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Friday, December 17, 2021

Vaxart to Test Cross-Reactivity of COVID Oral Vaccine Against Omicron

 Vaxart Inc (NASDAQ: VXRT) plans to test the cross-reactivity of its oral tablet COVID-19 vaccine candidate against the omicron SARS-CoV-2 variant in two different studies expected to begin next month.

  • Vaxart will test its COVID-19 oral vaccine candidate against omicron in the first study.

  • The Company will analyze mucosal and serum samples from subjects administered in Vaxart's current COVID-19 vaccine Phase 2 trials.

  • In the second study, Vaxart will conduct an animal omicron challenge study to assess how its current Phase 2 COVID-19 vaccine candidate performs compared to an omicron-specific vaccine candidate that Vaxart is developing.

  • Vaxart deliberately engineered its COVID-19 vaccine candidate to be cross-reactive against emerging variants.

  • In May, the Company announced Phase 1 results demonstrating that its vaccine candidate, VXA-CoV2-1, produced broad cross-reactive T cell and IgA responses against other, non-COVID coronaviruses.

  • In October, Vaxart reported that a Duke University-led study published in bioRxiv showed that its oral vaccine reduced the airborne transmission of the SARS-CoV-2 virus in an animal model.

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