Kiniksa misses endpoint in Phase 3 covid-related ARDS trial

 Kiniksa Pharmaceuticals, Ltd. (Nasdaq: KNSA) (“Kiniksa”), a biopharmaceutical company with a portfolio of assets designed to modulate immunological pathways across a spectrum of diseases, today announced that the Phase 3 portion of the Phase 2/3 trial of mavrilimumab in COVID-19-related acute respiratory syndrome (ARDS) did not meet the primary efficacy endpoint. Mavrilimumab is an investigational fully human monoclonal antibody that targets granulocyte macrophage colony stimulating factor receptor alpha (GM-CSFRα).

“The Phase 3 study of mavrilimumab in COVID-19-related ARDS did not provide the expected outcome, however we are proud of our efforts to help patients in need during this unprecedented time. We greatly appreciate the participation of the patients, their families, the investigators, and the Kiniksa employees who made this study possible,” said Sanj K. Patel, Chairman and Chief Executive Officer of Kiniksa. “We continue to believe in the potential broad utility of mavrilimumab and are evaluating next steps for the molecule. Our current strategy focuses our resources on the ARCALYST franchise, including the commercial execution in recurrent pericarditis, as well as the development of vixarelimab and our anti-CD40 program, KPL-404.”

https://finance.yahoo.com/news/kiniksa-announces-results-phase-3-115900335.html