Immune Design: Longer Response, Survival in Lymphoma with Combo

• Overall Response Rate (ORR) of 46% in Patients Receiving the Combination
• TLR4 Biomarker Continued to Show Higher Response Rate for Patients with High TLR4 Expression (71% ORR)
• Long-term Follow Up Shows 11.1 Months Progression Free Survival

Immune Design (Nasdaq: IMDZ), an immunotherapy company focused on next-generation therapies in oncology, today announced long-term follow up results from a randomized Phase 2 clinical trial of 10 ug intratumoral G100, a TLR4 agonist, with or without pembrolizumab, in follicular lymphoma patients.

In the 26 naïve and relapsed/refractory patients in the randomized trial, the data continue to support the clinical activity of G100, with overall response rates of 46% and 23% in patients receiving a G100 regimen that includes low-dose radiation, with or without pembrolizumab, respectively. Also, disease control was shown in 92% and 85% of patients treated with the G100 regimen with or without pembrolizumab, respectively.  In addition, responses appeared to be durable, with overall progression free survival at 11.1 or 7.4 months in patients treated with the G100 regimen with or without pembrolizumab, respectively. The data were presented today at the American Society of Hematology Annual Meeting being held in San Diego.

“Follicular lymphoma continues to be a difficult-to-treat malignancy, particularly in the relapsed setting, and to date immunotherapy has not been successful and the current standard of care is associated with a number of serious adverse events,” said Carlos Paya, M.D., chief executive officer of Immune Design.  “We are encouraged by the potential for lymphoma patients with G100, a first in class immuno-modulatory agent that leads to systemic anti-lymphoma benefit when injected intratumorally. The high response rates, favorable durability and excellent safety profile we’re seeing for G100 has prompted us to embark on a potentially pivotal clinical trial in the relapsed refractory setting, as well as pursue additional trials in earlier lines of therapy in follicular lymphoma and other malignancies.”

https://www.marketscreener.com/IMMUNE-DESIGN-CORP-16953839/news/Immune-Design-Reports-Increased-Overall-Response-Rate-and-Longer-Progression-Free-Survival-of-Pati-27693665/