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Thursday, May 7, 2026

ECT v. Magnetic Seizure Therapy for Bipolar Depression

 Daniel M. BlumbergerM.D. daniel.blumberger@camh.caFidel Vila RodriguezM.D.Shawn M. McClintockPh.D.Kevin E. ThorpeM.Math.Amer M. BurhanM.B.Ch.B.Karen FoleyM.D.Michelle S. GoodmanPh.D.… Show All … , and Zafiris J. DaskalakisM.D. 

https://doi.org/10.1176/appi.ajp.20250955


Abstract

Objective:

Despite the established clinical effectiveness of electroconvulsive therapy (ECT) in the treatment of bipolar depression, its acceptance is limited by concerns over cognitive adverse effects. Magnetic seizure therapy (MST) has shown promise in treating patients with depression, with fewer cognitive adverse effects. The aim of this pilot study was to assess the clinical efficacy and cognitive adverse effects of MST compared to right unilateral ultrabrief-pulse (RUL-UB) ECT in patients with bipolar depression.

Methods:

In this double-blind, randomized, parallel-group pilot clinical trial, participants with bipolar depression received either RUL-UB ECT or MST until they achieved remission, dropped out, or received a maximum of 21 treatments. The primary outcomes were 1) clinical remission as assessed with the 24-item Hamilton Rating Scale for Depression and 2) cognitive adverse effects as assessed with the Autobiographical Memory Test (AMT).

Results:

Of 55 participants who were randomized, 45 received an adequate trial of treatment, of whom 6/20 (30%) in the ECT group and 5/25 (20%) in the MST group achieved remission. Clinically important worsening in autobiographical memory (≥25% decline in AMT score) occurred in 6/27 (22.2%) participants in the ECT group and 2/28 (7.1%) in the MST group. Secondary clinical outcomes were similar in both groups.

Conclusions:

This pilot study demonstrated similar effects on depression symptoms between MST and ECT. MST appeared to have resulted in less worsening of autobiographical memory and was better tolerated, suggesting that it may be a safe clinical application to treat bipolar depression. Given the relatively small sample size of this pilot study, these findings should be considered preliminary.

Healthcare Economist Likes High-Deductible Plans

 In this interview, Stephen Parente, PhD, MPH, chair of health finance at the University of Minnesota, who served on the U.S. Council of Economic Advisers during both the first Trump administration and the Biden administration, says he likes high-deductible plans because people need to "have some skin in the game."

"A serious event like a cancer diagnosis, they might be out $10,000, but the lion's share of recovery that will cost $300,000 will be paid," he said. "My benchmark is that if the out-of-pocket payment is less than the base model Kia, then we're okay."

What has been the greatest contributor to high healthcare costs in the U.S.?

Parente: Probably the greatest contributor is the relatively higher prices that we have in the U.S. compared to most other countries. It's well documented that many of our providers ... get paid more than others. And there are also more of our folks [that have jobs] in the healthcare industry than in other places. That probably contributes to the lion's share of it.

Has physician pay contributed to high costs?

Parente: It has ... but with a big caveat. If you look at the average salary for an internal medicine physician ... it might be a little higher in the U.S. compared to most other industrialized countries, say Germany or France. But where there really is a difference is in the specialties. So there are not many instances where physicians say, even in Switzerland, would be earning more than a million dollars, whereas in the U.S., that's quite common, whether it's orthopedics, anesthesiology, radiology, oncology. They're really vital specialty areas, but they're also ones that have a much higher net payment to physicians than most others.

Have administrative costs contributed to high costs?

Parente: It definitely is a factor. I wouldn't say it's the most overwhelming factor. It's hard to quantify these things in different countries.

Just through our insurance system and third-party payments, whether or not it's through Medicare or Medicaid, we pay more to process the money that keeps our healthcare system operational. Whereas if you look at the U.K. or other countries, there's a central budget model. It's collected through taxation. People are paid salaries. There might be some elements of public insurance that's associated with it. But they're generally government-run and a little more efficient.

One thing to keep in mind, too, is while we say Medicare is very efficient, it's important to understand that Medicare itself does not pay any claims. Medicare contracts out all of its claims payments to this entire ecosystem of private health insurers and has since its inception in 1967. And that cost is never adequately accounted for when we talk about all the administrative savings that, say, a Medicare-for-All plan would have.

What is the best solution you've heard for lowering the cost of healthcare?

Parente: I think people need to ... have some skin in the game. They need to have some coverage for something that's serious and catastrophic. They need to have some coverage for preventive care. But by-and-large ... people should be paying out of their own pockets.

I'm a big fan of high-deductible health plans. They are, by their design, more affordable because it's just like car insurance. If you have a higher deductible car insurance policy or homeowners policy, your premium is less. They're more affordable. But there are rules in the Affordable Care Act that say that even if you have a high-deductible policy, there still needs to be coverage, pre-deductible, for office visits and certain preventive services and tests. I actually worked on policy so that in addition to primary coverage, secondary coverage -- meaning if I have diabetes, I can get insulin pre-deductible for free or at a very low cost -- that was something that came about 5 or 6 years ago, but it's not talked about quite as much.

Those types of things typically put into check this issue that I and other economists talk about, moral hazard, where it's like the benefit designs are too generous if they have first-dollar coverage all the way through. It's just a statistical fact that if you have a high-deductible health plan, the premiums will be less, consumers will be more engaged. A serious event like a cancer diagnosis, they might be out $10,000, but the lion's share of recovery that will cost $300,000 will be paid. My benchmark is that if the out-of-pocket payment is less than the base model Kia, then we're okay.

[It has to be] combined with price transparency. If we're actually going to have this work like a market and give people the incentives to shop for things ... the Trump administration and the Biden administration, too, has tried to make that information more available. It's just that we haven't really gotten to that point where what we see on Amazon or Expedia allows us to buy things as easily as what we see in the marketplace today. But it's coming, I'm hoping.

Would greater transparency in pricing help bring costs down?

Parente: Greater transparency at the margin can definitely bring costs down for consumers. Full disclosure, I've worked in this space wearing three different hats -- an academic hat, a government hat, and an entrepreneur hat. I actually have an app that anyone can use called MyMedVita. What we've tried to do is take what CMS defines as shoppable services -- there are 70 of them. This is where the money could be saved. Those shoppable services account for about 10% of spend in healthcare dollars.

The truth is, most consumers are just not used to thinking this way. ... They don't think of it the way we think about shopping for lawnmowers or anything else. But what I'm hoping is, eventually ... let's appeal to the digital natives while they're young and they're shopping and they're relatively healthy and they don't need that coronary artery bypass. Let's see if they get it and then tell their friends and family, why are you paying so much money? Check out this [app] instead.

As an academic and someone who's been evangelical about this, what frustrated me was that I played a role in getting that data out there, but just saw that no one was using it for years.

Would having a single payer help control costs?

Parente: I think a single payer would probably help control [costs], but the question is how that single payer is going to operate. The most extreme illustration of a single payer controlling costs is the British National Health Service. ... A certain percent of GDP [gross domestic product] is allocated. There are different ways that the money is incentivized with general practitioners, but for the most part, it's a central budget model. It's predictable. But there's also the potential for rationing as well, depending upon where people flex in their budget.

The other model people talk about is Medicare for All. Taxation comes in, money goes out. The question then becomes, if it is that system, how generous is the design? Is it first-dollar coverage or are there other criteria for it? The thing that people have to understand about Medicare for All is that if it truly operates under the Medicare fee-for-service rules, it's a very expensive system to operate because there is no medical management. There's no utilization management. There's no disease management that you'd see in managed care, by law. It sticks to the original 1967 statute that more or less says the physician's decision is sacrosanct.

Another opportunity is instead of Medicare for All, do Medicare Advantage for All. That would effectively take the system that we have now that people are generally comfortable with, put them into a bid structure for their plans, have performance metrics, have some utilization management, and probably would work better. Then again, there's a question of budget constraints that people have to worry about too.

Will artificial intelligence (AI) be able to help control healthcare costs?

Parente: I think AI has potential to help control costs. There are certainly some ways that AI can play a role to help consumers navigate benefits and other things better. But there are still some realities that FDA has not really weighed in on, [such as] to what extent AI can replace a practitioner.

I think what people are most excited is about drug discovery, new innovations, things that people haven't seen before. And there we have a problem because to make these things work, like a large language model, the more data, the better to find those edge cases that really show something that really might be never seen before. And our data, while it's electronic for healthcare, doesn't move that freely. You know, this is where the hospital systems that invest in Epic or something else like that are more or less closed wall systems. There is the possibility, you know, Epic allows for the data to be linked, but it's not ubiquitous.

We as a culture are very concerned about privacy of our data, particularly medical data. Other cultures are not. And so not naming countries per se, but to the extent that the data flows more freely to a large language model that looks at all medical records and imaging, and ours doesn't, that could be a strategic disadvantage to us.

https://www.medpagetoday.com/special-reports/features/121027

'KFF: New Medicare Option for Weight Loss Drugs'

 Starting in July, Medicare beneficiaries may be able to get a GLP-1 prescription for weight loss for $50 a month. It's a notable shift for Medicare, which has long been barred from covering weight loss treatments.

The drugs, such as semaglutide (Wegovy) and tirzepatide (Zepbound), are effective but can be expensive without insurance coverage. They're available in injection or pill form. Even with discounts, current cash prices typically range from $149 to $699 per month.

About half of GLP-1 users say these drugs were difficult for them to afford, according to KFF polling. A quarter said they were "very difficult" to afford.

But the new Medicare benefit comes with caveats, particularly around clinical guidelines and what happens when the short-term program ends.

What Is This Program?

The initiative, announced by CMS, is a short-term pilot program known as the Medicare GLP-1 Bridge. It will run from July 1, 2026, through Dec. 31, 2027. It's meant to "bridge" the gap before a longer-term program that might -- or might not -- begin in 2028.

The pilot program will offer coverage for the following GLP-1 medications approved for weight loss: the pill and injectable formulations of semaglutide, the KwikPen formulation of tirzepatide, and the orforglipron (Foundayo) pill.

Who Can Participate?

To get access to these weight loss medications, a patient must be enrolled in Medicare Part D, which covers prescription drugs. After that, eligibility is based mainly on body weight and health status. People will qualify if they have a body mass index (BMI) of 27 or higher and have a condition such as heart disease or prediabetes, among others. People with BMIs of 35 or higher automatically qualify. About 40% of American adults are clinically obese, with a BMI of 30 or higher, according to the CDC.

How the Program Works (It's a Bit Unusual)

This is not a typical Medicare benefit. Even though Part D enrollment is required, the Bridge program itself works differently.

Instead of going through the regular Part D plan, patients will need a prior authorization. Doctors will need to send the prescription to a central system run by CMS contractor Humana, using a system already in place for another Medicare drug program. Doctors don't need to be enrolled as Medicare providers to write a prescription or submit a prior authorization request under this program. Once they get approval, patients will pay the flat $50 copayment at the pharmacy when they pick up the prescription.

What Are the Benefits?

The cost savings could make these drugs accessible to patients who simply couldn't afford them before. Even with discounts, the prices can be daunting without insurance coverage. TrumpRx, a new government website, provides links to direct-to-consumer prescription drug discounts for patients not using their health insurance. On that site, semaglutide injectables range in price from $199 for a lower dosage for the first 2 months to $399 for a higher dosage. The KwikPen formulation of tirzepatide costs up to $699 per month. At the highest dosages, the daily semaglutide pill for weight loss costs up to $299 while orforglipron tops out at $349.

Most people who use these drugs will need a higher dose to maintain weight loss. The Bridge program is unique in that it offers a predictable $50 copayment that does not go up as dosages increase.

What Are the Downsides?

Like many pilot programs, there are trade-offs. The $50 copay will not count toward the Part D deductible, nor does it count toward the $2,100 annual out-of-pocket cap on prescription drug costs. The pilot program will also end in December 2027. Most studies have shown that many people who stop using the GLP-1 drugs regain weight they lost while taking them.

Still Obstacles for Those With Low Incomes

If a patient receives a low-income subsidy, also known as the Medicare Extra Help program, they cannot use that assistance for the drugs covered by the GLP-1 Bridge program. For beneficiaries accustomed to paying a $5 or $10 copay for their pharmaceuticals, a $50 copay could still be a big financial barrier.

"Fifty dollars a month sounds like a great deal compared to paying the discounted prices through TrumpRx and these other direct-to-consumer options, but it's a lot of money for somebody who's living on a $750-a-month Social Security check," said Juliette Cubanski, PhD, MPH, deputy director of the Program on Medicare Policy at KFF, a health information nonprofit that includes KFF Health News.

The $50 Copay Is Only for Weight Loss

Patients already taking one of these medications for a qualifying condition -- such as type 2 diabetes, cardiovascular disease risk reduction, or sleep apnea -- will continue to get it through their regular Part D plan. That means they'll pay the plan's price, which may be higher than the $50 Bridge copay, meaning the same drug could cost different amounts depending on the reason it is prescribed.

Patients already on GLP-1 drugs for weight loss may qualify for the Bridge program. Prescribers will need to attest that the patient met the clinical criteria when they first started the medication. For example, if a patient started a GLP-1 drug in September 2024 with a BMI of 37 but in July 2026 they've lost weight and now have a BMI of 34, the prescriber should attest in the prior authorization request that they met the BMI criteria of 35 or over when the GLP-1 therapy started.

What Happens After 2027?

The Trump administration had proposed a two-step approach to expand coverage of GLP-1 medications for obesity in Medicare. The Bridge program was initially planned to last 6 months -- after that, the idea was to launch a longer-term program that would shift the cost of the drugs from the government to insurers. A recent study found the long-term program would have cost insurance companies billions of dollars in the first year. Not enough insurers signed on for the voluntary plan by the April deadline, so CMS instead announced it would extend the Bridge program to 18 months, with a new end date of December 2027.

The move will give insurance companies more data on how many people with Medicare get GLP-1 drugs during the Bridge program and more time to negotiate with the Trump administration.

But extending the Bridge program will be "really expensive" for Medicare, Cubanski said, because the program heavily subsidizes the cost of the drugs.

"There's no sense right now of the cost of the Bridge model, but it is likely to be billions of dollars a year in additional spending for Medicare," Cubanski said.

The cost to Medicare will depend largely on how many people use the Bridge program. CMS has not provided any projections publicly, but a previous KFF analysis estimated that in 2020 close to 14 million Medicare beneficiaries were overweight or obese.

"This will just cost additional money, and we don't know how much, because they haven't disclosed it," Cubanski said.

https://www.medpagetoday.com/publichealthpolicy/medicare/121154

'"Stunning Quarter": Highest Earnings Growth In Over Two Decades: DB'

 Yesterday, Deutsche Bank's head of thematic research published his latest chartbook, "The Great 2026 Reset," which delves into the market and political implications of the Iran conflict (available here to pro subs).

One key topic explored by Reid is the remarkable US Q1 earnings season. As we previewed ahead of the start of reporting seasons, earnings are significantly exceeding consensus estimates across all metrics, despite a high bar.

S&P 500 earnings growth is projected to accelerate sharply from 13.4% in Q4 to 24.6% in Q1 – a four-year high and a level rarely seen outside of post-shock recoveries. Excluding special factors, this represents arguably the strongest earnings growth in two decades.

The AI boom is a clear contributor, but strength is widespread, with double-digit growth seen in average and median companies, and all 11 sectors posting positive growth for the first time in four years. This strong performance has in many places been driven by higher prices amid supply constraints, surging demand within the AI value chain, and other disruptions.

In light of these robust Q1 results, DB has raised its 2026 EPS forecast from $320 to $342, driven by strong Q1 beats, gravity-defying performance in MCG & Tech, and higher oil and commodity prices.

Reid says it's worth noting that while the US equity market has outperformed many markets since the start of the Iran conflict, this has only moved it from the bottom quartile to the middle of the global pack year-to-date.

Even with a surge since the conflict began, tech performance over the past six months (since the end of October) shows only a modest increase.

Given current high valuations, strong earnings growth is helping the US market "grow into" these valuations, yet other markets have demonstrated notably better performance over the last 18 months.

https://www.zerohedge.com/markets/stunning-quarter-highest-earnings-growth-over-two-decades


'Iran issues new Hormuz transit rules for vessels - CNN'

 

Tehran has introduced new rules for vessels seeking to transit the Strait of Hormuz, CNN reported on Thursday, citing a document it reviewed, as Iran moves to formalize control over the waterway despite US warnings.

The document, titled “Vessel Information Declaration,” is an application form issued by Iran’s newly created Persian Gulf Strait Authority (PGSA) and must be completed by all vessels seeking safe passage through the strait, the report said.

CNN said the document, shared by Lloyd’s List and another anonymous shipping industry source, contains more than 40 questions requiring ships to disclose their name, identification number, any previous name, country of origin and destination.

The form also asks for the nationalities of the vessel’s registered owners, operators and crew, as well as details of the cargo on board, the report added.

According to the PGSA, the information must be emailed to the authority before vessels can transit the strait.

An email from the Persian Gulf Strait Authority cited by CNN warned that “complete and accurate information is essential” to processing transit requests and that “further instructions will be communicated via email.”

“Any incorrect or incomplete information provided will be the sole responsibility of the applicant, and any resulting consequences will be borne accordingly,” the email added.

https://www.iranintl.com/en/liveblog/202604294038

Iran lawmaker says Tehran will not reopen Hormuz

 

Iran will not reopen the Strait of Hormuz and no oil can pass through the waterway without Tehran’s permission, spokesperson for the Iranian parliament’s National Security and Foreign Policy Committee Ebrahim Rezaei said on Thursday.

“They cannot pass even one liter of oil through the Strait of Hormuz without the permission of the Islamic Republic,” Rezaei said.

“If the Americans see the slightest concession or retreat from our side, they will definitely become more emboldened,” he added.

https://www.iranintl.com/en/liveblog/202604294038

More drones downed while flying to Moscow

 The number of Ukrainian drones shot down while flying toward the Russian capital climbed to 59, according to the city's Mayor Sergey Sobyanin on Thursday.

The interceptions occurred during the afternoon and evening hours. Emergency services have been dispatched to deal with the situation, Sobyanin said. Meanwhile, Russia's Defense Ministry announced that 101 Ukrainian drones were downed over various Russian regions and the waters of the Black Sea.

Increased drone raids into Russian territory coincide with tensions surrounding the upcoming Victory Day Parade celebrations in Moscow on May 9. Russian authorities have repeatedly vowed to launch massive attacks on Kiev if Ukraine disrupts the manifestations.

https://breakingthenews.net/Article/More-drones-downed-while-flying-to-Moscow/66246626