Constellation Pharma Updates Prelim Data from MANIFEST Trial at ASH

• Preliminary data showed continuing signs of activity across a broad range of parameters, suggesting possible disease-modifying effects of CPI-0610
• In the first-line treatment arm, 12 out of 15 (80%) evaluable JAK-inhibitor-naïve patients treated with a CPI-0610 / ruxolitinib combination achieved at least a 35% spleen volume response (SVR35) at 12 weeks
• Clinical activity, including SVR35 responses, TSS50 responses, and conversion from transfusion dependence to transfusion independence, was seen at 24 weeks in patients in the second-line treatment arm who added CPI-0610 to ruxolitinib, suggesting that treatment with CPI-0610 may have durable effects
• An investor event to discuss the MANIFEST update at ASH is scheduled for 12:30 PM EST today

https://www.globenewswire.com/news-release/2019/12/09/1958004/0/en/Constellation-Pharmaceuticals-Provides-Updated-Preliminary-Data-from-MANIFEST-Clinical-Trial-with-CPI-0610-in-Oral-and-Poster-Presentations-at-ASH.html