Hundreds of thousands of the UK’s most vulnerable people could be set to benefit from innovative treatments that stop them catching COVID-19, as 2 new government-funded clinical trials launch in the UK.
The trials will test the effectiveness of treatments - which have already shown promising early results for treating COVID-19, in preventing the virus and therefore its transmission among care home residents and those with weakened immune systems, such as transplant patients or those on dialysis.
Any treatment proven to be safe and effective will be rapidly made more widely available on the NHS, and will mean people for whom COVID-19 vaccines may be less effective due to their lowered immune systems - such as cancer patients - will have additional protection to prevent infection and serious illness.
Matt Hancock, Health and Social Care Secretary, said:
Since the beginning of the pandemic, we have worked to find the best treatments the world has to offer for COVID-19.
It’s down to this dedication and the renowned expertise of British scientists, supported by taxpayers, that the UK was able to identify and rollout 2 lifesaving treatments for COVID-19 to NHS patients – dexamethasone and tocilizumab.
The government is backing 2 more innovative UK-based clinical trials into effective therapeutics, this time specifically for the most vulnerable groups who need them most.
We have been clear from the outset that it will be a combination of safe and effective vaccines, testing and therapeutics that will bring an end to this pandemic, and we will not rest until every individual in the country is protected against this awful disease.
Professor Chris Whitty, Chief Medical Officer for England and co-lead for the National Institute for Health Research (NIHR), said:
These 2 important NIHR-funded studies will evaluate prophylactic treatments for COVID-19 in care homes and for those with compromised immune systems.
The more proven clinical tools we can use to protect these very vulnerable groups the better, so I encourage as many eligible individuals, care home operators and residents to take part in these studies.
The PROTECT-V trial, run by the University of Cambridge, will look at potential COVID-19 treatments’ effectiveness in reducing the spread of the virus amongst immunocompromised groups. It launched this month and will last at least 12 months.
There are at least 500,000 people who could benefit from these treatments in England alone, and 2,250 are expected to take part in the clinical trial.
The PROTECT-CH trial, run by the University of Nottingham, will also look at treatments for reducing transmission and serious illness from the virus, for care homes, their residents and staff. The trial will begin in May 2021 and last around 2 years.
It aims to recruit more than 400 care homes to take part, covering approximately 12,000 elderly residents, with any approved treatments having the potential to be rolled out to the 420,000 care home residents across the UK.
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