AB Science SA (Euronext - FR0010557264 - AB), together with the University of Chicago, today announces the signing of an exclusive licensing agreement for conducting research on the prevention and treatment of humans infected with nidoviruses, coronaviruses and picornaviruses.
This collaboration follows the discovery by the University of Chicago that masitinib inhibits the main protease (3CLpro) necessary for the SARS-CoV-2 viral replication cycle [1].
Under this agreement, AB Science will supply masitinib and more than 130 other AB Science proprietary drugs that have demonstrated activity against SARS-CoV-2 main protease 3CL-Pro via virtual screening methodology, and will benefit from the proprietary research platform of the University of Chicago.
The University of Chicago will perform the following research activities:
- Enhance the preclinical program of masitinib against SARS-CoV-2
- Initiate investigation with masitinib against other viruses that are dependent on protease 3CL-Pro for replication
- Test and identify analogues of masitinib active against SARS-CoV-2 protease 3CL-Pro
To secure and consolidate patent positions, AB Science and the University of Chicago will merge their patent rights related to masitinib or masitinib analogues related to virology applications. The University of Chicago’s Polsky Center for Entrepreneurship and Innovation worked with the researchers to file the associated patents and then completed the license agreement with AB Science.
In case of commercialization in viral disease, AB Science will benefit from an exclusive, royalty-bearing license on any discoveries made with AB Science products (1% of net sales on first registered product and 0.3% of net sales on further registered product to be paid to the University of Chicago).
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