In the worldwide battle against COVID-19, scientists are
investigating whether a century-old tuberculosis vaccine might offer
some additional protection against the novel coronavirus.
And Bulgaria—one of the world’s leading manufacturers of the vaccine—is holding out hope of new markets for the many millions of doses it produces each year.
Bacillus Calmette-Guerin, or BCG, was developed by two French
researchers, Albert Calmette and Camille Guerin, in 1921 as a vaccine
against tuberculosis, a lung disease
that, according to the World Health Organization, is the world’s top
infectious killer and the cause of 1.5 million deaths globally every
year.
In the fevered search for a treatment against COVID-19, clinical
trials are under way—in Australia, South Africa, Europe and the United
States—to examine a hypothesis that BCG might provide a complementary
shield against the novel coronavirus.
The WHO, for its part, said last month that there is no evidence that BCG protects people against infection with COVID-19.
Nevertheless, Bulgarian scientists suggest that the Balkan country’s
high rate of BCG vaccination—as well as an early lockdown—helped it to
escape the worst of the pandemic.
“BCG generates a powerful immune stimulation. And while we are
waiting for a specific treatment or vaccine against the novel
coronavirus, we must put our bets on immunity,” immunology professor
Bogdan Petrunov told BNT public television.
Neonatologist Valentina Gerginova said that those who have had the
vaccine experience “milder forms of other bacterial and viral
infections” and that it could therefore also benefit those who are
exposed to the novel coronavirus.
Gerginova has administered BCG shots to newborn babies for more than 30 years at a private Sofia hospital.
While many countries now carry out only targeted BCG vaccination
campaigns, Bulgaria insists on the mandatory vaccination of all newborn
babies.
Bulgaria is also a major producer of the vaccine, exporting it to 140
countries. Its state-owned company Bul Bio is one of 22 pharmaceuticals
firms worldwide that manufactures it, and only one of three in the
European Union.
Bulgaria is also one of just four suppliers to the WHO—alongside
India, Japan and Denmark—for the United Nations’ anti-tuberculosis
campaigns in Africa and Asia.
‘Beneficial effects’
“We have known for many years that the BCG has some more general beneficial effects,”
Camille Locht, head of research at the National Institute of Health and
Medical Research (Inserm) in the northern French city of Lille, told
AFP.
The government hopes that Bulgaria, the EU’s poorest country, could
benefit from its leading position as a major producer of BCG.
On a recent visit to Sofia-based Bul Bio, Prime Minister Boyko
Borisov pledged additional funding of 10.4 million leva (5.2 million
euros, $5.8 million) for a new production line that would double the
company’s annual production to more than four million vials, the
equivalent of 40 million shots.
“Due to the slim profit margins and the complex production process,
there is real pressure on the supply of the vaccine on an international
scale,” Bul Bio chief executive Rumen Kofinov told AFP.
Bulgaria’s expertise with BCG goes back a long way.
Among several different versions of the vaccine that were developed,
one was tested in Bulgaria as far back as 1926. And large-scale
production of BCG began in 1949 in a state laboratory that was Bul Bio’s
predecessor.
In 1951, the country made the BCG vaccination obligatory for newborn
babies, reducing to just one-tenth the number of tuberculosis cases in
30 years.
“We are the most BCG-ed country in the world,” with four obligatory
shots administered before adulthood, the chief of Bulgaria’s National
Centre for Infectious and Parasitic Diseases, Todor Kantardzhiev, said
in a recent interview.
Despite this—and the fact that some other European states have never
implemented mass BCG vaccination—tuberculosis infection rates are still
twice as high in Bulgaria than the European average because of
persistent poverty in some parts of the country.
https://medicalxpress.com/news/2020-05-bulgaria-pins-tb-vaccine-coronavirus.html
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