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Wednesday, December 13, 2023

Israel Orders Ports To Hide Online Shipping Schedules Due To Yemen Threat

 Via The Cradle,

Israel’s National Security Council issued an “urgent instruction” on Tuesday ordering Israeli ports to remove information on the arrival and departures of ships from their websitesGlobes newspaper reported. The directive comes in light of the recent Yemeni attacks on Israeli shipping and vessels headed towards Israel. 

"As soon as it becomes clear in the future that there is no longer a problem that must be taken into account, it will be possible to return to the previous situation immediately," Israeli officials told Globes.

The National Security Council’s instruction came the same day as a Yemeni naval attack, carried out by Yemen-based Houthis, on a Norweigan vessel north of the Bab al-Mandab strait. The ship was carrying oil and was en route to Italy. 

However, the Norwegian ship was scheduled to dock in Israel’s Ashdod port next month. "Before attacking the STRINDA, the Houthis would have been able to discover that the Norwegian ship was calling at Ashdod through a simple Internet search," Globes writes. 

Ansarallah and Yemen’s Armed Forces have launched numerous drone and missile attacks on Israeli targets since the Gaza-Israel war began in October, particularly on the southern-occupied port of Eilat. 

As part of its operations in solidarity with Palestine, Sanaa’s forces have declared war on Israeli shipping in the Red and Arabian seas and elsewhere. Since November 19, Yemen has seized one Israeli-linked ship and has launched drone attacks against at least two others.

The missile attack on the Norweigan STRINDA ship comes days after Yemeni Armed Forces spokesman Yahya Saree announced that Yemen will prevent the passage of any vessel headed for Israel in the Red and Arabian Seas if food and medicine do not enter the Gaza Strip. 

The announcement was a response to the US veto of a UN resolution calling for a ceasefire in Gaza. As a result of Yemen’s naval operations, shipping companies, including Israeli firm Zim and others, have resorted to price hikes and costly reroutes around Africa

Zim’s new ZMP route, which connects ports in China with Turkiye, recently said that its 12 vessels will not pass through the Red Sea. The cost of shipping in the Red Sea, in general, is on the rise due to Yemen’s maritime campaign, industry sources told Reuters this week. 

War risk premiums – required to be paid by vessels sailing through high-risk areas – have risen this week to up to 0.2 percent of the value of a ship, from 0.007 percent last week, market estimates showed, translating “into tens of thousands of dollars of additional costs for a seven-day voyage,” Reuters reported.

"These attacks have the potential to become far more of a global strategic economic threat than simply a regional geopolitical one," said Duncan Potts, a former vice admiral in the British navy. 

https://www.zerohedge.com/geopolitical/israel-orders-ports-hide-online-shipping-schedules-due-yemen-threat

Biden ‘familiar’ with Hunter’s plan to disregard congressional subpoena over foreign dealings: White House

 President Biden knew ahead of time that his son Hunter would make a plea to the media Wednesday morning instead of complying with a congressional subpoena for his testimony, the White House confirmed.

“The president was certainly familiar with what his son was going to say and I think what you saw was from the heart, from his son,” press secretary Karine Jean-Pierre said during her regular briefing.

Jean-Pierre declined to say whether the 81-year-old president, who was a senator for 36 years, approved of his 53-year-old son’s plans to flout the legally binding demand that he sit for questions about his foreign business dealings.

“Look, I don’t have anything else to add,” Jean-Pierre added in response to follow-up questions. “The president was familiar with what Hunter was going to say today. And he’s proud of his son.”

Hunter’s refusal to comply came ahead of an expected Wednesday evening vote by the full House of Representatives to authorize an impeachment inquiry into the president for his alleged role in Hunter’s and first brother James Biden’s foreign dealings during his eight-year vice presidency.

The first son said in his five-minute speech that “my father was not financially involved in my business” — despite evidence of Joe Biden meeting with Hunter’s Chinese, Kazakhstani, Mexican, Russian and Ukrainian associates while vice president.

U.S. President Joe Biden's son Hunter Biden talks to reporters outside the U.S. Capitol on Dec. 13, 2023 in Washington, DC.
U.S. President Joe Biden’s son Hunter Biden talks to reporters outside the U.S. Capitol on Dec. 13, 2023 in Washington, DC.Getty Images

Republicans argued that formalizing the inquiry, which began Sept. 12, would strengthen congressional power to compel testimony from Hunter and others, including James Biden, who also did not appear for a scheduled deposition last week.

Jean-Pierre also reaffirmed Wednesday that Biden does not plan to pardon Hunter, who faces federal gun charges in Delaware and tax fraud charges in Los Angeles after walking away from a probation-only plea deal — after demanding courtroom assurances of immunity for other conduct, such as possible violations of the Foreign Agents Registration Act, which would implicate his father.

“The president is not going to pardon his son,” the press secretary said

https://nypost.com/2023/12/13/news/biden-familiar-with-hunter-plan-for-subpoena-flouting-speech-white-house-admits/

'High-Dose Recombinant Flu Vax Offers More Protection for Adults 50 to 64'

 A high-dose recombinant influenza vaccine (Flublok Quadrivalent) was more protective than an egg-based standard-dose influenza vaccine in adults, according to results of a cluster-randomized, observational study

opens in a new tab or window.

Among adults ages 50 to 64, the high-dose vaccine was 15.3% more effective in preventing influenza than the standard-dose vaccine (95% CI 5.9-23.8, P=0.002) and 15.7% more effective against influenza A (95% CI 6.0-24.5, P=0.002), reported Nicola Klein, MD, PhD, from the Kaiser Permanente Vaccine Study Center in Oakland, California, and colleagues in the New England Journal of Medicineopens in a new tab or window.

Although the relative benefit of the high-dose vaccine appears to be modest, "reducing breakthrough influenza cases by 15% would provide a substantial public health benefit, especially during more severe influenza seasons," Klein told MedPage Today in an email.

Georges Benjamin, MD, executive director of the American Public Health Association in Washington, D.C., agreed. "The high-dose vaccine increased protection by about 15% overall," he told MedPage Today in an interview. "When you think about the fact that we don't usually get more than 40% to 50%, maybe 60% efficacy in a good year to begin with, that's a nice boost. The study authors convinced me, that for this age range, it does provide better protection than the standard dose," he said.

Researchers did not find that the recombinant vaccine was significantly more protective than the standard-dose vaccine against influenza-related hospitalization. However, "a post hoc analysis combining hospitalization for PCR-confirmed influenza and hospitalization for community-acquired pneumonia yielded a relative vaccine effectiveness of 19.7% (95% CI 2.8-33.7)," the authors wrote.

The Advisory Committee on Immunization Practices (ACIP) currently recommendsopens in a new tab or window high-dose influenza vaccines for adults ages 65 and older. However, for people younger than 65, ACIP does not preferentially recommend any age-appropriate influenza vaccine over another. Recommended options for this age group include inactivated influenza vaccine, recombinant influenza vaccine, or live attenuated influenza vaccine.

The high-dose recombinant influenza vaccine evaluated in this trial is FDA-approved for adults 18 and olderopens in a new tab or window, and is three times the dose of standard-dose influenza vaccines.

Participants included all members of a large U.S.-based integrated healthcare delivery system over seven geographic regions. The study population included 1,630,328 people from the ages of 18 and 64 who were vaccinated for influenza in the healthcare system -- 632,962 received the high-dose recombinant vaccine and 997,366 received the standard-dose vaccine.

Although the study was observational, it had a unique cluster-randomized design "intended to emulate a randomized trial," the authors wrote. Facilities in each region were assigned to Block A or Block B to even out differences in facility size. To achieve balance between the two vaccine groups, facilities alternated on a weekly basis between administering the high-dose recombinant vaccine and the standard dose vaccine. Patients were unaware of which vaccine they received.

During the study period of the 2018-2019 and 2019-2020 influenza seasons, 1,386 cases of PCR-confirmed influenza were diagnosed in the recombinant-vaccine group and 2,435 cases in the standard-dose group. Among those who were ages 50 to 64, 559 participants (2 cases per 1000) tested positive for influenza in the recombinant-vaccine group and 925 participants (2.34 cases per 1000) tested positive in the standard-dose group.

The study data were limited to two influenza seasons and relative vaccine effectiveness may vary across seasons, the researchers acknowledged. In addition, participants included in the study might not be representative of other U.S. populations.

Disclosures

The study was funded by Sanofi.

Klein has received grants from GlaxoSmith Kline, Merck, Pfizer, and Sanofi Pasteur.

Co-authors reported no relevant disclosures.

Benjamin also reported no relevant disclosures.

Primary Source

New England Journal of Medicine

Source Reference: opens in a new tab or windowHsiao A, et al "Recombinant or standard-dose influenza vaccine in adults under 65 years of age" N Eng J Med 2023; DOI: 10.1056/NEJMoa2302099.


https://www.medpagetoday.com/infectiousdisease/uritheflu/107842

Biden says COP28 reached ‘historic milestone’ as Gore sees it on verge of ‘complete failure’

 President Biden and former Vice President Al Gore appear to have offered vastly different assessments of the 28th United Nations Climate Change Conference, or COP28 summit, that ended Wednesday with world leaders agreeing to move away from fossil fuels.

The president heralded the commitment as "another historic milestone." 

"While there is still substantial work ahead of us to keep the 1.5 degrees C [Celsius or 2.7 Fahrenheit] goal within reach, today’s outcome puts us one significant step closer," Biden said in a statement

Biden Gore photos

President Joe Biden, left, speaks during a meeting of the National Infrastructure Advisory Council in the Indian Treaty Room at the White House. Al Gore, former U.S. vice president, speaks to The Associated Press at the COP28 U.N. Climate Summit, Sun (AP / AP Images)

He deemed the climate crisis "the existential threat of our time," but was confident America would turn this crisis into an opportunity that creates clean energy jobs, revitalizes communities, and improves the quality of life. 

But Gore has made a more somber assessment. On Monday, he lamented in a post on X that COP28 was "on the verge of complete failure." 

"The world desperately needs to phase out fossil fuels as quickly as possible, but this obsequious draft reads as if OPEC dictated it word for word," Gore posted, arguing that it puts "Petrostates" in the driver’s seat. 

"In order to prevent COP28 from being the most embarrassing and dismal failure in 28 years of international climate negotiations, the final text must include clear language on phasing out fossil fuels," Gore added. 

On Wednesday, nearly 200 countries present at COP28 agreed for the first time to move away from planet-warming fossil fuels, though many warned of significant shortcomings in the agreement.

COP28 President Sultan Ahmed Al Jaber at podium

Sultan Ahmed Al Jaber, President of the COP28 Conference, speaks during a plenary session Wednesday in Dubai, United Arab Emirates.  (Fadel Dawod/Getty Images / Getty Images)

The agreement was approved without the floor fight many feared and is stronger than a draft floated earlier in the week that angered several nations. But it didn't call for an outright phasing out of oil, gas, and coal, and it gives nations significant wiggle room in their "transition" away from those fuels.

Gore called the decision to link the climate crisis to the fossil fuel crisis an "important milestone," even if "it is also the bare minimum we need." 

"The influence of petrostates is still evident in the half measures and loopholes included in the final agreement," Gore said. 

The document is the central part of the 2015 Paris accord and its internationally agreed-upon goal to try to limit warming to 1.5 degrees Celsius [2.7 Fahrenheit] above pre-industrial times. The goal is mentioned 13 times in the document. 

The deal says that the transition would be done in a way that gets the world to net-zero greenhouse gas emissions — where emissions entering the atmosphere are balanced by those removed — in 2050, and carbon pollution to peak by the year 2025, but gives wiggle room to individual nations like China to peak later.

It was the third version presented in about two weeks and the word "oil" does not appear anywhere in the 21-page document. "Fossil fuels" appears twice.

https://www.foxbusiness.com/politics/biden-says-cop28-reached-historic-milestone-al-gore-deems-negotiations-verge-complete-failure

Codexis, Aldevron in Licensing Agreement for Codex® HiCap RNA Polymerase

 Aldevron will acquire a global exclusive license to Codexis’ Codex® HiCap RNA Polymerase. Under the terms of the deal, Aldevron will receive global manufacturing and commercialization rights to the Codex® HiCap RNA Polymerase and Codexis will receive payments for near-term technical milestones, along with commercial milestones and sales-based royalties. Codexis and Aldevron will work together to ensure a smooth changeover for customers during a transitional period.

https://www.globenewswire.com/news-release/2023/12/13/2795874/24825/en/Codexis-and-Aldevron-Enter-Exclusive-Licensing-Agreement-for-Codex-HiCap-RNA-Polymerase.html

Streamline Signs new RevID™ Contract with 2,300-Bed Health System

 2,300-bed, Maryland-based health system to leverage RevID’s automated charge reconciliation for improved financial performance

https://www.globenewswire.com/news-release/2023/12/13/2795891/0/en/Streamline-Health-Announces-Signing-of-new-RevID-Contract-with-2-300-Bed-Health-System.html

Priority Review to Amgen's Tarlatamab Application for Advanced Small Cell Lung Cancer

 Currently There are no Approved Therapeutic Options for Third-Line Treatment of Advanced SCLC1

If Approved, Tarlatamab Would be the First BiTE® Therapy for a Major Solid Tumor

FDA Target Action Date is June 12, 2024

https://www.prnewswire.com/news-releases/fda-grants-priority-review-to-amgens-tarlatamab-application-for-advanced-small-cell-lung-cancer-302014639.html