Cognition: Positive Topline Results for CT1812 Phase 2 SEQUEL Study for Mild-to-Moderate Alzheimer’s

 Positive Treatment Effect of CT1812 on Global and Regional Brain Activity

Management Holding Webcast Conference Call at 8:00am ET Today

Cognition Therapeutics Inc. (NASDAQ: CGTX), a clinical-stage neuroscience company developing drugs that treat age-related degenerative disorders by regulating cellular damage response pathways, today announced topline results from its Phase 2 double-blind, single-crossover SEQUEL study (NCT04735536) of CT1812 in 16 adults with mild-to-moderate Alzheimer’s disease. The study, which was conducted in the Netherlands, met its primary endpoints for safety and tolerability and showed positive effects for CT1812-treated participants as measured via quantitative electroencephalogram (qEEG).

Research suggests that overall slowing of brain activity in Alzheimer's disease can be measured by an increase in relative theta power using qEEG and other measures of brain connectivity. The SEQUEL study examined brain wave changes over 4 weeks of treatment and showed that participants treated with CT1812 experienced a numerical reduction in relative theta power compared to the period when they were on placebo. While not statistically significant, these data indicate a positive impact on underlying brain function and are supported by nominally significant and directionally positive changes in AECc and alpha power.

In addition to global measures of brain activity, this study assessed brainwave changes in frontal, central, temporal and posterior (occipital and parietal) regions. Treatment with CT1812 was associated with decreases in relative theta in each of these regions, with statistical significance in the change in relative theta in the central region.

Cognition will host a conference call and webcast on June 28, 2023, at 8:00am ET to discuss these topline results. The call can be accessed by dialing (800) 715-9871 for U.S. Callers and (646) 307-1963 for international callers five minutes prior to the start of the call and providing the conference ID 7557195. A live webcast will be available on the company's website at www.cogrx.com/events and will be archived for 90 days.

https://www.biospace.com/article/releases/cognition-therapeutics-announces-positive-topline-results-for-ct1812-phase-2-sequel-study-for-mild-to-moderate-alzheimer-s-disease/