DelMar Updates Results on Twenty Glioblastoma Patients in Phase 2 Trial

DelMar Pharmaceuticals, Inc. (NASDAQ: DMPI) ("DelMar" or the "Company"), a biopharmaceutical company focused on the development of novel cancer therapies, provided an update on the first 20 patients enrolled in its ongoing Phase 2 clinical study investigating the first-line treatment of VAL-083 in combination with radiation therapy in newly-diagnosed, MGMT-unmethylated GBM.
As of August 1, 2019, 17 of the first 20 enrolled patients have received at least their first assessment (two patients have not been enrolled long enough to receive their first assessment and one patient died before their first assessment). "Best Overall Response" for these patients per investigator assessment were:

• Nine have been assessed as having achieved a complete response (CR) (9/17, or 53%)
• Seven have been assessed with stable disease (SD), (7/17, or 41%)
• One has been assessed as disease progression (PD) (1/17, or 6%)

Importantly, 16 of the 20 patients enrolled (80%) were still alive as of the August 1, 2019 data cut-off date.  The Company recently announced the enrollment of the 20th patient into this trial.
Dr. David Reardon, clinical director of the Center for Neuro-Oncology at the Dana-Farber Cancer Institute and Professor of Medicine at the Harvard Medical School, and Dr. John de Groot, Professor and Chairman ad interim in the Department of Neuro-Oncology at The University of Texas MD Anderson Cancer Center (MDACC), are considered key opinion leaders in the brain cancer field and currently serve as DelMar Scientific Advisory Board members.  Dr. Reardon commented, "Both John and I agree that we desperately need something better to offer our patients and we feel that VAL-083 has some promise and potential."
Dr. Reardon added, "For a tumor such as GBM, which is intrinsically infiltrative and destructive in the brain, stabilization of disease is an important achievement."
Professor Zhong-ping Chen, Founder Chairman of the Department of Neurosurgery/Neuro-oncology at Sun Yat-sen University Cancer Center (SYSUCC), who is the study's principal investigator, stated, "We are pleased to be leading this Phase 2 trial for first-line GBM treatment with DelMar, and are encouraged by the enhanced levels of tumor shrinkage and the complete responses we are observing after treatment with VAL-083 in combination with radiation. These preliminary data appear to support the premise that VAL-083 has the potential to provide a valuable treatment option for these patients. We look forward to completing full enrollment in the study as soon as possible."
https://www.prnewswire.com/news-releases/delmar-pharmaceuticals-reports-updated-results-on-twenty-patients-from-the-phase-2-clinical-trial-of-val-083-as-first-line-treatment-in-newly-diagnosed-mgmt-unmethylated-glioblastoma-multiforme-gbm-300900547.html