Vertex Positive, Updated VX-880 Results From Ongoing Phase 1/2 Study in Type 1 Diabetes

 All patients treated with VX-880 in Parts A and B have follow-up data beyond Day 90 and have demonstrated islet cell engraftment and glucose-responsive insulin production -

- All patients showed improvement across all measures of glucose control, including decreases in HbA1c, increases in blood glucose time-in-range, and reduction or elimination of insulin use -

- The two patients with at least 1 year of follow-up met the criteria for the primary endpoint of elimination of severe hypoglycemic events (SHEs) and HbA1c <7.0% -

- VX-880 was generally well tolerated -

- Part C concurrent dosing well underway -

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