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Tuesday, April 7, 2020

Colorado county threatens tourists with fines, jail time amid coronavirus

A Colorado county is closing its doors to tourists amid the coronavirus outbreak, threatening anyone who violates a new public health order with up 18 months in jail and a $5,000 fine.
Gunnison County officials issued a public health order Friday barring non-residents and tourists from staying in the central Colorado community or to request a waiver to explain why they should be allowed to stay, according to the order.
“The public health director finds that non-residents, visitors and non-resident homeowners from lower altitudes are at a greater risk for complications from COVID-19 infection than residents, who are acclimatized to the high altitude environment of Gunnison County,” the order states.
Anyone who doesn’t live in the county is further “imposing unnecessary burdens” on health care, food supplies, first responders and other essential public services, the new directive reads.
“Accordingly, the presence of non-residents and visitors, including non-resident homeowners, is no longer permitted in Gunnison County in order to maintain public health and safety and to continue to address the COVID-19 pandemic,” it reads.
The public health order makes Gunnison County the first jurisdiction in the state to impose criminal charges for violating Colorado’s stay-at-home order, KREX reports.
“Our goal is to maintain the health and safety of our residents and the integrity of our health care system,” Gunnison County Emergency Operations Center spokesman Daniel Kreykeys told the outlet. “To that end, there’s some language in that health care order that allows for folks to apply for an exemption. We realize there are certain things going on with out residents that may require that. We want to give people that option, if needed.”
It’s unclear exactly how the order will be enforced, KREX reports.
County officials alerted residents to the new guidance on Facebook Thursday, telling would-be visitors and those with second homes to stay home.
“Help Gunnison County begin to sink the spike of positive COVID-19 tests by simply not visiting Gunnison County,” the post read. “We miss you. We value you. We can’t wait to see you again. Just please. Not until we begin to reverse the aggressive trend of this global pandemic in our neck of the woods.”
https://nypost.com/2020/04/07/colorado-county-shuts-door-to-tourists-amid-coronavirus-crisis

Thousands of NY COVID patients are being treated with anti-malarial drug

As many as 4,000 seriously ill coronavirus patients in New York are being treated with the anti-malarial drug hydroxychloroquine, state health officials say.
President Trump has touted hydroxychloroquine as a potential life-saver, although there is no widespread scientific evidence to date showing it helps battle COVID-19.
But Gov. Andrew Cuomo last month said health care providers in the state would be using the drug in combination with the antibiotic Zithromax, or azithromycin, for some last-ditch cases, based on potentially promising research.
“Time is of the essence,’’ Albany University Public Health Dean David Holtgrave, who is on the state’s research team, said in a statement.
A state Health Department official said the DOH has shipped doses of hydroxychloroquine to 56 hospitals across New York, distributing enough “to treat 4,000 patients to date.”
Patients have received doses as part of four- or 10-day regimens, officials said.
The University of Albany’s School of Public Health is observing the drug’s impact on the patients, and its preliminary study could come back in weeks instead of the usual months, officials said.
There are also clinical trials being conducted to see whether the drug can help block transmission.
NYU Langone Medical School is conducting a random trial with a $9.5 million grant from the Bill & Melinda Gates Foundation.
“Currently, there is no proven way to prevent COVID-19 after being exposed,” said Anna Bershteyn, an assistant professor with the Department of Population Health at NYU Langone and the study’s co-principal investigator.
“If hydroxychloroquine provides protection, then it could be an essential tool for fighting this pandemic. If it doesn’t, then people should avoid unnecessary risks from taking the drug.”
The drug has long been used to treat malaria, rheumatoid arthritis and lupus.
Its potential side effects include everything from fatal heart arrhythmia to vision loss, ear-ringing, vomiting, mood changes, skin rashes and hair loss.
Health officials are treading cautiously, saying they don’t anticipate hydroxychloroquine will be a “miracle drug” against the coronavirus — but the studies are worth the gamble.
In terms of the NYU clinical trial regarding prevention, researchers are enrolling 2,000 adult volunteers at six sites.
They are recruiting people who lack any COVID-19 symptoms but have been in close contact with others who have a confirmed or pending diagnosis.
On a random basis, the trial participants will receive either hydroxychloroquine or a placebo pill — vitamin C — every day for two weeks.
Each day during the 14-day period and then again on Day 28, the participants will swab their nasal passages and send the samples to researchers to detect potential COVID-19 infection.
“If everything goes as planned, the eight-week trial could provide answers by summer on whether a preventive dose of the drug is safe and effective,’’ NYU Langone said in a release.
“If so, the strategy could give health officials a much needed boost in slowing person-to-person transmission.”
The federal Food and Drug Administration granted emergency-use authorization to use hydroxychloroquine to treat COVID-19 patients amid the pandemic.
There has been anecdotal evidence — including from China — that the drug helps patients clear the virus sooner.
But Dr. Anthony Fauci of the National Institutes of Health, asked recently whether the drug was considered a treatment for the novel coronavirus, said, “The answer is no … The evidence that you’re talking about … is anecdotal evidence.”
Meanwhile, Northwell Health facilities — including Lenox Hill, Long Island Jewish and Staten Island University hospitals — and Maimonides Medical Center are giving moderately to seriously ill coronavirus patients certain antiviral drugs such as Sarilumab, an IL-6 inhibitor, and Remdesivir, a drug that incorporates itself into the genome.
Northwell has recruited 143 patients for a Sarilumab trial.
Mount Sinai’s-Icahn School of Medicine also is one of 34 institutions nationwide participating in the National COVID-19 Convalescent Plasma Project. The program seeks blood-plasma donations from recovered coronavirus patients that contain antibodies that can be used to fight the virus in seriously ill patients.
https://nypost.com/2020/04/05/ny-coronavirus-patients-being-treated-with-anti-malarial-drug/

Lilly Offering $35 Insulin Co-Pays During Pandemic

Eli Lilly & Co. Tuesday unveiled a program offering $35 co-pays for its key insulin products during the coronavirus crisis.
The Indianapolis drug maker said the Lilly Insulin Value Program allows anyone with commercial insurance and those without insurance to fill their monthly prescriptions for $35.
Eli Lilly said the program covers most of its insulins, including all Humalog formulations.
The company in early March said it doesn’t expect any shortages of its insulin products during the pandemic.

https://www.marketscreener.com/ELI-LILLY-AND-COMPANY-13401/news/Eli-Lilly-and-Offering-35-Insulin-Co-Pays-During-Pandemic-30376571/

GSK, AstraZeneca Partner to Tackle Covid-19 Test Shortages

AstraZeneca PLC and GlaxoSmithKline PLC have teamed up with the University of Cambridge to combat shortages of Covid-19 tests, the companies said Tuesday.
The British drug companies said they would set up a laboratory at the university to develop “alternative chemical reagents for test kits in order to help overcome current supply shortages.”
“While diagnostic testing is not part of either company’s core business, we are moving as fast as we can to help where possible,” the companies said.
In late March, GSK joined a coalition of drugmakers who agreed to share their “proprietary libraries of molecular compounds” for screening with the Covid-19 Therapeutics Accelerator, which was launched by the Bill & Melinda Gates Foundation, Mastercard Inc. and U.K.-based nonprofit Wellcome.
That effort could result in human or animal trials in as little as two months, the Gates Foundation said at the time.

https://www.marketscreener.com/ASTRAZENECA-PLC-4000930/news/AstraZeneca-GSK-AstraZeneca-Partner-to-Tackle-Covid-19-Test-Shortages-30378815/

African Americans may be bearing brunt of Covid-19, but access to data limited

Stark statistics are coming to light only now and only in piecemeal fashion showing that African Americans are disproportionately affected by Covid-19. The racial divide in who gets infected, who gets tested, and who dies from Covid-19 is emerging from the few cities and states whose data are public.
African Americans in Illinois, for example, accounted for 29% of confirmed cases and 41% of deaths as of Monday morning, yet they make up only 15% of the state’s population, according to the Illinois Department of Public Health, one of just a handful of government agencies sharing information on who is hardest hit by the virus. Michigan mirrors Illinois, with 34% of Covid-19 cases and 40% of deaths striking African Americans, even though only 14% of Michigan’s population is Black. The story is similar in Wisconsin, where Pro Publica first reported that African Americans number nearly half of the 941 cases in Milwaukee County and 81% of its 27 deaths while the population is 26% Black.
The Centers for Disease Control and Prevention distributes data on age, gender, and location of Covid-19 patients but not their race or ethnicity. (The CDC did not respond to a request for comment made on Monday.) That posture has set off challenges from legal and medical professionals to release that data so resources can be better allocated to the people who need them the most.
The Lawyers’ Committee for Civil Rights Under Law and nearly 400 medical professionals have demanded that the U.S. Department of Health and Human Services release daily racial and ethnic demographic data on Covid-19 tests, cases, and outcomes. They cited both the 1964 Civil Rights law and the Affordable Care Act, which prohibit discrimination in health care services. The absence of data amounts to denial of appropriate care, the group argues.
“We are deeply concerned that African American communities are being hardest hit by the Covid-19 pandemic, and that racial bias may be impacting the access they receive to testing and healthcare,” Kristen Clarke, president and executive director of the committee, said in a conference call with reporters on Monday.
The grim reality reflected in those limited statistics fits with longstanding research on the social determinants of health as well as the very specific risk factors that come into play for the spread of the coronavirus.
Lisa Cooper, an internal medicine physician and a professor at the Johns Hopkins Bloomberg School of Public Health, said she’d have to speculate, given the dearth of data, but she listed multiple reasons why as a group African Americans of lower income are more likely to become ill: People working for an hourly wage don’t have the luxury of being able to shelter at home or the means to buy two weeks’ worth of healthy food. They may work in jobs deemed essential, such as in public transportation, public safety, or health care. If they quit, they would lose their health insurance, if they have it, and access to health care. If they continue working, they risk exposure to the coronavirus. And they are more likely to have diabetes, high blood pressure, or asthma, chronic conditions that put them at higher risk for more serious Covid-19 illness.
“African Americans in many large cities began to practice social distancing behavior much later than whites, largely due to the fact [whites] could stay at home to work,” Cooper told STAT.
Like dominoes, one risk factor topples into another, said Brian Williams, a trauma surgeon, intensive care doctor, and associate professor at University of Chicago Medicine. He was shocked when he learned that in his city, 70% of the people who died from the virus were African American, according to data analyzed by WBEZ.
“I’m disheartened because the disparity is so great and I wish I could do more, although I’m a doctor with a certain skill set that is useful right now,” he said in an interview. “I wish I could do a lot more.”
If there were more complete information, more could be done to help people who are sick and stanch the spread of disease, he said.
“We need to have a demographic breakdown of who will be impacted and how we as a health care system can deploy all our resources and personnel in the most efficient and effective manner to ensure the safety and well-being of the entire American public,” Williams said. “Now we’re flying blind because we don’t know.”
That racial and ethnic demographic data are being collected — it’s just not being reported out to the public, said Uché Blackstock, an emergency physician in Brooklyn, N.Y.
“I think it speaks to just how broken our system is,” she said. “We actually have the data in our city. All of the electronic medical records systems collect racial and ethnic demographic data. It’s a matter of getting our Department of Health to disclose what that data shows. ”
Williams is looking beyond the current crisis, beyond the surge of patients he fears is still coming.
“This affects all of us, either directly or indirectly,” he said before returning to the ICU. “And when the pandemic is over, our recovery plan should be one of unity in order to rebuild a better society that recognizes the shared humanity of everyone living within our borders.”
‘We’re flying blind’: African Americans may be bearing the brunt of Covid-19, but access to data are limited

NOVO NORDISK Gets a Buy rating from Goldman Sachs

In a research note published by Keyur Parekh, Goldman Sachs advises its customers to buy the stock. The target price remains unchanged at DKK 475.
https://www.marketscreener.com/NOVO-NORDISK-A-S-1412980/news/NOVO-NORDISK-Gets-a-Buy-rating-from-Goldman-Sachs-30362552/?countview=0

Mallinckrodt shares halted pending news

The NYSE has suspended trading in Mallinckrodt (NYSE:MNK) pending the release of news. Anxious longs are hoping it is not a bankruptcy filing.
https://seekingalpha.com/news/3558949-mallinckrodt-shares-halted-pending-news