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Monday, April 17, 2023

US Navy Sails Destroyer Through Taiwan Strait After China's War Games

 he US Navy sailed its guided-missile destroyer, the USS Milius, through the Taiwan Strait on Monday as part of a "freedom of navigation" exercise just days after China's large-scale military drills around Taiwan, reported Reuters

According to the Navy's 7th Fleet, the USS Milius conducted a "routine Taiwan Strait transit" through waters "where high-seas freedoms of navigation and overflight apply in accordance with international law." 

Last week, Beijing initiated a three-day military exercise around Taiwan on April 8, simulating targeted strikes and an island blockade. The drills were in reaction to Taiwan President Tsai Ing-wen's meeting with US House of Representatives Speaker Kevin McCarthy earlier this month

The 7th Fleet tweeted images of the destroyer sailing through the strait. 

"The ship transited through a corridor in the Strait beyond the territorial sea of any coastal State," the Navy said. It added the mission demonstrated the US commitment to a free and open Asia-Pacific region. 

In response, the Eastern Theatre Command of the Chinese military reported that they were monitoring the movements of the US warship.

According to a statement from the Eastern Theater Command's spokesperson Shi Yilu, China stands ready at any time to "resolutely safeguard the country's sovereignty, safety, and regional peace and stability." 

Meanwhile, Taiwan's defense ministry said it detected 18 Chinese military warplanes and four naval vessels operating around the island. 

https://www.zerohedge.com/geopolitical/us-navy-sails-destroyer-through-taiwan-strait-after-chinas-war-games

Anixa Biosciences Clarifies Poster Presentation on Company Website

  Anixa Biosciences, Inc. (NASDAQ: ANIX), a biotechnology company focused on the treatment and prevention of cancer today announced that a technical error was made by the company's website hosting service provider, causing a poster presentation unrelated to Anixa to be posted on the Corporate Presentations page of the company's website.  The correct presentation of the company's breast cancer vaccine clinical trial from the 2023 AACR Annual Meeting may be found on the Events page of the company's website at https://ir.anixa.com/events.

https://finance.yahoo.com/news/anixa-biosciences-clarifies-poster-presentation-192700976.html

AACR: Nurix presents on lead BTK degrader for the treatment of B-cell malignancies

  Nurix Therapeutics Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company developing targeted protein modulation drugs designed to treat patients with hematologic malignancies and solid tumors, today announced presentations covering its targeted protein degradation programs, including the structural disclosure of NX-2127 and new preclinical data for NX-2127 and NX-5948, highlighting their superior activity against acquired mutations in Bruton’s tyrosine kinase (BTK), a key therapeutic target in the treatment of B-cell malignancies. These data are being presented at the American Association for Cancer Research (AACR) Annual Meeting which is being held from April 14-19, 2023, in Orlando, FL.

https://www.biospace.com/article/releases/nurix-therapeutics-presents-data-at-the-american-association-for-cancer-research-aacr-annual-meeting-highlighting-activity-of-its-btk-targeted-protein-degraders-nx-2127-and-nx-5948-against-a-broad-range-of-btki-resistance-mutations/

Cutera Updates on Recent Steps to Protect Stockholder Interests

 The Special Committee of the Board of Directors (the “Special Committee”) ofCutera, Inc. (the “Company”) (Nasdaq: CUTR), a leading provider of aesthetic and dermatology solutions, today issued an open letter to stockholders.

The full text of the letter is as follows:

Dear Fellow Stockholders,

We are writing to you as five independent directors on the Cutera, Inc. Board of Directors (the “Five Independent Directors”)1 and as fellow stockholders of this promising company.

We want to be sure you have the facts about our efforts to protect your interests and the actions of the former Executive Chairman, J. Daniel Plants, to serve, by contrast, his own interests at the expense of stockholders.

Let us start by acknowledging that we serve on the Board at your pleasure and as your fiduciaries. We are elected each year by you and embrace the accountability that comes from knowing we are your representatives.

As you may know, Mr. Plants is seeking to remove us as directors at a Special Meeting of Stockholders. As you would expect, we have facilitated the scheduling of that meeting so that Cutera stockholders may consider Mr. Plants’ perspectives and his proposals. That said, the five of us are confident that all our actions have served stockholder interests and that, once you have been provided with the background to the current and unfortunate situation, you will agree.

The Board Decided to Replace David Mowry as CEO Due to Poor Execution and Ineffective Leadership

One of the most important responsibilities of any board is to ensure that the company has the right leadership to execute its strategy. While the Board recognizes and respects the strong relationships that David Mowry, then our Chief Executive Officer, has built with both our customers and our sales organization, during 2022, it became apparent to the Board that he was neither executing well nor enabling the Company to capitalize on its significant opportunities.

The Board, including Mr. Plants, was concerned about Mr. Mowry’s ability to build and retain a world-class executive team. Then, as a Board, we concluded that Mr. Mowry had not effectively executed the limited commercial rollout of our AviClear solution in the Fall of 2022. In our view, Mr. Mowry failed to appropriately train and incentivize our sales teams, accurately forecast demand and usage, or precisely develop commercial terms that our customers would accept. These missteps were unforced errors that diminished our confidence in Mr. Mowry’s ability to execute our attractive AviClear strategy.

In the months that followed, Mr. Mowry was not able to develop a budget for the business that was grounded on supportable assumptions in a timely fashion, and the budget process dragged into the new year. The Company’s inability to execute well was evident even from the outside; for example, Cutera filed its Form 10-K late.

As a Board, including Mr. Plants, we determined that we needed to hire a new Chief Executive for the Company and ramped up that process in late 2022.

Mr. Plants Desires to be Named CEO and Effectively Seize Control of the Company Without Paying a Premium

Mr. Plants, who had been serving as our Executive Chairman, expressed a strong desire to be named Cutera’s new CEO. (This was not the first time he had expressed such a desire; he had previously sought the role in 2020.) Despite the fact that Mr. Plants had never served as a CEO of an operating company, or in any other operating or executive position for that matter, the Board duly considered his interest.

For months, beginning in late 2022, three directors of the Board, including two of the Five Independent Directors and Joseph Whitters (another Cutera director with whom Mr. Plants has frequently collaborated at other companies), once again negotiated in good faith with Mr. Plants. However, it became apparent during our discussions that Mr. Plants was far more interested in his own personal enrichment than in leading the Company for the benefit of all stakeholders.

Mr. Plants sought compensation that was significantly higher than the pay package we had in place with Mr. Mowry and, our compensation consultant noted, would have immediately made Mr. Plants – a first-time CEO with no operating experience – one of the highest-paid executives in our peer group. Moreover, Mr. Plants sought off-market terms for governance that would have impaired the Board’s oversight and demanded significant change-of-control payments and upfront awards of equity.

The Five Independent Directors were surprised and disappointed by Mr. Plants’ persistent demands for special treatment in matters of company policy, compensation and governance. But we found those conversations with Mr. Plants to be revelatory: while Mr. Plants vigorously negotiated matters of compensation and personal privilege, he showed little concern for the cultural impact his demands for special treatment would likely engender. His focus was overwhelmingly on compensation and much less on developing a plan for the Company. In our experience, those are not the qualities or focus of great leaders.

The Board Decides to Hire an External Candidate and Mr. Plants Is Seeking Revenge

So, even as Mr. Mowry announced to the Board on February 22, 2023, that he was thinking about retiring as CEO given the strains of the job, the Board concluded Mr. Plants was not the appropriate permanent replacement.

As a result, Mr. Plants (according to information shared by Mr. Mowry) stopped showing up at the Company and pulled back from his duties as Executive Chairman, further validating his lack of regard for either his fiduciary duties or the welfare of the stockholders.

Over the ensuing period, Mr. Plants did everything he could to try to frustrate and delay the Board’s search process. And now, to exact retribution and further his own self-serving agenda, Mr. Plants is seeking to remove the Five Independent Directors who refused to let Mr. Plants strong-arm the Board into appointing him CEO.

In all events, Mr. Plants and Mr. Mowry have now published a series of public communications that blatantly mischaracterize Board deliberations in violation of their employment agreements and in breach of their fiduciary obligations as directors and officers under Delaware law. Mr. Plants and Mr. Mowry have been terminated for this misconduct.

The Path Forward

Mr. Plants is seeking to remove the Five Independent Directors, without cause. In our view, his goal is to create vacancies on the Board that he can then fill with hand-picked replacements who will, in turn, appoint Mr. Plants CEO. We think it would be a mistake for stockholders to give Mr. Plants that role, but he will have a chance to make his case to stockholders in June at the Special Meeting of Stockholders. While we regret the disagreements, we welcome the debate.

For our part, we believe Cutera’s next CEO should be an experienced operating executive who has uncompromising standards and the background to effectively execute the Company’s AviClear strategy and spearhead the pursuit of additional growth opportunities. We are committed to running a thorough but expeditious CEO search process to identify that candidate. To help us do so, we have retained a leading executive search firm.

In the meantime, the Board has appointed Sheila A. Hopkins as Interim CEO. While Ms. Hopkins is an accomplished executive, neither she nor any other of the Five Independent Directors is being considered for the role of permanent CEO. Ms. Hopkins intends to remain Interim CEO only until the Board appoints a successor, and no longer. To be clear, the only member of Cutera’s Board who has ever sought a permanent executive role at the Company is Mr. Plants.

Since stepping into the role of Interim CEO just a few days ago, Ms. Hopkins has been focused on stabilizing the organization. She has met with the leadership team and other employees. It is clear they share our enthusiasm for the AviClear strategy and are focused on executing.

The Five Independent Directors have full confidence in the foundational strength of the business, including the integrity of the Company’s financial statements. Ms. Hopkins expects to report First Quarter 2023 results in a timely manner in May, and the Cutera executive team will provide updated observations about our exciting opportunities and projected performance at that time. As directors, we remain as enthusiastic about the business as ever.

Our Commitment

We embrace our role as fiduciaries for stockholders and are committed to doing right by you, even when it is uncomfortable or complicated for us. Our mission is clear: maximize the value of Cutera for its stockholders by ensuring the Company is pursuing the right strategy with the right leadership team.

We will not waver from that mission, no matter how many false accusations are thrown our way.

The Five Independent Directors welcome stockholder feedback and look forward to engaging further over the coming weeks.

Until then, we will continue to work tirelessly on your behalf.

Sincerely,

The Five Independent Directors

Additional details will be made available in the Company’s definitive proxy statement to be filed with the SEC in connection with the Special Meeting. Stockholders are not required to take any action at this time.

https://www.biospace.com/article/releases/cutera-inc-s-special-committee-updates-stockholders-on-its-recent-steps-to-protect-stockholder-interests/

Spanish hospital carries out lung transplant using 4-armed robot dubbed 'Da Vinci'

 A Spanish hospital carried out a lung transplant using a pioneering technique with a robot and a new access route that no longer requires separating the ribs and opening up the chest, experts said on Monday.

Surgeons at Vall d'Hebron hospital in Barcelona used a four-arm robot dubbed "Da Vinci" to cut a small section of the patient's skin, fat and muscle to remove the damaged lung and insert a new one through an eight-centimetre incision in the lower part of the sternum, just above the diaphragm.

The new procedure is less painful for the patient, they said, as the wound closes easily, and is safer than the traditional method which requires a 30-centimetre incision and a very delicate post-operative period.

"We believe it is a technique that will improve patients' life quality, the post-surgery period and reduce pain. We hope this technique will eventually spread to more centres," Albert Jauregui, head of the Thoracic Surgery and Lung Transplants Department at Vall d’Hebron, told reporters on Monday.

Medical staff from Vall d'Hebron University Hospital conducts a robotic lung operation in Barcelona, Spain, on April 3, 2023. The operation was conducted using a four-armed robot dubbed "Da Vinci."

Medical staff from Vall d'Hebron University Hospital conducts a robotic lung operation in Barcelona, Spain, on April 3, 2023. The operation was conducted using a four-armed robot dubbed "Da Vinci." (Vall dHebron University Hospital/Handout via REUTERS)

The pioneering procedure, which until now has only been used to treat lung cancer, was performed on Xavier, a 65-year-old man who required a lung transplant due to pulmonary fibrosis.

Xavier said he benefited from the new technique.

"The result is that I can talk to you and tell a bit of my story," he said.

Spain is a global leader in organ transplants, with an average of 7 donors and 15 transplants per day in 2002, according to Spanish health ministry data.

https://www.foxnews.com/world/spanish-hospital-carries-lung-transplant-using-4-armed-robot-dubbed-da-vinci

14 million cases of type 2 diabetes linked to diet

 An estimated 14 million cases of type 2 diabetes were caused by a poor diet, a recent study published in Nature Medicine found.

Diets that lacked whole grains or had too much refined rice, wheat or processed meats were linked to the disease.

Those that included overconsumption of fruit juice or insufficient amounts of non-starchy vegetables, nuts or seeds also had some impact on diagnoses, though not as much.

The rise of type 2 diabetes cases represents “a growing burden on individuals, families, and healthcare systems,” a press release noted.

Type 2 diabetes occurs when the pancreas fails to produce enough insulin, impeding the body’s ability to regulate and use sugar as fuel.

More than 37 million Americans — about 1 in 10 — already have incurable diabetes, making it the seventh leading cause of death in the nation. 

In the new study, researchers at Tufts University analyzed the diets of 184 countries worldwide using data from 1990 and 2018, revealing that more than 70% of new diagnoses in 2018 were believed to have been caused by unhealthy dietary patterns.

More than 70% of new type 2 diabetes diagnoses in 2018 were believed to have been caused by unhealthy dietary patterns.
Shutterstock

Of the 184 countries included in the study, all reported a rise in type 2 diabetes in the nearly 30 years that were analyzed.

There is no cure for diabetes but a myriad of recommended lifestyle changes to help manage the condition, such as losing weight, exercising and eating well.

The research focused on 11 dietary factors and concluded that three had a disturbing influence on the rise of diabetes diagnoses.

“Our study suggests poor carbohydrate quality is a leading driver of diet-attributable type 2 diabetes globally, and with important variation by nation and over time,” said senior author Dariush Mozaffarian.

“These new findings reveal critical areas for national and global focus to improve nutrition and reduce devastating burdens of diabetes.”

The analysis also found that poor diets are leading to a larger proportion of men versus women, younger versus older adults, and urban versus rural residents being diagnosed with the chronic disease.

Central and Eastern Europe and Central Asia were found to have the highest rates of type 2 diabetes cases linked to diet.

Researchers noted that was likely due to data from countries including Poland and Russia, where diets were reported to incorporate high amounts of red meat, processed meat and potatoes.

“Left unchecked and with incidence only projected to rise, type 2 diabetes will continue to impact population health, economic productivity, health care system capacity, and drive heath inequities worldwide,” study author Meghan O’Hearn explained.

“These findings can help inform nutritional priorities for clinicians, policymakers, and private sector actors as they encourage healthier dietary choices that address this global epidemic.”

Overconsumption of rice and wheat was also found to have an oversized connection to the chronic disease.
Shutterstock
A collection of cold meats and vienna on a wooden board in a studio
Eating large quantities of processed meats was another major factor that research correlated to type 2 diabetes.
Shutterstock
This informational study comes as experts warn that type 2 diabetes cases are on track to surge 700% in young Americans.

The Centers for Disease Control and Prevention and the National Institutes of Health alerted the public that the number of young Americans with type 2 diabetes is projected to skyrocket nearly 700% by 2060 if current upward trends continue unchecked.

https://nypost.com/2023/04/17/14-million-cases-of-type-2-diabetes-linked-to-these-foods-study-says/

Hospital Sues AG Over Probe Into Transgender Care Services

 By Kelly Gooch of Becker's Hospital Review

Children's Mercy Hospital in Kansas City, Mo., is suing Missouri Attorney General Andrew Bailey over his demand for records and testimony on gender-affirming care, The Kansas City Star reported. 

The lawsuit, filed April 14 in Jackson County, asks a judge to deny Mr. Bailey's investigative demands, saying the requests are a "burdensome overreach" despite "no allegations of wrongdoing," according to the newspaper.  

Mr. Bailey's office made the demand for records and testimony in a letter sent in late March. In February, his office had already confirmed an investigation by Missouri agencies into whistleblower allegations against the Washington University Transgender Center at St. Louis Children's Hospital. The whistleblower raised allegations that individuals at the transgender center had harmed hundreds of children each year, including by using experimental drugs on them. 

Now, Mr. Bailey's office is also looking at Children's Mercy and made more than 50 requests for documents and information in his office's March 24 investigative demand letter to the hospital. Requests include all instances when child abuse was reported to law enforcement and questions of whether Children's Mercy prescribes hormone blockers for, or performs surgery on, transgender individuals, according to The Kansas City Star.

Madeline Sieren, a spokesperson for Mr. Bailey's office, said in a statement shared with the newspaper that Children's Mercy "is refusing to provide even a single document to explain its practices."

"That is very concerning," she said, adding that Mr. Bailey's office looks forward to "prevailing in this request for information and learning what is truly going on."

Children's Mercy argues that Mr. Bailey is not authorized to investigate and enforce medical standards under the state's merchandising practices act, and that complying with his requests would require the hospital to violate state and federal laws, including HIPAA, according to NBC affiliate KSHB. The system also said in its suit that it has no connection to the Washington University center under investigation. Children's Mercy is not mentioned in the allegations against Washington University Transgender Center, according to KSHB

The lawsuit filed April 14 comes after Mr. Bailey announced emergency rules targeting gender transition procedures for minors, which take effect April 27. The emergency regulations include prohibiting gender-affirming care unless patients have at least 15 sessions with a mental health provider and have experienced at least three consecutive years of a "medically documented, long-lasting, persistent and intense pattern of gender dysphoria." 

https://www.zerohedge.com/markets/hospital-sues-ag-over-probe-transgender-care-services