultimately achieving regional and global peace, security and stability,” Mr al-Busaidi wrote on X. “We will continue to work together and put further efforts to assist in arriving at this goal.”

That the two men spoke face-to-face satisfied a demand of the Americans. Mr Trump and Mr Witkoff both had described the talks as being “direct”.

Mr Trump repeatedly has threatened to unleash airstrikes targeting Iran’s nuclear programme if a deal is not reached.

Iranian officials have increasingly warned they could pursue a nuclear weapon with their stockpile of uranium enriched to near weapons-grade levels.

https://uk.news.yahoo.com/trump-says-nuclear-talks-iran-013741438.html

Trump says Ukraine-Russia talks might be going ok

 Trump says Ukraine-Russia talks might be going ok, adding there's a time when you have to put up or shut up.

At a meeting between US and Russian envoys earlier this week, it was said that the fastest way to broker a ceasefire in Ukraine was to support a strategy that would give Russia ownership of four eastern Ukrainian regions it attempted to annex illegally in 2022, people familiar with the situation told Reuters.


https://www.jpost.com/breaking-news/article-849951

Alphabet, Nvidia invest in OpenAI co-founder Sutskever's SSI, source says

 Alphabet and Nvidia have joined prominent venture capital investors to back Safe Superintelligence (SSI), a startup co-founded by OpenAI's former chief scientist Ilya Sutskever that has quickly risen to become one of the most valuable artificial intelligence startups months after its launch, a source familiar with the matter said.

The funding illustrates renewed interest from the big tech and infrastructure providers in making strategic investments in the startups developing cutting-edge AI that requires massive amounts of computing power. Alphabet, which has its own AI models, earlier in the week announced a deal by its cloud computing arm to sell SSI access to tensor processing units (TPUs), its in-house AI chips.

SSI, which sources say was recently valued at $32 billion in a round led by Greenoaks, is one of the highest-profile startups working on AI model research, thanks to Sutskever's stellar track record in predicting the next big thing in AI development.

Like many of its competitors, it has a huge demand for chips.

Reuters could not determine the exact terms of Alphabet's and Nvidia's investment in SSI. Spokespeople for all three companies declined to comment.

The twin moves by Alphabet's corporate and cloud division with high-profile AI labs including SSI and Anthropic show the tech giant's evolving AI hardware strategy.

Google originally reserved TPUs for in-house use. The deal to sell SSI chips in significant quantities to support its frontier AI research exemplifies the company's ongoing strategy to expand sales to external customers, Darren Mowry, a managing director in charge of Google's partnerships with startups, said in an interview with Reuters this week.

"With these foundational model builders, the gravity is increasing dramatically over to us," he said.

AI developers have historically preferred Nvidia's graphics processing units, which hold more than 80% of the AI chips market.

But SSI is so far primarily using TPUs rather than GPUs for its AI research and development, two sources said.

Google offers both Nvidia GPUs and its own TPUs through its cloud service. Its own chips are intended to excel at specific AI tasks and are more efficient than general-purpose GPUs. These chips have been used to build large-scale AI models, such as Apple and Anthropic, an OpenAI competitor that has received billions of dollars of funding from Google and Amazon.

Google and Nvidia also face a challenger in Amazon, which is building its own competing processors called Trainium and Inferentia. Amazon has said as far back as 2023 that Anthropic would develop its technology on those chips. The tech giant announced in December that Anthropic would be the first customer to use a massive supercomputer powered by hundreds of thousands of its own chips.

In the meantime, Anthropic continues to use TPUs for its AI development and has not decreased spending on Google's chips, two sources said.

It is increasingly common for major cloud providers to invest heavily in AI startups that not only build foundational models but also serve as significant customers of their infrastructure. For instance, Amazon and Google have both invested in Anthropic, while Microsoft has placed substantial bets on OpenAI. Nvidia has also backed OpenAI, as well as Elon Musk's xAI.

https://www.aol.com/news/exclusive-alphabet-nvidia-invest-openai-012945048.html