Kiora Pharmaceuticals, Inc. (NASDAQ: KPRX), ("Kiora" or the "Company") announced that results from a Phase 1 study of KIO-100 (formerly PP-001) demonstrate its potential as a treatment for non-infectious uveitis, an ophthalmic inflammatory disease. The results were published today in a paper titled "A new small molecule DHODH-inhibitor [KIO-100 (PP-001)] targeting activated T cells for intraocular treatment of uveitis - a phase I clinical trial," in the journal Frontiers in Medicine.
This first-in-man, open-label, phase-1 clinical trial investigated the use of KIO-100 for treating uveitis, a T cell-mediated, intraocular inflammatory disease. Results showed that a single intravitreal injection of KIO-100 decreased intraocular inflammation in a dose dependent fashion, and improved visual acuity significantly during the duration of the study. The drug was well tolerated, with no serious side effects on intraocular tissues or other adverse events observed.
KIO-100 is a dihydroorotate dehydrogenase (DHODH) inhibitor, a validated drug target in the treatment of systemic autoimmune conditions. As a third generation DHODH inhibitor with an intravitreal formulation and a high potency for suppressing T and B cells, KIO-100 is a promising non-steroidal anti-inflammatory agent.
https://finance.yahoo.com/news/kiora-pharmaceuticals-announces-publication-phase-120000476.html
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