Athira Pharma, Inc. (NASDAQ: ATHA), a late clinical-stage biopharmaceutical company focused on developing small molecules to restore neuronal health and slow neurodegeneration, today announced the peer-reviewed publication of data from a Phase 1 clinical trial of fosgonimeton (ATH-1017) in The Journal of Alzheimer's Disease.
The article, titled “Safety, tolerability, pharmacokinetics and pharmacodynamics of the positive modulator of HGF/MET, fosgonimeton, in healthy volunteers and subjects with Alzheimer’s disease: randomized, placebo-controlled, double-blind, Phase 1 clinical trial,” and includes results demonstrating that fosgonimeton showed a positive safety and tolerability profile across all dose levels tested and dose-proportional pharmacokinetics and encouraging pharmacodynamic activity.
"These encouraging results showed a positive safety and tolerability profile of fosgonimeton across a wide dose range, and the pharmacodynamics support blood brain barrier penetration. Importantly, we believe the significant reduction of ERP P300 latency levels seen in the Alzheimer’s disease patient cohort on active treatment may be suggestive of enhanced synaptic function and, ultimately, the potential procognitive properties of fosgonimeton,” said Hans Moebius, MD, PhD, Chief Medical Officer of Athira. “These data support our ongoing Phase 2 ACT-AD and Phase 3 LIFT-AD trials evaluating fosgonimeton's potential as a treatment for Alzheimer’s disease. We look forward to sharing the Phase 2 ACT-AD top-line data in the second quarter of 2022.”
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