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Monday, May 19, 2025

Protagenic, Phytanix Business Combination for Obesity and Metabolic Disorders

 Protagenic Therapeutics, Inc. (Nasdaq:PTIX) (the "Company") and Phytanix Bio Inc. have entered into a definitive share exchange agreement pursuant to which the two entities will combine in an all-stock transaction (the "Combination"). The combined entity, to be called Phytanix, Inc., will bring together two pipelines focused on stress-related and CNS disorders, five preclinical assets and one clinical-stage asset.

Pipeline Assets

  • PT-00114 (Phase I/IIa): peptide asset in BLA pathway; may qualify for regulatory data exclusivity

  • PHYX-001: potassium channel modulator with mechanism similar to XEN1101 and BHV-7000

  • Cannabinoid Assets: multiple cannabinoid-based compounds with composition-of-matter IP; potential in CNS, cardiometabolic, and other indications. Including a proprietary molecule with significant potential in the obesity, metabolic dysfunction sector, where the GLP-1 agonists have become blockbuster medications

  • Modified Stilbenoid Assets: modified stilbenoid compounds with composition-of-matter IP and anticonvulsant activity in preclinical models

Key Benefits for Protagenic Shareholders

  • Pipeline Expansion: adds new CNS programs to existing stress-disorder portfolio

  • Pipeline Diversity: clinical- and preclinical-stage assets with potential significant milestones over the next 18 months

  • CNS Expertise: integrates Phytanix Bio team members who worked on Sativex® and Epidiolex® at GW Pharma

  • Patent Estate: broader composition-of-matter coverage across the pipeline

  • Talent Pool: combined teams to advance development and regulatory activities

https://finviz.com/news/60493/protagenic-therapeutics-and-phytanix-announce-business-combination-to-form-neuroactive-biopharmaceutical-company-with-six-drug-candidates-in-development-including-treatments-for-obesity-and-metabolic-disorders

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