Array BioPharma Inc. (Nasdaq: ARRY) announced that it will present data from the Phase 3 COLUMBUS trial of encorafenib and binimetinib in advanced BRAF-mutant melanoma in an oral presentation on June 4, 2018, at the 54th Annual Meeting of the American Society of Clinical Oncology (ASCO) in Chicago, Illinois.
“Binimetinib and encorafenib is the first targeted therapy to demonstrate over 30 months median overall survival in a Phase 3 trial and we look forward to presenting the results from the COLUMBUS trial at ASCO,” said Ron Squarer, Chief Executive Officer. “With nearly 15 months median progression-free survival and an attractive tolerability profile, these data underscore the potential of this combination to become an important new treatment option for patients with BRAF-mutant advanced, unresectable or metastatic melanoma.”
As previously announced, the most common Grade 3/4 adverse events (AEs) seen in more than 5% of patients were increased gamma-glutamyltransferase (GGT) (9%), increased creatine phosphokinase (7%), and hypertension (6%) in the encorafenib plus binimetinib group.
Oral Presentation:
| |
Title:
|
Overall Survival in COLUMBUS: A Phase 3 Trial of Encorafenib (ENCO) Plus Binimetinib (BINI) vs Vemurafenib (VEM) or ENCO in BRAF-Mutant Melanoma
|
Presenter:
|
Reinhard Dummer, M.D.
|
Abstract:
|
Abstract #223875/Publication #9504
|
Session:
|
Melanoma/Skin Cancers
|
Date:
|
Monday, June 4, 2018
|
Time:
|
9:12 a.m. – 9:24 a.m. Central Time (10:12 a.m. – 10:24 a.m. Eastern Time)
|
Location:
|
Arie Crown Theater
|
The abstract can be accessed through the ASCO website, http://abstract.asco.org/, beginning May 16, 2018, at 5:00 p.m. Eastern Time. Following the presentation on June 4, the slides will be available as a PDF on Array’s website at http://www.arraybiopharma.com.
Array will host an encore webcast presentation of the COLUMBUS trial data.
Encore Webcast:
| |
Date:
|
Monday, June 4, 2018
|
Time:
|
11:15 a.m. Central Time (12:15 p.m. Eastern Time)
|
Toll-Free:
|
(844) 464-3927
|
Toll:
|
(765) 507-2598
|
Pass Code:
|
9615719
|
Webcast, including replay and conference call slides: https://edge.media-server.com/m6/p/8juh6tcn
No comments:
Post a Comment
Note: Only a member of this blog may post a comment.