Altamira: Positive In vitro Efficacy for Nasal Spray v. Sars-CoV-2 Delta Variant

 

• Significant reduction of infectious viral titer in human nasal epithelium model with either prophylactic or therapeutic application

• Results provide further confirmation for broad applicability in viral infections

Altamira Therapeutics Ltd. (NASDAQ:CYTO), a company dedicated to addressing unmet medical needs through RNA therapeutics, allergy and viral infection protection, and inner ear therapeutics, announced today positive efficacy data from testing its Bentrio™ nasal spray in vitro against the Delta variant of the SARS-CoV-2 virus.

Bentrio™ is a drug-free nasal spray for protection against airborne viruses and allergens, which has previously shown positive outcomes in a test against the Alpha variant of the virus.

For the Delta variant study, BentrioTM or saline control were applied in the same type of assay either prophylactically 10 minutes prior to or therapeutically 24 hours following viral inoculation of reconstituted nasal epithelium cells from human donors, followed by once daily application for four days. In saline-treated control cultures, SARS-CoV-2 replicated efficiently, resulting in a rapid increase in viral titer (as measured by the Median Tissue Culture Infectious Dose, TCID50). In contrast, at Days 3 and 4 both prophylactic and therapeutic treatment with Bentrio™ resulted in significantly lower virus titers, reaching -83% when the application was started prior to infection, and -69 to -85% when the application was initiated only when the infection was already ongoing (all values significant at p<0.01 and <0.05).

"We are very pleased to see the protective effects of Bentrio against SARS-CoV-2 confirmed also with the highly contagious and fast replicating Delta variant," commented Thomas Meyer, Altamira Therapeutic's founder, Chairman and CEO. "These fresh results provide further support for the broad applicability of Bentrio. By forming a protective film on the nasal mucosa and trapping particles, Bentrio has a purely physical mode of action and is thus suitable for use across different types of viruses and virus variants. We look forward to continuing the commercial roll out of the product, making it available to all those seeking protection."

https://finance.yahoo.com/news/altamira-therapeutics-reports-positive-vitro-140000877.html