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Friday, October 7, 2022

Discovery of additional function of cerebellum

 The cerebellum is known primarily for regulation of movement. Researchers at the University of Basel have now discovered that the cerebellum also plays an important role in remembering emotional experiences. The study appears in the journal PNAS.

Both positive and  are stored particularly well in memory. This phenomenon is important to our survival, since we need to remember  in order to avoid them in the future. Previous studies have shown that a  called the amygdala, which is important in the processing of emotions, plays a central role in this phenomenon. Emotions activate the amygdala, which in turn facilitates the storage of information in various areas of the cerebrum.

The current research, led by Professor Dominique de Quervain and Professor Andreas Papassotiropoulos at the University of Basel, investigates the role of the cerebellum in storing . In a large-scale study, the researchers showed 1,418 participants emotional and neutral images and recorded the subjects' brain activity using magnetic resonance imaging.

In a memory test conducted later, the positive and negative images were remembered by the participants much better than the neutral images. The improved storage of emotional images was linked with an increase in  in the areas of the cerebrum already known to play a part. However, the team also identified increased activity in the cerebellum.

The cerebellum in communication with the cerebrum

The researchers were also able to demonstrate that the cerebellum shows stronger communication with various areas of the cerebrum during the process of enhanced storage of the emotional images. It receives information from the cingulate gyrus—a region of the brain that is important in the perception and evaluation of feelings. Furthermore, the cerebellum sends out signals to various regions of the brain, including the amygdala and hippocampus. The latter plays a central role in memory storage.

"These results indicate that the  is an integral component of a network that is responsible for the improved storage of emotional information," says de Quervain. Although an improved memory for emotional events is a crucial mechanism for survival, it does have its downsides: in the case of very negative experiences, it can lead to recurring anxiety. This means that the findings, which have now been released, may also be relevant in understanding psychiatric conditions such as post-traumatic stress disorder.


Explore further

Why do we remember stressful experiences better?

More information: Matthias Fastenrath et al, Human cerebellum and corticocerebellar connections involved in emotional memory enhancement, Proceedings of the National Academy of Sciences (2022). DOI: 10.1073/pnas.2204900119
https://medicalxpress.com/news/2022-10-discovery-function-cerebellum.html

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