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Tuesday, September 2, 2025

Arrowhead Nabs up to $2B Novartis Commitment for siRNA Parkinson’s Program

 

Novartis is licensing ARO-SNCA, a preclinical siRNA therapy for synucleinopathies, a group of neurodegenerative disorders including Parkinson’s disease.

Arrowhead Pharmaceuticals has notched another major partnership with billion-dollar potential. Novartis has signed on to develop the RNA interference specialist’s preclinical Parkinson’s disease program for $200 million upfront.

On the back end, Arrowhead could be eligible for up to $2 billion in milestones, plus royalties on future sales, according to a Tuesday morning press release.

The deal adds to the list of heavyweight partners Arrowhead has collected, which already included Amgen, GSK and Takeda. Its biggest partnership, though, is with Sarepta Therapeutics; the November 2024 deal is worth upwards of $11 billion if all the programs are a success.

Novartis is licensing ARO-SNCA, a preclinical siRNA therapy for synucleinopathies, or neurodegenerative disorders such as Parkinson’s, that are caused by the buildup of the protein alpha-synuclein in the brain. The deal also includes other targets using Arrowhead’s Targeted RNAi Molecule, or TRiM, platform that have yet to be named, according to the release.

Arrowhead will continue with preclinical work for the programs up to a clinical trial application, when Novartis will take over.

Besides the partnered programs, Arrowhead has a wholly owned pipeline that includes lead asset plozasiran. The drug is currently awaiting a November decision from the FDA to treat familial chylomicronemia syndrome (FCS), a rare genetic metabolic disorder that prevents the body from breaking down fats.

The company is also working on two obesity assets, including ARO-ALK7, which is meant to silence the ACVR1C  gene, in turn reducing the risk of obesity-related metabolic complications. 

CEO Chris Anzalone told BioSpace last month that he aspires to build Arrowhead into a company like Vertex or Regeneron by building long-term value as an independent entity.

Novartis’ neurodegenerative pipeline is stacked with assets in multiple sclerosis, myasthenia gravis and Huntington’s disease. The program is anchored by approved therapies Mayzent and Fabhalta.

This is not Novartis’ first foray into siRNA therapies, however. The Swiss pharma has Leqvio, which is approved for lowering lipoprotein cholesterol. The drug was licensed from Alnylam, Arrowhead’s more-senior peer in the RNAi world, in January 2020.

https://www.biospace.com/business/arrowhead-nabs-up-to-2b-novartis-commitment-for-sirna-parkinsons-program

Violence Is Back As A Tool Of National Policy

 By Benjamin Picton, senior market strategist at Rabobank

Flying Blind

News broke yesterday that a jet carrying European Commission president Ursula von der Leyen had to land using paper charts after its GPS navigation systems were apparently jammed by Russia. Traveling to Plovdiv in Bulgaria, VDL’s jet apparently circled for an hour before the pilot took the decision to do things the old-fashioned way and consult the map.

Such an incident targeting a head of not-quite-a-state is shocking to say the least, but serves as a neat metaphor for relations between Russia and Europe in recent years (decades?): European liberal internationalists assume old norms apply -> Russia disagrees and demonstrates that it views violence as a legitimate tool of national policy -> Europeans left stunned.

Some will remember the images of German diplomats guffawing at the United Nations in 2018 as Donald Trump admonished Germany for placing itself at the mercy of Russia for its energy supplies. Fast-forward to 2022 and suddenly Trump’s speech wasn’t so funny, and anyone who cares to bring up a chart of German industrial production can see the fruits of the lack of imagination of Germany’s leaders. Germany’s factories are now struggling to replace lost production for civilian applications with new production for military applications. But how to do this without cheap energy?

So, yes, violence is back as a tool of national policy. Russia is unapologetic about this. So is Israel. So is the United States if you consider the decisiveness of using B-21 bombers to drop bunker busters on Iranian nuclear facilities. Hamas and the Houthis are certainly unapologetic and China has also been stepping up the frequency and scale of ‘rehearsals’ for the invasion of Taiwan while the Chinese navy and coast guard have had semi-regular clashes with the Philippines over territories that China claims as its own through the ten-dash line. Those Chinese territorial claims are not supported by the United Nations Convention on the Law of the Sea, but that is really part of the point.

Despite being permanent members of the UN Security Council, China and Russia have never really fully subscribed to the legitimacy of the post-war global architecture. Many Western leaders continue genuflect to the ‘rules-based international order’ as if it was chiselled in stone and handed down from Mount Sinai. In reality, that rules-based order has always been a US-led order, upheld by US force of arms, and has always been viewed by China and Russia as such. Russia has demonstrated that the it is quite willing to flout the ‘rules’ when its national interest demands it. This does not mean that war is inevitable, but it does mean that it is a policy option that other countries need to dissuade revisionist powers from using. As Bismarck reputedly said “do I want war? Of course not! I want victory.”

Both the United States and China are now interested in re-writing the rules of the road to suit their own interests. The US now sees the liberal economic order as a threat to its position as global hegemon while China seeks to push the US out and establish itself as an Asian hegemon. In the view of the United States, a persistently overvalued dollar and unequal trade terms has offshored production from the US into China (and elsewhere) while the US got hooked on the drug of artificially high living standards courtesy of the strong dollar and the subsidized production of consumer goods in China.

As Scott Bessent explained to Fox News last week, the United States got a major wakeup call during Covid when it became apparent that many of the things that the United States needed (pharmaceuticals, personal protective equipment etc) were not made in the USA and could not be easily imported while global shipping was snarled up and the countries who DID produce the goods and own the ships were focusing on supplying themselves. Consequently, the US now cares about controlling supply chains for strategic goods, is using state-intervention to guide production and is increasingly autarchic. This is seen as a national security priority in the context of geopolitical competition with China. Everything must be understood through this prism.

A logical corollary of the MAGA program seeking to re-orient the US economy from being characterised by consumption to being characterised more by production (as it was at the end of WWII) is that there will have to be less consuming going on. The question then becomes which segments of society are going to see their consumption power curtailed? Trump and Bessent say the people at the top have had it too good for too long and will have to pay, while the losers from 40 years of globalization (those at the bottom of the income distribution) will see their living standards safeguarded.

China, as the main power of the emerging BRICS bloc, is seeking partners in a new multilateralism aimed at replacing the US-led order with something that better suits the interests and ambitions of China and its partners. The events of the Shanghai Cooperation Organisation summit over the weekend demonstrate that Russia, Iran and Belarus are on board. India and Brazil (not an SCO member) seemingly are too, but there are problems.

Firstly, many of these countries have had territorial skirmishes in the recent past (e.g. the Sino-Soviet war in the 1960s and China-India border skirmishes more recently). Secondly, it is not immediately apparent how these powers could be incorporated into a new economic and financial architecture. The trade flows need to net and somebody needs to play the role of deficit runner if they are going to provide a replacement for the US Dollar as reserve currency. Nobody wants to do this because everybody wants to produce and export.

Additionally, the Chinese conception of world order historically posits the Chinese emperor as the intermediary between earth and heaven. That is to say, China has the ‘mandate of heaven’ that legitimises Chinese hegemony, and delegitimises the claims of anyone else to be on equal footing with China. How does India’s ambition for a multipolar Asia fit into this conception of world order? How does Iran’s conception of itself as a central Asian hegemon fit this view? How does Russia’s view of itself as a top-tier Eurasian power fit? The answer is: they don’t.

The UK Telegraph today claims ‘China unveils plan for new world order’. However, while team BRICS appears united in grievance against the US order, it is not yet clear that they are offering a coherent alternative. Xi Jinping made his pitch to the global south by encouraging them to embrace “free trade” and announcing that the Shanghai Cooperation Organisation would establish a new development bank to build influence in Eurasia by providing infrastructure loans for green industry. Establishing development banks extending loans in (presumably) Renminbi has the added benefit of de-risking the emerging bloc of the extraterritorial power of the US Dollar. Xi also said he would open up China’s BeiDou satellite system to SCO members as an alternative to the US GPS system (perhaps Ursula von der Leyen will be tempted?).

While the BRICS bloc coalesces towards a new conception of world order and seeks an economic and financial architecture to support it, Western powers seem unsure about the direction of their own political economy. Europe wants to be green but it also wants to re-arm, and the two are not compatible. Far right parties now hold polling leads in Germany, France and the UK as popular discontent at ‘the way things are going’ continues to rise.

European style anti-immigration protests recently broke out in Australia where a Canada style net inward migration rate of ~1.7% at a time where the country can’t house its own young is testing the social fabric. Recent comments by an Indian Minister suggesting that he was “in deep negotiations with my counterpart in Australia to create 1 million homes” using Indian labour trained in Australia and funding from the UAE is sure to add fuel to the fire. The supposed plan has not been corroborated by Canberra, but could be the most sensational economic chicanery since the Khemlani loans affair if it turned out to be true.

Whether fact or fiction, the plan does highlight an important point: for economies like Australia that have labor markets at ‘full-employment’, there is simply no surplus labour to do important stuff that needs doing. Labor is a factor of production subject to scarcity, and when scarcity strikes governments take on responsibility for directing the factors of production into their most useful employment. The United States is now doing this through ‘state capitalism’ and cherry-picking high value-add industries for its own economy.

This dynamic poses a question. Is Australia best served by having 55% of school leavers attend university to add to the oversupply of law graduates carrying unserviceable student loan debts? Or would it make more sense to direct the youth into trades training to address the undersupply of builders, tilers, plasterers, welders, farm workers etc etc? These are the trade-offs of economic policymaking under real constraints, but the Australian trade minister recently implied that a more active approach to organising production would not be taken when he said that Australia could be an example to the world by abolishing 500 “nuisance” tariffs.

So, the US is taking a more active role in directing economic activity, the BRICS are seeking to reshape the world order in their own image and Europe is searching for a new model of political economy that simultaneously delivers growth, security and social cohesion. Australia, meanwhile, wants to be an example to the rest of the world by evangelising an economic model that others are rejecting as failed. In this fractious new global environment leaving decisions of what gets produced, where, and by who completely in the hands of Mr Market really would be flying blind.

https://www.zerohedge.com/markets/violence-back-tool-national-policy

Paul Singer's Elliott Management Goes Activist On Pepsi

 Activist hedge fund Elliott Management has amassed a $4 billion stake in PepsiCo, as shares of the beverage and snack giant have declined by more than 24% from their peak in the summer of 2023. This comes as PepsiCo's soda and food business units have been hemorrhaging market share to competitors.

Elliott is one of the world's most aggressive activist hedge funds. Founded by the billionaire Paul Singer, it has a long track record of successfully restructuring companies.

Now, with PepsiCo in its crosshairs, according to a Wall Street Journal report citing people familiar with the situation, Singer and his team have built one of their largest-ever equity stakes, making the hedge fund one of the top five active investors, excluding index funds, in the company. 

Singer's move comes after PepsiCo's market cap has fallen to about $200 billion, down more than 24% from its 2023 peak of $270 billion.

PepsiCo share drawdown... 

The declining share price has been attributed to sliding soda sales, which have put it behind Coke, Dr Pepper, and Sprite. Besides soda, food sales have been slowing across its North America food unit since late 2022. 

Some Wall Street analysts have pitched to clients that PepsiCo should rethink its structure...

"We admit that refranchising the bottling business would take time and not be an easy undertaking," RBC Capital Markets analyst Nik Modi told clients in a note late last year. "However, we consider it a critical step for the long-term health of the beverage business."

Elliott has not revealed its plan of action regarding PepsiCo, but it has a long history of initiating turnarounds and restructurings for companies, as it did with Honeywell and Starbucks.

https://www.zerohedge.com/markets/paul-singers-elliott-management-goes-activist-pepsi

US Manufacturing Surveys Surged In August As New Orders Jumped

 After tumbling in July, expectations for August's US Manufacturing surveys were optimistic (with both ISM and S&P Global both expected to tick higher, though the former expected to remain in contraction).

  • S&P Global's US Manufacturing PMI rose dramatically from 49.8 in July to 53.0 in August (down very marginally from its preliminary print of 53.3) - the strongest in over three years

  • ISM's US Manufacturing PMI rose from 48.0 in July to 48.7 in August (below the 49.0 expected)

And both of these increases in 'soft' survey data come as hard data has disappointed...

Source: Bloomberg

Under the hood of the ISM data, we see prices falling significantly, nmew orders jumping, but employment remaining significantly weaker (as we suggested will happen)...

Source: Bloomberg

“Purchasing managers reported that the US manufacturing was running hot over the summer," according to Chris Williamson, Chief Business Economist at S&P Global Market Intelligence.

“The past three months have seen the strongest expansion of production since the first half of 2022, with the upturn gathering pace in August amid rising sales. Hiring also picked up again in August as factories took on more staff to meet an influx of new orders and an accumulation of uncompleted work for waiting customers."

“The manufacturing sector is therefore on course to provide a boost to the US economy in the third quarter.

But inflationary fears loom...

“The upturn is in part being fueled by inventory building, with factories reporting a further jump in warehouse holdings in August due to concerns over future price rises and potential supply constraints. These concerns are being stoked by uncertainty over the impact of tariffs, fears which were underpinned by a further jump in prices paid for inputs by factories, linked overwhelmingly by purchasing managers to these tariffs.

Cost increases are being passed on to customers via widespread hikes to factory gate prices. The big question is the degree to which these price rises will then feed through to higher consumer price inflation in the coming months.”

So S&P Global sees prices higher and hiring improving while ISM sees prices falling and employment still badly lagging... take your pick!!

https://www.zerohedge.com/economics/us-manufacturing-surveys-surged-august-new-orders-jumped

British Comedy Writer Arrested For Three Gender-Critical Tweets; Hospitalized As A Result

 by Steve Watson via Modernity.news,

An acclaimed comedy writer in the UK was arrested and thrown in a jail cell over three tweets that were critical of gender ideology, causing him to become extremely stressed and require hospitalisation.

In a recent Substack post, Graham Linehan recounts his arrest at Heathrow Airport upon returning from the US, a development he attributes to complaints from trans activists over three tweets.

Author JK Rowling shared the news via her X account.

The ordeal began even before Linehan boarded his flight in Arizona. “When I handed over my passport at the gate, the official told me I didn’t have a seat and had to be re-ticketed,” he writes, initially dismissing it as a typical travel mishap. In hindsight, however, he believes it was a sign he’d been “flagged” by authorities, speculating that “Someone, somewhere, probably wearing unconvincing make-up and his sister/wife’s/mum’s underwear, had made a phone call.”

Upon landing at Heathrow, Linehan says he was met by “five armed police officers” who escorted him to a private area and informed him he was under arrest for the tweets. He emphasizes the absurdity of the situation, noting “In a country where paedophiles escape sentencing, where knife crime is out of control, where women are assaulted and harassed every time they gather to speak, the state had mobilised five armed officers to arrest a comedy writer for this tweet (and no, I promise you, I am not making this up.”

The tweets in question included one showing a man in women’s clothing with the caption implying a call to challenge such individuals, and a follow-up referencing a “punch in the bollocks” as a metaphorical point about height differences and self-defense, not literal violence.

Linehan’s initial reaction was one of disbelief and humor: “When I first saw the cops, I actually laughed. I couldn’t help myself. ‘Don’t tell me! You’ve been sent by trans activists,'” he writes.

At the Heathrow police station, Linehan recounts how his belongings were confiscated, including his belt, bag, and devices. He was placed in a “small green-tiled cell with a bunk, a silver toilet in the corner and a message from Crimestoppers on the ceiling next to a concave mirror that was presumably there to make you reflect on your life choices.”

During the police interview, Linehan remarks that the tone became more intense. An officer questioned him about each tweet “with the sort of earnest intensity usually reserved for discussing something serious like… oh, I dunno—crime?”

Linehan defended his posts, explaining that the ‘punch’ tweet was “a serious point made with a joke,” explaining that “Men who enter women’s spaces ARE abusers and they need to be challenged every time.”

The conversation touched on terminology when the officer used “trans people,” prompting Linehan to challenge: “I asked him what he meant by the phrase. ‘People who feel their gender is different than what was assigned at birth.’ I said ‘Assigned at birth? Our sex isn’t assigned.'” He dismissed the officer’s response as “semantics” and accused him of using “activist language,” lamenting that “The damage Stonewall has done to the UK police force will take years to mend.”

Linehan recounts that the stress of the situation took a huge physical toll on him, and when a nurse checked on him, it was discovered that his blood pressure was “over 200—stroke territory,” and he was rushed to A&E for observation.

Linehan attributes this to “The stress of being arrested for jokes,” combined with travel fatigue, and his ongoing eight-year battle against “trans activists working in tandem with police in a dedicated, persistent harassment campaign because I refuse to believe that lesbians have cocks.”

Linehan’s account paints a picture of a surreal clash between free speech, activism, and law enforcement, highlighting his frustration with a system that now prioritises ideological complaints over real crimes.

Is it a coincidence that Linehan was on the world’s most popular podcast just three weeks ago talking about how much of a police state Britain has become?

Linehan has been targeted for cancellation and much worse for years now, since making his views on the gender issue clear:

The Free Speech Union in the UK has announced that it will back Linehan, posting on X:

We do not believe Graham’s arrest or the bail conditions imposed were lawful. We will be backing him all the way in his fight against these preposterous allegations and the disproportionate response from the police.

When @Glinner landed at Heathrow, he was met by five armed police officers, and immediately arrested.

His ‘crime’? Three gender-critical tweets.

As Graham says in his Substack:

“In a country where paedophiles escape sentencing, where knife crime is out of control, where women are assaulted and harassed every time they gather to speak, the state had mobilised five armed officers to arrest a comedy writer.”

Graham’s single bail condition is that he does not go on X.

All of this comes in the wake of Prime Minister Kier Starmer repeatedly claiming that the UK is proud of free speech.

*  *  *

https://www.zerohedge.com/political/british-comedy-writer-arrested-three-gender-critical-tweets-hospitalized-result

Monday, September 1, 2025

Omar’s net worth skyrockets to as much as $30M, months after denying millionaire status

 Rep. Ilhan Omar (D-Minn.) reported a net worth of up to $30 million in her latest financial disclosure – a document filed just months after the congresswoman dismissed claims she was a millionaire as “ridiculous” and “categorically false.” 

The disclosure, filed in May, shows the far-left “Squad” lawmaker and her husbandTim Mynett, experienced a roughly 3,500% increase in net worth last year, compared to 2023

Rep. Ilhan Omar speaking at a news conference.
The surge in wealth detailed in Omar’s disclosure is the result of an explosion in the value of assets held by her husband’s venture capital firm and winery.AP

The surge in the couple’s wealth was first reported by the Washington Free Beacon on Monday. 

The financial gains came from Mynett’s two businesses, a Santa Rosa, Calif.-based winery and venture capital firm headquartered in Washington, DC. 

Omar valued the winery’s assets at between $1,000,000 and $5,000,000 in her latest disclosure. By comparison, the winery, eStCru LLC, was only worth between $15,000 and $50,000 in Omar’s previous financial disclosure. 

More dramatic was the explosion in growth experienced by Mynett’s venture capital firm, Rose Lake Capital LLC. 

Rose Lake Capital’s assets were valued at between $5,000,000 to $25,000,000 by the end of 2024. The company had less than $1,000 in assets the previous year. 

Notably, income from the venture capital firm is listed as “none” in 2024 but between $15,000 and $50,000 the previous year. 

Rose Lake Capital claims to have $60 billion in assets under management, according to the company’s website. 

The company touts its “deep global networks built from on-the-ground work in more than 80 countries working across business, politics, banking and diplomacy.” 

It offers clients “expertise” in several facets of business, including structuring “legislation.” 

Ilhan Omar campaigning, waving to supporters.
Ilhan Omar denied she was a millionaire earlier this year.AP

The congresswoman cried “disinformation” in February, when asked about online speculation that she was a secret millionaire. 

“Since getting elected, there has been a coordinated right-wing disinformation campaign claiming all sorts of wild things, including the ridiculous claim I am worth millions of dollars which is categorically false,” Omar told Business Insider

“I am a working mom with student loan debt. Unlike some of my colleagues — and similar to most Americans — I am not a millionaire and am raising a family while maintaining a residence in both Minneapolis and DC, which are among the most expensive housing markets in the country,” she added.

The disclosure does list as much as $100,000 in credit card and student loan debt owed by Omar.

She also has between $1,000 and $15,000 in her congressional credit union savings account and another $15,000 to $50,000 in a retirement fund from her time in the Minnesota state legislature.

Omar’s office did not immediately respond to The Post’s request for comment. 

https://nypost.com/2025/09/01/us-news/rep-ilhan-omars-net-worth-skyrockets-to-as-much-as-30-million-months-after-denying-she-was-a-millionaire/