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Friday, November 13, 2026

National Trends in Congenital Syphilis Among US Newborns, 2012–2022

 



Abstract

Congenital syphilis among US birth hospitalizations increased 5.9-fold (95% CI = 4.9–7.2) from 2012 to 2022 in the Kids’ Inpatient Database. Increases were observed across all demographics, income levels, and hospital settings, with the largest increase among Native Americans (21.5-fold; 95% CI = 8.8–52.1). These findings underscore the need for improved syphilis prevention and prenatal screening efforts.

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