IGM Biosciences Increases Focus On Autoimmune Diseases, Stops All Blood Cancer-Related Studies

 IGM Biosciences Inc 

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 said it will focus on two strategic areas: treating colorectal cancer using IgM death receptor 5 (DR5) agonist antibodies and treating autoimmune diseases using IgM T cell engager antibodies. 

As an expansion of its autoimmune efforts, the company also announced that it plans to file an Investigational New Drug (IND) application in 2024 to begin the clinical development of IGM-2644, its CD38 x CD3 T cell engager antibody, for the treatment of autoimmune diseases. 

As part of its strategic refocus, IGM Biosciences is halting all hematologic oncology clinical development and the clinical development of its targeted cytokine product candidate, including:

• Aplitabart in acute myeloid leukemia and combination with birinapant.
• IGM-2644 (CD38 x CD3) in multiple myeloma.
• IGM-2537 (CD123 x CD3).
• IGM-7354 (IL-15 x PD-L1).

The company will continue focusing on developing oncology, immunology, and inflammation product candidates under its collaboration with Sanofi SA 

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With this strategic refocusing, the company will reduce its workforce by approximately 22 percent. As a result of these actions, IGM expects to extend its cash runway into the second quarter of 2026.

https://www.benzinga.com/general/biotech/23/12/36113907/igm-biosciences-increases-focus-on-autoimmune-diseases-stops-all-blood-cancer-related-studies