Ionis reports third quarter 2025, ups outlook

 - TRYNGOLZA® generated $32 million in net product sales in the third quarter 2025 -

- DAWNZERA™ (donidalorsen) launch off to encouraging start -

- Olezarsen significantly reduced triglycerides and acute pancreatitis events in severe hypertriglyceridemia (sHTG) in landmark Phase 3 studies; sNDA submission on track by year-end –

- Positive pivotal zilganersen results in Alexander disease position Ionis for first independent neurology launch in 2026 -

- Increasing 2025 financial guidance driven by continued strength across the business –

https://ir.ionis.com/news-releases/news-release-details/ionis-reports-third-quarter-2025-financial-results-and