Leap Starts Study of DKN-01 in Colorectal Cancer

 Leap Therapeutics, Inc. (Nasdaq:LPTX), a biotechnology company focused on developing targeted and immuno-oncology therapeutics, today announced that, based on the early efficacy and momentum seen in the enrollment of 33 patients with colorectal cancer (CRC) in its DeFianCe study, it has initiated the 130 patient randomized controlled Part B of the Phase 2 study. The study evaluates Leap's anti-Dickkopf-1 (DKK1) antibody, DKN-01, in combination with standard of care bevacizumab and chemotherapy as a second-line treatment for patients with advanced CRC.

https://www.biospace.com/article/releases/leap-therapeutics-announces-initiation-of-randomized-controlled-part-b-of-the-defiance-study-of-dkn-01-in-colorectal-cancer-patients/