- In Phase 2a arm investigating IMM-1-104 in combination with modified gemcitabine/nab-paclitaxel, complete or partial responses have been observed in the first two patients (2/5) to date, for an initial response rate of 40% and an initial disease control rate of 80%, with all five patients continuing on treatment -
- Initial data are at 240 mg QD (safety lead-in dose) of IMM-1-104; additional patients have now been dosed at 320 mg QD in this arm; IMM-1-104 has been well-tolerated to date in combination with gemcitabine/nab-paclitaxel -
- Initial data are consistent with preclinical data presented at AACR, which demonstrated that IMM-1-104 combined with chemotherapy induced deeper responses than either agent alone -
- Clear path forward expected for clinical development of IMM-1-104 in combination with gemcitabine/nab-paclitaxel for pancreatic cancer, assuming initial data is representative; FDA previously granted IMM-1-104 Fast Track designation for the treatment of first- and second-line pancreatic ductal adenocarcinoma -
- Enrollment progressing in all Phase 2a arms with further data expected by year end -
- Company to hold webcast today at 4.30 pm ET /1.30 pm PT -
Immuneering will host a conference call and live webcast at 4:30 p.m. ET / 1:30 p.m. PT on September 12, 2024, to discuss the results and provide a business update. Individuals interested in listening to the live conference call may do so by dialing (800) 715-9871 for U.S callers and (646) 307-1963 for other locations and reference conference ID 8890310, or from the webcast link in the “investors” section of the company's website at www.immuneering.com A webcast replay will be available in the investor relations section on the company’s website for 90 days following the completion of the call.
In six years, Tim Walz took our state budget from $44 billion to $70 billion, squandered a $19 billion surplus and turned it into a deficit even though Minnesotans overwhelmingly wanted tax cuts, raised taxes by $10 billion, increased state government spending by 40%, adopted a California emissions standard, created more government mandates and regulation including expensive leave policies, welcomed illegal immigrants and gave them drivers licenses, and cemented Minnesota as a sanctuary state, to name a few of his accomplishments.
The waste, fraud, and abuse in Walz’s administration shows just what his leadership could bring to Washington, D.C. He failed at government oversight of a massive Feeding Our Futures scandal, and another Walz administration program is under FBI investigation for potential fraud – the program saw 3,000% growth over the period of just a few years.
Minnesota started following in California’s footsteps as a liberal bastion in the Midwest. Our neighboring states reaped the benefits. In two years, Minnesota lost more than 50,000 residents – and not to warmer states like Florida, but the majority moved to Wisconsin, Iowa, and the Dakotas – all with much friendlier economic policies and lower cost of living. IRS data shows Minnesota lost $2.1 billion in income migration, which will likely only be accelerated when Walz-approved taxes on businesses and high-income earners go into effect.
Two years ago, Tim Walz ran for reelection as an unpopular sitting governor. COVID-19 and Walz’s handling of it was very fresh in our minds. At the same time, Minneapolis and surrounding cities were literally burning after George Floyd’s murder accelerated the Defund the Police movement, during which there was no leadership from our governor.
When Walz first ran for governor, he had positioned himself as a hokey member of Congress, a former educator with bad dad jokes. Now he had a record. Many thought he would be a one-term governor. What happened is very Minnesota Nice of Republicans.
I’ve worked in Republican politics for a long time, at the Republican National Committee and on campaigns in Minnesota and across the country. I have never seen such a futile effort to replace an unpopular sitting Democrat governor than when Tim Walz was reelected in 2022.
As governor, Walz kept his COVID emergency powers in place for 400 days, was an empty plaid shirt when Minneapolis burned after George Floyd’s death, oversaw historic crime rates as a radical anti-police movement was encouraged by the Democrat party, brought the fifth-highest taxes in the country, and had more people leaving the state than moving to it. And he was reelected.
There were two lessons from the 2022 election cycle that allowed Tim Walz to catapult to the vice presidential nomination.
First was the Minnesota Republican Party nearly single-handedly reelecting him with their broken endorsement process that they protect at all costs.
In 2022, there was a wide field of Republicans who were exceptionally qualified to take on Tim Walz. Instead of one of those candidates becoming the nominee, the convention endorsement process – that allows a couple thousand of the most right-wing Republican delegates to make the decision for the masses – nominated a candidate who couldn’t be elected statewide.
Because of a gentleman’s agreement that says candidates will “respect the endorsement” and drop out of the primary after the convention, there was no actual primary that allowed the rest of the Republican Party to have a say on their nominee. So unfortunately, Minnesota was left with a false choice – Tim Walz, who wasn’t as moderate as he pretended, or someone who was automatically labeled as extreme.
The second lesson was a passive-aggressive Minnesota press corps that gave Tim Walz a pass. They let him talk out of both sides of his mouth and pretend to be something he wasn’t. They allowed the Democrats to completely change the size and scope of government in Minnesota unchecked.
He shouldn’t get the same treatment nationally as he did in Minnesota. As many of us say, he will have his turn in the barrel where he’ll be getting questions from all sides. It will be the first time he will be tested.
Walz’s approval rating before COVID-19 was 65%, and by 2021 he was under 50%. Today, he’s at 48%. There are many reasons why, and they should be examined for all Americans to see.
Walz and Kamala Harris are doing their best to ride out their honeymoon. I don’t blame them. National Democrats will find they have one of the most untested and liberal tickets we have ever seen. Walz’s old congressional district is made up of the exact voters who oppose him today, and they vote a lot like Western Wisconsin.
Now we will see if Donald Trump can be disciplined enough to expose it.
Kirsten Kukowski is a former Republican National Committee press secretary and was communications director for former Wisconsin Gov. Scott Walker’s presidential campaign in 2016. She runs K2 and Company, a public affairs company based in Minnesota where she lives and works.
Americans are quickly realizing that the Biden-Harris administration's disastrous open southern border policies that flooded the nation with millions of unvetted illegal aliens from third-world countries are quickly overwhelming towns and local municipalities nationwide.
The nation has been shocked by the 20,000 Haitians that were dumped into Springfield, Ohio, by the Biden administration's expansion of the Temporary Protected Status program for immigrants from that failed Caribbean nation. By the way, the small town only had 58,000 before the migrant crisis began.
Springfield resident Diana Daniels told Fox News on Thursday that life in the metro area, with thousands of Haitian migrants, has been chaotic. She said local resources like housing and health care are quickly being drained, warning it's "like living in a dystopian nightmare."
Another Springfield resident is frustrated with the Biden-Harris team importing the third world into the first world:
"I see what's going on in the streets. And I see you guys sitting up there and, comfy chairs and suits… I really challenge you guys to get out here and do something, said Anthony Harris, 28, adding, "These Haitians are running into trash cans. They're running into buildings. They're flipping cars in the middle of the street, and I don't know how like, y'all can be comfortable with this."
And another...
Besides Springfield, Americans were shocked weeks ago to find out that Venezuelan prison gangs were roaming parts of a Denver metro area, causing chaos and seizing apartment buildings. Leaked US Army documents show there are thousands of Venezuelan prison gang members, some of which are armed and dangerous, running amok nationwide. And America's top oil-producing region in West Texas has been under threat by migrant gangs. This indicates that the nation's critical energy infrastructure is at risk.
Back to small towns overwhelmed by migrants, the next area to focus on is Charleroi, Pennsylvania, a small town 21 miles south of Pittsburgh, with a population of around 4,200, according to 2020 Census data.
The new think tank America 2100 wrote in a post on X that the blue-collar town of Charleroi has seen its migrant population soar by 2,000% over the past two years. The group said the migrants are mainly Haitians. This is very similar to the situation in Springfield, of what appears to be the Biden-Harris team precision dumping migrants in small bull-collar towns.
"Why was it [migrants] all dumped on us? We're not being funded with anything, okay. And again, we can't even make ends meet with our budget. So, now, how are we going to get all this extra revenue to pay for it [caring for migrants]?" Councilman Larry Celaschi of Charleroi told America 2100 in a phone interview.
The spread of migrant chaos overwhelming local municipalities across the nation is only expected to worsen. Readers were supplied with a list of the areas across the country that obstruct immigration enforcement and shield criminals from ICE. These areas will likely experience a migrant crisis and are to be avoided for safety travel reasons.
A California car rental company was found to be at the center of a nationwide crime-tourism spree, authorities in Los Angeles revealed this week.
U.S. Attorney Martin Estrada said during a news conference in on Wednesday: "Those thinking they can come to our country, take advantage of our liberties and steal from the American people should think again."
Estrada claimed that two operators of Driver Power Rentals, a Los Angeles car rental company, brought in South American criminals to steal millions in cash and property from businesses and homes in Southern California and nationwide, according to KFOX TV.
"There will be serious consequences for those people and we will collaborate with our local partners in creative ways to make sure we're holding you accountable," Estrada added.
“These defendants facilitated and directed crime tourists who committed hundreds of robberies across the country – in essence, they acted as quarterbacks for a team of thieves. We will continue to work with our local partners to hold accountable those who would come to our country and take advantage of our liberties to steal from the American people.”
The KFOX report writes that Juan Carlos Thola-Duran and his girlfriend, Ana Maria Arriagada, allegedly rented vehicles to criminals they directed to commit hundreds of crimes nationwide, including burglaries, thefts, and money laundering, according to a 46-count indictment.
The thefts spanned 80 cities and involved 120 cases, with the pair earning $5.5 million.
Most of the criminals were from Chile, taking advantage of a visa waiver program. The defendants also allegedly used stolen money to buy real estate and horses and fraudulently obtained $275,000 in COVID-19 relief loans.
Each defendant now faces a maximum of 30 years behind bars.
Ventura County Sheriff James Fryhoff concluded: “Since 2019, we have arrested over 130 suspects responsible for perpetrating these crimes, with the vast majority using cars supplied by Driver Power Rentals.”
This summer saw a slew of court cases over the issue of ballot access. Now the litigation is threatening to undermine voters’ confidence in this fall’s election.
The ability to reflect on and elect our own leaders is the core of our democracy. Democrats should have been thrilled to see third-party candidates like Jill Stein and Cornel West stepping up to provide voters with an alternative choice to the two-party monopoly.
They were not.
The Democratic Party has filed multiple lawsuits in key swing states to restrict third parties’ ballot access. This lawfare will undermine voter confidence in the 2024 election by limiting voters’ ability to exercise choice.
Jill Stein, the Green party nominee, launched her White House campaign in November of 2023. Since then, Democrats have filed multiple lawsuits across the country to keep her off the ballot in swing states such as Wisconsin and Georgia. She survived the challenge in Wisconsin after Democrats claimed that the Green Party’s candidates should be barred from the ballot because the party lacked officeholders to nominate them. Unfortunately for Stein, Democrats’ efforts have been successful in Georgia after the court held that the Georgia Green Party cannot prove they will have ballot access in twenty states by Georgia’s ballot printing deadline – mainly because the documentation used to prove ballot access is not provided to the Green Party until after the deadline. According to her website, Jill Stein or the Green Party have ballot access in thirty states.
Cornel West has faced similar technical challenges to his ballot access. Just last weekend it was confirmed that he survived a challenge to his ballot appearance in Michigan after Democrats argued technical errors with signatures and his affidavit of identity precluded his inclusion. West has fared worse in other swing states. A Pennsylvania judge sided with the Democratic secretary of the commonwealth to bar West from the ballot on a technicality. In Georgia, an administrative law judge sided with the Georgia Democratic Party and barred him from access to the ballot on a technicality despite finding his petitions met Georgia’s minimum signature threshold.
These actions by the Democratic Party are self-serving. In Michigan, a recent poll shows Trump leading Harris by 1 point, with Jill Stein and Cornel West each earning 1% in the state. The CBS estimates tracker shows similar results in Wisconsin, where Harris is barely edging Trump and with third-party candidate Jill Stein sitting at 1%. Finally, a recent poll conducted by Cook Political Report composed of voters in the swing states of Arizona, Michigan, Wisconsin, Georgia, Pennsylvania, North Carolina, and Nevada shows Harris with a meager 3-pont lead over Trump, with third-party candidates garnering 10% of the vote. Democrats must prevent third parties from appearing on the ballot so they can bolster Kamala Harris’ fledgling campaign.
This use of lawfare to limit voters’ choice is a far cry from the democracy messaging Democrats have been utilizing. On the contrary – it is the exact opposite of what democracy looks like. A robust democracy is one where multiple parties compete for votes in free and fair elections. Democrats are attempting to limit free elections by using lawfare to bar from the ballot candidates who inconvenience their grasp on power. In effect, this use of lawfare subverts our democracy. Consequently, this tactic will undermine voters’ faith in our election system and republic.
Voters are already wary of the U.S. electoral system. A recent poll found that 40% of Republicans and 26% of independents are not confident that their votes will be accurately counted. Moreover, a separate poll found over 50% of voters are concerned that ballots are not counted accurately and that mail-in ballots or drop boxes are illegally used or misused.
Democrats must cease the lawfare and enable all candidates who meet the thresholds for ballot access to appear on the ballot. The continued use of lawfare to restrict voter choice will exasperate voters’ wavering faith in the electoral process.
Ryan Silverstein is a J.D. candidate at Villanova University and a fellow with Villanova’s McCullen Center for Law, Religion and Public Policy. His work has previously appeared in the New York Daily News, Post & Courier, and the Las Vegas Review-Journal.
Department of Homeland Security Secretary Alejandro Mayorkas criticized Texas’s attempts to stop illegal immigration while praising Vice President Kamala Harris’s role in addressing the “root causes” of the border crisis.
Mayorkas spoke Sept. 6 at the Texas Tribune Festival in Austin.
The annual festival hosts a slate of political speakers, newsmakers, and journalists who discuss current events.
“This is the first time that in my 20 to 22 years of government service that I have seen a state act in direct contravention of national interests,” Mayorkas said.
Some 10 million illegal immigrants have entered the United States since President Joe Biden took office in January 2021. In March 2021, he put Harris in charge of dealing with illegal immigration. Harris, now the Democratic Party nominee for president, faces criticism for the border crisis as the 2024 election draws near.
Texas has spent $11 billion on Operation Lone Star, deploying thousands of Texas National Guard soldiers and Texas Department of Public Safety troopers, transporting illegal immigrants to self-declared sanctuary cities, installing strategic barriers, and building the state’s border wall, according to Andrew Mahaleris, Texas Gov. Greg Abbott’s press secretary.
Texas’s Operation Lone Star was introduced in March 2021 to address “dangerous gaps” in border security created by Biden and Harris, Mahaleris said in an email to The Epoch Times.
Those efforts have decreased illegal border crossings by 85 percent, he said.
“Until President Biden and Border Czar Harris step up and do their jobs to secure the border, Texas will continue utilizing every tool and strategy to respond,” Mahaleris said.
Mayorkas called Abbott’s efforts to bus illegal immigrants to other states and cities without notice to or coordination with receiving cities “incomprehensible” and not good governance.
“Is it purely to wreak havoc and disorder in the receiving communities to make a political point?” Mayorkas said.
He also criticized Senate Bill 4, which Abbott signed into law and was meant to go into effect on March 5, but it instead remains in limbo after the Biden administration sued. Mayorkas said immigration is the federal government’s responsibility.
SB 4 makes crossing into Texas unlawfully from a foreign nation a state felony and empowers state and local law enforcement to make arrests and carry out deportations. The law has some similarities to a 2010 Arizona law that ended up being mostly struck down in a 5–4 Supreme Court decision in 2012. Texas Attorney General Ken Paxton has said the Supreme Court got the Arizona decision wrong and that it needs to be relitigated.
Homeland Security Secretary Alejandro Mayorkas speaks during a Senate Homeland Security and Governmental Affairs committee hearing on the department's budget request on Capitol Hill in Washington on April 18, 2024. Andrew Harnik/Getty Images
In Austin, Mayorkas defended Harris, saying she had done her job in addressing the “root causes” of mass migration to the United States.
“The vice president has done an extraordinary job in a public-private partnership driving resources to the countries in the Northern Triangle: El Salvador, Honduras, and Guatemala specifically,” he said.
The public–private partnerships invest in those countries to build industries and generate jobs as a way of addressing why migrants leave their countries, he said.
Root causes include violence, poverty, extreme weather events, and corruption, he said.
Mayorkas said the Senate’s failed bipartisan border bill would have helped control immigration, but “forces stepped in to prevent the solution.”
Republicans blocked the bill twice, and former President Donald Trump said it would do more harm than good, writing on Truth Social that it gives border shutdown authority only after 5,000 illegal immigrant encounters per day.
Trump maintains that the president has the authority to close the border like he did without additional legislation.
Tensions between congressional Republicans and Mayorkas caused the House of Representatives to impeach him on Feb. 13. However, the effort died in the Democrat-controlled Senate.
Mayorkas did not address the potential for a new wave of illegal immigrants following the resumption of a controversial parole program and a coordinated effort with Mexico to assist migrants to the U.S. border.
U.S. Customs and Border Protection (CBP), which is part of the Department of Homeland Security, announced on Aug. 23 that its updated CBP One app was expanded to operate south of Mexico City for migrants seeking appointments at U.S. ports of entry.
Illegal immigrants at an Annunciation House facility after being released by the U.S. Immigration and Customs Enforcement in El Paso, Texas, on Jan. 14, 2019. Joe Raedle/Getty Images
The app allows would-be illegal immigrants to be processed for asylum claims by CBP agents at ports of entry in border states, with most being released into the country.
Mexico recently announced that it will offer migrants in the southern parts of its country free bus rides and meals to the U.S. southern border if they have a confirmed appointment through the app.
A few weeks ago, Mexico was rounding up migrants and busing them back to the southern part of Mexico, where the app wasn’t in operation.
The result was a decrease in illegal immigrants crossing the U.S.–Mexico border between ports of entry.
Homeland Security has also resumed its parole program after it shut down over fraud concerns revealed by a government watchdog agency. The Federation for American Immigration Reform obtained the U.S. Citizenship and Immigration Services report, which showed instances in which the same Social Security numbers, addresses, and phone numbers were used hundreds of times.
Up to 30,000 foreign nationals from Cuba, Haiti, Nicaragua, and Venezuela are allowed to fly directly into U.S. airports every month under the program.
The program was resumed with additional vetting of the sponsors, their financial records, and their criminal backgrounds, a Homeland Security spokesperson said on Aug. 29.
The program enables most to stay up to two years and receive work permits.
Parole applicants need a sponsor and to purchase their airplane tickets to qualify for the program.
Homeland Security Committee Chairman Rep. Mark Green (R-Tenn.) has called the mass parole an “unlawful” program that was introduced to obscure the problem of an overrun border.
On Friday, August 30, I received an email from an entity known asCorrlnks. The email read, “This is a system generated message informing you that the above-named person is a federal person in custody who seeks to add you to his/her contact list for exchanging electronic messages.”
The above-named person is Sara Carpenter, a medically retired NYPD officer who in December had been sentenced to 22 months in prison and 24 months of supervised release for her innocuous role in the largely peaceful protest at the Capitol on January 6, 2021.
I was sad to see this. Of the eight surviving women I profile in my book, Ashli: The Untold Story of the Women of January 6, Sara was the last one to be incarcerated. She left behind an adolescent son and a life in ruins. The month she spent at Ground Zero in September 2001 counted for naught in the DoJ’s cruel calculus.
To Attorney General Merrick Garland, Sara Carpenter was literally just a number. On August 25, Garland dismissed as a “quibble” whether the DoJ has had “1500 or slightly less than 1500” prosecutions so far. “I think that’s shown to everybody,” he added, “how seriously we take an effort to interfere with the peaceful transfer of power.”
No, what these prosecutions have shown is Garland’s sociopathic indifference to the human wreckage he has wrought. Two days after Garland’s boastful threat, I received an email from the daughter of Rebecca Lavrenz, a great-grandmother from Colorado Springs who walked into the Capitol through an open door and prayed for ten minutes and left of her own accord. Wrote Laura Lavrenz, “6 months of house arrest, beginning today.”
The home arrest comes with an ankle bracelet, a six month ban on using the internet for any purpose, the mandatory installation of government spyware on her phone and computer, and a $103,000 fine. For the record, this is a stiffer sentence than the ubiquitous provocateur Ray Epps received for, in his words, having “orchestrated” the riot.
This is a perversely stiffer sentence than protestors received for obstructing an official proceeding in September 2018, namely the Senate confirmation hearings for Justice Brett Kavanaugh. Days ago, I just happened on a video of then Senator Kamala Harris grilling Kavanaugh on some inane point.
During this exchange, first one woman and then another started screaming in an effort to interrupt the peaceful selection of a Supreme Court justice. Both times, the hearings ground to a stop as a half-dozen police officers forcibly removed the women who resisted every step of the way. The consequences? As NPR reported in a sympathetic piece, “Most of those charged this week with disorderly conduct, crowding or obstructing paid fines of $35 or $50.”
Lisa Eisenhart was charged with obstructing an official proceeding on January 6. As the court later acknowledged, Lisa “was not a member of any suspect group, did not do any advance planning, nor did she use force to enter the Capitol on January 6.” Her son Eric Munchel recorded their brief journey through the Capitol.
For a few minutes, the pair followed a group of rowdy young men whom Eric repeatedly cautioned, “Don’t vandalize anything, we aren’t Antifa,” and then, more forcefully, “You break shit. I break you.” The viewer sees what Lisa saw, and that was a total absence of violence and vandalism.
At one point, Lisa picked up a pile of zip-ties lying loose, and this act is what did her in. Said their prosecutor, “They stole the flexi-cuffs and carried them into the Senate gallery because they intended to take senators hostage, if possible.” Yes, without “advance planning,” an unarmed 57-year-old woman and her son were planning to take hostages. Seriously? A judge apparently thought so. He sentenced Lisa to 30 months in prison, followed by 36 months of supervised release.
None of the women I profiled resisted the police as aggressively as did the women at the Kavanaugh hearings. In fact, their inquisitors were at pains to document any resistance at all. Said the DoJ in its sentencing document for Sara Carpenter, “During the confrontation, Carpenter slapped away the arm of an officer, who was trying to push her back, with her tambourine.” That was it.
Of the ten women profiled only one committed anything resembling a crime. Rachel Powell, 40, helped some men smash a makeshift battering ram through a Capitol window. When asked how she got swept up in the mayhem, Rachel answered, “I am completely in pain. I was hit with a baton, grabbed and thrown, sprayed. My whole body was on fire.” In October 2023, Rachel was sentenced to 57 months in prison and 36 months of supervised release.
The presence of women in the crowd seemed to provoke the police. Victoria White, 39, endured what was arguably the most severe police beating of a female ever captured on video. Stuck in a tunnel entrance from which she could not escape, Victoria was sprayed in the face with mace and beaten over the head with a baton at least twenty times.
Metropolitan D.C. police officer Lila Morris improvised when she saw Rosanne Boyland lying unconscious after having been pulled out from under a human pile. Morris picked up a stick lying nearby and swung it at Boyland’s head full force three times until the stick broke. All of this was captured on video. Boyland died soon after. And finally, of course, there was Ashli Babbitt, the unarmed 14-year Air Force veteran shot and killed without warning by Capitol Police Lieutenant (now Captain) Michael Byrd.
What Garland has presided over is the greatest mass injustice against American citizens since Japanese internment. Four protestors died, three by police action, and 1500 more had their lives ruined. Not a one of the accused was allowed a change of venue, and not a one was acquitted by D.C. juries no more committed to justice than those of Moscow circa 1937-39.
As Garland knows, the damage extends well beyond the 1500 to friends and relatives, employers and employees, parents and children. Rachel Powell, for instance, has eight children, Victoria White four. Lisa Eisenhart is a grandmother. Rebecca Lorenz, a great grandmother. As to Rosanne Borland and Ashli Babbitt, both in their mid-thirties, there will be no children.
The damage won’t end when that last J6er is sentenced. It will ripple down the ages for a generation, maybe more. The toll in human lives destroyed or distorted has already reached five figures. In time, it may reach six, but as, Merrick Garland cautions us, why quibble?
