Positive new colorectal cancer data has Pfizer envisioning a launch
for its newly acquired Array BioPharma meds. And the company is getting
prepared.
Monday at the European Society for Medical Oncology annual meeting,
the New York drugmaker presented data showing that its Braftovi and
Mektovi, when combined with anti-EGFR drug Erbitux, could extend
previously treated patients’ lives for a median nine months, compared
with just 5.4 months for standard-of-care therapy. In other words, it
decreased the risk of death by 48%.
The numbers have Pfizer “very excited” and planning an FDA submission
for the fourth quarter of this year, Andy Schmeltz, global president
and general manager of Pfizer’s oncology unit, said.
The prognosis for this patient pool is “very poor, and to have a new
option that can really extend life … is very significant,” he said.
But the company is also “mindful of the resources that will be
required for a successful launch” in that arena—resources that hadn’t
yet been allocated when Pfizer swallowed Braftovi and Mektovi’s maker,
Array, for $11.4 billion in July.
“There had not been the scaling up to prepare to launch in colorectal
cancer, and that’s what we’re partnering right now to prepare for,”
Schmeltz said, adding that “we’re going to size and scale as
appropriate.”
Thanks to the acquisition, the pharma giant now also has the chance
to throw its weight behind the duo in melanoma, where Array got off to a
flying start. After just a year on the market, the combo is already
grabbing 1 in 3 new patient starts, despite competition from two other
in-class combos.
Still, “the focus for Array had really been in the cancer centers,”
Schmeltz said. Given that the company had only been marketing the drugs
for a year when it agreed to tie the knot with Pfizer, its reps “hadn’t
really had the opportunity yet to engage more broadly with
community-based oncologists.”
“This gives us the opportunity to do that,” he noted.
While Pfizer will add staffers and funding to the effort, though,
it’ll still be leaning on Array for its experience in the melanoma
field. “Pfizer Oncology did not have a presence in melanoma, so we need
the expertise that the Array colleagues bring to the table,” Schmeltz
said. He pointed out that “it’s not an integration about synergy,” which
is a pharma favorite term for cost-cutting.
“We’re working together to bring” the Array employees on board, and everything’s going very smoothly, he said.
https://www.fiercepharma.com/pharma/esmo-pfizer-eyes-commercial-scale-up-as-array-colorectal-cancer-combo-hits-its-marks
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