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Monday, October 3, 2022

NetScientific Shares Rise After FDA Meeting on HPV Carcinoma Therapy


NetScientific PLC shares rose on Monday after the company said that its portfolio company PDS Biotechnology Corp. has successfully completed an end-of-Phase-2 meeting with the U.S. Food and Drug Administration regarding the combination of its treatment with Merck & Co.'s therapy for papillomavirus carcinoma.

Shares at 1307 GMT were up 0.05 pence, or 13%, at 0.5 pence.

The life-sciences and technology investment company said that PDS has received guidance from FDA on key elements to submit a biologics license application for its PDS0101 asset treatment.

The end-of-Phase-2 meeting was to determine the safety of proceeding to the last phase of the study and identify any additional information necessary to support a marketing application for the uses under investigation.

The combined therapies are targeting the treatment of unresectable, recurrent and metastatic human-papillomavirus-16-positive head-and-neck squamous-cell carcinoma, the company added.

https://www.marketscreener.com/quote/stock/NETSCIENTIFIC-PLC-14285587/news/NetScientific-Shares-Rise-After-FDA-Meeting-on-HPV-Carcinoma-Therapy-41915449/

Walgreens expanding robot network

 

Walgreens is expanding a robotic network effort when it comes to fulfilling prescriptions in an

 effort to ease the labor load of its pharmacy staff.

The automated centers can reduce the pharmacist workload by at least 25% and deliver

 a cost savings of more than $1 billion each year, according to a Wall Street Journal report. 

The drugstore chain has opened eight centers in the past two years and plans to have up to 

24 more up and running in three years.

Pharmacists will have more time to offer patient services and medical services.

"This frees up the capacity of our most skilled professionals," Rina Shah, group vice

 president of pharmacy operations and services at Walgreens, told the news outlet.

 "We looked at our system and said, 'Why are we filling prescriptions the way we did in 1995?'"

https://www.marketscreener.com/quote/stock/WALGREENS-BOOTS-ALLIANCE-19356230/news/Walgreens-expanding-robot-network-to-bolster-pharmacy-operations-41916586/

Rite Aid reports $5M in losses in recent quarter

 Shoplifting cost Rite Aid $5 million in its most recent quarter, with its New York stores taking the hardest hit.

In response the pharmacy chain is testing and deploying new security and theft prevention strategies, according to a Business Insider report.

One approach could include securing "everything," via a lock and key, according to Arnaud Persaud, the company's chief revenue officer.

The company made the announcements during its latest investor call.

"We're looking at literally putting everything behind showcases to ensure the products are there for customers who want to buy it," Persaud said during the call. "We've even had to go to the extent of using off-duty police officers in some of our stores."

https://www.marketscreener.com/quote/stock/RITE-AID-CORPORATION-57476359/news/Rite-Aid-reports-5M-in-losses-in-recent-quarter-41916587/

As NTSB Calls for Passive Alcohol Detection for Drivers, SOBRsafe Offers Solution

  SOBR Safe, Inc. (NASDAQ:SOBR) (SOBRsafe™ or the Company), providers of passive, touch-based alcohol detection technology, today announced that its Safe Driver solutions are in active market use, with broad expansion announced and underway. The National Transportation Safety Board (NTSB) recently highlighted "the need for technology solutions to eliminate impaired driving", and its Chair Jennifer Homendy implored, "We need to implement the technologies we have right here, right now to save lives."​

SOBRsafe's passive alcohol detection in its stationary SOBRcheck™ form is currently helping ensure driver safety for companies like Continental Services and its 1,800 employees across four states. As Continental CEO Matt Hubbard stated, "SOBRsafe provides an innovative solution to proactively manage our existing alcohol policy, while complementing our existing safe operations. SOBRsafe supports our mission to provide a safe environment and community." View an introductory video on SOBRcheck here.

SOBRsafe has now launched its continuous mobile monitoring solution, the fitness-style wearable wristband SOBRsure™. The Company has entered the rideshare industry with partner RubiRides, a service specializing in safe transportation for children. Explained RubiRides Founder and CEO Noreen Butler, "SOBRsafe is revolutionizing preventative alcohol monitoring solutions. SOBRsafe's devices will add yet another layer of confidence to our trips, protecting both drivers and riders and helping ensure that our trips are alcohol-free."

SOBRsafe intends to launch a version of its wearable band for teen drivers in the first quarter of 2023.

"We started SOBRsafe to support recovery and help save lives, and we believe our technology is making a positive contribution now, in real-time," stated SOBRsafe Chairman & CEO Dave Gandini. "Our touch-based technology is hygienic and non-invasive - no breath, blood or urine samples required. With its adoption by employers, agencies and parents, we feel we can bring safer roads to communities across the nation."

Belite 12-Month Interim Results of Phase 1b/2 Study in Adolescent Stargardt Disease Disappoint

 

  • LBS-008 (aka Tinlarebant) was safe and well tolerated in adolescent Stargardt Disease (STGD1) subjects at 12-month time point
  • The majority of the subjects showed stabilization of BCVA in at least one eye
  • A trend for preventing or slowing expansion of autofluorescence continue to be observed
  • No atrophic lesion (DDAF) in 12 of 13 subjects at the 12-month treatment period
  • 12-month interim data from the ongoing Phase 2 study continue to show stabilization in several parameters, including halting or slowing lesion growth, preservation in retinal thickness, reduction in Ellipsoid Zone (EZ) defect width, and stabilization of visual acuity.

Digital health funding in Q3 slides to 2019 levels on investor caution

 With the market under pressure, digital health funding continues to cool down as investors write smaller checks and focus on early-stage startups.

Digital health companies raised $2.2 billion across 125 deals in the third quarter, marking the smallest funding quarter for all of 2022—in fact, it’s the lowest quarter by dollars raised in digital health since the fourth quarter of 2019, according to the latest quarterly report from Rock Health, a venture fund dedicated to digital health. Startups raised $2.1 billion in Q4 2019.

Coming out of 2021’s breakthrough year when funding reached a record level $29.2 billion, industry watchers questioned whether digital health could keep up the momentum. Now the signs are pointing toward funding in 2021 standing out "as an anomaly" rather than the norm with 2022 shaping up to be a year of market adjustments.

Digital health funding slowed in the first quarter, with companies bringing in $6.1 billion, down from $6.7 billion during the same period in 2020. Funding then dropped to $4.1 billion in the second quarter, also down from $8.3 billion the same time a year ago.

With Q3 included, 2022 year-to-date funding totals $12.6 billion across 458 deals, raising doubts that this year’s digital health pot will reach even half of last year’s haul, according to Rock Health.

"Q3’s lack of funding isn’t altogether surprising. Earlier this year, we discussed funding froth drying up in digital health and in VC more broadly in response to macroeconomic forces (inflation, interest rates, supply chain woes) as well as a shift in investor mindset from the high times of 2021," wrote Rock Health research associate Mihir Somaiya in the report.

"However, the sharp decline in funding reflects a deeper underlying change: this quarter’s near-complete absence of late-stage digital health investments," he wrote.

In the first three quarters of 2022, several key themes have emerged: smaller checks across the board, a focus on early-stage funding and reprioritization of technology investments, Rock Health researchers wrote.

This past quarter also saw the exit market beginning to thaw. Digital therapeutics maker Akili Interactive's SPAC merger with Social Capital Suvretta Holdings Corp marked the first digital health public exit all year.

While overall funding dropped 48% from $4.2 billion in the second quarter, deal count fell less sharply, by 14%. Analysis of Rock Health’s funding database suggests that the number of smaller and generally earlier-stage deals remained relatively stable. Smaller deal size—rather than fewer deals—pushed down the overall quarterly total, according to the report.

There were only six funding raises of series C or higher in Q2, accounting for less than 5% of the quarter’s total deal volume—a marked departure from Q2’s 19 series C+ raises and Q1’s thirty-two, according to Rock Health data.

The third quarter logged just two digital health mega raises totaling $100 million or more: one from heart attack prediction app Cleerly ($223 million) and another from mental health provider support toolkit Alma ($130 million). By comparison, the quarterly average number of megadeals across 2021 was 22 deals, totaling 88 megadeals through the year. While 2021’s trend of $100 million+ raises held somewhat steady throughout Q1 of 2022 (18 megadeals), the pace of megadeal funding started to fall in Q2 (11 megadeals) before nose diving in Q3, the Rock Health report states.

Rock Health researchers surmise that late-stage deals were raised early to strike while the iron was hot in 2021 so many companies chose to accelerate rounds into 2021 that may otherwise have been offered in 2022. 

The pullback in late-stage digital health funding in Q3 also reflects more quiet cash infusions as growth-stage digital health startups in need of additional cash turned to investors for inside or extension rounds, bridge rounds, or venture debt.

The third quarter also saw a shift in technology investment that could signal digital health growth areas for quarters to come. In short: interest in telehealth is waning while immersive and decentralized health-tech enablers are on the upswing.

Digital health startups catalyzing R&D for biopharma and medtech fell from first place to third place with $1.7 billion raised so far in 2022, while digital health players specializing in nonclinical workflow solutions jumped to first place with $1.8 billion in funding, led by Alma’s megadeal, Grow Therapy’s $75 million haul, and a $72 million check for practice management suite Tebra. Strong funding flows to workflow tools  mean that addressing healthcare staff shortages and employee burnout remain top priorities, the researchers wrote.

This trend is also reflected in funding for healthcare marketplaces, the fifth most-funded value proposition, led by nurse staffing platform Incredible Health’s $80 million raise in August.

Funding for digital health startups applying augmented and virtual reality (AR/VR) technologies reached a new high, logging $239 million through Q3 2022 compared to $198 million in all of 2021. Average deal size in this sector has doubled from $18 million in 2021 to $34.2 million through Q3 2022, bolstered by rounds like Apprentice.io’s $100 million in January. Other hot areas of investment include digital health startups addressing complex disease states with oncology care-focused companies raising $946 million in Q3.

While startups incorporating telehealth retained the second-top spot in investment activity—a position held since 2015—an oversupplied market, declining yields on direct-to-consumer advertising, virtual prescribing scrutiny, and difficult trajectories of public telemedicine leaders like Teladoc have increased investor skepticism toward telemedicine’s cash crop of virtual care providers, Rock Health researchers wrote.

Telehealth startups raised only $2 billion so far this year. If this funding pace holds steady, investment in telemedicine startups will close 2022 with $2.7 billion—just over one-third of the category’s 2021 total and its lowest funding pot since 2019. 

While 2022 started off as an adjustment period from the funding fever pitch in 2021, Rock Health researchers view Q3 as a clear departure from the COVID-driven digital health financial market, including "changed market dynamics, shifts in investor focus to prioritize workflow support and complex diseases, and growing excitement for new technologies and immersive solutions."

It remains to be seen how these trends will shape the investment market going into 2023.

Investors at Rock Health Capital have seen a gradual return to pre-pandemic asset pricing in the pre-seed through series A deal flow.

"Rational prices promote long-term market health and, if anything, diminish near-term worries," the researchers wrote. 

https://www.fiercehealthcare.com/digital-health/digital-health-funding-drops-2019-levels-investors-make-more-cautious-bets

Acne is a 'disease of Western civilization'

 In the Western world, it’s rare to find someone who hasn’t faced a bout of acne at least once. Regardless of race, everyone seems to succumb to this unsightly skin condition, which occurs when hair follicles become plugged with oil and dead skin cells. At 80% to 90% prevalence among adolescents living in modernized countries, acne is basically a rite of passage. It persists for about half of people over age 25.

But fascinatingly, researchers have discovered that acne is essentially nonexistent among non-industrialized communities. The Kitavan people living on the Trobriand Islands near Papua New Guinea, the Aché hunter-gatherers of Paraguay, the Okinawans prior to the colonization of their island during World War II, the Inuit before becoming more Westernized, and many others have no pimples, whiteheads, or blackheads — not even on the faces of hormone-filled teenagers.

This isn’t simply due to genetics, either. When individuals from these cultures move to the U.S., Europe, Australia, industrialized parts of Asia, or pretty much anywhere where modernization has taken hold, they get acne just as much as the rest of us. This implies that a few, or many, facets of modern society predispose people to pimples. So what are these factors?

Pimple factors

For the acne sufferers out there, a simple answer would certainly be convenient, but unfortunately there isn’t one. Science hasn’t pinpointed one overriding cause. Comparing how we live with how acne-free cultures live can yield insights, however.

  • Our diets are much different. Particularly, acne-free peoples tend to consume far fewer refined carbohydrates and simple sugars that spike insulin levels and are devoid of fiber. Although when studies have been pooled and analyzed together, there really isn’t a clear signal linking any aspect of diet to acne.
  • We exercise less. Regular physical activity can lower stress, reduce inflammation, and increase blood flow to the skin, all of which can reduce acne. But again, studies haven’t revealed a clear link between exercise and acne.
  • We are exposed to less sunlight. Humans obtain much of our Vitamin D from sunlight. The vitamin may speed wound healing and lower inflammation. A 2016 study found that people with acne are more than twice as likely to suffer from Vitamin D deficiency as people without acne.
  • We are more stressed out. The relentless grind of modern life may exact a toll on our skin by messing with hormone levels and diminishing the immune response.
  • We shower too much. Maybe all the hygiene products we apply and the excessive scrubbing we do throw the skin microbiome out of balance? If left to its own devices, our skin might take care of itself just fine, although probably with more pungency.
  • We tend to be exposed to more air pollution. Exposure to nitrous dioxide and other air pollutants may exacerbate inflammatory acne

Though we still don’t know exactly why modern society predisposes its citizens to acne, one thing we can say with some certainty is that acne’s prevalence is rapidly increasing. Last year, researchers noted a global rise of about 48% since 1990, with the burden “most pronounced in Western Europe and high-income countries in Asia Pacific and East Asia”.