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Monday, February 4, 2019

Diamandis’ right hand man wants to reverse aging via $100M longevity fund

Inspired by British billionaire Jim Mellon, chairman of anti-aging upstart biotech venture Juvenescence, Sergey Young unveiled a $100 million fund on Monday to catalyze the development of a comprehensive solution to counteract the damaging consequences of aging.
“I’ve never looked like my age…and with my name, I think it was predetermined that I was going to work in the space (of aging),” Young told Endpoints News. The 47-year-old considers himself a product of Peter Diamandis — the man behind the non-profit XPRIZE and venture capital fund BOLD Capital Partners — and is in charge of all things longevity at both organizations.

Like Mellon, who penned Juvenescence: Investing in the Age of Longevity prior to the launch of the company Juvenescence, Young is in the embryonic stage of writing his own book designed to decode the science of aging for the masses. Meanwhile, his $100 million Longevity Vision Fund will back organizations who are working on technology to reverse the aging process and prolong healthy human life.
“Adding 20 to 30 healthy years on a person’s life is likely to be the largest market opportunity on earth. The convergence of Genome Sequencing, AI & Cellular Medicine will enable breakthroughs that will make 100 years old the new 60. I’m proud through our BOLD Capital partnership to support Sergey Young and the Longevity Vision Fund,” Peter Diamandis said in a statement.
Young did not disclose the deals his fund is currently exploring but laid out the areas he is interested in pursuing.

“We are currently working on 6 deals…and are looking at all the usual suspects in terms of themes” he said. These areas include early detection of serious diseases using ultrasound technology; early diagnostics for heart, cancer and neurodegenerative diseases; stem-cell and microbiome-based therapeutics; and big data as well as AI-based applications.
Unsurprisingly, Young is in dialogue with Alex Zhavoronkov’s AI shop at Insilico Medicine. Zhavoronkov has deep connections in the R&D space — last year he raised funds at the behest of Shanghai high-flyer WuXi AppTec, Singapore’s Temasek, Peter Diamandis and Juvenescence.
“We do plan to participate in the next round of funding to become a shareholder of Insilico,” Young said. It is a mutual appreciation society here at the Longevity Leaders Congress in London, where Zhavoronkov is heard introducing Young as a visionary fund manager to a conference attendee. Young, Zhavoronkov, Mellon and a host of others high-profile C-suite regulars involved in aging R&D have flocked to a hotel near the renowned St Paul’s Cathedral to discuss recent developments in anti-aging. In the first keynote panel of the day, vice president of Juvenescence-backed AgeX Aubrey de Grey ambitiously claims that that longevity space will eventually “dwarf the dotcom boom.”

But more funding is necessary, Zhavoronkov told Endpoints News at the conference. Other than Google’s anti-aging biotech Calico that has seen a large influx of funds, the field of anti-aging is ripe for investment, he said.
For long-time investor and venture capitalist Young, who has insight into the aging R&D effort within the US and to a lesser extent in the UK, China and India’s sizable populations pose compelling prospects for deals for his fund.
“In the next decade, advancements will allow us to be a lot more predictive and preventative in the most damaging diseases,” he said. “I’m thinking AI-enabled medicine will empower doctors…technological advances to improve sleeping and meditation will emerge — and these are an essential part of a healthy, long life, along with a plant-based diet.”

Aimmune to present AR101 and peanut allergy data at AAAAI

Aimmune Therapeutics announced that it will present data on AR101, oral immunotherapy, and peanut allergy at the 2019 American Academy of Asthma, Allergy and Immunology Annual Meeting, taking place February 22-25 in San Francisco. “We are excited by the new data being presented at AAAAI, which deepen our understanding of AR101 and how it may benefit children, teens and families struggling with the uncertainty of life with peanut allergy,” said Daniel Adelman, M.D., Chief Medical Officer of Aimmune. “Our goal with AR101 oral immunotherapy is to train the immune system so that allergic reactions with accidental exposures are less frequent and severe. Taken together, the new data presented at AAAAI help to elucidate how AR101 delivers on our therapeutic thesis, providing continued immunomodulation throughout the course of the treatment period studied, as evidenced by greatly reduced adverse events due to accidental exposures to peanuts. These data provide further evidence of the effects demonstrated in the exit food challenge in PALISADE, with a 94% reduction of epinephrine use in the AR101-treated patients at the 600-mg exit food challenge dose. Also, we are seeing increases in efficacy over time, as nearly two thirds of the AR101 patients who tolerated less than the highest dose at the PALISADE exit were able to tolerate more peanut protein in the follow-on study challenge, and half the patients overall were able to tolerate 2,000 mg as the single highest tolerated dose.”
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Alexion Pharmaceuticals gains after Q4 beat

Alexion Pharmaceuticals (ALXN +2.7%Q4 results: Revenues: $1,128.8M (+24.1%); SOLIRIS: $976.7M (+23.3%); STRENSIQ: $126.1M (+31.9%); KANUMA: $25.7M (+17.4%).
Net Loss: ($45M); Non-GAAP Net Income: $486.4M (+44.1%); Loss Per Share: ($0.20); Non-GAAP EPS: $2.14 (+44.6%).
2019 Guidance: Revenues: $4,625M – $4,700M; SOLIRIS/ULTOMIRIS revenues: $3,970M – 4,020M; EPS: $6.14 – 7.26; Non-GAAP EPS: $9.10 – 9.30.
U.S. launch underway for ULTOMIRIS (ravulizumab-cwvz) in adults with paroxysmal nocturnal hemoglobinuria; EU and Japanese applications under review.
The Company has filed U.S. and EU submissions for SOLIRIS in neuromyelitis optica spectrum disorder and is on track to file in Japan later in 2019.
ALXN has also collaborated with Caelum Biosciences.
The consensus non-GAAP EPS and Revenue estimate were $1.82 and $1.06B, respectively.
Shares are up 3% premarket.

Alexion Pharmaceuticals, Inc. 2018 Q4 – Results – Earnings Call Slides

The following slide deck was published by Alexion Pharmaceuticals, Inc. in conjunction with their 2018 Q4 earnings call.

CVS Health No Cost Heart Health Screenings Valentine’s Day for Women


As part of its ongoing commitment to building healthier communities, CVS Health (NYSE: CVS) today announced it will be offering no cost “Know Your Numbers” heart health screenings at MinuteClinic, the company’s retail medical clinic, every Thursday in February, including Valentine’s Day. MinuteClinic locations can be found inside select CVS Pharmacy and Target stores in 33 states and the District of Columbia.

The company also announced it has extended its support of the American Heart Association’s Go Red for Women campaign with a new three-year, $15 millioncommitment to life-saving cardiovascular research and education. CVS Pharmacy customers will have an opportunity to give the gift of heart health by making a donation at the register at their local CVS Pharmacy stores through February 23.
According to the American Heart Association, nearly 80 percent of cardiac events can be prevented, yet most women don’t know their personal health numbers that are critical to determining one’s risk.
“Women tend to put others before themselves, but it is imperative that women make their heart health a priority. The stark reality is cardiovascular diseases continue to be a woman’s greatest health threat, claiming the lives of 1 in 3 women. But by empowering women to be aware – which includes knowing your numbers – move more, eat smart and manage blood pressure, we can change that fact,” said Jennifer Mieres, M.D., an American Heart Association’s Go Red for Women medical expert.
Consumers can visit their local MinuteClinic on February 7, 14, 21, and 28 and receive a no-cost heart health preventive screening, supported by TYLENOL®, to learn the five key personal health numbers that can help them determine their risk for heart disease: total cholesterol, HDL (good) cholesterol, blood pressure, blood sugar and body mass index. MinuteClinic is a high-quality, convenient and affordable destination for preventive care all year long, with 1 in 2 Americans living within 10 miles of a MinuteClinic.
“Knowing your risk for cardiovascular disease and stroke is critical to improving community health, which is why we’re pleased to be offering no cost Know Your Number screenings at all of our MinuteClinic locations on Valentine’s Day, and every Thursday during February,” said Lisa Bisaccia, Chief Human Resources Officer, CVS Health, and national volunteer chair for Go Red for Women. “Health starts at the community level, and that’s why we feel we can make a real difference by increasing access to cardiovascular screenings and providing customers with an opportunity to show their support for family, friends and neighbors who are affected by cardiovascular disease.”
To receive a free screening, download the voucher, print a copy and bring it with you to scan at the MinuteClinic registration kiosk. Alternatively, you can use your mobile phone to show the voucher to the provider after you register at the kiosk.

Baird Upgrades Addus HomeCare (ADUS) to Outperform

Baird analyst Matthew Gillmor upgraded Addus HomeCare (NASDAQ: ADUS) from Neutral to Outperform with a price target of $75.00

Dr. Reddy’s upgraded to Buy from Neutral at CL King

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