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Thursday, September 19, 2024

Track Live: UPS Jumbo Jets Loaded With iPhone 16s Head To America

 The iPhone 16 is set to hit Apple stores this Friday. Ahead of the launch, the flight tracking website FlightAware is tracking a fleet of UPS air freighters loaded to the brim with new iPhones. This mode of rapid delivery from China to US distribution centers is aimed at meeting the preorder surge, given the time-sensitive nature of these shipments. However, Apple's decision to rely on fuel-guzzling jumbo jets instead of more eco-friendly container ships raises serious questions about its commitment to sustainability. 

"Once you've received your UPS tracking number from Apple, use this page to figure out what flight is carrying your iPhone or Apple Watch. The "departure scan" in your UPS tracking should match the departure time for a flight listed below," FlightAware wrote on its website. 

FlightAware's live tracking map shows a fleet of UPS jets loaded with iPhones taking off from Shenzhen Bao'an International Airport—formerly Shenzhen Huangtian Airport—located in the city of Shenzhen in South Central China's Guangdong province and Hong Kong International Airport. The final destinations are Anchorage International Airport in Alaska and Louisville International Airport in Kentucky. 

In light of this week's incidents involving exploding pagers, it's time to ask the question:

FlightAware's activity log of the UPS jets.

Two reports this week...

... suggest soft demand for more expensive iPhone models. 

https://www.zerohedge.com/markets/track-live-ups-jumbo-jets-loaded-iphone-16s-head-america

Aligos off after call on MASH candidate trial

 

  • ALG-055009 dose groups met the primary endpoint with statistically significant reductions in liver fat at Week 12 as measured by MRI-PDFF
  • Placebo-adjusted median relative reductions in liver fat were up to 46.2% with a clear dose response
  • ALG-055009 was well-tolerated with no serious adverse events or dose reductions. Importantly, ALG-055009 dose groups had a similar incidence of gastrointestinal-related adverse events with less diarrhea compared to placebo
  • Significant reductions in atherogenic lipids, including LDL-C, lipoprotein (a), and apolipoprotein B were observed
  • Conference call scheduled for 8:30am ET/5:30am PT today
The company will host a conference call and webcast with a slide presentation today at 8:30am ET/5:30am PT. To access the live webcast with slides, please visit the Presentation & Events page on the Aligos website at www.aligos.com. Please register ten minutes prior to its start. Following the live webcast, a replay will be available on the company’s website for 90 days.

Achilles to discontinue development of TIL-based cNeT therapy

 –Cash position of $95.1 million as of June 30, 2024–

–BofA Securities engaged to provide strategic financial advice–

https://www.globenewswire.com/news-release/2024/09/19/2948865/0/en/Achilles-Therapeutics-Announces-Strategic-Update.html

TANG CAPITAL MANAGEMENT LLC Acquires New Stake in Singular Genomics

 On September 16, 2024, TANG CAPITAL MANAGEMENT LLC (Trades, Portfolio), a prominent investment firm, executed a significant transaction by purchasing 372,000 shares of Singular Genomics Systems Inc (NASDAQ:OMIC). This acquisition, marked as a new holding for the firm, was carried out at a price of $12.81 per share, reflecting a strategic move in the healthcare sector. The total shares now held by the firm in OMIC amount to 372,000, representing a 0.48% position in their portfolio and a substantial 14.90% ownership of the company's available stock.

Insight into TANG CAPITAL MANAGEMENT LLC (TradesPortfolio)

Located at 4747 Executive Drive, San Diego, CA, TANG CAPITAL MANAGEMENT LLC (TradesPortfolio) is known for its sharp focus on the healthcare and technology sectors. With an equity portfolio valued at approximately $979 million and 127 stocks under management, the firm has a significant influence in its chosen fields. Top holdings include KalVista Pharmaceuticals Inc (NASDAQ:KALV), AnaptysBio Inc (NASDAQ:ANAB), and several others that underscore its investment philosophy geared towards innovative healthcare solutions.

https://finance.yahoo.com/news/tang-capital-management-llc-acquires-230310149.html

Edgewise Surprise Victory In Cardiomyopathy; Cytokinetics Dips

 Edgewise Therapeutics (EWTX) stock skyrocketed — and is posed to hit a three-year high — on Thursday after a single dose of its drug improved heart function in cardiomyopathy patients.

The biotech company tested its drug, EDG-7500, in healthy volunteers and patients with obstructive hypertrophic cardiomyopathy. In this disease, a genetic mutation causes the heart ventricles to thicken. This limits cardiac function and exercise capacity.

After a single dose, patients showed improved blood flow from the left ventricle. But sometimes drugs can do their job too well, suppressing cardiac function — a measure known as reduced left ventricular ejection fraction, or LVEF. But patients didn't show meaningful reductions in LVEF.

In response, Edgewise Therapeutics stock soared 33.8% to 25.51. That put shares on deck to open at their highest point since June 2021. Shares have a nearly perfect IBD Digital Relative Strength Rating of 98, putting them in the leading 2% of all stocks in terms of 12-month performance.

Meanwhile, shares of Cytokinetics (CYTK), slipped 2.3% to 54.63. Cytokinetics is working on an experimental treatment for the same condition. Bristol Myers Squibb (BMY), which sells the only approved drug for the disease, rose a small fraction to 49.78.

https://www.investors.com/news/technology/edgewise-therapeutics-obstructive-hypertrophic-cardiomyopathy/

Galmed Expansion of Activities to Cancer and major Cardiometabolic Diseases

 

  • Aramchol is the most clinically advanced, first-in-class, Stearoyl-CoA desaturase1 (SCD1) oral inhibitor, demonstrating in Ph2 and Ph3 (open label part) an excellent safety profile with metabolic and anti-fibrotic effects.
  • Galmed raised an aggregate of $7.5 million in warrant exercises and drawdowns on its recently adopted equity line

Galmed Pharmaceuticals Ltd. (Nasdaq: GLMD) ("Galmed" or the "Company"), a clinical-stage biopharmaceutical company for fibroinflammatory indications announced today that based on the recently published results from the Open-Label part of its Phase 3 NASH study, new scientific publications on the role of SCD1 as a critical metabolic signaling hub as well as an extended cash runway, it plans to broaden its drug development activities. 

The planned expansion consists of two additional programs over the next two years. One program aims to identify novel Aramchol-based drug combinations to overcome resistance to standard-of-care oncological treatments for patients with advanced colorectal and hepatic cancers. Another program aims to unravel new mechanisms of action that will allow the development of a novel Aramchol-based drug combination targeting cardiac fibrosis, or scarring of the heart, which occurs in many cardiovascular diseases that can lead to heart dysfunction and failure. The Company plans on releasing new data from in-vitro and ex-vivo studies in these programs during the fourth quarter of 2024.

https://www.prnewswire.com/news-releases/galmed-announces-an-expansion-of-its-activities-to-cancer-and-major-cardiometabolic-diseases-302252949.html

Wednesday, September 18, 2024

DeWine’s History Raises Concerns About Potential Conflict Of Interest With Haitian Migrants

 Republican Ohio Gov. Mike DeWine has faced a series of conflicts of interests on key issues in his state, including with the ongoing Haitian migrant crisis affecting Springfield.

DeWine recently pledged support to Springfield to assist with the influx in Haitian migrants, according to Spectrum News. Over a period of years, DeWine and his wife have developed extensive ties to a charity in Haiti.

The charity was established in honor of Becky DeWine, their daughter who died in a car accident. The DeWine Family Foundation Inc. gave a $400,000 grant to the group “Hands Together” to fund a school in Haiti, according to the foundation’s 990 form that was filed in 2023.

Hands Together established the Becky DeWine school and dedicated it to the governor’s late daughter in 1999, according to its website. DeWine’s family held fundraisers for years on behalf of the charity in Ohio.

The governor recently expressed support for Temporary Protected Status, the program that allowed many Haitian migrants to enter the U.S.

“I want to be very clear, totally very clear, I’m not against this program,” the governor stated. “I’m not against this program.” He added that there needs to be a plan and Ohio requires assistance from the federal government.

His support for Haitian migrants has drawn criticism from some conservatives online.

DeWine and his wife, Fran, have long had ties to Haiti. For over 20 years, the two made frequent trips to the country, ABC News 5 Cleveland reported.

“During his tenure as a U.S. senator from 1995-2007, DeWine kept Haiti on his political agenda,” YS News reported in 2010. The outlet went on to say that DeWine believes the “U.S. has an interest in promoting stability” in Haiti.

This isn’t the first time DeWine has had personal interests that ran into important issues under his purview as governor.

DeWine’s office came under scrutiny last year when a Norfolk Southern train derailed in East Palestine, polluting the town with dangerous chemicals. The company donated $10,000 to Gov. Mike DeWine almost a month before the derailment, an investigation conducted by the outlet revealed.

Norfolk Southern had donated to the governor’s political funds since his first gubernatorial campaign in 2018, according to the Columbus-based outlet. The investigation revealed the company lobbied Ohio officials on various transpiration issues, including persuading officials to oppose legislation that would have created stricter rail safety regulations.

A DeWine spokesman said the campaign contributions had “no effect on his decisions,” WYSX reported.

DeWine also received thousands of dollars in donations from donors that oppose bans on transgender procedures for minors, the Daily Caller News Foundation (DCNF) previously reported. The Ohio Children’s Hospital Association (OCHA) donated $10,000 in 2018 to the Mike DeWine and Jon Husted Transition Fund and another $10,000 in 2022.

He also received donations from Nationwide Children’s Hospital, ProMedica Children’s Hospital, and Cincinnati Children’s, all organizations that support transgender sex change procedures, the DCNF reported.


“We are thankful for Governor DeWine’s thoughtful approach in thoroughly researching the issue of gender-affirming care and vetoing sub HB 68 today,” The OCHA President Nick Lashutka told the DCNF in a statement. “Gender-affirming care” is a euphemism for irreversible sex change procedures.

The governor vetoed a bill, HB 68, in 2023 that would have banned sex changes for minors and prohibited men from competing in women’s sports.

That bill is not the only issue DeWine allied with the left on – critics of the governor have also noted his past support for accepting refugees in Ohio.

DeWine previously told the Trump administration that Ohio would continue to accept refugees after the former president signed an executive order mandating State Department officials only resettle refugees in places that consented to the resettlement, according to the Cincinnati Enquirer.

Springfield, a city of roughly 60,000, has been overwhelmed with 20,000 Haitian migrants in just a few years.

https://dailycaller.com/2024/09/17/mike-dewine-haitian-migrants-haiti-charity-springfield-ohio/