- Clinical efficacy, as measured by EASI (Eczema Area and Severity Index) changes, was numerically greater for SB414 treated groups compared to vehicle
- Strong anti-pruritic (itch) effect as measured by improvement on the pruritus (itch) numeric rating scale (NRS) compared to vehicle
- Clinical data additive to established non-clinical results supporting nitric oxide’s role in affecting the underlying immunology of atopic dermatitis
Novan, Inc. (“the Company” or “Novan”) (NASDAQ:NOVN) today announced that clinical results from the Company’s Phase 1b trial with SB414 cream for the treatment of atopic dermatitis will be presented at the 3rd Inflammatory Skin Disease Summit in Vienna, Austria.
Tomoko Maeda-Chubachi, M.D., Novan’s Vice President of Medical Dermatology, is scheduled to present “A Topical Nitric Oxide-Releasing Cream SB414: Results of a Phase 1b Double-Blind, Randomized, Vehicle-Controlled Study in Patients with Mild-to-Moderate Atopic Dermatitis” during a poster session on December 12, 2018 and an oral presentation on December 15, 2018.
“We are excited by the data we are presenting with SB414 as it demonstrated trends suggestive of clinical efficacy within only 2 weeks of treatment,” said Tomoko Maeda-Chubachi, M.D., Novan’s Vice President of Medical Dermatology. “Nitric oxide has the potential to impact multiple mechanisms of atopic dermatitis and the results from this trial give us the confidence to move forward with a more robust Phase 2 program.”
Top line results from Novan’s Phase 1b clinical trial with SB414 for the treatment of atopic dermatitis were previously announced in August and the Company intends to conduct a Phase 2 trial.
About the Presentations
Title: “A Topical Nitric Oxide-Releasing Cream SB414: Results of a Phase 1b Double-Blind, Randomized, Vehicle-Controlled Study in Patients with Mild-to-Moderate Atopic Dermatitis”
Authors: Tomoko Maeda-Chubachi, Todd Durham, Stephen Schleicher, Phoebe Rich, Emma Guttman-Yassky
Presenting Author: Tomoko Maeda-Chubachi, M.D., Novan’s Vice President of Medical Dermatology
Poster Presentation: Wednesday, December 12, 2018 at the “Säulenhalle” (Level 1) and the “Science Café” (Level 0) between 6:00 p.m. – 9:00 p.m. Central European Standard Time
Oral Presentation: Saturday, December 15, 2018 from 1:00 p.m. – 1:30 p.m. Central European Standard Time
Authors: Tomoko Maeda-Chubachi, Todd Durham, Stephen Schleicher, Phoebe Rich, Emma Guttman-Yassky
Presenting Author: Tomoko Maeda-Chubachi, M.D., Novan’s Vice President of Medical Dermatology
Poster Presentation: Wednesday, December 12, 2018 at the “Säulenhalle” (Level 1) and the “Science Café” (Level 0) between 6:00 p.m. – 9:00 p.m. Central European Standard Time
Oral Presentation: Saturday, December 15, 2018 from 1:00 p.m. – 1:30 p.m. Central European Standard Time
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