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Saturday, November 8, 2025

Alnylam Vutrisiran Improved Measures of Heart Structure, Function in ATTR-CM

 − Analyses Presented at the American Heart Association Scientific Sessions 2025 Underscore Vutrisiran’s Differentiated Profile –

− Cardiovascular Magnetic Resonance (CMR) and Echocardiographic Analyses Demonstrate that Treatment with Vutrisiran Resulted in Significant Changes on Multiple Functional and Structural Cardiac Parameters 

– In a Cohort of HELIOS-B Patients, CMR Imaging Showed Amyloid Regression in 22% of Vutrisiran Treated Patients with No Regression Found in Patients Who Received Placebo –

– Treatment with Vutrisiran Preserved Kidney Function in HELIOS-B Patients, and Reduced Risk of Death and Cardiovascular Events in Patients with Advanced Chronic Kidney Disease –

https://markets.financialcontent.com/wral/article/bizwire-2025-11-8-new-post-hoc-analysis-from-the-helios-b-phase-3-study-shows-vutrisiran-improved-measures-of-heart-structure-and-function-in-patients-with-attr-cm

Trump: No more money for 'really bad' Obamacare

 United States President Donald Trump declared via Truth Social that Democrat-linked health insurance companies will no longer receive funds for what he described as "really bad Obamacare," adding that the money would instead go directly to the people.

The US president elaborated that it would take THE 'FAT CAT' INSURANCE COMPANIES OUT OF THE CORRUPT SYSTEM OF HEALTHCARE. THE PEOPLE CAN BUY THEIR OWN, MUCH BETTER POLICY, FOR MUCH LESS MONEY, SAVING, FOR THEMSELVES, AN ABSOLUTE FORTUNE!!!."

His announcement comes amid the ongoing disagreement between Senate Republicans and Democrats over healthcare, fuelling the longest government shutdown in American history. Trump repeatedly urged an immediate end to the shutdown.

https://breakingthenews.net/Article/Trump:-No-more-money-for-'really-bad'-Obamacare/65148607

Shooter opens fire at Border Patrol agents in Chicago

 Authorities are searching for a man who allegedly opened fire Saturday on Border Patrol agents in Chicago.

The shooter was behind the wheel of a black Jeep when they fired off the shots near 26th Street and Kedzie Avenue, as the agents conducted immigration enforcement operations on the city’s Southwest side, the US Department of Homeland Security wrote on X.

DHS says the shooter was driving a jeep.WFLD
The shots were fired right around 26th Street and Kedzie Avenue.WFLD
The shooting occurred during a raid conducted by Border Patrol agents.Reuters

Agitators also hurled a paint can and bricks at the agency’s vehicles during the incident. 

Chicago cops cleared the scene, and the shooter remains at large.

Agitators near the area threw bricks at the officer’s vehicles.REUTERS

“The shooter and vehicle remain at large, and this is a dynamic situation,” the agency said in its post.

No one was hurt, according to reports.

A paint can was also thrown during the confrontations.REUTERS

“This incident is not isolated and reflects a growing and dangerous trend of violence and obstruction,” DHS said.

“Over the past two months, we’ve seen an increase in assaults and obstruction targeting federal law enforcement during operations. These confrontations highlight the dangers our agents face daily and the escalating aggression toward law enforcement. The violence must end.”

Last month, Border Patrol agents shot a woman in Chicago after an angry mob tried to attack the officers. 

The scene was later cleared by Chicago police.Reuters

Marimar Martinez was arrested on Oct. 4, and accused of driving within inches of a Border Patrol vehicle — running red lights and driving erratically, the FBI claimed. 

Officers said the suspect is still at large.REUTERS

The agents opened fire. Martinez pleaded not guilty, and the case is pending.

On Oct. 14, two illegal immigrants used their vehicle to ram into a border patrol convoy that sparked a dangerous car chase and riot in the Windy City, officials there confirmed.

Venezuelan nationals Yonder Enrique Tenefe-Perez and Luis Gerardo Pirela-Ramirez were arrested for allegedly ramming into a Border Patrol SUV on Oct. 14. They were arrested shortly after the attack, but not before it caused a mob of protesters to hurl objects at agents.

https://nypost.com/2025/11/08/us-news/border-patrol-agents-shot-at-in-chicago-mob-throws-bricks-at-dhs-vehicles/

SanegeneBio Announces RNAi Licensing and Research Collaboration with Lilly

 -Companies will collaborate on RNAi research for metabolic disease targets

SanegeneBio, a clinical-stage biotechnology company developing innovative RNAi therapeutics, today announced a global research and licensing collaboration with Eli Lilly and Company ("Lilly"). The companies will collaborate to advance RNAi candidates for metabolic diseases, based on SanegeneBio's proprietary tissue selective delivery technology, LEAD™ (Ligand and Enhancer Assisted Delivery).

SanegeneBio will be responsible for discovery and identification of the optimized LEAD™-based RNAi molecule for each program, while Lilly will be responsible for the subsequent IND-enabling studies, clinical development and commercialization.

SanegeneBio's LEAD™ platform has the potential to generate breakthrough therapies for metabolic diseases that could be administered subcutaneously as infrequently as twice per year.

"Partnering with Lilly represents a strong validation of our innovative and differentiated LEAD™ platform for tissue-selective delivery of RNAi medicines" said Weimin Wang, Chief Executive Officer and Founder of SanegeneBio. "We look forward to working closely with Lilly, a global leader in innovation for metabolic diseases, to unlock novel approaches for the treatment of metabolic disorders and to advance durable, disease-modifying therapies for patients worldwide."

Under the terms of the agreement, SanegeneBio will receive an upfront payment and equity investment and will be eligible to receive near-term milestone payments. SanegeneBio will also be eligible to receive up to $1.2 billion in discovery, development, regulatory, and commercial milestone payments, as well as tiered royalties on future product sales.

About SanegeneBio
SanegeneBio is a global, venture-backed, fully-integrated biotechnology company focused on developing RNAi-based therapeutics. Founded in 2021 and led by a team of RNAi veterans, the company has R&D operations in Boston, Shanghai and Suzhou. Their clear vision is that RNAi technology will power blockbuster medicines in diverse therapeutic areas, improving the quality and longevity of life for patients worldwide. This vision is being realized by advancing a fast-growing pipeline, which includes experimental medicines for autoimmune nephropathies, obesity, and cardiometabolic indications. SanegeneBio has initiated clinical trials for four experimental medicines to-date, and is committed to developing potential best-in-class and first-in-class therapeutics which leverage our industry-leading and differentiated LEAD™ tissue-selective RNAi delivery technology. 

https://www.morningstar.com/news/pr-newswire/20251108cn19576/sanegenebio-announces-rnai-licensing-and-research-collaboration-with-lilly

Zakharova ridicules Biden's 'no kings' remark

 Russian Foreign Ministry spokesperson Maria Zakharova on Saturday mocked remarks by former United States President Joe Biden, who said there are no kings in democracy.

Zakharova stated that Biden's words, aimed at US President Donald Trump, instead cast doubt on European monarchies, including the United Kingdom under King Charles III. Zakharova argued that Biden's statement implied Britain lacks democracy, adding that the Parliamentary Assembly of the Council of Europe should now consider resolutions against Spain, the Netherlands, Belgium, Denmark, Sweden and other monarchies.

https://breakingthenews.net/Article/Zakharova-ridicules-Biden's-'no-kings'-remark/65148458

Randi Weingarten’s Revisionist Narrative

 Why Fascists Fear Teachers: Public Education and the Future of Democracy, by Randi Weingarten (Thesis, 256 pp., $30)

The title of American Federation of Teachers president Randi Weingarten’s new book is eye-catching and designed to attract readers, though by now the word “fascist” is thrown around routinely. The book’s subtitle, Public Education and the Future of Democracy, is more significant—and deceptive.

The book’s purported intention is to argue for public schools’ crucial role in our democratic society. But it offers little in the way of education policy or ideas that would truly benefit teachers and students.

The real aim is revealed in Weingarten’s choice to devote most of its pages to attacking her political opponents—especially supporters of school choice—and defending the interests of the American Federation of Teachers.

Claiming that 90 percent of kids in America attend public schools, Weingarten argues that the school-choice movement will destroy the institutions responsible for educating our citizens and nurturing democracy. For starters, that figure is outdated. Data from the 2021 Census indicate that the share of public school students stood at 81.9 percent. And that’s before the expansion of universal school choice in states like Texas and New Hampshire. Half of American children now have access to school choice.

Weingarten characterizes the school-choice movement as a conspiracy orchestrated by Christopher Rufo, Moms for Liberty, and other right-wing activists—a “plot to destroy public education,” in her words. The real drivers of the choice movement, however, are parents like Virginia Walden Ford, a black, low-income mother in Washington, D.C., who grew frustrated watching her son struggle in public school and helped create the D.C. Opportunity Scholarship Program—the nation’s first federally funded voucher initiative.

Weingarten also insists that vouchers are devised by whites to undermine desegregation. This isn’t just wrong—it gets the history completely backward. In fact, some teachers’ unions fought vouchers because they facilitated integration.

Weingarten claims that she is “willing to work with anyone who wants to actually address the problems facing our public schools.” But she refuses to engage with school-choice advocates, who propose concrete and constructive options for students underserved by traditional district schools.

Weingarten is correct to point out that the Right sometimes goes too far in its efforts to remove inappropriate books from school libraries—ill-considered campaigns against Toni Morrison’s Beloved and even the Bible come to mind. She’s also right to criticize President Trump’s budget cuts, which have negatively affected administration of the Nation’s Report Card, forcing it do fewer voluntary assessments; and the Oklahoma Superintendent of Public Instruction, who tried to integrate the Bible into lesson plans.

These mostly sound points aside, she goes out of her way to denigrate “religious schools, whose very purpose is indoctrination.” This animus causes her to overlook the many advantages of faith-based education, such as the “Catholic school effect,” which has been demonstrated to benefit disadvantaged minority students in particular.

The biggest deception in Weingarten’s book is its portrayal of her role during the pandemic. “I led the AFT in developing a concrete plan to reopen schools as quickly and safely as possible,” she claims. Not so. Weingarten and her union colleagues kept American children out of schools until the government approved her request for a $750 billion federal aid package. It has since come to light that Weingarten was texting Rochelle Walensky, the director of the Centers for Disease Control and Prevention, to pressure the CDC into keeping schools closed in 2021.

The book is primarily an attempt to rehabilitate Weingarten’s image after she backed the longest school closures in American history, which yielded the largest drop in student performance ever recorded. Weingarten writes that the “fascists” of her title “replace facts and critical thinking with propaganda that romanticizes the nation’s past.” Yet this is precisely what her book does in misrepresenting her actions during Covid.

Parents like me, who vividly remember attending reopened restaurants and gyms long before our children were allowed to return to the classroom, will not be fooled by Weingarten’s revisionist narrative. We will continue to cite her disastrous record and to advocate for our children’s interests.