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Friday, February 24, 2023

Food makers, feeling squeezed, pull the plug on slow-selling products

 Major consumer companies including Kraft Heinz Co and Conagra Brands Inc are culling product lines to combat sky-high costs and falling consumer demand, their executives said this week.

Many companies started slimming their offerings during the pandemic and are aggressively renewing those efforts, eliminating less-popular items to focus on products on which they can more easily raise prices amid prolonged inflation on food items.

Executives at Nestle SA and Unilever Plc said they have seen billions in savings after ditching the laggards in their product portfolios.

Conagra recently discontinued a Marie Callender's chocolate chip cookie dough cream pie to make room for what the U.S. food company hopes will be a faster-selling no sugar added apple pie.

"No one will have a perfect batting average," said Chief Executive Sean Connolly in an interview. "The key is to have more winners than losers."

Eliminating less popular products is part of a "decomplexity program" underway at Kraft Heinz, its executives said at the Consumer Analyst Group of New York Conference this week. It recently discontinued Heinz Real Mayonnaise.

Mondelez International Inc CEO Dirk Van de Put told Wall Street analysts at the conference that the Oreo maker had clear rules on replacing old products with new ones - "one in, one out."

Martin Renaud, a top marketing executive at Mondelez, told Reuters the chocolate manufacturer has "too many flavors."

"We sometimes have the tendency to launch a lot of things because they are exciting but we need to be very rigorous," Renaud said. As Mondelez adds products with different price points, it adds complexity, he added. "I am a big advocate of simplicity."

Companies cull product offerings to make room for new iterations of their most popular items, such as smaller-sized versions for dollar stores or larger ones for warehouse chains like Costco, said Justin Cook, U.S. consumer products research leader at Deloitte. Cash-strapped shoppers are more frequently looking for bargains at both types of retailers.

"It’s more expensive to make a lower-volume product," Cook said. “If it’s not a high-performing item that people absolutely have to have, companies feel it’s harder to raise price."

Nestle said cutting products saved 1 billion Swiss francs last year ($1.06 billion), while Unilever said the practice saved $2 billion.

Retailers are also demanding new, fast-selling products to enhance their own faltering sales. Products most likely to get the boot are those with niche or limited popularity.

Heinz Real Mayonnaise has a small share of the global market, according to the research firm Euromonitor.

For some consumers, such cuts can be jarring.

Vinh Banh said in an email he has long used Heinz Real Mayonnaise for sandwiches and deviled eggs. He was disappointed to discover this month that Kraft had killed the product, which it launched in 2018. Banh, 34, from Garland, Texas, said he is on the hunt for any remaining jars he can find.

Kellogg Co ditched its line of Special K protein shakes and Nestle axed Lean Cuisine paninis, frozen Sweet Earth Benevolent Bacon and Sweet Earth Vegan Hot Dogs, spokespeople for the companies confirmed.

'PREPPING FOR A SLOWDOWN'

In some cases, suppliers are bowing to retailer plans to reduce inventory, hoping that cutting product lines will make stores more efficient and less costly to run and stock.

Walmart told Reuters it was seeking more data from suppliers to justify pricing and pushing for more creative ways to defray costs and cushion price hikes to consumers.

"We recognize that price concerns are more elevated at this point in time, but that's where we can lean in and have data driven negotiations with our suppliers," Chief Financial Officer John David Rainey said.

"I have seen a lot of reduction in inventory purchases this year," Kelly Pedersen, a partner at PwC, said at the National Retail Federation conference in January. "Everyone is prepping for a slowdown."

Unilever, which makes Magnum and Ben & Jerry's, is slimming the variety of ice cream it sells, finance chief Graeme Pitkethly said this month on an earnings call.

The company has for over two years used artificial intelligence in its 'Polaris' program to help manage its assortment. It credited Polaris as it cut its variety of products by about 20%.

Unilever also trimmed about 5,000 types of products in the personal care category.

Food makers tend to cull products without much fanfare. At the consumer products conference they highlighted new offerings, many of them increasingly popular handheld foods that people can eat while scrolling on phones.

That does not mean consumers don't notice when a beloved item disappears from the shelf.

John Finn, 35, runs a Twitter page called "Discontinued Foods" with over 23,000 followers.

"You'd be shocked by the loyalty and personal connections people have to food products," he said.

https://www.yahoo.com/lifestyle/food-makers-feeling-squeezed-pull-195610953.html

Biden doesn’t sanction billionaire linked to Hunter — despite actions against prominent Russians

 President Biden kept his son Hunter’s alleged business associate Yelena Baturina off the list of new sanctions he announced Friday against prominent Russians to mark the first anniversary of the Kremlin’s invasion of Ukraine.

Biden’s administration touted in a press release that it adopted “more than 2,500 sanctions” so far to cripple Russia’s economy and halt the war, but Baturina again skated by as about 200 more people and entities were sanctioned Friday.

White House spokespeople would not supply an on-record comment about Baturina’s remarkable good fortune.

Baturina, the billionaire widow of Moscow’s longtime former Mayor Yury Luzhkov, allegedly paid $3.5 million to a firm associated with first son Hunter Biden in February 2014 while his father was vice president. 

Records from a laptop abandoned by Hunter Biden years later indicate that the then-second son met with his business partner Devon Archer and Baturina less than two months later at Lake Como in Italy. 

Baturina’s $3.5 million transfer was first revealed in a September 2020 report by Republican-led Senate committees, which cited suspicious activity reports filed by banks with the US government. 

Further reporting has linked Baturina’s funds to US real estate purchases, including in Brooklyn.

Like many other business dealings of Hunter Biden and first brother James Biden, the Biden family’s financial relationship with Baturina remains murky.

Hunter and Joe Biden
Baturina allegedly paid $3.5 million to a firm associated with Hunter Biden in February 2014 while his father was vice president. 
Teresa Kroeger

Biden allies point to an April 2022 fact check from the Washington Post that cites an anonymous source saying that Archer’s associates believed he had dissolved the corporate entity to which Baturina sent money, but that Archer, who has since been jailed for defrauding an American Indian tribe, secretly kept the entity in existence for his own use.

There’s been no documentation supporting that version of events and Hunter Biden’s laptop documents indicate the first son engaged with the Russian billionaire as she pumped funds from risky Russia into the relatively secure US.

“Hunter Biden had no interest in and was not a ‘co-founder’ of Rosemont Seneca Thornton, so the claim that he was paid $3.5 million is false,” his lawyer George Mesires said in 2020.

But emails show Hunter continued the association long after the transfer and even invited Baturina and her husband to an April 2015 dinner at a Georgetown restaurant, where then-Vice President Biden mingled with his son’s associates from Ukraine and Kazakhstan, according to photos and emails. Laptop documents do not make clear whether the Russian power couple attended.

Additional reporting has generated even more questions about the scale and breadth of Baturina’s financial links to the Bidens — with the revelation in October that she poured up to $100 million into her American investments

The White House has bristled at the suggestion that Biden has any conflicts of interest in foreign affairs due to his family’s consulting enterprises dating to his vice presidency.

Hunter Biden
Hunter Biden’s lawyer said that the claim that he was paid $3.5 million is false.
CQ-Roll Call, Inc via Getty Images

Biden as a presidential candidate in 2020 said at a debate the $3.5 million claim was false and, growing flustered at the inquiry, called then-President Donald Trump a “clown.”

White House press secretary Jen Psaki last year tried to talk past a question from The Post about the president’s apparent conflict of interest when it comes to sanctions decisions.

“He’s continued to sanction oligarchs more than we’ve ever sanctioned in the past, so I’m not sure that’s a conflict of interest,” Psaki insisted, without recognizing that the oligarch in question, Baturina, has not faced sanctions that were applied to many other Russian billionaires in response to Russia’s Feb. 24, 2022, invasion of Ukraine.

At a different press briefing shortly after Biden took office in 2021, Psaki went so far as to say she was “not familiar” with the widely circulated claim that a firm linked to her boss’ son may have received the $3.5 million.

In a counterpunch, some Democrats have circulated a report by Politico noting that former President Donald Trump sought to build a shopping mall and renovate a hotel in Moscow during Baturina’s husband’s corrupt 18-year reign from 1992-2010.

The Trump plans didn’t pan out and his then-communications director, Alyssa Farah, rejected the comparison, telling Politico, “while President Trump was leading a global real estate brand with properties all over the world, Hunter Biden was profiting off of his father’s government service by accepting $3.5 million from the Moscow Mayor’s wife. No comparison.”

House Oversight Committee Chairman James Comer (R-Ky.) is requesting from the Treasury Department records of all suspicious activity reports involving the Biden family’s international business deals.

Hunter Biden is under criminal investigation by the US attorney’s office in Delaware for possible tax fraud, money laundering, illegal foreign lobbying and lying about his drug use on a gun-purchase form.

https://nypost.com/2023/02/24/biden-doesnt-sanction-russian-billionaire-linked-to-hunter/

Moderna to make milestone payments to NIH for COVID vaccine

 

Moderna Inc will make certain contingent development, commercial and regulatory milestone payments to the U.S. National Institutes of Health (NIH) related to the development of COVID-19 vaccines, the company said in a filing on Friday.

Moderna and the U.S. government agency had entered into a license agreement in December related to certain patents concerning the COVID vaccine products, the filing showed.

The vaccine maker first disclosed the deal in its fourth-quarter earnings release stating it missed profit estimates hurt by the royalty payment to NIH.

Moderna said under the agreement it would pay low single-digit royalties on future net sales and also minimum annual royalties.

https://www.marketscreener.com/quote/stock/MODERNA-INC-47437573/news/Moderna-to-make-milestone-payments-to-NIH-for-COVID-vaccine-43083872/

ARCA in strategic review, evaluating additional development of assets, collaborations, other options

 ARCA biopharma, Inc. (Nasdaq: ABIO), a biopharmaceutical company applying a precision medicine approach to developing genetically targeted therapies for cardiovascular diseases, today reported 2022 financial results and provided a corporate update.

In May 2022, the Company retained Ladenburg Thalmann & Co. Inc. to act as its financial advisor to explore and evaluate strategic options. The Board has not set a timetable for the conclusion of this review, nor has it made any decisions related to any further actions or potential strategic options at this time. There can be no assurance, however, that this process will result in any such transaction.

https://www.marketscreener.com/quote/stock/ARCA-BIOPHARMA-INC-56870636/news/ARCA-biopharma-Company-is-currently-engaged-in-a-strategic-review-process-evaluating-additional-d-43083870/

Picking Up A Shovel Might Solve The Masculinity Crisis

 The crisis of masculinity in the movie "Fight Club."

Fight Club follows the boring life of the narrator (Edward Norton). He is a middle-class, white-collar worker who feels emasculated and unfulfilled in his everyday existence.

Through the narrator's encounters with Tyler Durden (Brad Pitt), a charismatic and enigmatic soap salesman, he is introduced to a world of underground fight clubs where men gather to release their primal urges and reconnect with their sense of masculinity.

This leaves us with today: Masculinity is in crisis across the Western world as 'wokeism' spreads like a virus. 

Research and critical studies have shown that global sperm counts are declining worldwide—at an accelerating rate. There's a war on masculinity by Western governments and megacorporations; and there are even early school education programs transforming a generation of men into 'beta males' while some young adults become confused about their gender. 

It might make sense why there's a concerted effort to change men into beta status, generally because they play by the rules of society. They don't question and stay compliant with the government -- just as the narrator of Fight Club did when working in his boring cubicle.  

Only through fight club, or rather exercise, was the narrator able to regain the alpha male status.

Not everyone needs to join a boxing club or find some underground fight club, as new research shows simple blue-collar work has benefits and boosts masculinity. 

"Occupational factors, such as physical demands and work schedules, were associated with higher sperm concentrations and serum testosterone among men in the EARTH study.

"We already know that exercise is associated with multiple health benefits in humans, including those observed on reproductive health, but few studies have looked at how occupational factors can contribute to these benefits.

"What these new findings suggest is that physical activity during work may also be associated with significant improvement in men's reproductive potential.

"What these new findings suggest is that physical activity during work may also be associated with significant improvement in men's reproductive potential," first study author Lidia Mínguez-Alarcón, a reproductive epidemiologist in Brigham's Channing Division of Network Medicine and co-investigator of the EARTH study, stated in the press release

The study was a collaborative effort between scientists at the Harvard T. Chan School of Public Health and Mass General Brigham to evaluate the effects of the environment and lifestyle factors on masculinity/fertility.

https://www.zerohedge.com/medical/how-picking-shovel-might-solve-masculinity-crisis

Supplement linked to reduced biomarkers of Alzheimer's in the brain

 For the first time, a researcher at the University of Delaware College of Health Sciences in collaboration with a team at the National Institute on Aging, a division of the National Institutes of Health, has determined that the naturally occurring dietary supplement known as nicotinamide riboside (NR) can enter the brain.

The discovery was made by Christopher Martens, assistant professor of kinesiology and applied physiology and director of the Delaware Center for Cognitive Aging Research, and Dr. Dimitrios Kapogiannis, a senior investigator at the National Institute on Aging. The finding is significant because it supports the idea that NR, upon reaching the brain, can alter the metabolism of relevant biological pathways involved in  like Alzheimer's. Their work was recently published in the journal Aging Cell.

Upon consumption, NR is readily converted into nicotinamide adenine dinucleotide (NAD+), which is critical to cellular repair and the repair of damaged DNA.

"NAD+ is gradually lost as we get older or develop . Loss of NAD+ is linked to obesity and other negative lifestyle habits like smoking," Martens said. "Because more NAD+ is needed to counteract those negative consequences, it's more likely to be depleted in the face of negative lifestyle habits."

Martens has been studying the compound since he was a postdoctoral fellow at the University of Colorado Boulder. In an initial study published in Nature, he found that levels of NAD+ could be boosted in the blood if people ingested NR, but it was not clear if it could reach other tissues in the body.

"We had some preliminary signs of efficacy, including  in people who had high blood pressure to begin with," he said. "But until now, it was unknown whether NR reached targeted organs like the brain to have a real therapeutic effect."

Measuring the level of NAD+ in the brain in humans is challenging. There are emerging techniques involving MRI, but these only provide an indirect measure and are costly and difficult to perform. Instead, Martens and colleagues measured NAD+ directly in tiny particles called extracellular vesicles that originated from neurons and ended up in the blood. These  can provide cutting-edge blood-based biomarkers for brain disorders and serve as a "liquid biopsy" of neurons, giving researchers a rare look at what's inside them.

"Each vesicle has a unique  on its surface, including proteins that give you clues about its origin," Martens said. "In our case, we selected vesicles that carry markers that are characteristic of neurons, and so we have confidence that the NAD+ we measured in them reflects what happens in the neurons, and by extension the brain."

Using samples from their first initial clinical trial, the researchers determined, first, that NAD+ levels went up in these vesicles after six weeks.

"When NAD+ goes up in these vesicles, we see an association with some of the biomarkers of neurodegenerative disease," Martens said. "Particularly, in people where we saw an increase in NAD+, we also saw changes in biomarkers like  beta and tau, which are both related to Alzheimer's disease," Martens said.

Martens and Kapogiannis also found a correlation between these neurodegenerative biomarkers and change in NAD+.

"If NAD+ went up a lot, there was typically a larger change in some of the disease biomarkers," Martens said. "That tells us the NAD+ is not only getting into the brain but it's likely also having some effect on its metabolism and multiple interrelated pathways."

Some of these blood-based biomarkers could be used down the road to determine if NAD+ depletion is a cause of Alzheimer's and other neurodegenerative diseases. It is even possible that these types of tests could become more accessible to the population for more routine testing.

Martens is leading a 12-week study involving NR in older adults with . The study is actively seeking more participants.

Through the study, Martens seeks to determine whether increased consumption of NR has an even larger effect in people with cognitive impairment.

"They're coming in with cognitive deficits, and as a result, are more likely to have an accumulation of some of these biomarkers in their , so there's a chance we'll see bigger reductions in these biomarkers because they have more of them in their cells," Martens said.

Nearly all drugs on the market for patients with Alzheimer's have only a modest effect on the symptoms but do not significantly stop the underlying progression of the disease.

"In our ongoing trial, we're measuring markers of cognitive function and other things related to functional independence and quality of life, but we're also hoping to gain some insight on the underlying disease process," Martens said. "We're hoping that the people who take the NR might have preserved function."

After proving its efficacy, Martens and Kapogiannis will test whether increased use of NR improves cognition, and ultimately, whether it can be used to slow neurodegenerative disease progression.

"We were among the first to do a chronic dosing study in humans, and as a result, we've been at the forefront of this field for a few years," Martens said. "Now, we're at a turning point, where we can start to determine whether NAD+ increases in other tissues as well, and that's likely where the more important signal will be in terms of resolving disease."

More information: Michael Vreones et al, Oral nicotinamide riboside raises NAD + and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin, Aging Cell (2022). DOI: 10.1111/acel.13754


https://medicalxpress.com/news/2023-02-link-supplement-biomarkers-alzheimer-brain.html

Poor balance may indicate changes in brain volume

 Historically, the brain has been known to change with age and disease. But now, researchers from Japan have found that the volume of a specific brain region is correlated with physical balance.

In a study recently published in Gait & Posture, researchers from the University of Tsukuba have revealed that the volume of the hippocampus is correlated with a measure of balance ability in healthy older people.

The hippocampus is involved in consolidating memory information about navigation, spatial awareness, and motor sequences. Recent studies have indicated that information from the , which regulates balance and the position of the body, is important for both hippocampal function and spatial memory. Although changes in the hippocampus have been linked to vestibular dysfunction, the  between balance and hippocampal volume is not well understood, which the researchers at the University of Tsukuba aimed to address.

"Postural balance requires the integration of different  systems," says senior author of the study Professor Tetsuaki Arai. "To comprehensively examine the  associated with balance, we wanted to first assess the characteristics of healthy older individuals."

To do this, the researchers asked a group of 30 healthy older adults to undergo tests of balance, cognition, and , which enabled them to evaluate hippocampal volume. Balance was measured using the index of postural stability (IPS) with the participants standing on various types of surfaces in "eyes open" and "eyes closed" conditions.

"The results were surprising," explains author Professor Miho Ota. "We found a  between balance function and the volume of specific regions of the hippocampus, known as the hippocampal subfields." This relationship was strongest for balancing on a soft surface with eyes closed.

"This study is the first to evaluate the connection between hippocampal volume and balance function in healthy older adults, and we obtained novel information about the nature of this relationship," says Professor Tetsuaki Arai.

The findings indicate that it may be possible to use the IPS to explore the relationship between vestibular function and balance in people with dementia. Furthermore, this study sets the stage for future research evaluating whether treatments for balance disorders can increase hippocampal volume, as well as whether  can be used to predict the outcomes of therapeutic interventions for balance disorders in people with dementia.

More information: Ryotaro Ide et al, Relationship between hippocampal subfields volume and balance function in healthy older adults, Gait & Posture (2023). DOI: 10.1016/j.gaitpost.2023.02.003


https://medicalxpress.com/news/2023-02-poor-brain-volume.html