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Monday, February 10, 2025

Merck KGaA sets its sights on acquisition of Ogsiveo-maker SpringWorks

As SpringWorks Therapeutics nears a key regulatory decision in the U.S., the Connecticut-based cancer and rare disease drugmaker appears to have attracted the attention of a biopharma bigwig from overseas.

Darmstadt, Germany’s Merck KGaA is said to be in advanced talks to acquire SpringWorks, which has a market value of around $3 billion, Reuters reported Monday, citing people close to the matter.

Should everything go to plan, the deal could be inked in the coming weeks, Reuters’ sources said.

SpringWorks declined to weigh in on the situation, with a company spokesperson telling Fierce Pharma that “SpringWorks does not comment on market rumors or speculation.”

Merck KGaA did not immediately respond to Fierce Pharma’s request for comment, though a company spokesperson told Reuters that it “continuously assesses options that could support our businesses and enhance our strategic positioning.”

Any details on a potential transaction will be announced “when they materialize,” Merck KGaA’s spokesperson told the news service.

Word of the potential acquisition comes as SpringWorks awaits an FDA approval decision on its MEK inhibitor mirdametinib toward the end of February. If approved with the company’s hoped-for label, mirdametinib—slated to become SpringWorks’ second commercial medicine behind the desmoid tumor drug Ogsiveo—would be the first therapy cleared by the FDA for both adults and children with neurofibromatosis type 1 (NF1) who have symptomatic plexiform neurofibromas (PN).

Should SpringWorks’ drug pass muster with the FDA, mirdametinib will have to go toe-to-toe with AstraZeneca’s Koselugo on the U.S. market.

After 2024 proved to be a more muted year for large-scale biopharma M&A, 2025 has already ushered in a pair of substantial transactions.

Issuing an opening salvo at this year’s J.P. Morgan Healthcare Conference, Johnson & Johnson last month said it was paying $14.6 billion to get its hands on New York City-based central nervous system biotech Intra-Cellular Therapies.

More recently, investment firm Bain Capital last week said it was laying out 510 billion Japanese yen ($3.3 billion) to acquire Mitsubishi Tanabe Pharma in a carve-out transaction from the Japanese drugmaker’s parent company, Mitsubishi Chemical Group.

The deal, which is expected to close in 2025’s third quarter, will set up Tanabe Pharma as an independent company poised to benefit from Bain’s financial prowess and industry expertise. 

https://www.fiercepharma.com/pharma/merck-kgaa-sets-its-sights-acquisition-ogsiveo-maker-springworks-report

Hamas Suspends Further Hostage Releases As Trump Says No 'Right Of Return' Under His Plan

Hamas has announced Monday it is suspending the release of hostages planned for Saturday until further notice due to "Israeli violations" and amid international backlash at Trump's proposed plan to "take over" Gaza which would block a Palestinian 'right of return'.

The last three emaciated-looking Israeli hostages were freed on Saturday in exchange for over 180 Palestinians released from Israeli jails. The Israeli captives have been held for over 490 days. Since the ceasefire took effect last month 21 people have freed by Hamas and Islamic Jihad - 16 of them Israelis and five Thai citizens. Victims' families in Israel are desperately hoping more will be freed according to plan.

Until now the truce was looking promising, and is on the brink of entering a second phase of the deal, given the Israeli military this weekend withdrew from from the Netzarim Corridor, which cuts Gaza in half, allowing tens of thousands of Gazans to return to the north and move more freely.

Via Associated Press

Hamas has announced the next round of release of captives is postponed "until further notice" while accusing Israel of  violating the terms of the ceasefire deal. Israel has put its military on 'high alert'.

Several Palestinians have been shot by IDF forces in Gaza City, but Israel in turn has blamed Hamas for violating agreements, including parading hostages in front of propaganda posters before they are handed over to the Red Cross.

Hamas has also been fiercely condemning Trump's plan which would see Gazan's leave the strip en masse. He's been pressuring Egypt and Jordan to take in over one million Palestinians. His latest statements have inflamed tensions further. According to Fox, CNN and other outlets on Monday, Trump has expressly said his plan would not support a right of return:

President Donald Trump said explicitly in an interview this weekend that Palestinians would not have a right to return to Gaza under his plan to take US ownership of the strip and rebuild it.

“No, they wouldn’t,” Trump said in an interview on Fox News when asked whether the Palestinians would have a right to return. “Because they will have much better housing. Much better – in other words, I’m talking about building a permanent place for them.”

Hamas has responded by saying the US President tackling the "Palestinian issue with the mentality of a real estate dealer" and this is "a recipe for failure."

Many analysts have warned that this White House rhetoric could collapse an already fragile ceasefire deal, and this is precisely what appears to be happening now, also given PM Netanyahu has hailed Trump's words as "creative" and "revolutionary". 

Trump and his top foreign policy officials haven't been fully on the same page, it appears:

Afterward, some Trump aides sought to soften or clarify aspects of the plan. Karoline Leavitt, the White House press secretary, said Trump was proposing only a temporary relocation of Palestinians while Gaza was being rebuilt.

Secretary of State Marco Rubio, who was traveling in Latin America when Trump revealed his idea, suggested the resettlements from Gaza would be only on an interim basis.

“What he very generously has offered is the ability of the United States to go in and help with debris removal, help with munitions removal, help with reconstruction — the rebuilding of homes and businesses and things of this nature, so that then people can move back in,” Rubio said last week.

But a stance of 'no right of return' means that Palestinians would not be allowed back to their homes or communities. Already tens of thousands are returning, and it remains unlikely that Trump's plan could be practically achievable. 

The reality is that hardliners within Netanyahu's government don't want to see a truce deal stick, as they prefer a military solution. Trump's words give them an incentive to 'cleanse' Gaza of Palestinians, continuing the IDF air and ground operation.

https://www.zerohedge.com/geopolitical/hamas-suspends-further-hostage-releases-trump-says-no-right-return-under-his-plan

NY Fed Survey Shows 1 Year Inflation Expectations Unchanged, Makes Mockery Of UMich Propaganda

 In a surprising twist, last Friday's disappointing - and massively revised - jobs data was unexpectedly upstaged by the inflation expectation prints in the February UMichigan consumer sentiment survey (where the presence of socialist "economist" Justin Wolfers seems to be increasingly skewing the numbers) and which indicated an absolutely ridiculous surge in 1Yr inflation expectations (from 3.3% to 4.3%), but not because everyone expects more inflation but because Democrats now expect something approaching hyperinflation at 5.1%, even as Republicans expect 0.0% inflation in 1 year (and how the average of these two adds up to 4.3%, maybe Justin Wolfers can tell us). Yet despite the clearly political, and thus unreliable, nature of the print the market moved dramatically, and hundreds of billions of market cap was wiped out as stocks sold off on fear of more Fed tightening in coming months.

And just because the number was so galactically stupid, we said that when the NY Fed's inflation expectations print at 11am ET today, they would show an unchanged print and "dunk on the UMich idiocy."

And that's precisely what the Fed revealed moments ago, when it confirmed that far from soaring, 1-Year inflation expectations were not only unchanged at 3.00% - as we said they would be - but they came in below the median analyst estimate of 3.1%.

As a result, the gap in 1 Year inflation expectations between the NY Fed survey and the UMich survey, has exploded so wide...

... even WSJ Fed mouthpiece Nikileaks Timiraos was compelled to comment on it.

3 year ahead inflation expectations were also unchanged at 3%, while the longer-dated, 5 Year, bucket rose to 3%, the highest since May 2024, although this is a series that has been capped at 3% for the past three years and which tend to track 5Yr breakevens closely.

And for those who claim that this is all due to confusion by the respondents, the NY Fed dunked on that as well, reporting that the median inflation uncertainty was unchanged at the one-year horizon, declined at the three-year horizon, and increased at the five-year horizon.

As Bloomberg notes, inflation expectations have taken on a new importance in the debate over next steps for monetary policy amid President Donald Trump’s moves to impose tariffs on the country’s biggest trading partners. On Feb. 1, Trump announced tariffs against goods imported from China, Mexico and Canada, though he subsequently delayed the Mexico and Canada decisions.

Several Fed officials have said in recent weeks that the central bank’s response to higher prices resulting from tariffs will depend on whether inflation expectations remain well anchored, and this is where Democrats are doing everything in their power to indicate that at least their expectations are becoming unanchored to the upside, while Republicans are seeing deflation!

The New York Fed survey showed a rise in inflation expectations for various items over the next year, including gas, food, medical care, college tuition and rent. It also revealed a growing divergence among respondents over estimated inflation in the year ahead, with the gap between the 25th- and 75th-percentile respondents widening to the largest since mid-2023.

Median home price growth expectations rose by 0.1 percentage point to 3.2%. This increase was driven by respondents in the West census region. This series has been moving in a narrow range between 3.0% and 3.3% since August 2023.

Other indicators in the New York Fed survey were more mixed. Expectations for growth in household spending fell in January to a four-year low and respondents reported more pessimism about their financial situations (which is hardly inflationary). 

Paradoxically, the perceived probability that the unemployment rate would be higher a year from now also fell, to the lowest level since July 2021.

And if that wasn't confusing enough, the survey found that the mean perceived probability of losing one’s job in the next 12 months increased by 2.3% to 14.2%, the highest since July

Meanwhile, adding to the confusion, results from a separate survey published Monday by the Cleveland Fed indicated chief executives and other business leaders polled in January said they expect the consumer price index to rise 3.2% over the next 12 months, down from 3.8% in October.

  • Here are some more observations from the latest survey, first looking at the Labor Market:
  • Median one-year-ahead earnings growth expectations increased by 0.2 percentage point to 3.0% in January. This series has been moving within a narrow range between 2.7% and 3.0% since January 2024.
  • Mean unemployment expectations—or the mean probability that the U.S. unemployment rate will be higher one year from now—decreased by 0.6 percentage point to 34.0%, the measure’s lowest reading since July 2021. The decline was driven by respondents with no college degree, those with an annual income below $100,000, and those above age 40.
  • The mean perceived probability of losing one’s job in the next 12 months increased by 2.3 percentage points to 14.2%. This increase was broad based across demographic groups, but most pronounced for those over the age of 60. The mean probability of leaving one’s job voluntarily in the next 12 months also increased by 1.7 percentage points to 19.9%. This increase was most pronounced for those with an annual household income below $50,000.
  • The mean perceived probability of finding a job in the next three months if one’s current job was lost increased by 1.3 percentage points to 51.5%. This increase was driven by those with an annual household income below $100,000.

... and Household Finance

  • The median expected growth in household income increased by 0.2 percentage point to 3.0% in January. The series has been moving in a narrow range between 2.8% and 3.1% since August 2023.
  • Median household spending growth expectations declined by 0.4 percentage point to 4.4%, its lowest reading since January 2021, but remains above pre-pandemic levels. The decline was broad-based across age, income, and education groups.
  • Perceptions of credit access compared to a year ago improved in January, with the net share of households reporting it is easier versus harder to obtain credit than one year ago increasing. Expectations for future credit availability also improved.
  • The average perceived probability of missing a minimum debt payment over the next three months decreased by 0.9 percentage point to 13.3%. This series remains above its 12-month trailing average of 13.0%.
  • The median expected year-ahead change in taxes at current income level increased by 0.2 percentage point to 3.2%, but remains well below its 12-month trailing average of 3.9%.
  • Median year-ahead expected growth in government debt increased by 0.1 percentage point to 6.0%. This reading is well below the series 12-month trailing average of 8.6%.
  • The mean perceived probability that the average interest rate on saving accounts will be higher in 12 months decreased by 0.2 percentage point to 25.0%.
  • Perceptions about households’ current financial situations compared to a year ago deteriorated in January, with the net share of households reporting a worse versus better situation compared to a year ago rising. Similarly, year-ahead expectations about households’ financial situations also deteriorated in January.
  • The mean perceived probability that U.S. stock prices will be higher 12 months from now increased by 0.5 percentage point to 40.3%.

More in the full survey available here.

https://www.zerohedge.com/economics/ny-fed-survey-shows-1-year-inflation-expectations-unchanged-makes-mockery-umich

DocGo Acquires PTI Health To Expand Mobile Proactive Healthcare

 DocGo Inc. (Nasdaq: DCGO) (“DocGo” or the “Company”), a leading provider of technology-enabled mobile health services, today announced the acquisition of PTI Health, a mid-Atlantic mobile lab collection and phlebotomy services company. This strategic move expands DocGo’s healthcare service offering to include mobile phlebotomy lab services, addressing critical gaps in diagnostic care for underserved populations. With this acquisition, DocGo will facilitate timely, convenient blood collection and additional at-home testing services for patients, offering a new level of care to those with limited access to traditional labs or transportation options.

https://www.businesswire.com/news/home/20250210820237/en