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Tuesday, February 6, 2024

Gilead quarterly revenue drops 4%, oral COVID drug fails trial

 Gilead Sciences on Tuesday said its fourth-quarter revenue dipped 4% on lower sales of HIV drugs and Veklury, an infused drug for hospitalized COVID-19 patients, while its adjusted profit rose 3% due to lower expenses.

Gilead also said a large trial of its experimental oral COVID antiviral drug, obeldesivir, did not meet its primary goal.

"The average time to symptoms alleviation is now less than a week in people who are getting the placebo," Gilead's Chief Medical Officer Merdad Parsey said, adding that vaccination rates and increasing immunity to the virus have shortened the overall duration and severity of COVID symptoms.

Gilead's fourth-quarter revenue totaled $7.1 billion, in line with analysts' estimates, according to LSEG data.

Adjusted profit per share rose to $1.72 from $1.67 a year earlier, but just missed analyst expectations of $1.73 per share.

Net earnings per share decreased to $1.14 a share from $1.30 a year earlier.

HIV product sales for the quarter fell 2% to $4.7 billion due to a increase in sales to government-run programs that receive price discounts.

Quarterly sales of HIV drug Biktarvy rose 7% to $3.1 billion, which was slightly below analysts' estimates of $3.2 billion. Veklury sales fell 28% to $720 million, but still came in above Wall Street expectations of $519 million.

Oncology sales rose 24% to $765 million.

For full-year 2024, Gilead said it expects adjusted earnings of $6.85 to $7.25 per share on product sales of $27.1 billion to $27.5 billion. Analysts have projected 2024 earnings of $7.24 per share on revenue of $27.7 billion.

https://finance.yahoo.com/news/gilead-quarterly-revenue-drops-4-210620406.html

Inspire Medical 2023 Financial Results and Reaffirms 2024 Outlook

 Inspire Reports First Quarter with Operating Income and Year-over-Year

Revenue Growth of 40% in the Fourth Quarter

 Inspire Medical Systems, Inc. (NYSE: INSP) (Inspire), a medical technology company focused on the development and commercialization of innovative, minimally invasive solutions for patients with obstructive sleep apnea, today reported financial results for the quarter and year ended December 31, 2023.

Recent Business Highlights and Full Year 2024 Guidance

  • Generated revenue of $192.5 million in the fourth quarter of 2023, a 40% increase over the same quarter last year, and revenue of $624.8 million in full year 2023, a 53% increase over full year 2022
  • Achieved gross margin of 85.4% in the fourth quarter of 2023
  • Reported net income of $14.8 million and diluted net income per share of $0.49 in the fourth quarter of 2023
  • Activated 78 new U.S. centers in the fourth quarter of 2023, bringing the total to 1,180 U.S. medical centers providing Inspire therapy
  • Created 13 new U.S. sales territories in the fourth quarter of 2023, bringing the total to 287 U.S. sales territories
  • Reaffirms full year 2024 revenue to be in the range of $775 million to $785 million, which would represent year-over-year growth of approximately 24% to 26%

Arvinas and Pfizer’s Breast Cancer Therapy) Receives FDA Fast Track

 Arvinas, Inc. (Nasdaq: ARVN) and Pfizer Inc. (NYSE: PFE) today announced that the U.S. Food and Drug Administration (FDA) has granted Fast Track designation for the investigation of vepdegestrant (ARV-471) for monotherapy in the treatment of adults with estrogen receptor (ER) positive/human growth epidermal growth factor 2 (HER2) negative (ER+/HER2-) locally advanced or metastatic breast cancer previously treated with endocrine-based therapy. Vepdegestrant is a novel oral PROteolysis Targeting Chimera (PROTAC®) ER degrader that is being jointly developed by Arvinas and Pfizer.

https://www.globenewswire.com/news-release/2024/02/06/2824113/0/en/Arvinas-and-Pfizer-s-Vepdegestrant-ARV-471-Receives-FDA-Fast-Track-Designation-for-the-Treatment-of-Patients-with-ER-HER2-Metastatic-Breast-Cancer.html