– Achieved Full Year 2023 Preliminary Global Net Product Revenues of $1,241 Million for ONPATTRO®, AMVUTTRA®, GIVLAARI®, and OXLUMO®, Representing 39% Annual Growth (39% Using Constant Exchange Rate**) –
– Maintained Strong Balance Sheet with Year-End Cash and Investments Balance of Approximately $2.4 Billion –
“We are delighted to have ended the year on a strong note, with continued execution across our commercial portfolio delivering top-line product revenue within our guidance range. These preliminary results reflect growing patient demand for our transformative products, along with strong commercial execution by our teams in delivering these important medicines to patients in need globally. We were also pleased to have reported positive clinical results across multiple programs in 2023. This includes zilebesiran, with which we aim to reimagine the treatment of hypertension, and ALN-APP in Alzheimer’s disease, which provided the first ever clinical demonstration of gene silencing in the human brain using an RNAi therapeutic,” said Yvonne Greenstreet, MBChB, Chief Executive Officer of Alnylam. “As we consider the progress we made across our business in 2023 and as we look ahead to reporting results from the HELIOS-B Phase 3 study in early 2024, we believe we are well on our way to achieving our Alnylam P5x25 goals, positioning Alnylam as a top-tier, global, multi-product commercial company with a broad pipeline and organic platform poised to deliver sustainable innovation well into the future, a profile rarely seen in our industry.”
Alnylam management will discuss these preliminary selected financial results and commercial updates during a webcast presentation at the 42nd Annual J.P. Morgan Healthcare Conference in San Francisco, California tomorrow, Monday, January 8, 2024 at 9:45 a.m. PT (12:45 p.m. ET).
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