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Wednesday, July 2, 2025

Obama’s Trump-Russia collusion report was corrupt from start: CIA review

 by Miranda Devine

A bombshell new CIA review of the Obama administration’s spy agencies’ assessment that Russia interfered in the 2016 presidential election to help Donald Trump was deliberately corrupted by then-CIA Director John Brennan, FBI Director James Comey and Director of National Intelligence James Clapper, who were “excessively involved” in its drafting, and rushed its completion in a “chaotic,” “atypical” and “markedly unconventional” process that raised questions of a “potential political motive.” 

Further, Brennan’s decision to include the discredited Steele dossier, over the objections of the CIA’s most senior Russia experts, “undermined the credibility” of the assessment.

The “Tradecraft Review of the 2016 Intelligence Community Assessment [ICA] on Russian Election Interference” was conducted by career professionals at the CIA’s Directorate of Analysis and was commissioned by CIA Director John Ratcliffe in May. 

The “lessons-learned review” found that, on December 6, 2016, six weeks before his presidency ended, Barack Obama ordered the assessment, which concluded that Russian President Vladimir Putin “aspired” to help Trump win the election. 

The review identified “multiple procedural anomalies” that undermined the credibility of the ICA, including “a highly compressed production timeline, stringent compartmentation, and excessive involvement of agency heads.”

It also questioned the exclusion of key intelligence agencies and said media leaks may have influenced analysts to conform to a false narrative of Trump-Russia collusion.

“The rushed timeline to publish both classified and unclassified versions before the presidential transition raised questions about a potential political motive behind the White House tasking and timeline.”

The review found that Brennan directed the compilation of the ICA, and that his, Comey’s and Clapper’s “direct engagement in the ICA’s development was highly unusual in both scope and intensity” and ”risked stifling analytic debate.”

President Barack Obama speaks about Iran and Israeli Prime Minister Benjamin Netanyahu’s speech to Congress during a meeting with Defense Secretary Ash Carter in the Oval Office of the White House in Washington, March 3, 2015.AP

Brennan handpicked the CIA analysts to compile the ICA and involved only the ODNI, CIA, FBI and NSA, excluding 13 of the then-17 intelligence agencies. 

He sidelined the National Intelligence Council and forced the inclusion of the discredited Steele dossier despite objections of the authors and senior CIA Russia experts, so as to push a false narrative that Russia secured Trump’s 2016 victory.

“This was Obama, Comey, Clapper and Brennan deciding ‘We’re going to screw Trump,’” said Ratcliffe in an exclusive interview. 

“It was, ‘We’re going to create this and put the imprimatur of an IC assessment in a way that nobody can question it.’ They stamped it as Russian collusion and then classified it so nobody could see it.

“This led to Mueller [special counsel Robert Mueller’s inquiry, which concluded after two years that there was no Trump-Russia collusion]. It put the seal of approval of the intelligence community that Russia was helping Trump and that the Steele dossier was the scandal of our lifetime. It ate up the first two years of his [Trump’s first] presidency.

“You see how Brennan and Clapper and Comey manipulated [and] silenced all the career professionals and railroaded the process.”

Former CIA Director John Brennan testifies before the House Permanent Select Committee on Intelligence on Capitol Hill, May 23, 2017, in Washington, DC.Getty Images

The CIA review notes that, before work even began on the ICA, “media leaks suggesting that the Intelligence Community had already reached definitive conclusions risked creating an anchoring.” The term “anchoring” refers to a cognitive bias in psychology and suggests that the media leaks may have influenced the analysts working on the ICA to shape their findings to conform with the leaked narrative rather than conducting an objective analysis. 

On December 9, 2016, both the Washington Post and New York Times reported the IC had “concluded with high confidence that Russia had intervened specifically to help Trump win the election.”

The Post cited an unnamed US official describing this as the IC’s “consensus view.”

The “highly compressed timeline was atypical for a formal IC assessment which ordinarily can take months to prepare, especially for assessments of such length, complexity, and political sensitivity,” the review found. “CIA’s primary authors had less than a week to draft the assessment and less than two days to formally coordinate it with IC peers before it entered the formal review process at CIA on December 20.”

Trump wound up winning the 2016 election against Hillary Clinton.REUTERS

When the draft ICA was completed and sent for review to Intelligence Community “stakeholders,” the timeline was “compressed to just a handful of days during a holiday week [which] created numerous challenges …

“Multiple IC stakeholders said they felt ‘jammed’ by the compressed timeline. Most got their first look at the hardcopy draft and underlying sensitive reporting just before or at the only in-person coordination meeting that was held on December 19 to conduct a line-by-line review.”

Drafts of the ICA were only permitted in hard copy, so needed to be hand-carried between various spy agency buildings. “The pressing timeline and limitations of hardcopy review likely biased the overall review process.”

The “direct engagement” of agency heads Brennan, Comey and Clapper in the ICA’s development was “highly unusual in both scope and intensity. This exceptional level of senior involvement likely influenced participants, altered normal review processes, and ultimately compromised analytic rigor. 

“One CIA analytic manager involved in the process said other analytic managers — who would typically have been part of the review chain — opted out due to the politically charged environment and the atypical prominence of agency leadership in the process.”

Former CIA Director John Brennan.UPI

The review criticizes the ICA for including the Steele dossier, a salacious and discredited opposition-research product written by former British spy Christopher Steele, who was working for the Hillary Clinton campaign, which claimed Russia possessed sexually compromising blackmail material on Trump.

Despite the fact that “the ICA authors and multiple senior CIA managers — including the two senior leaders of the CIA mission center responsible for Russia — strongly opposed including the Dossier, asserting that it did not meet even the most basic tradecraft standards,” Brennan insisted it be included.

“CIA’s Deputy Director for Analysis (DDA) warned in an email to Brennan on December 29 that including it in any form risked ‘the credibility of the entire paper.’”

But Brennan responded that “my bottom line is that I believe that the information warrants inclusion in the report.”

Republican President-elect Donald Trump gives a thumbs up to the crowd during his acceptance speech at his election night event at the New York Hilton Midtown in the early hours of November 9, 2016, in New York City.Getty Images

Brennan showed “a preference for narrative consistency over analytical soundness,” said the review. 

“When confronted with specific flaws in the Dossier by the two mission center leaders — one with extensive operational experience and the other with a strong analytic background — he appeared more swayed by the Dossier’s general conformity with existing theories than by legitimate tradecraft concerns.”

“The decision by agency heads to include the Steele Dossier in the ICA ran counter to fundamental tradecraft principles and ultimately undermined the credibility of a key judgment. The ICA authors first learned of the Dossier, and FBI leadership’s insistence on its inclusion, on December 20 — the same day the largely coordinated draft was entering the review process at CIA,” according to the review. “FBI leadership made it clear that their participation in the ICA hinged on the Dossier’s inclusion and, over the next few days, repeatedly pushed to weave references to it throughout the main body of the ICA.”

In the end, the spy agency heads decided to include a two-page summary of the Steele dossier as an “annex” to the ICA, with a disclaimer that the material was not used “to reach the analytic conclusions.” 

President Barack Obama delivers remarks at a Clean Power Plan event at the White House in Washington, DC, August 3, 2015.AFP via Getty Images

However, the review says that “by placing a reference to the annex material in the main body of the ICA as the fourth supporting bullet for the judgment that Putin ‘aspired’ to help Trump win, the ICA implicitly elevated unsubstantiated claims to the status of credible supporting evidence, compromising the analytical integrity of the judgment.”

The review is critical of the decision by Brennan, Clapper and Comey to “marginalize the National Intelligence Council (NIC), departing significantly from standard procedures for formal IC assessments.”

“The NIC did not receive or even see the final draft until just hours before the ICA was due to be published … Typically, the NIC maintains control over drafting assignments, coordination, and review processes.”

The review also quotes from Brennan’s memoir “Undaunted,” in which he revealed that he “established crucial elements of the process with the White House before NIC involvement, stating he informed them that CIA would ‘take the lead drafting the report’ and that coordination would be limited to ‘ODNI, CIA, FBI, and NSA.’ ”

The review says such “departures from standard procedure not only limited opportunities for coordination and thorough tradecraft review, but also resulted in the complete exclusion of key intelligence agencies from the process. … The decision to entirely shut out the Defense Intelligence Agency and the Department of State’s Bureau of Intelligence and Research from any participation in such a high-profile assessment about an adversary’s plans and intentions was a significant deviation from typical IC practices.

“It also was markedly unconventional to have Agency heads review and sign off on a draft before it was submitted to the NIC for review. The NIC did not receive or even see the final draft until just hours before the ICA was due to be published.”

President Trump and Russian President Vladimir Putin shake hands during a joint press conference after their summit on July 16, 2018, in Helsinki, Finland.Getty Images

There was only one meeting at which the IC analysts could coordinate, but one day before the meeting, Brennan sent a note to the CIA workforce saying he had already met with Clapper and Comey and that “there is strong consensus among us on the scope, nature, and intent of Russian interference in our recent Presidential election.”

The CIA review concludes: “With analysts operating under severe time constraints, limited information sharing, and heightened senior-level scrutiny, several aspects of tradecraft rigor were compromised — particularly in supporting the judgment that Putin ‘aspired’ to help Trump win.”

The Putin-Trump nexus “struggled to stand on its own” and its inclusion damaged the report because it “risked distracting readers from the more well-documented findings on Putin’s strategic objectives …

“The two senior leaders of the CIA mission center responsible for Russia argued jointly against including the ‘aspire’ judgment. In an email to Brennan on December 30, they stated the judgment should be removed because it was both weakly supported and unnecessary, given the strength and logic of the paper’s other findings on intent. They warned that including it would only ‘open up a line of very politicized inquiry.’ ”Ratcliffe points to the inclusion of Steele as a sign that “it was a politically corrupted process … They all knew the Steele dossier was garbage … The FBI knew full well that Christopher Steele couldn’t get paid the [FBI’s] million-dollar bounty because he couldn’t corroborate the claims and [Igor] Danchenko [the Steele dossier’s primary source] said it was all made up. Yet you see Brennan saying [the dossier] needs to be in there.”

Ratcliffe said the career professionals at the CIA who conducted the review are “just appalled.”

He drew the comparison between the bogus ICA and the cover-up of the Hunter Biden laptop by 51 former intelligence officials, who falsely claimed before the 2020 election that it was Russian disinformation.

“The comparison would be the Hunter Biden laptop. It’s the same people.

“In the Hunter Biden case, it’s ‘We’ve got to lie to win the election.’

“In this case, it is ‘We failed to influence the election and after we failed, we’re going to handicap the president [Trump] so we can win the next election by polluting the well.’

“They were trying to ruin the presidency after the fact.”

He said the blatant politicization of intelligence is “unprecedented in American history.”

“Obama commissioned this. There was no basis by which it had to be done [before the end of] the Obama administration. [Obama said] ‘I want this done,’ ” he said.

Ratcliffe also said the bogus ICA had risked dire national security consequences by further aggravating the already tense relationship with Russia. 

“The most destructive thing you can do with intelligence is to weaponize it for one party’s political gain against another, to blame an admitted adversary for something they didn’t do. It was like pouring gasoline on the fire …

“For all of the bad things Vladimir Putin has done and is capable of doing, they didn’t need to exaggerate it or run a fake story [in 2017] and again in 2020 with the laptop, claiming that Russia influenced the outcome.”

The bogus ICA is what launched the false narrative of “Trump as a Russian agent.” 

At the very least, Radcliffe said, Brennan, Clapper and Comey should be pariahs.

“These guys shouldn’t have a voice. They shouldn’t be able to influence the American people …

“Under my watch, I am committed to ensuring that our analysts have the ability to deliver unvarnished assessments that are free from political influence.”

https://nypost.com/2025/07/02/us-news/obamas-trump-russia-collusion-report-was-corrupt-from-start-cia-review/

Iran Reportedly Made Plans To Litter Strait Of Hormuz With Naval Mines

 The U.S. launched "Operation Midnight Hammer" on June 22, deploying stealth bombers to strike Iran's nuclear facilities at Fordow, Natanz, and Isfahan using Massive Ordnance Penetrator bombs. President Trump declared the sites were "totally obliterated." In retaliation, Iran's parliament voted to authorize the closure of the Strait of Hormuz—a critical maritime chokepoint through which 20% of the world's oil flows—sparking renewed anxiety among global energy traders over the threat to vital tanker lanes.

As readers understand, any move by Iran to close the critical waterway would instantly disrupt nearly one-fifth of the world's oil shipments and trigger substantial—and potentially cascading—economic harm (energy inflation) worldwide. However, those threats ultimately fell short in the days that followed, and Brent crude futures have since returned to the $67-a-barrel level, effectively roundtripping the entire move.

Iran has several military and asymmetric tools at its disposal to disrupt or close the Strait of Hormuz, including:

  • Naval Mines

  • Fast Attack Boats & Swarm Tactics

  • Anti-Ship Missiles

  • Submarine Operations

  • Seizing or Boarding Tankers

  • Shore-Based Artillery or Rocket Attacks or Drone Strikes 

  • GPS Scrambling 

  • Cyberattacks on Port Infrastructure

  • Coordinated Proxy Attacks

In the lead-up to and during Operation Midnight Hammer, widespread GPS interference was reported across the Strait of Hormuz. Multiple sources we highlighted indicated a noticeable slowdown in tanker traffic, as navigation systems were degraded and insurance premiums for vessels surged.

A new Reuters report, citing anonymous U.S. officials, reveals that intelligence indicated Tehran was preparing to blockade the Strait of Hormuz using one of its most effective and low-cost tactics: littering the narrow shipping corridor with naval mines.

More color on the report:

The previously unreported preparations, which were detected by U.S. intelligence, occurred some time after Israel launched its initial missile attack against Iran on June 13, said the officials, who requested anonymity to discuss sensitive intelligence matters.

The loading of the mines - which have not been deployed in the strait - suggests that Tehran may have been serious about closing one of the world's busiest shipping lanes, a move that would have escalated an already-spiraling conflict and severely hobbled global commerce.

. . . 

Reuters was not able to determine precisely when during the Israel-Iran air war Tehran loaded the mines, which - if deployed - would have effectively stopped ships from moving through the key thoroughfare.

It is also unclear if the mines have since been unloaded.

The sources did not disclose how the United States determined that the mines had been put on the Iranian vessels, but such intelligence is typically gathered through satellite imagery, clandestine human sources or a combination of both methods.

. . .

The two officials said the U.S. government has not ruled out the possibility that loading the mines was a ruse. The Iranians could have prepared the mines to convince Washington that Tehran was serious about closing the strait, but without intending to do so, the officials said.

Israel's 12-day war with Iran and Tehran's ultimately hollow threat (so far) to close the Strait of Hormuz appear to have had limited lasting impact on global oil markets, reflected in Brent crude trading around $68 on Wednesday afternoon.

https://www.zerohedge.com/geopolitical/iran-reportedly-made-plans-litter-strait-hormuz-naval-mines

US Officials Slam Iran's Suspending Cooperation With UN Nuclear Watchdog

 Update (1430ET): That didn't take long.

US State Department officials have reportedly said that Iran's suspension of cooperation with IAEA is "unacceptable", adding that Iran must cooperate fully without further delay.

UN spokesman Stephane Dujarric also chimed in, saying that Iran’s suspension of its cooperation with the International Atomic Energy Agency (IAEA) is “obviously concerning"

“We’ve seen the official decision, which is obviously concerning. I think the Secretary-General has been very consistent in his call for Iran to cooperate with the IAEA, and, frankly, for all countries to work closely with the IAEA on nuclear issues,” he told reporters.

*  *  *

In an official move which could bring Tehran into further conflict with the United States, Israel, and the West, Iran’s President Masoud Pezeshkian has signed a law which breaks all cooperation with the the International Atomic Energy Agency (IAEA), following Israeli and US large-scale strikes on Iranian nuclear facilities last month.

"Masoud Pezeshkian promulgated the law suspending cooperation with the International Atomic Energy Agency," Iranian state TV confirmed Wednesday.

Via Reuters

The announcement comes on the heels of Iranian parliament's initial decision last week to halt cooperation with the nuclear watchdog and monitoring body, a move triggered by Israel's surprise attack on the Islamic Republic which began on June 13.

Nearly two weeks of war followed, capped by the Trump-ordered B-2 bomber raids and huge attacks on the three key nuclear facilities of Fordo, Natanz and Isfahan.

Under the new parliamentary resolution, IAEA inspectors will need approval from Iran’s Supreme National Security Council before any access to nuclear facilities is given.

The IAEA merely said in response that it was "aware of these reports" of Tehran suspending cooperation and is waiting for formal communication from Iranian leaders.

Earlier this week, Iran’s foreign minister declared that IAEA Director General Rafael Grossi, whom Iranian officials have fiercely criticized for not condemning the Israeli and US attacks, as Persona non grata.

There was also this recent alarming diplomatic fiasco centered on Grossi and threats by an Iranian newspaper:

Iran’s ambassador to the United Nations said Sunday that Tehran poses no threat to the head of the UN nuclear watchdog nor its inspectors, after an Iranian newspaper claimed that Atomic Energy Agency chief Rafael Grossi was an Israeli spy and called for him to be executed.

Iran’s ultra-conservative Kayhan newspaper recently alleged that unspecified documents showed Grossi to be an Israeli spy.

“It should therefore be officially announced that he will be tried and executed upon arrival in Iran for spying for the Mossad and participating in the murder of the oppressed people of our country,” the newspaper said.

“No, there is not any threat” against the inspectors or the director general, Iran’s Ambassador to the UN Amir Saeid Iravani said in an interview with US broadcaster CBS. The ambassador said inspectors in Iran were “in safe conditions.”

Just the day prior to Israel's surprise assault on Iran using dozens of warplanes, Tehran officials were outraged with a rejected a June 12 resolution from the IAEA board that accused Iran of failing to meet its nuclear obligations.

Iranian authorities then alleged this resolution served as one of the "pretexts" used to justify the Israeli and later US attacks on its nuclear facilities, which Tehran has maintained is solely for nuclear energy purposes.

https://www.zerohedge.com/geopolitical/iran-president-signs-law-suspending-cooperation-un-nuclear-watchdog

'Long COVID Rates Higher in Women: Evidence Grows'

 When Brazilian scientist Letícia Soares contracted COVID-19 in April 2020, she was in the final stretch of her postdoctoral studies in disease ecology at a Canadian university. By August, she was bedbound.

What began as piercing migraines quickly escalated into a cascade of long COVID symptoms — gastrointestinal distress, sleeplessness, joint and muscle pain, and crushing fatigue. For Soares and many other women with long COVID, it also included sudden menstrual changes that exacerbated her other symptoms.

“It just baffled me,” said Soares, now 40. “It was debilitating.”

Before COVID, she had a stable, predictable cycle while using a hormonal IUD — light cramping, mild abdominal swelling, and consistent, manageable bleeding. Then, after her infection, her period disappeared entirely. A couple of years later, the pattern reversed: prolonged, heavy bleeding returned, compounding her long COVID symptoms and triggering severe crashes from post-exertional malaise — one of the hallmarks of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a condition linked to post-viral illness.

Cases like Soares’s are leading scientists to spend more time trying to understand the biologic sex disparity in chronic illnesses such as long COVID that initially had all but been ignored. New research from the National Institutes of Health RECOVER initiative, the largest observational study to date, confirms what many have long suspected: Women face a significantly higher risk of developing long COVID than men. While men are more likely to experience severe acute illness and higher mortality, growing evidence suggests women are more vulnerable to chronic symptoms.

Published in JAMA Network Open, the study analyzed data from over 12,200 participants who had been infected by COVID between 2021 and 2024. Even after adjusting for clinical and demographic factors, women had a 31%-44% higher likelihood of developing long COVID than men. The risk was especially pronounced among nonpregnant, nonmenopausal participants.

This study is the first to examine risk across different groups assigned women at birth, revealing that age, pregnancy, and menopause all play a role in long COVID likelihood, said lead author Dimpy Shah, MD, PhD, assistant professor of population health sciences at The University of Texas Health Science Center at San Antonio. “That is a very novel finding.”

Five years into the pandemic, with hundreds of millions of people worldwide affected by lingering symptoms, this emerging research on biologic sex disparities highlights the complexity of long COVID and how it intersects with hormonal cycles and life stages.

The study found that when adjusting for variables like age, race, and underlying health conditions, women had a 31% higher risk for long COVID. When only age and race were accounted for, the risk jumped to 44%, suggesting that other factors, including autoimmune conditions and post-viral illnesses, may influence the link between sex and long COVID.

The RECOVER study revealed notable patterns: Pregnant women aged 18-39 years had a lower long COVID risk than their nonpregnant counterparts compared with men in the same age group. Similarly, menopausal women aged 40-54 years had a lower risk than nonmenopausal women in that age group.

“This could be due to hormonal changes and variations in inflammatory responses, which shift with age,” Shah explained.

By identifying how biologic sex, pregnancy, and menopause affect long COVID risk, this study moves the field closer to understanding why some individuals experience prolonged illness — and how treatment strategies might be tailored accordingly.

While the latest RECOVER study wasn’t designed to analyze hormone levels, senior author Nora G. Singer, MD, director of Rheumatology at MetroHealth Medical Center in Cleveland, emphasized the need for future research in this area. “If we understood better the biologic mechanisms contributing to sex specificity, I think the question is, could we better stratify who we’re worried about developing long COVID? Could we target drugs? Are there ways we could manipulate things to make people less likely to get long COVID, and are there different levels of immune response at these different ages?”

Expanding this research is critical as long COVID and similar chronic conditions remain largely overlooked in medical funding and study. “These illnesses are underfunded and understudied relative to their disease burdens,” said Beth Pollack, a research scientist at the Massachusetts Institute of Technology, Cambridge, Massachusetts, who studies complex chronic illnesses.

Addressing knowledge gaps, especially around sex differences, could significantly improve our understanding of complex chronic illnesses, said Pollack, who co-authored a 2023 literature review of female reproductive health impacts of long COVID.

For example, several previous studies and surveys of female patients with long COVID report an increase in symptoms related to menstruation, which further suggests a possible link between sex hormone fluctuations and immune dysfunction in the illness.

Sex Hormones and Immunity

The pathologies of long COVID currently focus on four hypotheses: persistent viral infection, reactivation of dormant viruses (such as common herpes viruses), inflammation-related damage to tissues and organs, and autoimmunity (the body attacking itself).

It’s this last reason that holds some of the most interesting clues on biologic sex differences, said Akiko Iwasaki, PhD, a Yale University, New Haven, Connecticut, immunologist who has led numerous research breakthroughs on long COVID since the start of the pandemic. Women have two X chromosomes, for example, and although one is inactivated, the inactivation is incomplete.

Some cells still express genes from the “inactivated genes” on the X chromosome, Iwasaki said. Those include key immune genes, which trigger a more robust response to infections and vaccinations but also predispose them to autoimmune reactions. “It comes at the cost of triggering too much immune response,” Iwasaki said.

Sex hormones also factor in. Testosterone, which is higher in men, is immunosuppressive, so it can dampen immune responses, Iwasaki said. That may contribute to making men more likely to get severe acute infections of COVID but have fewer long-term effects.

Estrogen, on the other hand, is known to enhance the immune response. It can increase the production of antibodies and the activation of T cells, which are critical for fighting off infections. This heightened immune response, however, might also contribute to the persistent inflammation observed in long COVID, where the immune system continues to react even after the acute infection has resolved.

Of the more than 200 symptoms people with long COVID experience, Iwasaki said, several are also sex-specific. A draft study by Iwasaki and another leading COVID researcher, David Putrino, PhD, at Mount Sinai Health System in New York City, shows hair loss as one of the most women-dominant symptoms and sexual dysfunction among men.

In examining sex differences, another question is why long COVID rates in the trans community are disproportionately high. One of the reasons Iwasaki’s lab is looking at testosterone closely is because anecdotal evidence from female-to-male trans individuals indicates that testosterone therapy improved their long COVID symptoms significantly. It also raises the possibility that hormone therapy could help.

However, patients and advocates say it’s also important to consider socioeconomic factors in the trans community. “We need to start at this population and social structure level to understand why trans people over and over are put in harm’s way,” said J.D. Davids, a trans patient-researcher with long COVID and the co-founder and co-director of Strategies for High Impact and its Long COVID Justice project.

Where It All Leads

The possibility of diagnosing long COVID with a simple blood test could radically change some doctors’ false perceptions that it is not a real condition, Iwasaki said, ensuring it is recognized and treated with the seriousness it deserves.

“I feel like we need to get there with long COVID. If we can order a blood test and say somebody has a long COVID because of these values, then suddenly the diseases become medically explainable,” Iwasaki added. This advancement is critical for propelling research forward, she said, refining treatment approaches — including those that target sex-specific hormone, immunity, and inflammation issues — and improving the well-being of those living with long COVID.

This hope resonates with scientists like Pollack, who led the first National Institutes of Health-sponsored research webinar on less studied pathologies in ME/CFS and long COVID, and with the experiences of individuals like Soares, who navigates through the unpredictable nature of both of these conditions with resilience.

“This illness never ceases to surprise me in how it changes my body. I feel like it’s a constant adaptation,” said Soares. Now living in Salvador, Brazil, her daily life had dramatically shifted to the confines of her home. While her condition limits many aspects of her life, working remotely allows her to stay involved in disability advocacy as a co-lead and researcher at the international Patient-Led Research Collaborative.

Understanding sex differences in long COVID could also transform care for millions. From a public health perspective, new research could improve diagnosis in clinics, inform targeted therapies for high-risk groups, and encourage women to take their symptoms seriously.

“Because they are at potentially higher risk for long COVID, if they’re not feeling well, they should definitely talk to their primary care or internal medicine physicians,” said Shah, reflecting on the latest RECOVER study’s findings. “It’s a call to action.”

https://www.medscape.com/viewarticle/long-covid-rates-higher-women-evidence-grows-2025a1000hkl

'Cough Medicine Shows a Hint of Promise in Parkinson's Dementia'

 

  • Ambroxol showed target engagement in Parkinson's dementia but no significant cognitive improvement over placebo.
  • The drug, a common cough medicine in Europe, was safe and well-tolerated.
  • Ambroxol chaperones GCase and led to increased GCase levels.

Ambroxol, a common cough medicine used in Europe, demonstrated target engagement in people with Parkinson's disease dementia but did not show an effect on cognition compared with placebo, a year-long phase II trial showed.

Looking at the primary efficacy outcomes, there was no evidence to suggest differences in Alzheimer Disease Assessment Scale-cognitive subscale, version 13 (ADAS-Cog-13) and Clinician's Global Impression of Change scores between the groups at week 26 or week 52, reported Stephen Pasternak, MD, PhD, of the Cognitive Neurology and Alzheimer's Disease Research Centre at the Parkwood Institute in London, Ontario, and colleagues.

Ambroxol was safe and well-tolerated, the researchers noted in JAMA Neurologyopens in a new tab or window. Parkinson's patients who carried the beta-glucocerebrosidase (GCase) gene GBA1 appeared to have better scores on the ADAS-Cog-13 and the Neuropsychiatric Inventory (NPI).

Post-hoc analyses suggested that plasma glial fibrillary acidic protein (GFAP), a marker of astrogliosis, increased in the placebo group but remained stable in the ambroxol group at week 52.

"Primary outcome measures did not support therapeutic effects of ambroxol on cognition in Parkinson's disease dementia, although there may have been stabilization of neuropsychiatric symptoms," Pasternak and colleagues wrote.

Mutations in GBA cause Gaucher's disease and are an important risk factor for Parkinson'sopens in a new tab or window disease. These mutations lower GCase production, causing alpha-synuclein levels to rise.

Ambroxol chaperones GCase; in a previous studyopens in a new tab or window of people with Parkinson's disease, the drug led to increased GCase levels. It is approved for treating respiratory conditions in Europe, but not for any indication in the U.S. or Canada.

Three ongoing clinical trials are testing the effects of ambroxol in neurodegenerative diseases: the ASPro-PD trialopens in a new tab or window in Parkinson's disease, the ANeEDopens in a new tab or window study in dementia with Lewy bodies, and the AMBITIOUSopens in a new tab or window study in GBA-associated Parkinson's.

In their referral-based, single-center trialopens in a new tab or window, Pasternak and co-authors studied people who had Parkinson's disease for at least 1 year before cognitive impairment. All participants had mild to moderate dementia, were taking stable medications, and had a study partner.

Participants were randomized to low-dose ambroxol (525 mg/day), high-dose ambroxol (1,050 mg/day), or placebo. A total of 30 Parkinson's patients received ambroxol: eight patients (mean age 79) in the low-dose group, and 22 patients (mean age 71) in the high-dose group. The placebo group included 24 people with a mean age of 73.

More than 80% of study participants were male. Eight participants carried variants in GBA1.

Over 52 weeks, the ambroxol groups had more gastrointestinal adverse events than the placebo group (12% vs 5%).

Only people taking high-dose ambroxol were compared with placebo in efficacy measures. Mean high-dose ambroxol concentrations were 7.48 μM in plasma and 0.73 μM in cerebrospinal fluid at the end of titration. At week 26, mean GCase levels were higher in the high-dose ambroxol group compared with the placebo group (12.45 vs 8.50 nmol/h/mg, P=0.05).

Three of five GBA1 carriers treated with ambroxol showed a change greater than the minimal clinically important difference of 3 points in ADAS-Cog scores from baseline to the end of study (-11 points, -6 points, and -11 points). "Although this sample is too small to support any conclusion, these findings are highlighted given the proposed action mechanism of ambroxol in GCase activity that is particularly lower in carriers of the GBA1 gene variant," Pasternak and colleagues noted.

Among GBA1 carriers treated with ambroxol, three of four showed a clinically meaningful improvement on the NPI and one remained stable.

Cognitive symptoms did not worsen over time in the placebo group and a 52-week trial may not have been long enough to assess ambroxol, Pasternak and co-authors said. Future trials also should focus on recruiting more GBA1 carriers and assess GFAP as a potential biomarker, they suggested.

Disclosures

This trial was funded by a grant from the Weston Brain Institute.

Pasternak reported receiving grants from the Weston Brain Institute, the Canadian Institute for Health Research, and Zywie Bio; having a patent for Zywie Bio pending; and being a shareholder in Zywie Bio.

Co-authors reported relationships with pharmaceutical companies and other organizations.

Primary Source

JAMA Neurology

Source Reference: opens in a new tab or windowSilveira CRA, et al "Ambroxol as a treatment for Parkinson disease dementia: a randomized clinical trial" JAMA Neurol 2025; DOI: 10.1001/jamaneurol.2025.1687.


https://www.medpagetoday.com/neurology/parkinsonsdisease/116352

'California Migrants Weigh Health Coverage Against Deportation Risk'

 For months, Maria, 55, a caregiver to older adults in California's Orange County, has been trying not to smile.

If she opens her mouth too wide, she worries, people will see her chipped, plaque-covered front teeth. An immigrant without legal status, Maria doesn't have health or dental insurance. When her teeth start to throb, she swallows pain pills. Last summer, a dentist said it would cost $2,400 to fix her teeth. That's more than she can afford.

"It's so expensive," said Maria, who often works 12-hour days lifting clients in and out of bed and helping them with hygiene, medication management, and housework. "I need money for my kids, for my rent, for transport, for food. Sometimes, there's nothing left for me."

KFF Health News connected with Maria through an advocacy organization for immigrant workers. Fearing deportation, she asked that only her first name be used.

Maria is among what the federal government estimates are 2.6 million immigrantsopens in a new tab or window living in California without legal status. The state had gradually sought to bring these immigrants into its Medicaid program, known as Medi-Cal. But now, facing a state enrollment freeze, low-income California residents in the U.S. without legal permission -- along with the providers and community workers that help them -- are anxiously weighing the benefits of pushing forward with Medi-Cal applications against the risks of discovery and deportation by the federal government.

Seeking to close a projected $12 billion budget deficit, California Gov. Gavin Newsom, a Democrat, signed a balanced state budget on June 27 that will end new Medi-Cal enrollment in January 2026 for those over 19 without legal status.

Meanwhile, federal immigration raids -- which appear to have targeted at least one health clinicopens in a new tab or window in the state -- are already making some people afraid to seek medical care, say immigrant advocates and health providers. And the recent news that Trump administration officials are sharing Medicaid enrollee dataopens in a new tab or window, including immigration status, with deportation authorities is expected to further erode trust in the program.

HHS spokesperson Andrew Nixon said the agency, which oversees CMS, had the legal authority to share the data to address "unprecedented systemic neglect under the Biden-Harris administration that allowed illegal immigrants to exploit Medicaid while millions of Americans struggle to access care, particularly in states like California."

Further complicating matters, the Trump administration has threatened to withhold fundsopens in a new tab or window from states that provide health coverage to people without legal status. Currently, about 1.6 million people in the country without authorization are enrolled in Medi-Cal.

In 2016, California began opening Medi-Cal to low-income people lacking legal status, starting with children, then gradually expanded it to young people, older adults, and -- in January 2024 -- those ages 26 to 49. The state Department of Health Care Services, which oversees Medi-Cal, partnered with community health clinicsopens in a new tab or window to help get eligible people enrolled.

It's too early to tell what impact the latest state and federal developments are having on enrollment numbers, since data is available only through March. But many healthcare providers and advocates said they expect a chilling effect on immigrant enrollment.

Seciah Aquino, DrPH, is executive director of the Latino Coalition for a Healthy California, which supports community health workers -- also called promotores -- who help spread awareness about Medi-Cal's expansion to adults lacking legal status. Just over half of public health insurance recipients in Californiaopens in a new tab or window are Latino, compared with just 30% of Medicaid enrollees nationwideopens in a new tab or window.

Aquino said her coalition will tell promotores to disclose data-sharing risks so community members can make informed decisions.

"They take it very personally that advice that they provided to a fellow community member could now hurt them," Aquino said.

Newsom condemned the data sharing, calling the move "legally dubious," while U.S. Sens. Adam Schiff and Alex Padilla, both Democrats, have demandedopens in a new tab or window that the Department of Homeland Security destroy any data shared.

California's Department of Health Care Services announced June 13 that it is seeking more information from the federal government. The agency saidopens in a new tab or window it submitted monthly reports to CMS with demographic and eligibility information, including name and address, as required by law.

Medicaid enrollee data from Illinois, Washington state, and Washington, D.C., were also reportedly shared with DHS. Jamie Munks, a spokesperson for the Illinois Department of Healthcare and Family Services, the state's Medicaid agency, said the department was "deeply concerned" by the news and that the data was regularly passed along to CMS with the understanding that it was protected.

In Sacramento, Democratic lawmakers found themselves in the uncomfortable position of rolling back health benefits for low-income residents with unsatisfactory immigration status, including people without legal status, people who've held green cards for under 5 years, and some others who are in the process of applying for legal status or have statuses meant to protect them from deportation. In addition to the Medi-Cal enrollment freeze for immigrants 19 and older in the country without authorization, all enrolled residents with unsatisfactory immigration status from 19 to 59 years old will be charged $30 monthly premiums starting in July 2027.

"What I'm hearing on the ground is folks are telling me they're going to have a really hard time making these premium payments," said Carlos Alarcon, health and public benefits policy analyst with the California Immigrant Policy Center, an advocacy group. "The reality is most people already have limited budgets."

The legislature rejected a proposal from the governor to bar immigrants with unsatisfactory immigration status from receiving long-term nursing home and in-home care through Medi-Cal but went along with eliminating dental benefits starting in July 2026.

Healthcare providers said that without Medi-Cal coverage, many immigrants will be forced to seek emergency care, which is more expensive for taxpayers than preventive and primary-level care. Sepideh Taghvaei, DDS, chief dental officer at Santa Cruz County's Dientes Community Dental Care, saw this play out in 2009 when the state cut adult Medi-Cal dentalopens in a new tab or window benefits. Patients came in with swollen faces and excruciating pain, with conditions so advanced that they required hospital treatment. "It's not cost-effective," she said.

State Sen. Roger Niello, a Republican who serves as vice chair of the Senate budget committee, said he believes California shouldn't be funding Medi-Cal for people who lack legal status, particularly given the state's fiscal challenges. He also said he worries that coverage of people in the country without authorization could encourage others to move to California.

"If we maintain that expense to the noncitizen," he said, "we're going to have to cut someplace else, and that's undoubtedly going to affect citizens."

Californians, too, are going through a change of heart. In a May poll conducted by the Public Policy Institute of California, 58% of adultsopens in a new tab or window opposed the benefit.

For Maria, shifting healthcare policies have left her feeling paralyzed. Since she arrived here 5 years ago, the caregiver's focus has been on earning money to support her three children, whom she left with her parents in her home country, she said.

Maria didn't learn she might be eligible for Medi-Cal until earlier this year and hadn't yet found time to complete the paperwork. After a friend told her that the state could freeze enrollment in January, she began rushing to finish the sign-up process. But then she learned that Medi-Cal data had been shared with immigration authorities.

"Disappointed and scared" was how she described her reaction.

Suddenly, she said, enrolling in Medi-Cal doesn't seem like a good idea.

https://www.medpagetoday.com/publichealthpolicy/medicaid/116355

Humana begins offering Medicaid coverage in Virginia

 Humana Inc. (NYSE: HUM) announced that its Medicaid plan, Humana Healthy Horizons, is now available as a coverage option for Virginia Cardinal Care beneficiaries. The company was selected as one of five plan administrators in a statewide Medicaid managed care procurement conducted last year.

All individuals currently enrolled in Virginia Cardinal Care are eligible to select Humana’s plan for their healthcare coverage. The expansion builds upon Humana’s existing presence in Virginia, where it already serves Medicare Advantage and TRICARE members. 

"We have the privilege of serving Medicare Advantage and TRICARE members throughout Virginia, and we are honored to expand our human-centered care to Virginians covered by Cardinal Care," said Humana Healthy Horizons President John Barger in the press release.

As part of its commitment to Virginia, Humana announced it will invest an additional $2 million to the Virginia Health Care Foundation over the next five years. This follows an initial $500,000 investment aimed at expanding the Commonwealth’s behavioral health workforce.

Linda Hines, President of Humana Healthy Horizons in Virginia, stated the company will deliver comprehensive healthcare services addressing physical and mental health needs, as well as health-related social needs.

https://www.investing.com/news/company-news/humana-begins-offering-medicaid-coverage-in-virginia-93CH-4121513