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Thursday, April 23, 2026

Ozempic pill for children to launch in US market ‘soon’: Novo Nordisk

 Novo Nordisk said April 23 it plans to seek expanded FDA approval for its Ozempic pill in the second half of 2026, which would make the drug the first oral GLP-1 approved for children and adolescents with Type 2 diabetes. 

Currently, the Denmark-based drugmaker has FDA approval for the injectable form of Ozempic, which is indicated for adults with Type 2 diabetes, as well as diabetes-related cardiovascular disease and chronic kidney disease. The FDA approved the oral presentation of Ozempic in February, and Novo Nordisk said it would launch the pill in the U.S. in the second quarter of 2026. 

The world’s two largest manufacturers of brand-name GLP-1s, Novo Nordisk and Eli Lilly, already produce FDA-approved GLP-1 pills for obesity. Novo Nordisk also offers Rybelsus, an oral GLP-1 for Type 2 diabetes, which the FDA approved in 2017. 

The latest announcement comes alongside positive phase 3 trial results evaluating oral semaglutide (Ozempic) among Type 2 diabetes patients ages 10-17 years old. The 52-week study found “superior blood glucose lowering versus multiple comparators, together with consistent weight reduction, reduction in cardiometabolic risk factors and reduction in major adverse cardiovascular events,” Novo Nordisk said. 

“Pending regulatory approvals, oral semaglutide has the potential to be the first and only oral GLP-1 RA to demonstrate superior glycemic efficacy versus placebo in children and adolescents with Type 2 diabetes, while maintaining the well-established safety profile seen across the semaglutide portfolio,” the drugmaker said.

https://www.beckershospitalreview.com/glp-1s/ozempic-pill-for-children-to-launch-in-us-market-soon-novo-nordisk/

Quest Diagnostics added as new short idea at Hedgeye

 Quest Diagnostics (DGX) downgraded to a Hedgeye short with 20% downside risk as growth decelerates and valuation stays elevated. Hedgeye added Quest Diagnostics (DGX) as a new short idea, forecasting a potential 20% downside due to expected growth deceleration starting in Q2 2026. Analyst Tom Tobin noted that key growth drivers are lapping, signaling a bearish shift for the company. The call highlights a reversal from previous, more positive stances on the stock.

https://seekingalpha.com/news/4578775-quest-diagnostics-added-as-new-short-idea-at-hedgeye

Regeneron Agrees to Lower Drug Prices, Gets Gene Therapy Nod

 


Regeneron Pharmaceuticals Inc. reached a deal with the Trump administration to lower drug costs for some Americans and won US approval for its gene therapy to treat a rare form of deafness, according to a person who declined to be identified in order to speak before the announcement was made.

Regeneron was the last of the major drug companies that President Donald Trump had targeted as part of his plan to lower US costs in line with other developed nations.

https://www.bloomberg.com/news/articles/2026-04-23/regeneron-s-gene-therapy-for-deaf-children-wins-fda-approval-regn

Republicans Open New Front In Growing Battle Against "Climate Lawfare"

 Republicans in Congress are taking action to shield U.S. energy producers from “Climate lawfare,” the relentless barrage of frivolous lawsuits orchestrated by radical environmental activists.

Sen. Ted Cruz (R-TX) introduced S.4340, a bill that would bar frivolous lawsuits from green activist groups seeking damages, injunctions, or other relief for harms allegedly caused by the end use of energy products. Senators Ted Budd (R- NC), Tom Cotton (R-AR), and Mike Lee (R-UT) are cosponsoring the legislation. The House companion bill, H.R. 8330, was introduced yesterday by Rep. Harriet Hageman (R-WY). The bill would also void any energy penalty law and preempts any states’ attempts to regulate interstate and global emissions.

“Radical environmental groups have waged a coordinated campaign to weaponize our judicial system against American energy producers, including many in Texas,” Cruz said in a statement. “They’re using meritless lawsuits to bankrupt our energy industry, kill good paying jobs, and drive up the cost of electricity and gasoline for hardworking families. I am proud to lead this bill to stop that abuse to protect American jobs, lower energy costs, and defend American energy dominance.”

Energy security is national security, and we will not self-sabotage our critical industries with a cascade of costly lawsuits and extreme penalties that jeopardize American drilling. America’s energy producers should be protected from the dangerous legal precedent that would be set by the retroactive punishment of lawful activity,” Hageman said.

The bill has already won applause by energy groups aligned with President Donald Trump’s pro-growth agenda.

“Green left activists have always gone to extraordinary lengths to impose their anti-energy agenda on Americans. Filing sweeping lawsuits against oil and gas companies in an attempt to force policy outcomes they have failed to achieve in the legislative and administrative arenas is some of their most egregious work yet,” American Energy Alliance president Tom Pyle said. "This kind of politically motivated litigation threatens not only energy stability, security, and affordability but also the integrity of our legal system.”

The legislation arrives as California, Connecticut, Delaware, Hawaii, Maine, Massachusetts, Michigan, Minnesota, New Jersey, Rhode Island, and Vermont have taken landmark legal action aimed at holding fossil fuel companies accountable for misrepresenting to the public about their products’ role in climate change.

On Friday, the Supreme Court delivered a unanimous procedural victory for sanity, ruling that certain environmental damage lawsuits, including one against Chevron for alleged destruction of coastal wetlands in Louisiana, can be removed from hostile state courts to more neutral federal forums.

Chevron’s case fits comfortably within the ordinary meaning of a suit ‘relating to’ the performance of federal duties,” said Justice Clarence Thomas. “Chevron has plausibly alleged a close relationship between its challenged conduct and the performance of its federal duties —not a tenuous, remote, or peripheral one.”

https://www.zerohedge.com/political/republicans-open-new-front-growing-battle-against-climate-lawfare

43 Mexican Mafia Arrested in Cal. for Racketeering, Drug Trafficking, Kidnapping, Assault, Murder

 Thirty-seven members and associates of the Mexican Mafia prison gang were arrested today on three federal indictments charging them with committing scores of crimes in Orange County, including kidnapping, extortion, trafficking fentanyl and methamphetamine, running illegal gambling businesses, and murdering a victim last year at a gang-controlled Anaheim motel.

The defendants arrested this morning include:

  • Jaime Alvarado, 42, a.k.a. “Junior” and “Brian Barbas,” of Lake Elsinore;
  • Karina Cesena, 32, also of Lake Elsinore; and
  • Mario Flores, 40, a.k.a. “Happy,” of Anaheim.

Senior gang members already in state custody who are expected to make their initial appearances and be arraigned in the coming weeks include:

  • Luis Cardenas, 48, a.k.a. “Gangster,” “Pops” and “Tio,” an inmate at Ironwood State Prison;
  • Jose Antonio Ochoa Madrigal, 41, a.k.a. “Sparky,” of Santa Ana, who incarcerated in an Orange County jail.

“Gang members who murder, extort, kidnap, and traffic drugs and firearms are a

menace to our communities and our way of life,” said First Assistant United States Attorney Bill Essayli. “Today’s arrests highlight the continuing cooperation between federal and local law enforcement against violent felons and our unyielding determination to crack down on organized crime in our prisons and our streets.”

“The defendants accused of operating their own ‘Gangsta’s Paradise’ in Orange County by peddling illicit drugs and carrying out assault and murders, among other crimes, are being held accountable today,” said Akil Davis, the Assistant Director in Charge of the FBI's Los Angeles Field Office. “Orange County communities should be proud of their law enforcement professionals whose hard work and devotion to this case made the streets of Orange County safer today.”

“This type of criminal activity has a direct impact on our neighborhoods and our residents,” said Anaheim Police Chief Manny Cid. “Through strong partnerships, we will continue to identify, disrupt, and hold those responsible accountable.” 

“These arrests send a clear message: Organized crime and violence will not be tolerated in Santa Ana,” said Santa Ana Police Chief Robert Rodriguez. “Through strong partnerships with local and federal counterparts, we will continue to target those who threaten the safety and well-being of our communities.”

Fifteen defendants arrested today are expected to make their initial appearances and be arraigned this afternoon in United States District Court in Santa Ana. Ten defendants arrested today are expected to make their initial appearances and be arraigned this afternoon in United States District Court in Los Angeles. Twelve additional defendants are in state custody and are expected to make their initial appearances in United States District Court in Santa Ana in the coming weeks.

In connection with this investigation, law enforcement has seized four kilograms (8.8 pounds) of fentanyl, 54.4 kilograms (120 pounds) of methamphetamine, 0.9 kilogram (two pounds) of heroin, three kilograms (6.6 pounds) of cocaine, 25 firearms, and more than $30,000 in cash.

The Mexican Mafia, a.k.a. “La Eme,” is a U.S.-based prison gang that has immense control over Hispanic street gangs in Southern California, directing illegal activities from prisons and collecting a portion of the proceeds from drug trafficking, illegal gambling, and other crimes committed on the streets.

The case’s main indictment charges 40 defendants with a series of felonies, including racketeering conspiracy, conspiracy to operate an illegal gambling business, violent crimes in aid of racketeering, trafficking narcotics such as fentanyl, methamphetamine, heroin, and cocaine, and using firearms during a crime of violence.

According to this 66-count indictment, from June 2024 to April 2026, Cardenas oversaw the Mexican Mafia’s criminal activities in Orange County and within Orange County jail and prison facilities. Alvarado, Cesena, Madrigal, and Flores held the position of high-ranking associates for Cardenas.

From his prison cell, Cardenas used an encrypted messaging application on contraband cell phones to direct Alvarado in the operation of the Mexican Mafia’s activities in Orange County.

Cardenas directed others to kidnap and assault people in bad standing with him, and Alvarado, Cesena, and others carried out his directions. Defendants operating for the Mexican Mafia shot at and assaulted victims.

The gang also sold narcotics – including fentanyl, methamphetamine, heroin, and cocaine – via slap houses (illegal gambling houses), gangs, and drug dealers in Orange County.

It ran illegal gambling businesses within commercial strip malls and private residences. The gang collected extortionate taxes and provided security, including the use of violence, to protect the illegal gambling businesses.

Alvarado oversaw gang-controlled motels and, along with Cesena, directed violent retaliation against slap houses that did not pay the gang’s extortionate “taxes.”

On February 3, 2025, Matthew Kundrat, 29, a.k.a. “Bubba,” of Anaheim, and Manuel Ramos, 45, a.k.a. “Rhino,” of Santa Ana, murdered a victim at the Akua Inn, a gang-controlled motel in Anaheim. Kundrat and Ramos committed the murder for the purpose of gaining entrance to the Mexican Mafia and increasing their standing in the criminal enterprise.

Both Kundrat and Ramos are charged with committing a violent crime in aid of racketeering activity and, if convicted, would face a mandatory sentence of life in federal prison and would be eligible for the death penalty.

On March 14, 2025, Cardenas, Alvarado, Flores, and Cesena directed the kidnapping and assault of a victim who was an employee at a Cardenas-controlled slap house in Stanton. The penalty for kidnapping is life in federal prison.

Alvarado and Cesena stored methamphetamine and firearms at a storage unit in Orange County as well as at local private residences.

“When criminal organizations attempt to hide their profits behind violence, intimidation, and complex cash-based networks, IRS Criminal Investigation will uncover the truth,” said Darren Lian, Acting Special Agent in Charge, IRS Criminal Investigation’s Los Angeles Field Office. “Our agents followed the money through drug trafficking revenues, extortion schemes, and illegal gambling operations that fueled this enterprise’s power. By tracing and dismantling these financial pipelines, we cut directly into the organization’s ability to operate. IRS CI remains committed to protecting our communities by attacking the financial infrastructure that supports organized crime, no matter how deeply it is embedded.”

An indictment contains allegations that a defendant has committed a crime. Every defendant is presumed to be innocent until and unless proven guilty in court.

If convicted, the defendants would face decades in federal prison.

The FBI; the Anaheim Police Department; the Santa Ana Police Department; the Fullerton Police Department; IRS Criminal Investigation; the Drug Enforcement Administration; the California Department of Corrections and Rehabilitation; and United States Postal Inspection Service are investigating this matter. 

Assistant United States Attorneys Greg Scally, Caitlin Campbell, and Erin Kiss of the Orange County Office are prosecuting this case.

https://www.justice.gov/usao-cdca/pr/43-mexican-mafia-gangsters-arrested-indictments-alleging-racketeering-drug-trafficking

'Iran: We aren't seeking to make nuclear bomb'

 Iran's Foreign Ministry spokesperson Esmaeil Baghaei stated on Thursday that Tehran is not seeking to manufacture a nuclear bomb from the stockpile of highly enriched uranium.

"If we had wanted to make a nuclear bomb, we would have done so," Baghaei said.

Earlier this month, the spokesperson ruled out the possibility of transferring Iran's enriched uranium to the United States, claiming that "enriched uranium is as sacred to us as Iranian soil and will not be transferred anywhere under any circumstances."

https://breakingthenews.net/Article/Iran:-We-aren't-seeking-to-make-nuclear-bomb/66137835

Sheinbaum Points to Local Officials After CIA Agent Deaths

 


Mexico’s President Claudia Sheinbaum sought to ease tensions with the US after the death of CIA agents following a recent drug lab bust in northern Mexico, blaming an opposition state government for failing to adhere to proper security protocols.

Sheinbaum told reporters at her daily press conference that the breach of protocols kept federal security officials in the dark over the involvement of the US agents, who later died in a car crash after the drug lab was dismantled last weekend. The president also indicated that she expressed her condolences to US officials earlier this week for the loss of US lives.

https://www.bloomberg.com/news/articles/2026-04-23/sheinbaum-points-to-local-officials-after-cia-agent-deaths