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Thursday, November 9, 2023

Dr. Robert Malone Reveals How The Government Tore His Reputation Apart, "Piece By Piece"

  by Dr. Robert W. Malone, MD, MS via Who Is Robert Malone,

Fellow Americans, the government will take care of you!

They don’t want you to have to worry about information that they don’t approve in your social media accounts.

They don’t want you to worry that the US government would directly interfere with your First Amendment rights, and certainly would never meddle in an election or with your medical freedoms.

That said, the deep state will gladly “contract those jobs out to creepy left-wing “disinformation”-fighting firms”.

A bombshell new report has been published, titled: “WEAPONIZATION OF “DISINFORMATION” PSEUDO-EXPERTS AND BUREAUCRATS: HOW THE FEDERAL GOVERNMENT PARTNERED WITH UNIVERSITIES TO CENSOR AMERICANS’ POLITICAL SPEECH”, Interim Staff Report by the Committee on the Judiciary and the Select Subcommittee on the Weaponization of the Federal Government U.S. House of Representatives was released on November 6, 2023.

In that report, the committee laid out the role of the Election Integrity Partnership (EIP) and other astroturf organizations contracted (that means paid for) by the Department of Homeland Security to censor Americans.

Representative Jim Jordan on his Twitter account also provided the receipts how the Election Integrity Partnership was founded, by attaching a letter from the Atlantic Council advising a “sync-up” whereby they created the Election Integrity Partnership in 2020. Ergo, a partnership of four organizations working in collaboration with both the US Government and the Atlantic Council.

In fact, the EIP is made up of four “partners”. They are the Stanford Internet Observatory (SIO), The U. of Washington Center for an Informed Public (CIP), Graphika, and the Atlantic Council. Each organization has a distinct role to play, from identifying “spreaders of misinformation”, to identifying the networks of social media landscapes that those so accused interacted on, to actual recommendations to social media companies for removal of identified offending posts, and communications back and further between the government and the EIP. This was done with government monies and resources.

Below is a link for each partner, together with a description of their technologies or recent activities.

  • The University of Washington’s Center for an Informed Public (CIP)
    Their mission “is to resist strategic misinformation, promote an informed society, and strengthen democratic discourse”.

    AS of this month (Nov 2023), the CIP has now turned its identification of targets for censorship to identifying the flow of what they view as the “new elites” of X (ergo influencers with large followings) regarding how they share information regarding the Hamas/Israel conflict.

    The implication being that “X” will be targeted in the future for more harassment by the Election Integrity Partnership.

.

This is a company that specializes in “cutting-edge technology that creates large-scale explorable maps of social media landscapes”. Their in-depth analysis reveals insights to help “clients and partners understand complex online networks and take decisive action”. Graphika lists Harvard, Oxford and DARPA (DARPA = CIA) as its partners.

The Atlantic Council’s DFRL is staffed by former US intelligence establishment technology staffers (ergo, ex CIA and DIA = “Deep State” personnel), and of course the the Atlantic Council itself is known as a landing bed for deep state operatives (otherwise known as a cutout organization).

The DFRL website states:

Centralized and decentralized platforms share a common set of threats from motivated malicious users—and require a common set of investments to ensure trustworthy, user-focused outcomes…

Further research and capability building are necessary to avoid the further proliferation of these threats.

Within industry, decades of “trust and safety” (T&S) practice has developed into a field that can illuminate the complexities of building and operating online spaces. Outside industry, civil society groups, independent researchers, and academics continue to lead the way in building collective understanding of how risks propagate via online platforms—and how products could be constructed to better promote social well-being and to mitigate harms.

Take away all the flowery words and it sure sounds like organized government-sponsored Deep State censorship to me!

Beyond the websites listed above, the House Report does an excellent job of showing how the Election Integrity Partnership worked to censor the American People.

Lets go back to the the Congressional report on censorship, it reads:

Enter the Election Integrity Partnership (EIP), a consortium of “disinformation” academics led by Stanford University’s Stanford Internet Observatory (SIO) that worked directly with the Department of Homeland Security and the Global Engagement Center, a multi-agency entity housed within the State Department, to monitor and censor Americans’ online speech in advance of the 2020 presidential election. Created in the summer of 2020 “at the request” of the Cybersecurity and Infrastructure Security Agency (CISA), the EIP provided a way for the federal government to launder its censorship activities in hopes of bypassing both the First Amendment and public scrutiny.

This interim staff report details the federal government’s heavy-handed involvement in the creation and operation of the EIP, which facilitated the censorship of Americans’ political speech in the weeks and months leading up to the 2020 election. This report also publicly reveals for the first time secret “misinformation” reports from the EIP’s centralized reporting system, previously accessible only to select parties, including federal agencies, universities, and Big Tech. The Committee and Select Subcommittee obtained these nonpublic reports from Stanford University only under the threat of contempt of Congress. These reports of alleged mis- and disinformation were used to censor Americans engaged in core political speech in the lead up to the 2020 election.

As this new information reveals, and this report outlines, the federal government and universities pressured social media companies to censor true information, jokes, and political opinions. This pressure was largely directed in a way that benefitted one side of the political aisle: true information posted by Republicans and conservatives was labeled as “misinformation” while false information posted by Democrats and liberals was largely unreported and untouched by the censors. The pseudoscience of disinformation is now—and has always been—nothing more than a political ruse most frequently targeted at communities and individuals holding views contrary to the prevailing narratives.

<in other words, people that were saying things that the Deep State did not want to be said were the ones being censored>

The EIP’s operation was straightforward: “external stakeholders,” including federal agencies and organizations funded by the federal government, submitted misinformation reports directly to the EIP. The EIP’s misinformation “analysts” next scoured the internet for additional examples for censorship. If the submitted report flagged a Facebook post, for example, the EIP analysts searched for similar content on Twitter, YouTube, TikTok, Reddit, and other major social media platforms. Once all of the offending links were compiled, the EIP sent the most significant ones directly to Big Tech with specific recommendations on how the social media platforms should censor the posts, such as reducing the posts’ “discoverability,” “suspending [an account’s] ability to continue tweeting for 12 hours,” “monitoring if any of the tagged influencer accounts retweet” a particular user, and, of course, removing thousands of Americans’ posts.

The House committee (through Rep. Jim Jordan) also released a google doc (Jira Tickets) that lists some of those censored in chronological order and what their alleged “crimes” were.

In the Jira Tickets list, it is worth noting that on 11 June 2021, the list abruptly changed its focus from “election misinformation” to “vaccine misinformation” and renamed these efforts as the virality project. Almost like there was some sort of directive from the top <sarcasm>.

On the last page of Jira Tickets list, they have included the censorship of my original interview with Tucker Carlson for Fox News. Almost directly after that, the list ends. So, how many times I was recommended for censorship is an unknown. Except that based on the obvious shadow-banning over the past two years, most likely it was in the hundreds of times.

Some screenshots from the Jira Tickets report generated on me regarding the Tucker interview (page nine):

My sin, as shown in the screenshot below, was that I claimed on the Fox interview that the risks outweigh the benefits in teenagers and young adults (per June 30, 2021).

In the image below, the Election Integrity Partnership (now the Virality partnership) notes I am both “General anti-vaccination” and also “right wing” in my affiliations.

So this is really creepy. That fact that my political leanings are mentioned implies that being “right wing” was/is criteria enough for censorship. That this criteria was enough for censorship shows direct election interference.

As this list also labels me as being generally against vaccination. As if being against the mRNA gene therapy for specific vulnerable groups makes one against vaccination. This was enough apparently to be censored.

I believe that is a listing of where that had been shared prior to the censorship:

The Election Integrity Partnership also notes that I am a “repeat offender”

Frankly, the whole document and the House Committee report makes me feel violated.

The House report then goes to to document how even Congresspeople were censored and that under Biden, the censorship efforts were ramped up domestically.

This did not end with the 2020 election.

After President Biden was inaugurated in January 2021, the government’s censorship regime ramped up. At CISA, the CFITF team dropped any pretense of a “foreign”-focus and relabeled itself as the “MDM team” that would focus on foreign and domestic speech that the government considered mis-, dis-, or malinformation. Throughout 2021, the Biden White House engaged in a pressure campaign against Facebook and other social media companies to censor anti-vaccine content, even if it was true. By 2022, CISA invited Dr. Starbird, thenTwitter Executive Vijaya Gadde, and others to form an advisory MDM Subcommittee to consult with CISA about how the agency could and should combat Americans’ speech that the government considered to be mis-, dis-, or malinformation.

But by 2023, as Republicans retook the majority in the House of Representatives and initiated oversight of the censorship-industrial complex, CISA scrubbed its website of references to domestic censorship. The Committee and Select Subcommittee obtained and revealed how Facebook changed its policies because of pressure from the Biden Administration. Internal Facebook documents showed that the Biden White House in particular wanted true information and satire censored at a rate even Big Tech found objectionable.

Based on the Committee’s and Select Subcommittee’s work, even the mainstream media could no longer ignore these constitutional violations. The plaintiffs in Missouri v. Biden have obtained significant victories before a federal district court and the U.S. Court of Appeals for the Fifth Circuit, and now will have their case heard by the Supreme Court. Public reporting shows that universities are reconsidering whether to permit their professors to receive funding and engage in censorship work. But the work is not done yet. The Committee and Select Subcommittee’s investigation remains ongoing.

Clearly, the hit pieces on me by the Atlantic Monthly, New York Times, Washington post (twice), Business Insider, The Scientist and Rolling Stone and other main stream media outlets within a very short timeframe were a coordinated effort by the Deep State to bring me down . I believe that this effort was led by the intelligence agencies and DHS through the Deep State. Kash Patel nicely discusses how this these types of hits are conducted in his book, Government Gangsters. Whereby the government feeds information into operatives working in main stream media (ergo, as in CIA Operation Mockingbird). Now I am told that those same hit pieces were used against me in other government circles. The Supreme court case, Sullivan Versus New York Times, resulted in a situation whereby people in the public eye can almost never win a lawsuit for malicious defamation. The Deep State uses this fact to attack, malign, defame, harass and engage in direct character assassination. This is evil.

For me, I will never get my reputation back as it once was. However, I will not give up fighting for our freedoms, whether it be to bring back integrity to the FDA, CDC, NIH, DoD and HHS or whether it be reining-in the intelligence agency. We all must continue to bring our government to heel.

I will not concede to the Deep State character assassination. I will not let them ruin my life and reputation. And I will not allow them to victimize me.

https://www.zerohedge.com/political/dr-robert-malone-reveals-how-government-tore-his-reputation-apart-piece-piece

Antisemitic hate crimes soar, exposing lunacy of Biden team’s lectures on Islamophobia

 The gigantic rise in antisemitic incidents in the city in the aftermath of Oct. 7 shows the absurdity of the Biden administration’s focus on Islamophobia and lecturing about the dangers to both sides.

The 85th anniversary of the Kristallnacht — the “Night of Broken Glass,” the 1938 Nazi pogrom that preceded the Holocaust — is no time to the minimize the horrific Hamas pogrom that took the lives of 1,400 Israelis, including babies and children, along with mass rapes and hostage-taking.

Even before Israel’s righteous response, the terrorists’ horrific assault unleashed a new round of antisemitic assaults on Jews across the city and state.

The NYPD reports that hate crimes jumped 124% last month over October 2022 — driven by a 214% leap in anti-Jewish incidents.

Overall, the city saw 101 hate crimes last month (vs. 45 last October), including 69 anti-Jewish crimes, compared to eight anti-Muslim incidents.

Nationally, FBI chief Christopher Wray told Congress that while Jews make up 2.4% of the US population, they’re the targets in 60% of religion-based hate-crimes — and that’s in normal times.

Yes, some scattered idiots have harassed Muslims (and a few utter idiots have targeted Sikhs), and one deranged man killed a young Palestinian-American child.

But antisemitic violence is plainly a far larger problem; the White House shouldn’t be gaslighting the nation about that central, grim fact.

https://nypost.com/2023/11/09/opinion/antisemitic-hate-crimes-soar-exposing-lunacy-of-biden-teams-lectures-on-islamophobia/

'Brother of top White House aide makes $8M with boost from Biden agenda'

 The lobbyist brother of a senior White House aide has raked in more than $8 million from clients since President Biden took office in January 2021 — with several companies who retain the tied-in firm receiving direct boosts from the administration’s legislative agenda.

Jeff Ricchetti, the brother of counselor to the president Steve Ricchetti, took in $8.3 million between the first quarter of 2021 and the third quarter of 2023, according to Senate lobbying disclosures.

That’s roughly four times as much Jeff earned between the first quarter of 2017 and the third quarter of 2019, when Donald Trump was in the White House and the lobbying firm Ricchetti Inc. received around $2.2 million.

The windfall has come while the Biden administration repeatedly celebrated the work of businesses Ricchetti lobbied for — including one of the largest US auto manufacturers, medical and pharmaceutical companies and Amazon.

Jeff Ricchetti, the brother of senior Biden adviser Steve Ricchetti, took in $8.3 million between the first quarter of 2021 and the third quarter of 2023.
Finseca

The family ties have prompted ethicists to call for Steve Ricchetti to recuse himself from any discussions with lawmakers that could relate to his brother’s firm, where Steve worked from 2001 to 2012.

“Steve Ricchetti ought to completely recuse himself from any part of the legislation that his brother’s firm is lobbying on, and then have the White House not take calls from his brother,” Richard Painter, the former chief ethics lawyer in the George W. Bush administration, told the Washington Free Beacon, which first reported on the arrangement.

Walter Shaub, the Obama-era director of the US Office of Government Ethics, laid into the Biden administration in June 2021 for having engaged in “illegal” acts of nepotism during its first-year hiring spree.

“I’m sorry, I know some folks don’t like hearing any criticism of him. But this royally sucks. I’m disgusted,” he said. “A lot of us worked hard to tee him up to restore ethics to government and believed the promises. This is a real ‘f— you’ to us — and government ethics.”

​​“I do not lobby my brother, nor have I lobbied the White House this quarter,” Jeff Ricchetti told the Wall Street Journal in July 2021 when asked about his work.

The White House has also maintained that Steve Ricchetti recuses himself from his brother’s lobbying business efforts.

During his first year in office, Biden paid a visit to a General Motors electric vehicle factory in Detroit months after Congress passed his $1.2 trillion bipartisan infrastructure package.
Reuters

During his first year in office, Biden paid a visit to a General Motors electric vehicle factory in Detroit — months after Congress passed his $1.2 trillion bipartisan infrastructure package, which included $7.5 billion for electric vehicle charging stations and $5 billion for electric and low-emission buses.

Jeff Ricchetti’s lobbying disclosures for 2021 show he was paid six-figure sums to handle “issues related to tax incentives for electric vehicles and charging stations” and “issues related to climate policy that affect the automobile industry, generally.”

One month later, Biden also signed an executive order forcing vehicles purchased by the government to be zero-emission by 2035.

The younger Ricchetti also represents the semiconductor manufacturer Applied Materials, whose headquarters Vice President Kamala Harris visited in May 2023.
AP

Jeff Ricchetti also represents the semiconductor manufacturer Applied Materials, whose headquarters Vice President Kamala Harris visited in May to promote the passage of the CHIPS Act, which provided $52 billion in subsidies for domestic semiconductor production

The Taiwanese vaccine distributor Medigen also hired Jeff to lobby Congress on “issues related to Covid-19 vaccines accepted for foreign travelers to the United States.”

The following year the National Institutes of Health granted Medigen a global technology license to fight the rapidly spreading Omicron variant, which was later used to vaccinate nearly 1 million Taiwanese citizens.

Walter Shaub, the Obama-era director of the US Office of Government Ethics, laid into the Biden administration in June 2021 for having engaged in “illegal” acts of nepotism.
Getty Images

Other clients of Ricchetti Inc. include the health and pharmaceutical companies GlaxoSmithKline, Horizon Therapeutics, Vaxart Inc., Neurocrine Biosciences, Ipsen Biopharmaceuticals and Eisai.

At the same time, Jeff Ricchetti has worked for TC Energy Corporation, which runs the Keystone XL pipeline that Biden shut down shortly after assuming office.

The White House and Jeff Ricchetti did not immediately respond to requests for comment.

https://nypost.com/2023/11/09/news/lobbyist-brother-of-white-house-senior-aide-raked-in-8-million-with-boosts-from-biden-agenda/

'Pentagon Is Starting To Restrict Flow Of Military Aid To Ukraine As Money Runs Out'

 No more green for Zelenskyy.

With war funding for both Ukraine and Israel now seemingly snarled up beyond repair in Congress, on Thursday the Pentagon said that funding delays have forced the US to begin restricting the flow of military assistance to Ukraine, and the Pentagon has only $1 billion left to replenish stocks of weapons that were sent to the country, according to a spokeswoman.

“We have had to meter out our support for Ukraine,” Deputy Pentagon spokeswoman Sabrina Singh told reporters. “We’re going to continue to roll out packages but they are getting smaller.”

Singh urged Congress to break a deadlock and approve the Biden administration’s $61.4 billion request for emergency funds for Ukraine’s fight against Russia, part of a masive $106 billion package that would include aid for Israel and the US-Mexico border, but which now has virtually no chance of passing. House Republicans have sought to separate the aid for Ukraine and Israel, an idea both the Senate and the White House oppose.

Singh said the US had burned through about 95% of previous funding for Ukraine, which she said also totaled more than $60 billion; of course, much of that $60 billion was then rerouted back to the Military Industrial Complex and Deep state back in the US, where it served to boost various military companies, and their political supporters and assorted hanger-on lobbies. 

She said the remaining $1 billion is part of a program that allows President Joe Biden to send existing US military hardware to Ukraine and replace it with new orders.

Singh’s warning was only the latest from the administration, which has said repeatedly it’s scrambling to keep military aid flowing for President Volodymyr Zelenskiy’s forces. Last month, the Pentagon’s comptroller said a government shutdown, which is also looming later this month, would slow the pace of replacing weapons stockpiles sent to Ukraine.

Perhaps realizing that Ukraine's military forces are about to expire, Telegraph reported that Russia has amassed an estimated 40,000 troops around the key battlefront in Avdiivka as it prepares for a third wave assault on the shattered eastern town, the Ukrainian military has said.

“They are building up reserves. They’ve brought in about 40,000 men here along with ammunition of all calibres,” said Anton Kotsukon, spokesperson for the 110th separate mechanised brigade. “We see no sign of the Russians abandoning plans to encircle Avdiivka.”

Russian forces, he said, had surrounded the town on three sides and were “playing cat and mouse”, sending up “huge numbers” of drones to scout out Ukraine’s defences.

Ukrainian forces regard the town as a gateway for future advances to recapture territory in the east; alternatively the Russian army expects capture of the town to allow to penetrate deep into Ukraine territory.

https://www.zerohedge.com/markets/pentagon-starting-restrict-flow-military-aid-ukraine-money-runs-out

Pentagon Confirms Series Of New Attacks On Bases In Syria, Iraq After Latest US Airstrikes

 The overnight Pentagon airstrikes on alleged Iran-back militia targets in Syria's east has already been met with retaliation attacks. The US strikes marked the second major such aerial operation in Syria in recent weeks since the Gaza war began. 

"American troops were hit four times by Iranian-backed groups in the Middle East after a U.S. strike Wednesday on an Iranian facility in Syria," The Hill reports based on fresh defense official statements. 

Pentagon deputy press secretary Sabrina Singh in a Thursday briefing filled in more details on the continuing tit-for-tat as US troops are in the line of fire while occupying some one-third of Syrian territory.

She indicated that in 56 American soldiers were wounded in more than 46 attacks against US bases in Iraq and Syria in the period of time spanning Oct. 17 to Nov. 9

One of the Wednesday US strikes was reportedly against an "IRGC-linked weapons storage facility" - and Singh said it was 'successful' as "we were able to render that building pretty much non-usable." She described that the prior attacks on US bases have all involved rockets and suicide drones, which in total has been 24 attacks in Iraq and 22 in Syria.

"If these attacks continue against our personnel, we won’t hesitate at a time and place of our choosing to respond again," Singh added.

Defense officials have further said that all or most of the over 50 US troop injuries have been minor, and that all have since returned to duty.

Below: an initial round of US strikes in late October:

Map: BBC

The US has had some 1,000 or more troops and personnel in Syria for years. Originally claiming a "counter ISIS" mission, the US "mission" quickly became an oil and gas resource grab - ultimately with an eye toward regime change in Damascus, via suffocating sanctions and diverting of domestic energy.

https://www.zerohedge.com/military/pentagon-confirms-series-new-attacks-bases-syria-iraq-after-latest-us-airstrikes

Study shows children's antibodies are highly potent against COVID-19

 Children are an underutilized source of potential antibody therapies to counteract the "ever-evolving" COVID-19 pandemic, according to researchers at Vanderbilt University Medical Center.

Reporting Nov. 6 in Cell Reports Medicine, Ivelin Georgiev, Ph.D., and colleagues demonstrated that antibodies isolated from children's  displayed high levels of neutralization and potency against variants of the COVID-19 virus, SARS-CoV-2, even when the children had not previously been exposed to or vaccinated against those variants.

"These results indicate that children's samples can play an important role in the discovery of effective SARS-CoV-2 antibody therapeutics," the researchers concluded.

This is important because, while monoclonal antibodies developed at VUMC and elsewhere initially were quite effective in neutralizing SARS-CoV-2, the virus' ability to mutate rapidly has enabled it to escape from every monoclonal antibody product currently on the market.

It is crucial to find antibodies that can broadly neutralize all variants of the virus, said Georgiev, the paper's corresponding author, and associate professor of Pathology, Microbiology & Immunology, Biomedical Informatics, Chemical and Biomolecular Engineering, and Computer Science at Vanderbilt.

Children have been thought to be unlikely sources for new antibody therapies because their immune systems are immature, and they tend to be more susceptible to severe viral illnesses including those caused by influenza,  (RSV), and human metapneumovirus.

When it comes to SARS-CoV-2, however, children experience significantly less  compared to adults. Even when adolescents have severe disease, they are hospitalized less often than adults, require shorter hospital stays, and are less likely to die from COVID-related complications.

In the VUMC study, blood samples from children ages 5 months to 18 years old were collected between July and August 2021, and divided into two groups: those with no known exposure to SARS-CoV-2 infection or vaccination, and those who had been infected or vaccinated.

The researchers employed a variety of sophisticated techniques including LIBRA-seq (Linking B-cell Receptor to Antigen Specificity through sequencing), which was developed at VUMC, and which rapidly and efficiently identified multiple neutralizing  against SARS-CoV-2 in the samples.

Fluorescence-activated cell sorting, , and a computational pipeline enabled high-throughput mapping of the amino-acid sequences of antibodies that bound viral antigens.

The researchers found that neutralizing antibodies identified in children had similar genetic features to antibodies from adults, and that children use similar mechanisms for neutralizing the COVID-19 virus.

What was surprising was that the antibodies isolated from children potently neutralized SARS-CoV-2 variants that have become resistant to virtually all approved monoclonal antibody therapeutics.

Not only are  a potential source of new therapies against COVID-19, but deciphering their antigen-specific antibody repertoires could prove useful in improving the treatment of other infectious diseases, and the development of next-generation pediatric vaccines, the researchers reported.

More information: Steven C. Wall et al, SARS-CoV-2 antibodies from children exhibit broad neutralization and belong to adult public clonotypes, Cell Reports Medicine (2023). DOI: 10.1016/j.xcrm.2023.101267


https://medicalxpress.com/news/2023-11-children-antibodies-highly-potent-covid-.html

Drug screen points toward novel diabetes treatments

 A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a previously unknown mechanism for insulin regulation in type 2 diabetes, according to a new study by Weill Cornell Medicine investigators. The preclinical discovery, reported in Nature Chemical Biology, provides a new chemical tool for probing the biology of diabetes, and could point the way toward better treatments for the disease.

"We have known about  for a century, but when it comes to the major mechanisms controlling insulin secretion, there are still a lot of things which are unknown," said senior author Dr. Shuibing Chen, director of the Center for Genomic Health and the Kilts Family Professor of Surgery at Weill Cornell Medicine.

To search for new insulin-regulating mechanisms, Dr. Chen and her colleagues, including first author Dr. Angie Chi Nok Chong, a postdoctoral associate in Dr. Chen's lab, began by testing a library of drugs on cultures of mouse , looking for  that stimulated insulin secretion in response to glucose.

"Instead of running a large-scale  screening, we decided to do a focused library," said Dr. Chen who is also a member of the Hartman Institute for Therapeutic Organ Regeneration at Weill Cornell Medicine. "So, we had candidates that we knew might be involved in certain important biological processes."

The screen identified three compounds that promoted insulin secretion, two of which targeted known insulin-regulating mechanisms in pancreatic beta cells. A third, however, targeted a protein called CHEK2, which is often mutated in cancer but hadn't previously been associated with glucose metabolism.

With collaborators at two other institutions, the researchers confirmed that the compound increases glucose-mediated insulin secretion in multiple tests on human and non-human pancreatic cells grown in the laboratory, and various mouse models of type 2 diabetes. "That makes the data very exciting, because it's really consistent from mouse to human islets in vitro, as well as both mouse and nonhuman primate in vivo," said Dr. Chen.

Probing the mechanism more closely, the team uncovered a previously unknown insulin secretion-regulating molecular pathway that operates in multiple mammalian species. Dr. Chen says the compound they identified in their initial screen, called AZD7762, promises to be a useful tool for exploring other aspects of insulin regulation.

"We not only identified CHEK2 as a potential drug target; we can also use AZD7762 as a  to find new mechanisms for , and find new targets in the future," she said.

While AZD7762 is currently in  as a cancer therapy, it's unlikely to be directly adapted to a new diabetes treatment. "The safety requirement for  and diabetes therapy is completely different," Dr. Chen said, adding that the side effects of the cancer drug would likely make it unsuitable for long-term use in a chronic condition such as type 2 diabetes. However, compounds that affect CHEK2 only in pancreatic beta cells could prove very effective.

"If we can target delivery of the drugs to beta cells without affecting other cells, that could be an interesting approach to probe," said Dr. Chen.

The project has also laid the groundwork for future drug development. "We built up the foundation for the chemical screening and testing in animal and cell models," Dr. Chen said. "In the future if we find anything interesting, it can be immediately tested in this pipeline."

More information: Chong, A.C.N. et al, Checkpoint kinase 2 controls insulin secretion and glucose homeostasis, Nature Chemical Biology (2023). DOI: 10.1038/s41589-023-01466-4www.nature.com/articles/s41589-023-01466-4


https://medicalxpress.com/news/2023-11-drug-screen-diabetes-treatments.html