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Monday, February 4, 2019

Does Bristol-Myers Squibb’s new activist investor want to stall its Celgene buyout?

Analysts and investors have both expressed concerns over Bristol-Myers Squibb’s $74 billion Celgene deal agreement. And an activist may be joining that list.
Known agitator Starboard Value has taken a stake in the New Jersey drugmaker, Bloomberg’s sources say, though the size of that stake and the hedge fund’s plans are still unclear. A BMS spokeswoman declined to comment.
Bristol-Myers and Celgene agreed to tango early in the year, signing a mammoth deal they said would make a combined company a leader in oncology and immunology. But analysts have pressed Bristol on lower-than-expected revenue growth guidance it rolled out late last month.
One course of action Starboard may be angling for? A sale, Bloomberg Intelligence Sam Fazeli told the news service. “But there are only a very few companies that can actually do that,” he said. AbbVie, Pfizer and Novartis top the list, “but all these would require a lot of synergies to be accretive.”

At one time, analysts predicted Bristol’s sagging shares could make it a takeover target for rivals interested in getting their hands on its immuno-oncology assets. As recently as BMS’ fourth-quarter earnings call last week, analysts asked executives whether they did the Celgene deal to avoid an unwanted buyout bid.
But these days, there doesn’t seem to be a lot of interest in megamergers on the part of some of the most likely parties. Pfizer, who many thought could go after Bristol, has said repeatedly that it plans to stick to smaller bolt-on acquisitions.
AbbVie CEO Richard Gonzalez recently told investors that a “big deal” is “not something that we are contemplating.” And Celgene, which surveyed the landscape before inking its pact with Bristol, didn’t find much interest in megabuys, either; it approached just one other potential buyer that squarely turned it down.
“There has been activist involvement in Bristol over the past couple years that may have contributed to some changes at the company, but we would be surprised if activists are successful in pushing for a larger change, such as trying to get Bristol to sell itself,” Credit Suisse analyst Vamil Divan wrote in a Monday note to clients, adding that he and his colleagues continue to expect deal to close as planned.
Meanwhile, Starboard has been active in the pharma world over the last few years, most recently convincing Perrigo to jettison its prescription drugs business. Before getting involved with the Dublin drugmaker, it pressured California’s Depomed to go up for sale.

Allergan asks ITC to investigate new Botox rivals

Stat News reports

Piper sees ‘perplexing disconnect’ in Alexion fundamentals, stock price

Piper Jaffray analyst Christopher Raymond sees “yet another perplexing disconnect between fundamentals and stock action” following Alexion Pharmaceuticals’ Q4 results. With a beat and above consensus fiscal 2019 earnings guidance, the market seems focused on Alexion’s below consensus revenue guidance, Raymond tells investors in a post-earnings research note titled “Q418 Beat, FY19 Revenue Guidance a Bit of a Sandbag; Buyers Right Here.” The sales outlook “seems to presuppose everything but the kitchen sink with respect to any type of headwind,” says the analyst. He thinks Alexion’s management team has continued to deliver without reward from the market. Further, there is “very real potential” for the company to be taken out, Raymond adds. He’s a buyer of the stock at current levels with an Overweight rating and $180 price target. Alexion in afternoon trading is down 2% to $123.79.
https://thefly.com/landingPageNews.php?id=2858553

Idexx Laboratories under pressure as Wall Street digests quarterly results

Shares of Idexx Laboratories (IDXX) are slipping although the company reported better than expected quarterly results on Friday. Commenting on the earnings release, Bank of America Merrill Lynch analyst Michael Ryskin told investors that he believes the “story stays intact” despite lots of moving pieces and fiscal year guide refinements. QUARTERLY RESULTS: On Friday, Idexx Laboratories reported fourth quarter earnings per share of 98c and revenue of $549.39M, both above analysts’ consensus of 91c and $546.7M, respectively. For fiscal year 2018, the company reported earnings per share of $4.26, better than the expected $4.20, and revenue of $2.213B, which was also slightly better than analysts’ consensus of $2.21B. Additionally, Idexx raised its 2019 earnings per share outlook range by 4c from the midpoint of prior guidance to $4.66-$4.78, reflecting flow through of strong 2018 profit performance, partially offset by lower estimates for projected share-based compensation tax benefits. The company also reaffirmed 2019 revenue guidance of $2.385B-$2.425B and said it achieved revenue growth in the fourth quarter of 9% on a reported basis and 10% on an organic basis, driven by CAG Diagnostics recurring revenue growth of 12% reported and 13% organic. Analysts currently expected FY19 EPS of $4.69 and revenue of $2.41B. STORY REMAINS INTACT: In a post-earnings note, Bank of America Merrill Lynch’s Ryskin told investors that, for the most part, the Idexx core business continues to impress as CAG recurring revenues posted their best year since 2015, and Consumables finished the year on a “particularly good note.” The only pocket of softness continues to be the International reference lab, he pointed out, adding that with Idexx’s emphasis on driving in-clinic/point-of-care placements and revenues, it seems increasingly likely that OUS reference lab will remain somewhat subdued throughout 2019. Overall, Ryskin believes the negative reaction to the fourth quarter results seems to be largely driven by a number of refinements to the 2019 guide as the company now sees CAG recurring as 11%-12% versus prior 11.5%-12.5%, and constant currency OpM expansion is now 50-80bps versus prior 50-100bps. Following the analyst’s conversations with Idexx, he does not see these changes as an indication of any material change in the outlook, and are more reflective of fine-tuning the model following fourth quarter results. He reiterated a Buy rating and $235 price target on the shares. PRICE ACTION: In afternoon trading, shares of Idexx Laboratories have dropped just over 1% to $203.17.

Abiomed heart pump benefits continue to outweighs risks, FDA tells doctors

In a letter to cardiologists and transplant surgeons, the FDA said it is evaluating recent interim post-approval study results which suggest a higher mortality rate for patients treated with the Abiomed Impella RP System than the rate previously observed in the premarket clinical studies. The Impella RP System is a temporary right heart pump system intended to help patients maintain stable heart function without open chest surgery, the agency explained. “The FDA wants to ensure you are aware of the mortality rate that has been observed in the ongoing PAS,” the letter stated. It added, “Although the FDA is concerned about the high mortality rate from the interim PAS results, we believe that when the device is used for the currently approved indication in appropriately selected patients, the benefits of the Impella RP system continue to outweigh the risks.
https://thefly.com/landingPageNews.php?id=2858557

Abiomed drops $25.40 to $325.68 after FDA posts letter sent to doctors

https://thefly.com/landingPageNews.php?id=2858559

Uncommon Fungal Infections Affect Area Pets

In 2018, fungal infections rarely seen in the northeastern United States affected pets in New Jersey. Dr. Melanie Puchot, Internal Medicine specialist at NorthStar VETS, said, “These are uncommon infections in our area, especially in pets with no travel history. We want to make pet parents aware of this because the infections might otherwise be missed or misdiagnosed.”
Dr. Melanie Puchot of the NorthStar VETS Internal Medicine team examining a patient.
Dr. Puchot has done extensive research on two of these infections, Histoplasmosis and Cryptococcosis, which can be viewed at http://www.northstarvets.com/new-fungal-infections.  Dr. Puchot added, “Pets travel now more than ever, and get exposed to other pets in many settings like parks and retail stores. Combined with warmer, wetter weather, it has allowed for cases never-before seen in this area to start appearing.”
Histoplasmosis
  • Fungal infection that can infect dogs, cats and humans
  • Spread by inhalation of the fungus in soil (not transmissible from patient to patient)
  • Most commonly found in the Ohio and Mississippi River valleys and in the Southeastern U.S.
  • Major clinical signs include cough, rapid breathing, GI upset, anemia, enlargement of organs, and eye inflammation
  • In pets, can look like a growth, asthma, IBD, and heart failure
  • Can be treated and managed with a long course of appropriate anti-fungals
Cryptococcosis
  • Fungal infection that can infect cats, dogs and humans (but is most common in cats)
  • Spready by inhalation of the fungus in soil (not likely transmissible from patient to patient)
  • The fungus can be found worldwide, but in the United States is most commonly found on the west coast and in Canada
  • Major clinical signs include upper respiratory tract infection, ulcers and lesions, eye infection, and neurologic signs like inflammation of the brain
  • In pets, the nasal cavity is the primary site of infection and can cause rhinitis
  • Any travel history, even years prior, can be considered significant for risk of infection
About NorthStar VETS
Located in Robbinsville, NJ, NorthStar VETS is the region’s leader in providing advanced veterinary services by board-certified, residency trained, or highly experienced veterinarians 24/7. As an American Animal Hospital-Accredited (AAHA) Referral Practice, NorthStar VETS continues to set the standard in medical excellence for dogs, cats, birds, exotics, and other family pets. www.northstarvets.com