L. V. Shogenova , Thi Chyong Tue , N. O. Kryukova , K. A. Yusupkhodzhaeva , D. D. Pozdnyakova , T. G. Kim , A. V. Chernyak , E. N. Kalmanova , O.S. Medvedev , T. A. Kuropatkina , S. D. Varfolomeev , A. M. Ryabokon , O. A. Svitich , M. P. Kostinov , Kunio Ibaraki , Hiroki Maehara , A. G. Chuchalin
Inhaled hydrogen (“active form of hydrogen” (APV; (H (H 2 O) m )) has powerful antioxidant and anti-apoptotic properties and has been used in a number of experimental and clinical studies in recent years.
Purpose . To study the safety and effectiveness of inhalation (APV; (H (H 2 O) m )) in the rehabilitation program of patients who have had an infection caused by the SARS-CoV-2 virus (Severe Acute Respiratory Syndrome CoronaVirus 2) during the recovery period.
Material and methods. A randomized controlled parallel prospective study included 60 patients who underwent COVID-19 (COronaVIrus Disease 2019), post-covid syndrome (ICD-10: U09.9) during the recovery period, who had clinical manifestations of chronic fatigue syndrome (CFS) who received standard therapy according to the protocol for the management of patients with chronic fatigue syndrome (ICD-10: G93.3): physiotherapy and ancillary drug therapy with drugs containing magnesium, B vitamins and L-carnitine. The study participants were divided into 2 groups: group 1 (main, n = 30) received daily inhalation of APV; (H (H 2 O) m) for 90 minutes for 10 days. (apparatus "SUISONIA" Japan), group 2 (control, n = 30) received standard therapy. Patients of both groups were comparable in gender and average age: in the main group - 53 (22; 70) years old, in the control group - 51 (25; 70) years. All patients on the 1st and 10th days. Observations determined biological markers of systemic inflammation, oxygen transport, lactate metabolism, intrapulmonary shunting, 6-minute exercise test, and vascular endothelial function.
Results. In the main group, a decrease in indicators was revealed: the stiffness index (SI) from 8.8 ± 1.8 to 6.8 ± 1.5 m / s (p <0.0001), the activity of alanine aminotransferase from 24.0 ± 12.7 up to 20.22 ± 10.61 U / L (p <0.001), venous blood lactate level from 2.5 ± 0.8 to 1.5 ± 1.0 mmol / L (p <0.001), capillary blood lactate level from 2.9 ± 0.8 to 2.0 ± 0.8 mmol / l (p <0.0001), the calculated index of the intrapulmonary blood shunt (Qs / Qt, according to the Berggren method, 1942) from 8.98 ± 5 , 7 to 5.34 ± 3.2 (p <0.01), the number of leukocytes from 6.64 ± 1.57 to 5.92 ± 1.32 10x9 U / L and an increase in the following parameters: reflection index (RI) with up to 46.67 ± 13.26 63,32 ± 13,44% (p <0.0001), the minimum blood oxygen saturation (SpO 2) during exercise from 92.25 ± 2.9 to 94.25 ± 1.56% (p <0.05), direct bilirubin from 2.99 ± 1.41 to 3.39 ± 1.34 μmol / L , (p <0.01), partial tension of venous blood oxygen (PcO 2 ) from 26.9 ± 5.0 to 34.8 ± 5.6 mm Hg. (p <0.0001), venous blood oxygen saturation (SvO 2 ) from 020.6 ± 51.8 to 018.1 ± 61.1% (p <0.05), partial capillary blood oxygen tension (PsO 2 ) from 48.7 ± 15.4 to 63.8 ± 21.2 mm Hg (p <0.01), capillary blood saturation (SsO 2 ) from 82.2 ± 4.2 to 86.2 ± 4.8% (p <0.01), the distance covered in 6 minutes with a 429 ± 45 0 to 569 ± 60 m.
Conclusion. Inhalation therapy with AFV; (H (H 2 O) m ) in the rehabilitation program of patients who underwent COVID-19, during the recovery period, turned out to be a safe and highly effective treatment method. Positive dynamics was noted in the form of a decrease in the manifestations of latent hypoxemia, an increase in exercise tolerance, and a decrease in endothelial dysfunction. From laboratory tests, there is a decrease in the number of leukocytes, normalization of lactate metabolism, and a decrease in the fraction of intrapulmonary blood shunting from right to left.
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