Negative effect of 2nd dose of BNT162b2 after previous COVID infection

 ElviraBaos1AlbertoDelgado-Iribarren12SilviaO´Connor3IgnacioBardón3MarAlvaréz1IciarRodríguez-Avial12EstherCulebras12

DOI: https://doi.org/10.1016/j.ijid.2021.11.002

PDF: https://www.sciencedirect.com/science/article/pii/S120197122100847X/pdfft?md5=5b45fe8d553157b6db9a8606118dc2b5&pid=1-s2.0-S120197122100847X-main.pdf

Highlights

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Responses to immunization with Pfizer – BioNTech vaccine in health care workers.

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Immune response in partially vaccinated is as high as with fully vaccinated in those with no previous COVID infection (NI)

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38.8 % of those with no previous COVID infection (NI) showed a decrease in antibody titer with the second dose of BNT162b2

Introduction

Despite the efforts made since the beginning of the pandemic, the infection caused by SARS-CoV-2 is far from being under control. In the current situation, vaccines can be a turning point in the fight against the virus, and all countries attempt to encourage vaccination in their inhabitants, mainly in those groups with the highest risk.

To advance in pandemic control, some governments have decided to delay administering the second vaccine dose. They assume that the first dose would be enough to protect the population for a longer period than the pharmaceutical company recommended (Prendecki et al., 2021). Some previous studies support this supposition (Gobbi et al., 2021; Saadat et al., 2021), but high variability in vaccination response has been observed, and it is not clear what the situation will be with infection-naive people (Saadat et al., 2021; Prendecki et al., 2021, Thompson et al., 2021).

https://www.sciencedirect.com/science/article/pii/S120197122100847X