EyePoint Pharmaceuticals Inc. (NASDAQ:EYPT) stock is trading higher on Monday after the company revealed interim 16-week data from the ongoing Phase 2 VERONA trial of Duravyu for patients with diabetic macular edema (DME).
Duravyu is an investigational sustained-delivery therapy that delivers patent-protected vorolanib, a selective tyrosine kinase inhibitor formulated in bioerodible Durasert E.
Duravyu 2.7mg demonstrated an early, sustained, and clinically meaningful improvement in best-corrected visual acuity (BCVA) and anatomical control versus the Regeneron Pharmaceutical Inc’s (NASDAQ:REGN) Eylea (aflibercept) control arm.
A favorable safety and tolerability profile continued for both Duravyu arms.
The 2.7mg dose is also being evaluated in the Phase 3 pivotal trials for wet age-related macular degeneration (wet AMD).
The company expects to report the full topline results in the first quarter of 2025.
Duravyu 2.7mg demonstrated an early and sustained improvement in BCVA and CST (central subfield thickness) as measured by optical coherence tomography (OCT).
BCVA improved +8.9 letters versus +3.2 letters for aflibercept control compared to baseline.
CST improved 68.1 microns versus 30.5 microns for aflibercept control compared to baseline.
Visual and anatomical gains were observed at Week 4, demonstrating the immediate bioavailability of DURAVYU.
https://finance.yahoo.com/news/eyepoints-investigational-drug-shows-early-161651832.html
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