Humacyte, Inc. (Nasdaq: HUMA), a clinical-stage biotechnology platform company developing universally implantable bioengineered human tissue at commercial scale, today announced results evaluating the use of the small-diameter (3.5mm) Human Acellular Vessel (HAV) for coronary artery bypass grafting (CABG) in a non-human primate model. The HAV was observed to maintain structural integrity and patency for up to six months post-implantation and showed evidence of robust host cell repopulation and remodeling. The results were presented by Adam Williams, M.D., cardiothoracic surgeon, Duke University, at the American Heart Association Basic Cardiovascular Sciences Scientific Sessions (BCVS) 2022 in Chicago, IL on July 25, 2022, and will be published in the September issue of Circulation Research.
Humacyte’s HAVs are engineered replacement vessels designed to be durable, infection-resistant and off-the-shelf to address long-standing limitations in vessel tissue repair and replacement. CABG surgery, which treats the blockage of the coronary arteries to restore blood flow to the heart, is performed more than 400,000 times annually in the United States, with over 765,000 annual CABG procedures globally. Humacyte is developing a small-diameter HAV as a potential alternative to existing vascular conduit substitutes during CABG surgery, particularly in obese or diabetic patients, where the risks of saphenous vein harvesting are substantial.
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