Spectrum Pharma Presents Additional Twice Daily Dosing Data for Poziotinib at AACR

 Spectrum Pharmaceuticals (NasdaqGS: SPPI), a biopharmaceutical company focused on novel and targeted oncology therapies, today presented a data update on the safety and tolerability of twice daily (BID) administered poziotinib in NSCLC patients with EGFR or HER2 exon 20 insertion mutations. These preliminary data, from Cohort 5 of the ZENITH20 clinical trial, continue to show improved tolerability with BID dosing, reduced dose interruption compared to once daily (QD) dosing, and a reduction in treatment emergent Grade 3 or higher adverse events. The preliminary data also demonstrate improved anti-tumor activity with 8mg BID dosing. The presentation is part of the AACR Virtual Meeting 2021 taking place April 10-15, 2021.

“The 8mg BID dosing arm is showing the best performance we have seen across the various dosing arms for a mixed population of EGFR and HER2 exon 20 insertion mutations in NSCLC patients. There is clearly an improved therapeutic effect and a lower adverse event rate which is highly encouraging,” said Francois Lebel, M.D., Chief Medical Officer of Spectrum Pharmaceuticals. “We are currently expanding the 8mg BID dataset and look forward to evaluating this dose in additional NSCLC patients and other solid tumors.”

A copy of the AACR presentation titled “Poziotinib administered twice daily improves safety and tolerability in patients with EGFR or HER2 exon 20 mutations” is available on Spectrum’s website at https://investor.sppirx.com/events-and-presentations.

https://www.businesswire.com/news/home/20210410005020/en/Spectrum-Pharmaceuticals-Presents-Additional-Twice-Daily-Dosing-Data-for-Poziotinib-at-the-AACR-Virtual-Meeting-2021