Amarin Corporation plc (NASDAQ:AMRN), a pharmaceutical company focused on improving cardiovascular health, announced today the presentation of data and analysis which concluded that over nine million atherosclerotic cardiovascular disease (ASCVD) events are projected to occur in the United States within the next ten years in adults aged 40-79 for whom ASCVD is not established. Over three million of these events are projected to occur in persons with elevated triglyceride (TG) levels of ≥150 mg/dL, including approximately one million events in statin users. The research used a risk calculator to estimate 10-year risk and reported that increased cardiovascular (CV) risk was proportionally greater among persons with higher TG levels. This research highlights that millions of CV events will occur in people that haven’t had a CV event and supports the need for expanded education about the use of TG levels as an identifier of cardiovascular risk. It also highlights that there is an urgent need to address this immense risk and examine the capacity of lifestyle modification and other therapies to attenuate ASCVD risk beyond cholesterol management in patients with elevated TG levels.
These data and analysis were presented in a poster entitled “Burden of Atherosclerotic Cardiovascular Disease Risk in Persons with Elevated Triglyceride Levels According to Statin Use” at the American College of Cardiology’s (ACC) 68th Annual Scientific Session in New Orleans, LA. The research used the ACC/AHA risk calculator and NHANES data with corresponding projected population sizes to estimate a 10-year risk of cardiovascular death, nonfatal myocardial infarction (MI or heart attack), or fatal/nonfatal stroke in people without established atherosclerotic cardiovascular disease (ASCVD). The analysis did not include other major adverse cardiovascular events such as by-pass surgery, stents or hospitalization for angina.
“This presentation underscores that people with elevated triglycerides without established cardiovascular disease are at a high risk for cardiovascular events,” stated John F. Thero, president and CEO of Amarin. “While lowering triglyceride levels alone without reducing other cardiovascular risks may be insufficient to significantly lower cardiovascular risk, elevated triglyceride levels provide a means of identifying patients with increased cardiovascular risk beyond cholesterol levels. We encourage people to recognize this risk and to discuss elevated triglyceride levels with their medical professionals.”
This poster was authored by Nathan D. Wong, Wenjun Fan, Sephy Philip, Craig Granowitz, and Peter Toth.
Amarin Investor/Analyst Conference Call
Amarin plans to webcast live a physician panel discussion for investors and analysts on Monday, March 18 at 4:00 p.m. CT / 5:00 p.m. ET. During the panel discussion leading physicians are anticipated to review data pertaining to Vascepa presented at ACC’s 68thAnnual Scientific Session, including the scheduled presentation on Monday, March 18 at 9 a.m. CT / 10 a.m. ET in the late-breaker session regarding additional data from the REDUCE-IT cardiovascular outcomes study. The panel discussion may also cover data from the above described poster and from other posters presented at ACC.
This physician panel discussion will commence at the time shown above and will be accessible via webcast through the investor relations section of the company’s website at http://www.amarincorp.com. The panel discussion can also be heard via telephone by dialing 877-407-8033. A replay of the panel discussion will be made available for a period of two weeks following the webcast. To hear a replay of the call, dial 877-481-4010 (inside the United States) or 919-882-2331 (outside the United States). A replay of the panel discussion will also be available through the company’s website shortly after the webcast. For both dial-in numbers please use conference ID 44518.
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