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Thursday, April 24, 2025

Coya Therapeutics promising interim results from dementia study

 

  • Coya Therapeutics (NASDAQ:COYA) reported positive interim results from an open-label study testing a combination of low-dose IL-2 and CTLA4-Ig for the treatment of frontotemporal dementia.
  • In the interim results of the first five patients, the treatment led to a significant and lasting boost in both the number and function of regulatory T cells (Tregs), compared to their starting levels.
  • The company said that patients showed little to no decline in cognitive function during the study.
  • When it came to safety, the therapy was also well tolerated, with no serious side effects, and all five patients completed the study.

Galapagos NV Q1 2025 Results and Strategic Developments

 Galapagos NV announced its first quarter financial results and recent business highlights, including the dosing of the first U.S. patient in the ATALANTA-1 study of GLPG5101 for mantle cell lymphoma. The company is advancing its cell therapy pipeline, with pivotal development for GLPG5101 planned for 2026 and aims for approval in 2028. Additionally, Galapagos is undergoing executive leadership changes and planning a separation into two entities, with SpinCo focusing on oncology, immunology, and virology. The company reported €3.3 billion in cash and reaffirmed its annual cash burn guidance.


https://www.tipranks.com/news/company-announcements/galapagos-nv-reports-q1-2025-results-and-strategic-developments

Medtronic advances Abbott CGM partnership with FDA submission of interoperable insulin pump

 Medtronic plc (NYSE: MDT), a global leader in healthcare technology, today announced it has submitted 510(k) applications to the U.S. Food and Drug Administration (FDA) seeking clearance for an interoperable pump. FDA clearance of this pump would pave the way for system integration with a continuous glucose monitoring (CGM) sensor based on Abbott's most advanced CGM platform.

The submissions included a 510(k) application for its MiniMed™ 780G pump as an alternate controller enabled (ACE) insulin pump and a separate 510(k) application for its SmartGuard™ algorithm as an interoperable automated glycemic controller (iAGC). This milestone follows the announcement last August

(opens new window) that the companies will collaborate on an integrated system based on Abbott's most advanced CGM platform. Abbott will supply Medtronic with a CGM that will work exclusively with Medtronic smart dosing devices and software across both automated insulin delivery and smart multiple daily injections systems. These systems, including the Abbott CGM, will be sold exclusively by Medtronic.

https://news.medtronic.com/2025-04-24-Medtronic-advances-Abbott-CGM-partnership-with-FDA-submission-of-interoperable-insulin-pump

Fake It Till Trump Makes It

 By Michael Every of Rabobank

Fake it till Trump makes it

Markets were thrilled this week as Bloomberg reported US Treasury Secretary Bessent saying 145% US tariffs on China were “unsustainable” and a trade deal would be done soon; yet people *in the room* say that didn’t capture his real message - that China would see *it* needed to move first. Markets were just as excited by President Trump saying those tariffs would come down “substantially” but missed the context that this was *after a deal*, not as a unilateral US step.    

The Wall Street Journal caused another market surge in reporting ‘White House Considers Slashing China Tariffs to De-Escalate Trade War: Levies could be cut by more than half in some cases although Trump hasn’t yet made final decision’. Within hours, one of the authors tweeted: “UPDATE: Admin official said Trump wouldn’t act unilaterally and would need to see action from China. People close to admin said Trump has plenty of room to cut tariffs without changing overall picture. “It would be kind of a pressure valve release without actually doing anything.”” The original headline was still up at time of writing over 12 hours later.

The Financial Times claims Trump’s “latest retreat” is on auto tariffs. An hour later, the president denied it. Again, the story was still up unchanged at time of writing.

Bloomberg this morning has the top headline “New Rate – Trump: China May Get New Tariff Rate Soon.” If you listen to what he said, he’s negotiating with 90 countries, and those that strike deals in the next 2-3 weeks will get a lower rate, while those that don’t will get one imposed… and China could be in either camp, the implication being it depends on what *it* does.

Moreover, not being reported prominently at all in the financial press, Bessent gave a speech at the IIF yesterday in which he stated, “Everywhere we look across the international system today, we see imbalance… My goal… is to outline a blueprint to restore equilibrium to the global financial system and the institutions designed to uphold it.” While he stressed, “America First does not mean America alone”, he made clear the US seeks “expanded leadership in international institutions like the IMF and the World Bank… to restore fairness to the international economic system [which faces] the stark reality of large and persistent US deficits as a result of an unfair trading system,” a status quo which is, “not sustainable for the US, and ultimately,… not sustainable for other economies.” 

He said the US is eager to work with the IMF and World Bank, “so long as they can stay true to their missions. And under the status quo, they are falling short… We must make the IMF the IMF again… [It] must be a brutal truth-teller and not just to some members. Today, the IMF has been whistling past the graveyard. Its 2024 external sector report was entitled, “Imbalances Receding.” This Pollyannaish outlook is symptomatic of an institution more dedicated to preserving the status quo than answering the hard questions. Here in the US, we know we need to get our fiscal house in order… but we will not abide the IMF failing to critique the countries that most need it, principally surplus countries… the IMF needs to call out countries like China that have pursued globally distorted policies and opaque currency practices for many decades.” 

Bessent also said the World Bank “should no longer expect blank cheques for vapid, buzzword-centric marketing accompanied by half-hearted commitments to reform… Treating China, the second-largest economy in the world, as a developing country is absurd.”

In Q&A, he underlined the US wants to work with China to help it shift to consumption as it moves back to manufacturing: but if China won’t … join, or decouple, the dots. He welcomed European defence spending but laughed at the Euro being a global reserve currency, wishing them well with the consequences that would come with it on top of the appreciation just seen. He also stressed, “I think Wall Street can continue doing well. But I think it’s Main Street’s turn to share in the prosperity,” implying he wants more lending by smaller banks to make the latter happen.

Elsewhere, Secretary of State Rubio was singing the same tune, the Defence Secretary from his, as the US Trade Representative has just done too, hammering home the US point from all sides.

In short, as central bank “Think of the asset prices!” control of markets is replaced by economic statecraft “Think of the national security!” control of the economy, we are seeing normative financial journalism determined to fake-it-till-Trump-makes-it what they want it to be - “because markets again.” 

Yes, the White House worries about markets. If things get ugly enough, they offer a verbal carrot. No, Trump is not faking it, and he did not just fold. The US grand macro strategy is not changing. As wiser heads at the Wall Street Journal note, ‘Markets Think They Hold All the Cards Over Trump’, before adding, “The plunge in stocks, bonds, and the dollar matter to Trump. But there’s no assurance that he will be ruled by them.”

Yet with a de facto US-China trade embargo in place, the US economy could see shortages on shelves within weeks and/or of price rises; and even if there is a tariff U-turn, logistics would then be overwhelmed, true even if the Fed’s Beige Book overnight was typically beige in capturing those emergent risks. That’s as fake-it-till-Trump-makes-it MAGA thinking that a stronger US dollar would provide offset to any tariffs falls far short of reality. That might see some movement.

However, even a 60% tariff for China would mean the maximalist US position previously seen as unthinkable would be celebrated with relief. Moreover, those sneering at US assets as ‘uninvestable’ don’t see that these scarring experiences also mean real economy firms are scrambling to set up new supply chains in the US or outside China and will continue to do so even if tariffs go to 60% - when markets will be rallying while missing the longer-term big picture. Nobody in manufacturing assumes this goes away via a debunked Bloomberg, WSJ, or Financial Times headline. Where supply chains sit 3 to 5 years from now is open to question. Wheeling and dealing is thus underway:

  • 12 US states have sued Trump, saying tariffs have "brought chaos to the American economy.” They may bring chaos to a US constitution that only exists due to unity over the need for tariffs.
  • As allegations of China’s support for Russia emerge, the European Parliament is in the ‘final stages’ of talks with China to remove sanctions on it: apparently “free trade” trumps all for some. Good luck with that, as Bessent would likely say with a smile.
  • The US has made a final peace offer to Ukraine --which gets security guarantees from Europe only, and the potential ability to join the EU, not NATO-- and to Russia --which gets to keep most of what it’s taken for sanctions relief and US energy cooperation-- or it will walk away. Ukraine, supposedly to sign a minerals deal today again, has perhaps has already rejected it.
  • The US is reportedly telling Iran it will process nuclear fuel for it under a new deal, again bringing it in from the cold on sanctions. If it doesn’t agree, does the US opt for JCPOA 2.0, and then expanded Abraham Accords and the India-Middle East-Europe Economic Corridor, or war?
  • In response to a terror attack in Kashmir, India has cancelled visas for all Pakistanis; closed the border crossing; suspended the Indus Waters Treaty, which Pakistan has in the past stated could amount to an act of war; and rumours fly of possible Indian military action.
  • The ex-head of the WEF allegedly fiddled with the organisation’s Global Competitiveness Index ratings -- the data were faked by Schwab while the WEF were making it -- as well as engaging in financial and moral impropriety; and
  • The UK has decided to approve attempts to dim the sun to control climate change within weeks: it’s called British summer. Really – on both fronts. 

What a year 2025 is proving to be.

https://www.zerohedge.com/markets/fake-it-till-trump-makes-it

Judge Halts Order Demanding Details On Efforts To Return Abrego Garcia To US

 by Zachary Stieber via The Epoch Times,

The federal judge overseeing the case of Kilmar Abrego Garcia, an immigrant deported to his home country despite a court order, has paused her order demanding details on the U.S. government’s efforts to facilitate his return to the United States.

U.S. District Judge Paula Xinis on April 23 paused her order for one week. She did not detail the rationale behind the pause but wrote that it was entered “with the agreement of the parties.”

Lawyers for Abrego Garcia, an immigrant from El Salvador, and the government did not immediately respond to requests for comment.

Xinis previously ordered the government to facilitate the return of Abrego Garcia to the United States. When the government declined to provide details, she ordered officials to file daily updates with the court on its efforts.

The judge had also granted the plaintiff’s request for expedited discovery on the matter, including the terms of the agreement the United States reached with the Salvadoran government to house immigrants deported from America.

Xinis on Tuesday said that the U.S. government needed to address outstanding discovery requests, finding that the Trump administration has shown a “willful and bad faith refusal to comply with discovery obligations.”

“For weeks, Defendants have sought refuge behind vague and unsubstantiated assertions of privilege, using them as a shield to obstruct discovery and evade compliance with this Court’s orders,” she wrote in an order.

The government then filed a motion to stay that ruling. It was filed under seal, meaning it is not available to the public.

Lawyers for Abrego Garcia filed a sealed response to the motion.

Xinis referenced both sealed filings while entering the pause.

Garcia, who illegally entered the United States in 2011, was arrested in 2019. An immigration judge concluded that evidence showed he was a member of the MS-13 gang. A different immigration judge ordered Garcia deported but also issued a withholding of removal, which prevented the U.S. government from deporting him to his home country.

Garcia continued living in the United States until he was taken into custody by immigration agents on March 12. He was soon deported to El Salvador.

U.S. officials have said that the deportation there was a mistake because the withholding order was not listed on the flight manifest. They have more recently said the deportation was allowed because MS-13 was designated a terrorist group by President Donald Trump. Lawyers for Abrego Garcia say he should not have been deported to El Salvador and that he should be brought back to the United States to be with his wife, a U.S. citizen, and children.

In their last publicly available status report, dated April 21, U.S. officials said that the Salvadoran government told them that day that Abrego Garcia is being held at the Centro Industrial penitentiary facility in Santa Ana and is “in good conditions and in an excellent state of health.”

https://www.zerohedge.com/political/judge-halts-order-demanding-details-efforts-return-abrego-garcia-us

New Yorkers Are Paying Over $60 Million for Andrew Cuomo’s Legal Fights

 


Behind the scenes of Andrew Cuomo’s campaign to become New York City’s next mayor, the former governor is fighting an expensive legal battle to clear his name. New Yorkers are on the hook to pay for almost all of it.

In courtrooms across New York, Cuomo has been involved in more than a dozen lawsuits over allegations he sexually harassed former state employees, made an improper book deal and mishandled Covid-19 in nursing homes.

https://www.bloomberg.com/news/articles/2025-04-24/andrew-cuomo-legal-bills-over-sex-harassment-covid-paid-by-ny-taxes

Trump Says Could Meet Putin 'Shortly After' Upcoming Middle East Trip

 President Donald Trump has said he could meet with Russia's Vladimir Putin shortly after his upcoming trip to the Middle East in May, where's he expected to visit Saudi Arabia, Qatar and the United Arab Emirates.

The Gulf tour, set for May 13 through the 16th, will be the first such Mideast trip of Trump's second term. TASS reported this week, "In March, Russian presidential press secretary Dmitry Peskov told TASS that Trump and Russian President Vladimir Putin could meet in Saudi Arabia at some point."

Via Reuters

While there are no clear, concrete plans for this, Trump was asked by reporters Wednesday about the possibility of talks with Putin while in Saudi Arabia. 

That's when Trump responded, "It’s possible, but most likely not. I think we’ll meet with him shortly thereafter." But he didn't offer any details of when or where this could happen.

US special envoy Steven Witkoff has also recently suggested Saudi Arabia as a venue for a potential future Trump-Putin meeting.

The Kremlin has welcomed Trump administration suggestions that Ukraine finally give up claims to Crimea. Trump addressed Zelensky in a Wednesday social media statement and said "Crimea was lost years ago" and that he should face reality and give it up for the sake of peace.

Putin's office responded by saying, "This fully corresponds with our understanding and with what we have been saying for a long time."

But Trump had some strong words for Moscow on Thursday, following a deadly overnight Russian ballistic missile and drone attack on Kiev, which killed at least ten people.

"I am not happy with the Russian strikes on KYIV," Trump posted on Truth Social. "Not necessary, and very bad timing. Vladimir, STOP! 5000 soldiers a week are dying. Lets get the Peace Deal DONE!"

The Kremlin has laid out that it is willing to stop the finding, and that peace can be achieved if Ukrainian forces exit the four annexed territories of the East. 

Zelensky has shown no signs that he's willing to do this, also as he's citing the national constitution to say that not even Crimea can legally be given up. At this point, any earlier progression toward peace appears stalled. Can a Putin-Trump face to face meeting lead to a breakthrough?

https://www.zerohedge.com/geopolitical/trump-says-could-meet-putin-shortly-after-upcoming-middle-east-trip