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Friday, December 3, 2021

Forbes rips disappointing November jobs report: 'Government is the problem'

 Forbes Media Chairman Steve Forbes slammed the Biden administration on "The Faulkner Focus" Friday for hindering U.S. economic recovery with "artificial barriers" following weak November hiring numbers that were significantly below expectations.

STEVE FORBES: What you have is an economy that wants to move ahead but there's still artificial barriers there. Yes, we know the huge supply chain problems. Those are underestimated when you shut down a global economy, not helping that in the future. Europe is locking down again. But the fact is that lockdowns don't work. We know medically they don't work, economically they're hugely disruptive, in terms of health care they're hugely disruptive. So in terms of the economy, the administration is still waging war, for example, against the oil and gas industry. They haven't yet explained why getting a barrel of oil from Russia is somehow better for climate change than getting a barrel of oil from America. So they want Russia to produce more and we to produce less. And those kinds of mixed signals are hurting investment in the future. So if they just get out of the way, the American people would do it. One of the amazing things about this jobs report is that they have a thing called the household survey, and the employment numbers there fluctuate widely from month to month, but they do take account of small businesses. Those jobs numbers went up 1.1 million. So you have a lot of small businesses ready to go but now you have the vaccine mandate in there, which is going to hurt, especially in critical areas. So the government is the problem, not the -- and I think people fear what the government is going to do in response to this new variant more than they do the variant itself. 

https://www.foxnews.com/media/steve-forbes-november-jobs-report-numbers-economy

Smoking crack sanctioned at NYC ‘safe injection sites,’ driving businesses away

 Smoking crack cocaine is officially sanctioned at the “safe injection sites” Mayor Bill de Blasio brought to Manhattan this week in a move that’s infuriated the centers’ neighbors — and has at least one business owner packing his bags.

“People are allowed to bring the substance that they prefer to use here and they are permitted to consume the substance in the manner of their choice,” East Harlem site director Kailin See confirmed.

“We are there to make sure that no medical emergency occurs and to connect them into care if they need that,” she said, adding that many of her clients use drugs laced with fentanyl including heroin, cocaine, crack, methamphetamine, amphetamine and K2.

The nonprofit is one of two in Upper Manhattan that became the country’s first legal shooting galleries when they opened Tuesday.

And they have had an immediate effect — but maybe not the one de Blasio, who has just four weeks left in office, was hoping for as business owners still left standing try and dig out from the pandemic.

One merchant near the second center, in Washington Heights, said the junkie haven is forcing him to move his retail shop out of the neighborhood.

“Now they’re going to promote the drugs and people don’t have to worry if they get sick or they’re going to die because they’re gonna have medical people that are gonna take care of them so that they don’t overdose and die so that they can do their drugs again tomorrow?” the shop owner said.

glass pipe used to smoke illegal drugs
Sanctioning smoking crack cocaine at the safe injection sites has caused at least one business owner to leave.
Getty Images

“It doesn’t make any sense to me,” the frustrated businessman said, speaking on condition of anonymity for fear that his shop would be vandalized.

In East Harlem, Camila Casto, 35, said she opposed the E. 126th Street site.

“Some people argue that drugs shouldn’t be stigmatized. I disagree. The mentality needs to be that drugs are evil, drugs are criminal, drugs will kill you — not, ‘Drugs are OK if used in a controlled environment,'” Casto said.

A bin for dirty needles sits outside of an East Harlem health clinic
A bin for dirty needles sits outside of an East Harlem health clinic.
Spencer Platt/Getty Images

“What kind of example does it set for my daughter when she sees people walking out of here all wobbly from just having shot up, with bags of free needles in their hands?” she asked.

Another local resident, Bob Evans, 54, agreed with Casto.

“I know that drug use is a huge problem right now and that drugs are easy to get from dealers, I even know a few dealers myself, but I think that the criminal aspect keeps the number of addicts from being a lot higher,” Evans told The Post.

Smoking crack is officially sanctioned at one of the two 'safe injection sites' Mayor de Blasio rolled out this week
Smoking crack is officially sanctioned at one of the two safe injection sites.

“Also, I’m not sure an injection site is the best thing for my community. People who shoot up inside here tend to hang around, kind of like people outside a bar on a Saturday night. These aren’t the kinds of people you want hanging around on your block,” he said.

A rep for the Washington Heights CORNER Project on W. 180th Street confirmed that clients are not barred from using any type of substance including crack.

Still, the sites are primarily marketed as legal shooting galleries to users of injectable drugs by providing clean syringes and medications like Naloxone that can reverse opioid overdoses.

A kit of supplies containing syringes, adhesive bandages and antiseptic pads waits to be used by a drug addict inside a safe injection site known as Insite on Vancouver, British Columbia's eastside in this August 23, 2006 file photo
The sites will offer drug users a safe and clean space to inject their drugs while being supervised in case of a medical emergency.
REUTERS/Andy Clark/Files

“It’s a good program. It’s not just a place to only shoot up and smoke crack. They provide more than that,” longtime addict Julio Torres, 37, told The Post Tuesday outside New York Harm Reduction Educators on E. 126th Street.

De Blasio and his health officials have touted the life-saving effects of the centers but when asked by The Post on Wednesday, they couldn’t cite any specific studies backing up that claim. 

A rep for city Health Commissioner Dr. Dave Chokshi later sent The Post a 2021 article in the American Journal of Preventive Medicine that was inconclusive about such sites’ effectiveness.

“For people who inject drugs, supervised injection facilities may reduce the risk of overdose morbidity and mortality and improve access to care while not increasing crime or public nuisance to the surrounding community,” the article found based on 22 studies of sites largely in Vancouver, Canada.

The city sites are technically illegal under federal law but it’s unclear if President Biden’s administration would enforce the so called ‘crack house statue’ that prohibits owning or operating a premises for the purpose of using illicit drugs.

When asked how the city would regulate or inspect the sites, the spokesman said, “We maintain regular communication with the providers and offer technical assistance. The providers have decades of experience providing lifesaving services to their clients. Staff are medically trained and sites have very diligent protocol in place.”  

https://nypost.com/2021/12/01/smoking-crack-cocaine-sanctioned-at-nyc-safe-injection-sites/

East Harlem parents rip de Blasio for putting ‘safe injection site’ near daycare

 The Big Apple’s new supervised injection site for drug addicts in East Harlem sits right across the street from a daycare for toddlers, leaving parents with new worries about safety in the already tough neighborhood.

The Echo Park Children and Family Center at 1841 Park Ave. sits directly across the street from the legalized shooting gallery at 104-106 East 126th St., which previously just provided needle exchange services.

As The Post reported this week the center is one of two that also allows addicts to use whatever illicit drug they should choose on premises — even smoking crack.

“They shouldn’t be so close to the school because kids come here. I worry about the safety of my child,” said Jorge Molina, a barber whose four-year-old daughter goes to the daycare. “They should not have it there.”

Tasha Cucuta, whose 3-year-old attends Echo Park, ripped city officials for opening the site there as she picked up her kids.

Exterior of The Echo Park Children and Family Center.
The Echo Park Children and Family Center sit directly across from the safe injection site.
Matthew McDermott“Whatever you are going to do, you don’t put this kind of a center directly across the street from a pre-school. That makes no sense,” said the 44-year-old.

“It may be helping them not to overdose but when they come out high, we have to deal with them and it’s not something I want to subject my 3-year-old to.”

A recovered addict who lives in the neighborhood defended the program as one way to get drug addicts off the streets when they use.

“They are helping the addicts not to use drugs around the kids and everybody,” said Luis, who declined to give his last name.

Mayor Bill de Blasio
De Blasio announced earlier this week, with just weeks left in office, the opening of the new supervised injection sites.
AP / Richard Drew

The Post revealed Thursday that City Hall did an end-run around approvals it said were required from the state Department of Health just three years ago, and launched supervised drug injection services this week.

Officials now claim the needle exchange licenses held by the East Harlem location and the second spot, which is in Washington Heights, provide sufficient legal cover.

New York State law applies additional penalties to the sale of drugs near schools or childcare facilities, making them a Class B felony.

Asked about the concerns over having a legal shooting gallery so near a child daycare center, a de Blasio spokesman declined to answer the question and instead defended the operator.

Syringes and vials of Naloxone are shown during a media tour of the supervised drug injection site in New York.
Syringes and vials of Naloxone are shown during a media tour of the supervised drug injection site in New York.
AFP via Getty Images / Yuki Iwamura

“This organization has been providing lifesaving services in this neighborhood for decades,” said City Hall spokesman Mitch Schwartz. “Connecting people to services and care provides a real pathway out of this crisis – not repeating the same practices that got us here.”

The organization has been in the neighborhood previously as a needle exchange — not as a center that allows the use of illegal drugs on premises.

https://nypost.com/2021/12/03/nyc-parents-rip-de-blasio-for-drug-injection-site-near-daycare/

Maximum risks of COVID infection with and without masks

 Three meters are not enough to ensure protection. Even at that distance, it takes less than five minutes for an unvaccinated person standing in the breath of a person with COVID-19 to become infected with almost 100 percent certainty. That's the bad news. The good news is that if both are wearing well-fitting medical or, even better, FFP2 masks, the risk drops dramatically. In a comprehensive study, a team from the Max Planck Institute for Dynamics and Self-Organisation in Göttingen has investigated to what extent masks protect under which wearing conditions. In the process, the researchers determined the maximum risk of infection for numerous situations and considered several factors that have not been included in similar studies to date.

The Göttingen team was surprised at how great the  of infection with the coronavirus is. "We would not have thought that at a distance of several meters it would take so little time for the infectious dose to be absorbed from the breath of a virus carrier," says Eberhard Bodenschatz, Director at the Max Planck Institute for Dynamics and Self-Organisation. At this distance, the breathing air has already spread in a cone shape in the air; the infectious particles are correspondingly diluted. In addition, the particularly large and thus virus-rich particles fall to the ground after only a short distance through the air. "In our study we found that the risk of infection without wearing masks is enormously high after only a few minutes, even at a distance of three meters, if the infected persons have the high viral load of the delta variant of the SARS-CoV-2 virus," says Eberhard Bodenschatz. And such encounters are unavoidable in schools, restaurants, clubs or even outdoors.

Well-fitting FFP2 masks reduce the risk at least into the per thousand range

As high as the risk of infection is without mouth-nose protection, medical or FFP2 masks protect effectively. The Göttingen study confirms that FFP2 or KN95 masks are particularly effective in filtering infectious particles from the air breathed—especially if they are as tightly sealed as possible at the face. If both the infected and the non-infected person wear well-fitting FFP2 masks, the maximum risk of infection after 20 minutes is hardly more than one per thousand, even at the shortest distance. If their masks fit poorly, the probability of infection increases to about four percent. If both wear well-fitting medical masks, the virus is likely to be transmitted within 20 minutes with a maximum probability of ten percent. The study also confirms the intuitive assumption that for effective protection against infection, in particular the infected person should wear a mask that filters as well as possible and fits tightly to the face.

The infection probabilities determined by the Max Planck team indicate the upper limit of the risk in each case. "In , the actual probability of infection is certainly 10 to 100 times smaller," says Eberhard Bodenschatz. This is because the air that flows out of the mask at the edges is diluted, so you don't get all the unfiltered breathing air. But we assumed this because we can't measure for all situations how much breathing air from one mask wearer reaches another person, and because we wanted to calculate the risk as conservatively as possible," Bodenschatz explains. "Under these conditions, if even the largest theoretical risk is small, then you're on the very safe side under real conditions." For the comparative value without the protection of a mask, however, the safety buffer turns out to be much smaller. "For such a situation, we can determine the viral dose inhaled by an unprotected person with fewer assumptions," says Gholamhossein Bagheri, who as a research group leader at the Max Planck Institute for Dynamics and Self-Organization who is the lead author of the current study.

'Masks in schools are a very good idea'

In their calculations of the risk of infection, the Göttingen team considered a number of factors that had not previously been included in comparable studies. For example, the researchers investigated how a poor fit of the mask weakens the protection and how this can be prevented. "The materials of FFP2 or KN95 masks, but also of some medical masks, filter extremely effectively," says Gholamhossein Bagheri. "The risk of infection is then dominated by the air coming out and going in at the edges of the mask." This happens when the edge of the mask is not close to the face. In elaborate experiments, Bagheri, Bodenschatz and their team measured the size and amount of respiratory particles that flow past the edges of masks that fit differently. "A mask can be excellently adapted to the shape of the face if you bend its metal strap into a rounded W before putting it on," says Eberhard Bodenschatz. "Then the infectious aerosol particles no longer get past the mask, and glasses no longer fog up either."

The team also considered that droplets that people spread when they breathe or speak dry while in the air and become lighter. This means that they remain in the air longer but also have an increased virus concentration as equal size droplets directly after release. When inhaled, the opposite happens: the particles take up water again, grow like a drop in the cloud and therefore deposit more easily in the respiratory tract.

Although the detailed analysis by the Max Planck researchers in Göttingen shows that tight-fitting FFP2 masks provide 75 times better protection compared to well-fitting surgical masks and that the way a mask is worn makes a huge difference; even medical  significantly reduce the risk of  compared to a situation without any mouth-nose protection at all. "That's why it's so important for people to wear a mask during the pandemic," says Gholamhossein Bagheri. And Eberhard Bodenschatz adds, "Our results show once again that mask-wearing in schools and also in general is a very good idea."


Explore further

Sing on: Certain face masks don't hinder vocalists

More information: Gholamhossein Bagheri et al, An upper bound on one-to-one exposure to infectious human respiratory particles, Proceedings of the National Academy of Sciences (2021). DOI: 10.1073/pnas.2110117118
https://medicalxpress.com/news/2021-12-maximum-covid-infection-masks.html

Rapid test identifies antibody effectiveness against COVID-19 variants

 Biomedical engineers at Duke University have devised a test to quickly and easily assess how well a person's neutralizing antibodies fight infection from multiple variants of COVID-19 such as Delta and the newly discovered Omicron variant.

This test could potentially tell doctors how protected a patient is from new variants and those currently circulating in a community or, conversely, which  to treat a COVID-19 patient. The test is described online December 3 in the journal Science Advances.

"We currently really have no rapid way of assessing variants, neither their presence in an individual, nor the ability of  we possess to make a difference," said Cameron Wolfe, associate professor of medicine at the Duke University School of Medicine. "It's one of the lingering fears that, as we successfully vaccinate more and more people, a variant may emerge that more radically evades vaccine-induced antibody neutralization. And if that fear came true—if Omicron turned out to be a worst-case scenario—how would we know quickly enough?"

"While developing a point-of-care test for COVID-19 antibodies and biomarkers, we realized there could be some benefit to being able to detect the ability of antibodies to neutralize specific variants, so we built a test around that idea," said Ashutosh Chilkoti, the Alan L. Kaganov Distinguished Professor and Chair of Biomedical Engineering at Duke. "It only took us a week or two to incorporate the Delta variant in our test, and it could easily be expanded to also include the Omicron variant. All we need is the spike  of this variant, which many groups across the world—including our group at Duke— are feverishly working to produce."

The researchers have dubbed their test the COVID-19 Variant Spike-ACE2-Competitive Antibody Neutralization assay, or CoVariant-SCAN for short. The test's technology hinges on a polymer brush coating that acts as a sort of non-stick coating to stop anything but the desired biomarkers from attaching to the test slide when wet. The high effectiveness of this non-stick shield makes the test incredibly sensitive to even low levels of its targets. The approach allows researchers to print different molecular traps on different areas of the slide to catch multiple biomarkers at once.

In this application, researchers print fluorescent human ACE2 proteins—the cellular targets of the virus's infamous spike protein—on a slide. They also print spike proteins specific to each variant of COVID-19 at different specific locations. When the test is run, the ACE2 proteins detach from the slide and are caught by the spike proteins still attached to the slide, causing the slide to glow.

But in the presence of neutralizing antibodies, the spike proteins are no longer able to grab on to the ACE2 proteins, making the slide glow less, indicating the effectiveness of the antibodies. By printing different variants of the COVID-19 spike protein on different portions of the slide, researchers can see how effective the antibodies are at preventing each variant from latching onto their human cellular target simultaneously.

In the paper, the researchers tested the technology a number of different ways. They tried monoclonal antibodies either derived from real-life patients or from Regeneron's commercial prophylactic treatment. They also tested plasma taken from healthy vaccinated people and those currently infected with the virus.

Rapid test identifies antibody effectiveness against COVID-19 variants
The new test of how well antibodies work against multiple variants of COVID-19 works by releasing fluorescently labeled ACE2 proteins – the cellular targets of the COVID-19 spike protein – together with antibodies. If the antibodies are able to neutralize variants of COVID-19 spike proteins printed on the slide, they cannot attach to the ACE2 proteins, causing the fluorescent markers wash away and the slide to become dimmer. Credit: Jake Heggestad, Duke University

"In all of our tests, the results largely mimicked what we've been seeing in the literature," said Jake Heggestad, a Ph.D. student working in the Chilkoti lab. "And in this case, not finding anything new is a good sign, because it means our test is working just as well as the methods currently being used."

While they produce similar results, the critical difference between the CoVariant-SCAN and current methods is the speed and ease with which it can produce results. Typical current approaches require isolating live virus and culturing cells, which can take 24 hours or more and requires a wide variety of safety precautions and specially trained technicians. The CoVariant-SCAN, in contrast, does not require live virus, is easy to use in most settings and takes less than an hour—potentially just 15 minutes—to produce accurate results.

Moving forward, Heggestad and the Chilkoti lab are working to streamline the technique into a microfluidic chip that could be mass produced and report results with only a few drops of blood, plasma or other liquid sample containing antibodies. This approach has already been proven to work on a similar test that can distinguish COVID-19 from other coronaviruses.

"We would love to have real-time visibility of the emerging variants and understand who still has functional immunity," Wolfe said. "Additionally, this hints that there might be a technique whereby you could quickly assess which synthetic monoclonal antibody might be best to administer to a patient with a particular emergent variant. Currently we really have no real-time way of knowing that, so we rely on epidemiological data that can track weeks behind."

"The reverse is also true," Wolfe continued. "To be able to pre-screen an individual's antibodies and predict whether they were sufficiently protected against a particular variant they are perhaps about to run into while travelling, or that is emerging in their area. We have no way of doing that at the present time. But a test like the CoVariant-SCAN could make all of these scenarios possible."


Explore further

Regeneron says COVID antibody treatment may be less effective against Omicron

More information: Jacob Heggestad et al, Rapid test to assess the escape of SARS-CoV-2 variants of concern, Science Advances (2021). DOI: 10.1126/sciadv.abl7682www.science.org/doi/10.1126/sciadv.abl7682
https://medicalxpress.com/news/2021-12-rapid-antibody-effectiveness-covid-variants.html

The Future of Crisis Response

 Next year, Americans will start hearing a great deal about 988, a new alternative to 911 for “Americans in crisis to connect with suicide prevention and mental health crisis counselors.” Its purpose: to isolate such cases so that they can be responded to in a more specialized fashion—with social workers and, in some cases, specially trained cops, as opposed to just a random officer who happens to be closest to the emergency. The FCC has required phone companies to make 988 operational by July 2022, but the true significance of the move is less about a new number than about a new way of reacting to mental-health emergencies. Advocates believe that the new system may lead to fewer mental-health-related shootings by police and less involvement of the mentally ill in the criminal-justice system.

But after 30 years of experience with enhanced police training in techniques such as de-escalation, cities remain uncertain about what works, and to what degree. We should not expect social-services providers, who don’t always garner much respect from the population they’re trying to help, to perform miracles on the street. Without deeper reform that treats mental illness more thoroughly, the new initiative won’t make much headway. If crisis-response reform diverts attention from deeper reform, it may even prove counterproductive.

Mental-health emergencies are estimated to make up anywhere from 5 percent to 20 percent of police calls for service. Sending out police to respond to such calls is often said to be wasteful and dangerous. In the United States, 200 to 250 fatal police shootings that are in some way mental-health-related happen each year.

Fatal police shootings of mentally ill people are tragic but rare. Spread across a nation of nearly 20,000 law-enforcement agencies, 200 to 250 incidents annually translate to very few per jurisdiction per year, even in big cities—and, in most places, zero. The rarity of fatal shootings of mentally ill people explains much of why we know so little about how to stop them. Any evaluation of a de-escalation program designed to reduce such tragedies will be dealing with a vanishingly small sample size.

Training programs vary in quality and character. Departments don’t track and code mental-health crisis calls in a uniform manner. Even were a researcher to prove, conclusively, that one city’s de-escalation program deserves credit for cutting the number of fatal police shootings of mentally ill people from, say, three in one year to one in the following year, that would prove nothing about programs in other cities.

The essence of alternative-response protocols is persuasion. Advocates want to see cops resort less to force when handling tense situations. In these partisan times, a lack of experience with persuasion seems to have inspired credulousness about the conditions under which it is likely to happen. The situations in which persuasion will be most effective are those least likely to result in tragedy. Conversely, there could scarcely be worse conditions for persuasion than situations involving a man with untreated psychosis armed with a knife and charging at a cop. Antipolice activists heap scorn on the quality of the average officer, while also promoting a superhero conception of policing that implies near-magical powers of persuasion.

Nor should we expect that social-services personnel, in dangerous situations, will excel at persuasion. Police-defunding advocates exaggerate the degree to which mentally ill people like social-services personnel. Social workers are often seen, by the population they’re employed to help, as paternalistic and unreliable, constantly misleading them about being able to do something to help when they know they can’t. Street homeless individuals, in particular, develop notoriously deep “service resistant” instincts as a consequence of having been, as they see it, betrayed by the system for years.

Advocates also expect too much from “peers”—people who have overcome their mental illness and are now employed to help others do the same. It’s presumptuous to believe that someone with one kind of experience of mental illness will possess special influence over someone with an entirely different experience and whom he has only just met at a crisis scene. The appeal of social workers and peers, as response team members, is mainly negative: they are not armed and not authorized to arrest.

Supporters of 988 and reformed crisis protocols invoke the persistence of police shootings to make their case for the urgency of reform. But they lack evidence that proves that their reforms will reduce shootings. They thus retreat to safer ground. One good example is tracking arrests. Claiming that reforming crisis protocols is really about reducing arrests reframes the endeavor as one of “diversion,” which addresses the “criminalization” of mental illness—meaning the high rate of serious mental illness among jail and prison inmates. The goal is to divert as many mentally ill individuals away from more and deeper involvement in the criminal-justice system, and that must start at that system’s front end, with patrol officers.

But “diversion” raises the question: Diverted to where? What happened to someone instead of being arrested? The deinstitutionalization of the mentally ill was wildly successful in diverting, over the decades, hundreds of thousands of Americans away from mental hospitals—but it diverted them to homelessness and jails and prisons.

The success of diversion hinges on the strength of the local mental-health system and police departments’ relationship with it. The most admired crisis-response systems, such as those found in Arizona, utilize crisis-stabilization centers, facilities to which officers can quickly deposit people in a state of psychiatric emergency instead of booking them on a charge. They’re staffed and designed to feel less like a hospital ER, while also offering many of the same benefits of one. But not every jurisdiction has a crisis-stabilization center, and even the best-run of such facilities raise their own “diversion to where?” questions. Crisis-stabilization centers are meant only to address the 24 hours after a psychiatric emergency hits.

In the most immediate and concrete sense, what 988 will do in most places is direct calls, from anywhere in the country, to the national suicide hotline, which has long been in use but whose number is harder to remember than “988.” Modest federal funding will be provided to help localities develop new response systems, and enabling legislation authorizes states to impose fees on cell-phone bills for that purpose. But in general, it will be up to states and cities to decide how expansively they want to invest in peers, crisis-stabilization centers, and so on. Even where those options exist, dispatchers will have to decide which calls are safest to send social workers to handle.

It also remains to be seen how much 988 catches on with the public, and in what way. Will it function as more than just a suicide hotline—as a “911 system for the brain,” as some hope? In jurisdictions that already have mental-health crisis lines, one person sometimes calls that line about an incident while another calls 911 about the same incident.

Another metric of success to monitor, as 988 gets rolled out: How much does it promote authentic mental-health reform? Such reform targets the mental-health system proper, not cops and dispatch personnel. Crisis-response reform is better understood as a variety of criminal-justice reform, with a mental-health orientation. As the late DJ Jaffe relentlessly emphasized, real mental-health reform equates to a reduced rate of serious mental illness among the incarcerated and homeless populations. If fewer mentally ill are winding up in jail, on the street, and in shelters, we’re probably getting somewhere.

De-escalation is a reasonable idea that I’ve praised in the past. I continue to believe that training cops makes more sense than trying to replace them. Over time, though, I’ve grown increasingly concerned that, for some mental-health advocates, the crisis-response debate represents an elaborate attempt to change the subject. De-escalation could function as part of a substantive mental-health reform agenda. But too often, it functions as an alternative to such an agenda. Pushes to reform crisis response have done nothing to advance civil-commitment reform, the most necessary mental-health reform of all. During the last 30 years, we’ve witnessed the spread of de-escalation training programs and the loss of tens of thousands of inpatient psychiatric beds. Policymakers avoid civil-commitment reform because it’s controversial, though more so among disability-rights groups than with the broader public. Aghast at the spectacle of subway pushings and mass shootings, the public grasps the appeal of more court-ordered supervision for the mentally ill. But we never get around to debating it. We remain absorbed in numerous, far less consequential, matters. When should dispatchers send out social workers only, cops only, or “co-response” teams comprising both? How many crisis-stabilization centers does a community need, and where should they be sited?

Mental-health reform designed to help “everyone” rarely helps the hardest cases. Suicide hotlines represent a public-health response to mental-health emergencies. Public-health programs are, by definition, untargeted, set up to benefit the broader public. Mainstream mental-health organizations will tell you that one in four adults experiences a mental disorder in any given year. But one in four adults is not at risk of being fatally shot by police in any given year; one in four adults does not suffer from incapacitating mania or psychosis. A true “serious” mental illness can qualify people for disability benefits and lead to involuntary hospitalization. Only a small fraction of adults with a diagnosable mental disorder qualify for the former, and an even smaller segment will ever be institutionalized. Call lines will do the most to help people who know that they have a problem and want help. What about those who’ve sworn never to trust the system again, having been betrayed by it too many times? What about people so mentally ill that they don’t even believe that they’re mentally ill?

Pushes to reform response protocols are heavily premised on the idea that police are prejudiced toward mentally ill people—they think they’re violent, when they’re not. So cities have cops take time off from their patrol duties to listen to mental-health professionals give lectures about anxiety, PTSD, personality disorders, and “stigma.” This kind of instruction is poorly targeted. Teaching patrol officers about many mental disorders beyond just incapacitating mania and psychosis will elevate their general knowledge of mental health, yes—but we could elevate cops’ knowledge about many social-policy topics only loosely connected to their duties: housing, the ins and outs of Medicaid financing, the history of the subway system. Being force-fed lessons about how most mentally ill people aren’t violent serves as poor preparation for how to handle mentally ill people who demonstrably are violent. Between January 2015 and June 2021, the Washington Post documented 1,474 fatal police shootings that were somehow mental-health-related. In 916 of those cases (62 percent), the victim was attacking someone and was usually armed with a gun or knife. In two-thirds of the cases not coded by Washington Post researchers as involving an attack, the victims were armed with a gun or knife. The database codes only 43 out of the 1,474 incidents (3 percent) as involving victims definitively not attacking anyone and definitively unarmed. About 10 percent of police shootings are instances of “suicide by cop,” which mostly involve mentally ill people. The calls for service likeliest to end badly, such as those involving a psychotic person wielding a knife, are the ones that social workers are the least well suited to handle.

Knowledge is power in fast-moving crisis situations, but the most valuable form of knowledge may simply be that of the community. People with untreated schizophrenia or severe bipolar disorder behave erratically. They do and say things that strangers interpret as threats but that their families and neighbors know to be innocuous. Knowledge of a community and its members is not gained through listening to lectures about stigma but through experience: walking a beat or responding to hundreds of calls on patrol, attending barbecues, and so on. Giving cops knowledge of the community requires a serious commitment on the part of governments because experience is an expensive mode of instruction. “Community policing,” rightly understood, is labor-intensive. The cheapest model of policing is to keep a small number of cops in reserve and available to respond to dangerous emergencies, and not much beyond that. Experienced cops are costlier than new recruits. Knowledge of the community is, of course, jeopardized by waves of retirements of veterans.

One benefit of the “criminalization of mental illness” debate is that it incorporates the voices and experiences of criminal-justice-system participants. Judges, prosecutors, jail and prison staff and managers, and police commissioners and patrol officers have built up, over the years, extensive knowledge of serious mental illness. Some research suggests that over 90 percent of patrol officers have had encounters with mentally ill people. What percentage of the general population has substantial experience with people with mental illness, especially the particularly disturbing psychotic variety? What percentage of “mental-health professionals” has substantial experience with people with untreated psychosis and violent tendencies?

We will always need cops to be involved in responses to mental-health emergencies. Transportation alone guarantees it. Helping someone in crisis often entails taking him to another location, such as a jail, hospital, or crisis-stabilization facility. That will often require the assistance of police. We could, instead, hire entirely separate and new teams of “Crisis Transport Security Officers,” but if we did that right, they’d resemble cops in many ways. Social workers sometimes welcome the presence of cops on the scene of crises because not having to worry about their personal security helps them focus on their particular expertise.

Cops, for their part, would just as soon not have to deal with mental-health emergencies. But it’s not true to say that they’re unqualified to do so. Police have a great deal of hard-won knowledge about the nature of untreated mental illness that they can usefully bring to bear to resolve particular crises, or as contributions to the broader debate over mental-health-policy reform. Mental-health emergencies are too important to be left to the experts.

AbCellera-Lilly Combo Authorized as 1st/Only Antibody for Emergency Use in Under-12s

 AbCellera (Nasdaq: ABCL) today announced the U.S. Food and Drug Administration (FDA) has expanded the Emergency Use Authorization (EUA) for bamlanivimab and etesevimab administered together to include pediatric patients under the age of 12, including neonates (infants <1 year old). The EUA allows for bamlanivimab and etesevimab administered together in the treatment of mild to moderate COVID-19 as well as post-exposure prophylaxis in certain patients.

The expanded EUA is based on data from the BLAZE-1 Phase 2/3 clinical trial studying bamlanivimab and etesevimab administered together for the treatment of pediatric and infant patients with mild to moderate COVID-19 and who are at high risk for severe disease progression. The median time to complete symptom resolution as recorded in a trial specific daily symptom diary was 7 days for subjects treated with bamlanivimab 700 mg and etesevimab 1,400 mg and 5 days for subjects treated with weight-based dosing of bamlanivimab and etesevimab. No subject died or required hospitalization due to COVID-19.

Pseudovirus and authentic virus studies conducted by AbCellera’s partner, Eli Lilly and Company (Lilly), demonstrate that bamlanivimab and etesevimab together retain neutralization activity against the Delta variant, which is currently the predominant variant of concern within the U.S.

https://www.biospace.com/article/releases/abcellera-discovered-bamlanivimab-together-with-etesevimab-authorized-as-the-first-and-only-antibody-therapy-for-emergency-use-in-covid-19-patients-under-the-age-of-12/