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Tuesday, August 8, 2023

Newsom Funded Chinese COVID Lab Known To Biden’s FDA

 by MarkPellin via Headline USA,

The discovery last month of a Chinese COVID biolab in California shocked the nation, but likely came as no surprise to the state’s Democrat governor, Gavin Newsom.

He helped fund it.

The now-notorious secret facility, which contained a massive stockpile of “infectious agents,” including coronavirus, and nearly a thousand dead lab mice and vials of unidentified biological fluids, also likely came as no surprise to the Biden administration.

The FDA last year issued a recall warning for nearly 54,000 COVID rapid tests manufactured by the company that owned the lab.

Fresno County officials discovered the “unlicensed laboratory” in a warehouse owned by Prestige Biotech, which has ties to multiple Chinese pharmaceutical firms and a president who lives in China and can only be reached by email.

The company’s CCP links extend to Barry Zhang, who is listed as Prestige BioTech’s registered agent by the Nevada secretary of state. Zhang reportedly was a leader of the Chinese-American Society of CPAs and its work with China’s United Front espionage and propaganda network.

The founder of the law firm representing Prestige BioTech, Michael M Lin, is reportedly “a regular sponsor of CCP’s United Front events in Nevada.”

Prestige Biotech took over the lab from Universal Meditech, after that company went bankrupt following a series of fires. Universal Meditech, a company that also has strong CCP ties, received nearly $400,000 in tax credits from Newsom’s Office of Business and Economic Development.

Before going bankrupt, Universal Meditech was awarded its business license from the Newsom administration, “exactly one year to the day before Gov. Gavin Newsom’s State of Emergency Order locking down the entire state over the COVID-19 virus.”

Universal Meditech continued operations under its new owner Prestige Biotech, which didn’t have a state business license and was only outed when someone noticed a garden hose illegally attached to the bio-lab’s building.

The nearly 1,000 dead mice found at the Prestige Biotech lab, “were genetically engineered to catch and carry the Covid-19 virus,” Wang Zhaolin, a spokesman for Prestige Biotech, told the San Joaquin Valley Sun.

“This is an unusual situation,” said Nicole Zieba, a city official with the town of Reedley, where the lab was found.

I’ve been in government for 25 years. I’ve never seen anything like this,” Zieba told local news outlet KTLA. “There was a special room that was built housing about 1,000 white lab mice.”

Those would be the same lab mice that “were genetically engineered to catch and carry the Covid-19 virus” housed in a secret warehouse owned by reported CCP United Front agents. The same company that manufactured 54,000 FDA-flagged COVID rapid tests and received hundreds of thousands of dollars from Newsom’s office a year before he put California on a lockdown enforced by his and the Biden administration’s tyrannical mandates.

“Allowing a Chinese company to practice gain-of-function research on our shores is like inviting biological warfare into our backyard,” said Rep. Mark Green, R-Tenn., who chairs the House Homeland Security Committee.

Based on legal filings, business reports and court documents, it appears that the CCP’s United Front accepted the invitation. Meanwhile, with his entourage of CCP connections funded by his administration in line, Newsom reportedly is raising millions to back a potential 2024 presidential run, even as he continues to publicly back Biden.

https://www.zerohedge.com/political/newsom-funded-chinese-covid-lab-known-bidens-fda

401(k) hardship withdrawals on the upswing as inflation squeezes consumers

 A growing number of Americans are making emergency withdrawals from their 401(k) retirement plans to cover a financial emergency amid chronically high inflation, according to new data from Bank of America. 

About 15,950 workers taking part in employer-sponsored 401(k) plans made a "hardship" withdrawal during the first three months of 2023, according to Bank of America's analysis of clients' employee benefits programs, which tracks about 4 million accounts. 

That marks an increase of about 36% from the second quarter of 2022. 

Hardship withdrawals allow workers to tap their 401(k) for an "immediate and heavy financial need." 

Individuals who make these types of withdrawals owe income tax on the money and could be hit with a 10% early withdrawal fee if they are under the age of 59½. However, the penalty can be waived if workers provide adequate evidence that the money is being used for a qualified hardship, such as a medical expense. 

Someone who takes a hardship withdrawal also cannot pay it back to his 401(k) and cannot roll that money into another retirement savings account. 

The increase in workers tapping their 401(k)s for emergency purposes comes as they confront stubbornly high inflation that has rapidly eroded their purchasing power.

The government reported last month that the consumer price index, a broad measure of the price for goods, including gasoline, groceries and rents, rose 3% in June compared with the previous year. Although the gauge is down from a peak of 9.1%, it remains above the pre-pandemic average. 

On top of that, there are other signs of underlying inflationary pressures within the economy, with core prices running at a pace more than twice the Fed's 2% target.

Americans are increasingly relying on their savings and racking up credit card debt to pay for necessities.

The Federal Reserve reported Tuesday total credit card debt surged to $1.03 trillion at the end of June, an increase of $45 billion, or 4.6% from the previous quarter. It marks the highest level on record in Fed data dating to 2003. 

The rise in credit card usage and debt is particularly concerning because interest rates are astronomically high right now. The average credit card annual percentage rate, or APR, hit a new record of 20.33% last week, according to a Bankrate database that goes back to 1985. The previous record was 19% in July 1991.

"One trillion dollars in credit card debt is staggering," said Matt Schulz, chief credit analyst at LendingTree. "Unfortunately, it is likely only going to keep growing from here."

https://www.foxbusiness.com/money/401k-hardship-withdrawals-upswing-inflation-squeezes-consumers

States Stop Credit Card Companies From Tracking Gun Purchases, Though It May Not Last

 by Patricia Tolson via The Epoch Times (emphasis ours),

Credit card companies were preparing to track the purchase of firearms and ammunition of every American citizen. While a flurry of bills lobbed by state legislators caused all of them to reconsider those plans, it may only be a temporary victory.

Almost one year ago, an effort was launched to create a new Merchant Category Code (MCC) to track the purchases of firearms and ammunition. However, inspired by the uproar of Second Amendment constituents, Republicans in the United States Senate, as well as lawmakers in several states, have launched legislative efforts that have successfully shut them down—for now.

On March 21, United States Sen. John Thune (R-S.D.) introduced SB 898. This bill prohibits the Internal Revenue Service from auditing a taxpayer based on the MCCs.

So far, seven states have joined the resistance.

On March 29, West Virginia Gov. Jim Justice approved House Bill 2004. In summary, the measure will "prevent the use of payment card processing systems for surveillance of Second Amendment activity and discriminatory conduct." The bill would also preclude financial institutions that violate this law from qualification in bidding on state contracts.

On April 6, Idaho Gov. Brad Little signed House Bill 295 into law, also prohibiting financial institutions from using MCCs to identify or track firearms purchases.

On April 16, Mississippi Gov. Tate Reeves approved HB1110. In addition to prohibiting the use of MCCs to identify or track firearms purchases in Mississippi, the measure prohibits state governmental agencies as well as public or private individuals from keeping any record or list of privately owned firearms or their owners. The legislation also warns that data collected from this MCC would almost inevitably end up in some federal government databases.

On April 29, North Dakota Gov. Doug Burgum signed HB1487 (pdf).

On May 12, Florida Gov. Ron DeSantis approved CS/SB 214.

On May 19, Montana Gov. Greg Gianforte signed SB359 into law.

On June 10, Texas Gov. Greg Abbott signed HB2837, which will become effective on Sept. 1. The measure will prohibit financial institutions operating in Texas from requiring or assigning a firearms code, defined as “any merchant category code approved by the International Organization for Standardization for a firearms retailer, including Merchant Category Code 5723.”

On July 13, California's legislators introduced a gutted and amended version of Assembly Bill 1587, originally introduced on Feb. 17 as a measure about the state's Health and Safety Code regarding multifamily housing, which now requires credit card issuers to use the MCC unique to retailers of firearms and ammunition.

'They're Not Finished'

West Virginia Delegate Chris Phillips (R) called the legislative effort in his state "a caucus priority."

"I think it's vitally important that we protect citizen's Constitutional rights from intrusion by government and big business," Mr. Phillips explained.

He also believes that such an MCC "would have a chilling effect" on an individual's willingness to risk purchasing a firearm and a retailer's willingness to sell them.

"We've seen a lot of gun dealers being targeted by credit card companies that refuse to process transactions for them," he said. "This opens that door far wider for that, I'm afraid."

Mr. Phillips also suggests the MCC effort has more to do with restricting gun rights than preventing any shootings.

"Unfortunately, I'm afraid the aim of gun control advocates isn't stopping mass shootings, it's gun control, and they will piecemeal it and take every inch they get until they take a mile," he said.

Idaho Rep. Ted Hill (R) said, "The whole idea was clearly a back door surveillance mechanism for lawful gun owners," that "isn't going to solve anything else but that."

While the bill got "a lot of pushback from the banks," Mr. Hill said it was "overwhelmingly passed," with 62 of Idaho's 70 delegates voting in support of the measure.

While those pushing the MCC appear to have backed down, Mr. Hill firmly believes "they're not finished."

"The Credit Card companies have been backing out on this initiative to track these codes as the penalties are significant and the risk is high," said Mr. Hill. "It's a short-term victory for now. We suspect that they will try again. They will try to figure out another way to do it."

The Background

On September 9, the Switzerland-based International Organization for Standardization (ISO) announced that it would create a new MCC specific to merchants who sell firearms and ammunition.

As explained by Merchant Maverick, an MCC is a four-digit number that identifies a type of business and the sort of goods or services they provide. MCCs are assigned by credit card companies and can affect the fees a card user is charged for credit card purchases. While the ISO determines MCC codes and their meanings, it is the credit card companies that assign the codes to individual merchants.

Those codes are then used by banks and payment service providers to assess risk and establish fees.

According to its website, the ISO is "an independent, non-governmental international organization" comprised of 168 members. The ISO has a history of promoting guidance (pdf) for "social responsibility" and advocating the idea that "respect for society and environment" is the “right thing” to do.

Representing the United States in the ISO is the American National Standards Institute (ANSI). According to ANSI's 2023 Roster (pdf), Kristina Breen of Visa International Service Association is on the Board of Directors.

'Our Duty to Report Suspicious Activity'

The new code was in response to a petition by Amalgamated Bank, self-described as a conglomerate of "political animals" who support "hundreds of progressive political organizations, campaigns and candidates" like "Biden/Harris," "Warren Democrats," and "Nancy Pelosi."

Announcing the ISO's approval of the petition on Sept. 9, 2022, Priscilla Sims Brown, President and CEO of Amalgamated Bank, said, "We all have to do our part to stop gun violence, and it sometimes starts with illegal purchases of guns and ammunition."

Without explaining how the new MCC would "stop gun violence," Ms. Sims said, "The new code will allow us to fully comply with our duty to report suspicious activity and illegal gun sales to authorities without blocking or impeding legal gun sales."

"This action answers the call of millions of Americans who want safety from gun violence and we are proud to have led the broad coalition of advocates, shareholders, and elected officials that achieved this historic outcome,” she said.

Second Amendment advocates say these codes will be used to intimidate gun owners and dealers will be used by banks to deny financial services to gun merchants. Those concerns are not unfounded.

In 2019, gun dealers testified before Congress alleging that banks denied their loan applications because the gun industry had been blacklisted through an inter-agency initiative called Operation Choke Point, a secret program created under the administration of Barack Obama. The program—which involved the Federal Deposit Insurance Corporation, the Consumer Financial Protection Bureau, the Department of Justice, and additional government agencies—served to cut off banking and financial services for any business or industry the administration deemed to be political adversaries. The program ended when Mr. Obama left office.

On Sept. 20, 2022, a total of 24 attorneys general sent a letter (pdf) to the heads of credit card companies, banks, Congress, and President Joe Biden advising, "We will marshal the full scope of our lawful authority to protect our citizens and consumers from unlawful attempts to undermine their constitutional rights."

"Please keep that in mind as you consider whether to proceed with adopting and implementing this Merchant Category Code," the letter concluded.

The Credit Card Companies

On Sept. 13, 2022, Visa shared its perspective of the proposed MCC.

"We do not believe private companies should serve as moral arbiters," reads the statement in part. "Asking private companies to decide what legal products or services can or cannot be bought and from what store sets a dangerous precedent. Further, it would be an invasion of consumers’ privacy for banks and payment networks to know each of our most personal purchasing habits. Visa is firmly against this."

According to its 2023 Roster (pdf), Kristina Breen of Visa International Service Association is on the Board of Directors.

In response to the litany of bills drafted in opposition to the new MCC, Visa announced in a March 9 update that "These legislative actions disrupt the intent of global standards and create significant confusion and legal uncertainty in the payments ecosystem regarding this code and its use, including with acquirers, issuers, merchants and payment networks. We have therefore decided to pause implementation of the MCC at this time."

Discover told Reason by email that it was also eliminating the new code, MCC 5723, from its April 1 Network Release.

American Express announced in a March Special Bulletin, "The pause of the enablement of the Merchant Category Code for Gun and Ammunition Shops, which was to be effective on April 14, 2023."

Citing the same reason, Mastercard also "decided to pause work on the implementation of the firearms-specific MCC."

'This Is Getting Overblown'

Amy Swearer, a senior legal fellow at The Heritage Foundation, understands "the concerns." But she believes "this is getting overblown on both sides both in terms of what gun control advocates claim the MCC is for and in terms of the actual threat that they pose."

"It won't accomplish any of the gun violence prevention strategies that gun control advocates claim," Ms. Swearer told The Epoch Times. "At the same time, it's limited in what it enables the government to do in terms of more restrictive gun controls or tracking gun sales than it already has the capacity to do."

She also noted the "variety of ways people can circumvent this."

"They can use a debit card. They can use cash," she said.

"Gun control advocates think that this would somehow allow credit card companies to flag what they call 'suspicious purchases," Ms. Swearer said. "But they never define what that means, what the next steps would be, or how that would actually lead to gun violence prevention in a way that's practical and effective without being completely insane and tyrannical and involve thousands of investigations into perfectly legitimate gun sales."

"That's part of the problem," Ms. Swearer asserted, saying that an MCC "can't tell you what was purchased."

"If you are trying to flag suspicious purchases, what constitutes a suspicious purchase when you don't know what the purchase was?" She asked rhetorically. "Was it a gun and ammo? Was it five guns on sale, or was it $600 worth of beef jerky and camping supplies? You just have no idea."

'Veiled Gun Control'

In a statement issued to The Epoch Times, the National Rifle Association (NRA) condemned the MCC effort.

"The NRA vehemently denounces the use of a firearm-specific Merchant Category Code (MCC), a clear infringement on the sacred Second Amendment rights of every American," said Billy McLaughlin, Digital Director and Spokesman for the Office of Executive Vice President Wayne Robert LaPierre, Jr. "Orchestrated by left-wing institutions and anti-gun lobbyists, this underhanded maneuver aims to bypass federal laws, effectively implementing a de facto national firearms registry and trampling the Constitution. Amid an environment where lawful gun sales already undergo rigorous scrutiny, this scheme represents an unprecedented assault on the privacy of law-abiding gun owners."

The NRA also commended the states of West Virginia, Idaho, Mississippi, North Dakota, Florida, Montana, and Texas "for their proactive legislation against the MCC intrusion," saying "their commitment to safeguarding liberties is inspiring and crucial in upholding our nation's values.

Katie Pointer Baney, the Managing Director of Government Affairs for the United States Concealed Carry Association (USCCA), reiterated the NRA's opinion, calling the MCC effort "veiled gun control."

"The new coding approved by the non-governmental agency called the ISO effectively takes firearms and ammunition purchases and codes them into a specific MCC in order to track those sales and to flag so-called suspicious or potential criminal activity," she explained, echoing Ms. Swearer's point of the measure's ambiguity.

"What are the criteria for suspicious activity, and how will flagging this prevent gun violence?"

"The USCCA is staunchly opposed to this effort," she asserted, adding that, while the credit card companies have backed down, "the conversation doesn't stop here."

"It's an important reminder to Americans why you need to continue to be involved in the legislative process and to ensure that your representatives are fighting to protect your Constitutional rights," Ms. Pointer Baney admonished. "This pause came because Americans across the country stood up and complained to their representatives and their state AGs. There was outrage over this proposal and it worked."

The Epoch Times reached out to Mastercard, Discover, Visa, American Express, the ISO, and the ANSI for comment.

Stroke rehab at home is near: Researchers create portable EEG headset

 The world of at-home stroke rehabilitation is growing near, incredible news for the 795,000 people in the United States who annually suffer a stroke. A new low cost, portable brain-computer interface that connects the brain of stroke patients to powered exoskeletons for rehabilitation purposes has been validated and tested at the University of Houston.

"We designed and validated a wireless, easy-to-use, mobile, dry-electrode headset for scalp electroencephalography (EEG) recordings for closed-loop brain–computer (BCI)  and internet-of-things (IoT) applications," reports professor Jose Luis Contreras-Vidal, Hugh Roy and Lillie Cranz Cullen Distinguished Professor of electrical and computer engineering, in the journal Sensors. Contreras-Vidal is an international pioneer in noninvasive  and robotic device inventions.

An EEG-based brain-computer interface (BCI) is a system that provides a pathway between the brain and external devices by interpreting EEG. In other words, the device reads your mind, interpreting the brain's activity to initiate robotic movement. Brain-machine interfaces based on scalp EEG also have the potential to promote cortical plasticity following stroke, which has been shown to improve motor recovery outcomes.

The adjustable headset, designed from commercial off-the-shelf components, can accommodate 90% of the population. There is a patent-pending on both the BCI algorithm and the self-positioning dry electrode bracket allowed for vertical self-positioning while parting the user's hair to ensure contact of the electrode with the scalp.

"We used a multi-pronged approach that balanced interoperability, cost, portability, usability, form factor, reliability and closed-loop operation," said Contreras-Vidal.

In the current prototype, five EEG electrodes were incorporated in the electrode bracket spanning the sensorimotor cortices and three skin sensors were included to measure eye movement and blinks. An inertial movement unit, measuring head motion, allows for a portable brain-body imaging system for BCI applications.

"Most commercial EEG-based BCI systems are tethered to immobile processing hardware or require complex programming or set-up, making them difficult to deploy outside of the clinic or laboratory without technical assistance or extensive training. A portable and wireless BCI system is highly preferred so it can be used outside lab in clinical and non-clinical mobile applications at home, work, or play," said Contreras-Vidal.

The invention solves an array of needs.

"Current commercial EEG amplifiers and BCI headsets are prohibitively expensive, lack interoperability, or fail to provide a high signal quality or closed-loop operation, which are vital for BCI applications," said Contreras-Vidal.

More information: Alexander Craik et al, Design and Validation of a Low-Cost Mobile EEG-Based Brain–Computer Interface, Sensors (2023). DOI: 10.3390/s23135930


https://medicalxpress.com/news/2023-08-rehab-home-portable-eeg-headset.html

Inhalation drug may prevent severe pneumonia

 Overly active immune cells are often behind lung damage in diseases such as COVID-19. Researchers at the Technical University of Munich (TUM) have developed an RNA agent for a lung spray that slows the activity of these cells, known as macrophages. A new, sugar-based transport mechanism is especially effective in bringing the therapeutic to its target.

The team led by Stefan Engelhardt, Professor of Pharmakology and Toxikology, has developed an RNA-based  called RCS-21 to prevent severe  inflammation and fibrosis, i.e., scarring of the , for example in SARS-CoV2 infections.

In the cell, RCS-21 stops the activity of the molecule microRNA 21. This nucleic acid, which Engelhardt and his team have been researching for a long time, is one of the triggers for the excessive activity of macrophages in severe lung infections.

Drug docks onto sugar receptors

Publishing in the scientific journal Nature Communications, the team describes how the active substance RCS-21 is delivered to its target particularly effectively via an inhaler. To do this, the researchers took advantage of a special feature of macrophages. These scavenger  are also present in large numbers in the healthy lung. There, they perform the important task of destroying bacteria and fungal spores as quickly as possible.

The macrophages identify their targets among other things based on complex sugar molecules on the surface of the invaders. "We have determined in  analyses that the corresponding sugar receptors are, on the one hand, among the most common receptors on macrophages," says Stefan Engelhardt. "On the other hand, the receptors are, in a sense, a unique feature of macrophages—they hardly occur anywhere else."

Therefore team coupled its active ingredient to a sugar molecule, or more precisely, to trimannose. This approach had so far only been pursued with chemically less complex active ingredients. Studies with mice produced clear results. "When the drug was administered as a spray, macrophages took up the active ingredient significantly better than without sugar molecules. In contrast, other  even outright exclude the molecules," says Christina Beck, first author of the article together with Deepak Ramanujam.

Active substance successfully tested

In experiments with mice, RCS-21 ensured that microRNA 21 was reduced by more than half compared to control animals. Fibrosis and inflammation were also significantly reduced after treatment. Increased microRNA-21 activity was also stopped by treatment with RCS-21 in samples of human lung tissue infected with the SARS-CoV-2 coronavirus in the laboratory.

Studies to prove the drug's safety are already underway, the first clinical trials in humans are targeted for 2024. Responsibility lies with RNATICS, a TUM spin-off.

RNATICS co-founder Stefan Engelhardt sees great potential in the mannose technology. "We were able to show that nucleic acid-based active substances can be used in a very targeted manner, at least in the lungs. This technology opens up a wide field for the development of novel RNA-based drugs. I expect a lot to happen in this area in the next few years."

More information: Christina Beck et al, Trimannose-coupled antimiR-21 for macrophage-targeted inhalation treatment of acute inflammatory lung damage, Nature Communications (2023). DOI: 10.1038/s41467-023-40185-1


https://medicalxpress.com/news/2023-08-inhalation-drug-severe-pneumonia.html

Modulating type 1 Interferon may expand treatment options for COVID-19

 In their continuing work to limit the impact of COVID-19, Emory University researchers have, for the first time in nonhuman primates, studied how modulating the signaling of type 1 Interferon (IFN-I), one of the body's initial defenses against infection, impacts SARS-CoV-2 viral replication and disease progression. The findings, which are reported in Science Immunology, demonstrate a critical role of IFN-I in SARS-CoV-2 infection and could help in the development of new treatment strategies for COVID-19.

Senior author Mirko Paiardini, Ph.D., led the study that showed while early antiviral IFN-I responses are crucial for restraining SARS-CoV-2 replication, excessive IFN-I signaling contributes to hyperinflammation in rhesus macaques. This  is a critical model for studying mild/moderate COVID-19 and is helping researchers discover information to limit the virus' impact, which the WHO COVID-19 Dashboard lists as nearly 767 million cases and nearly 7 million deaths.

"Our finding reinforces how critical it is to prevent or quickly treat excessive inflammation, which is considered the main cause of severe COVID-19," Paiardini says. He is division chief of Microbiology and Immunology at the Emory National Primate Research Center (EPC), professor of Pathology and Laboratory Medicine at Emory University School of Medicine and at the Emory Vaccine Center, co-director at the Emory Center for AIDS Research and the lead principal investigator of the ERASE-HIV Martin Delaney Collaboratory for HIV Cure Research.

Working in close collaboration with Paiardini on this study were Steve Bosinger, Ph.D., co-first authors Elise Viox, Timothy Hoang, Ph.D., and Amit Upadhyay, Ph.D., and R. Paul Johnson, MD. Bosinger is director of the EPC Nonhuman Primate Genomics Core and assistant professor in the Emory School of Medicine Department of Pathology & Lab Medicine. Johnson is director of the EPC

The researchers used a mutated version of interferon (IFNmod) to modulate IFN-I signaling in rhesus macaques before and during acute SARS-CoV-2 infection. Their results showed IFNmod treatment weakened antiviral and inflammatory gene expression and led to lower levels of inflammatory cytokines, substances that have an effect on other cells, in the lower airways and reduced lung pathology.

"We were also surprised to find IFNmod treatment had a profound effect on SARS-CoV-2 viral loads, with a 3,000-fold reduction in viral loads in the lower airways of treated animals," says Viox.

The research team dedicates this scientific publication in loving memory to co-first author Hoang whose commitment to this project and to  were crucial in propelling this study forward. Hoang is remembered for his intelligence, drive and love for science, and all of the lives he touched during his short but impactful career.

The research reported in this release is supported in part by the National Institutes of Health, including Office of the Director, Emory University, Fast Grants, a private foundation, the German Research Foundation and the German Federal Ministry for Research and Education.

More information: Elise G. Viox et al, Modulation of type I interferon responses potently inhibits SARS-CoV-2 replication and inflammation in rhesus macaques, Science Immunology (2023). DOI: 10.1126/sciimmunol.adg0033


https://medicalxpress.com/news/2023-08-modulating-interferon-treatment-options-covid-.html

New molecule could treat shingles, herpes viruses

You've seen the commercial. The one that ominously tells you if you had chickenpox as a child, the virus that causes shingles is already inside you.

It's creepy, but it's also a good way to prompt people to get the shingles vaccine. Unfortunately, the shot doesn't always keep you from getting shingles. It just mitigates the symptoms.

That's why University of Georgia researchers David Chu and Uma Singh have developed and patented a molecule to serve as a potential treatment for the varicella zoster , the type of herpes that causes both chickenpox and shingles.

A new study published in the Journal of Medicinal Chemistry found the molecule can effectively treat the uncomfortable lesions that accompany shingles and suggests the molecule may also work against the viruses that cause oral and genital herpes.

"Many viruses are becoming  to the current medications on the market," said Uma Singh, lead author of the study and a lecturer in UGA's College of Pharmacy. "There is a continuous need for new , and the one we developed, called POM-L-BHDU, shows much more potency against the virus than current ones."

The researchers also found that the molecule is safe for treating varicella zoster virus in .

Additionally, the molecule can be applied topically in addition to being taken orally or intravenously, making it a great option for a future cream-based medication for both shingles and other herpes outbreaks.

No effective treatments exist for herpes, shingles viruses

While several drugs are on the market to treat the viruses caused by the varicella zoster virus, they aren't particularly effective or can have potentially life-threatening side effects.

For example, cidofovir is an antiviral commonly used for viral eye infections and used off-label to treat warts and herpes. But it can accumulate in the kidneys and potentially cause them to fail in severe cases.

A topical medication using the patented molecule can better target localized outbreaks, preventing the virus from spreading to other areas of the body. Topical medications also limit the amount of a drug that is absorbed into the bloodstream and cut down significantly on side effects.

"We want to develop this as a broad-spectrum molecule," Singh said. "It acts against both the  and herpes simplex 1 and 2 viruses. For patients who want to take it in capsules, they could. Those who want to take it intravenously, they could. And those who want to use it topically, they can easily apply it at home."

The researchers hope the topical formula will be sold over the counter, enabling patients to easily access treatment in the privacy of their own homes without needing a prescription.

Molecule shows success against viruses in multiple models

The molecule has already proven effective in vitro and in vivo mouse models.

Topical studies on adult human skin indicate that POM-L-BHDU, 0.2% formulated in  is highly effective against both herpes simplex 1 and the varicella zoster viruses. (These results are currently unpublished.)

The next step is to get the molecule into phase 1 , something Singh hopes will happen in the next couple of years.

"We want to push this project as soon as possible into large-scale synthesis," Singh said. "It has the potential to benefit society on a large scale."

Recently, the UGA Research Foundation has licensed this molecule to a company called Anterogen Co.

More information: Uma S. Singh et al, Prodrug Strategies for the Development of β-l-5-((E)-2-Bromovinyl)-1-((2S,4S)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl))uracil (l-BHDU) against Varicella Zoster Virus (VZV), Journal of Medicinal Chemistry (2023). DOI: 10.1021/acs.jmedchem.3c00545


https://medicalxpress.com/news/2023-08-molecule-shingles-herpes-viruses.html